TNFRSF13C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFRSF13C
Entrez Gene ID	115650
Full Name	TNF receptor superfamily member 13C
Synonyms	BAFF-R,BAFFR,BROMIX,CD268,CVID4,prolixin
General protein information	Preferred Names TNF receptor superfamily member 13C Names tumor necrosis factor receptor superfamily member 13C B cell-activating factor receptor BAFF receptor BLyS receptor 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.2
Summary	B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008].
Disorder MIM:	606269
Disorder Html:	Immunodeficiency, common variable, 4, 613494 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_052945.3	NP_443177.1	tumor necrosis factor receptor superfamily member 13C

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TNFRSF13C	XP_001154286.1
Mus musculus (house mouse)	Tnfrsf13c	NP_082351.1
	LOC712577	XP_001101623.2
Homo sapiens (human)	TNFRSF13C	NP_443177.1
Rattus norvegicus (Norway rat)	Tnfrsf13c	XP_576316.2

Gene Ontology
Bibliography

Related articles in PubMed

Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
Bloom DD, Reshetylo S, Nytes C, Goodsett CT, Hematti P
Journal of immunotherapy (Hagerstown, Md. : 1997)(2018 Jan)

B cell activating factor (BAFF) and BAFF receptors: fakes and facts.
Ferraccioli G, Gremese E
Clinical and experimental immunology190(3)291-292(2017 Dec)

B cell phenotypes in patients with rheumatoid arthritis relapsing after rituximab: expression of B cell-activating factor-binding receptors on B cell subsets.
Becerra E, De La Torre I, Leandro MJ, Cambridge G
Clinical and experimental immunology190(3)372-383(2017 Dec)

TNFRSF13C (BAFFR) positive blasts persist after early treatment and at relapse in childhood B-cell precursor acute lymphoblastic leukaemia.
Fazio G, Turazzi N, Cazzaniga V, Kreuzaler M, Maglia O, Magnani CF, Biagi E, Rolink A, Biondi A, Cazzaniga G
British journal of haematology(2017 Jun)

Profile of BAFF and its receptors' expression in lupus nephritis is associated with pathological classes.
Suso JP, Posso-Osorio I, Jim?nez CA, Naranjo-Escobar J, Ospina FE, S?nchez A, Ca?as CA, Tob?n GJ
Lupus961203317739132(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) do not change
Title: B cell activating factor (BAFF) and BAFF receptors: fakes and facts.

Relationships between serum BAFF and BBR expression [(BAFFR, calcium signal modulating cyclophilic ligand interactor (TACI) and B cell maturation antigen (BCMA)] were determined on B cell subsets, defined using immunoglobulin (Ig)D/CD38. Twenty pre-RTX and 18 rheumatoid arthritis patients relapsing after B cell depletion were included.
Title: B cell phenotypes in patients with rheumatoid arthritis relapsing after rituximab: expression of B cell-activating factor-binding receptors on B cell subsets.

up-regulated expression in intractable temporal lobe epilepsy
Title: Up-regulated BAFF and BAFF receptor expression in patients with intractable temporal lobe epilepsy and a pilocarpine-induced epilepsy rat model.

Inhibition of ADAM10 augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 increases BAFFR expression levels.
Title: BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.

The expression levels of serum BAFF and the three receptors (TACI, BCMA and BAFF-R) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls.
Title: The Correlation Between Non-Hodgkin Lymphoma and Expression Levels of B-Cell Activating Factor and Its Receptors.

The following TNFRSF13C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF13C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu24299	NM_052945.3 Latest version!	Homo sapiens TNF receptor superfamily member 13C (TNFRSF13C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFRSF13C ( NM_052945.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_443177.1 Homo sapiens TNF receptor superfamily member 13C (TNFRSF13C), mRNA.

Price & Availability↑

CloneID	OHu24299
Clone ID Related Accession (Same CDS sequence)	NM_052945.3
Accession Version	NM_052945.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	tumor necrosis factor receptor superfamily member 13C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z99716.4. This sequence is a reference standard in the RefSeqGene project. On Mar 13, 2008 this sequence version replaced NM_052945.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF373846.1, SRR1163657.117046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2155751 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGGCGAG GGCCCCGGAG CCTGCGGGGC AGGGACGCGC CAGCCCCCAC GCCCTGCGTC 
CCGGCCGAGT GCTTCGACCT GCTGGTCCGC CACTGCGTGG CCTGCGGGCT CCTGCGCACG 
CCGCGGCCGA AACCGGCCGG GGCCAGCAGC CCTGCGCCCA GGACGGCGCT GCAGCCGCAG 
GAGTCGGTGG GCGCGGGGGC CGGCGAGGCG GCGCTGCCCC TGCCCGGGCT GCTCTTTGGC 
GCCCCCGCGC TGCTGGGCCT GGCACTGGTC CTGGCGCTGG TCCTGGTGGG TCTGGTGAGC 
TGGAGGCGGC GACAGCGGCG GCTTCGCGGC GCGTCCTCCG CAGAGGCCCC CGACGGAGAC 
AAGGACGCCC CAGAGCCCCT GGACAAGGTC ATCATTCTGT CTCCGGGAAT CTCTGATGCC 
ACAGCTCCTG CCTGGCCTCC TCCTGGGGAA GACCCAGGAA CCACCCCACC TGGCCACAGT 
GTCCCTGTGC CAGCCACAGA GCTGGGCTCC ACTGAACTGG TGACCACCAA GACGGCCGGC 
CCTGAGCAAC AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443177.1
CDS	45..599
Translation	MRRGPRSLRGRDAPAPTPCVPAECFDLLVRHCVACGLLRTPRPKPAGASSPAPRTALQPQESVGAGAGEAALPLPGLLFGAPALLGLALVLALVLVGLVSWRRRQRRLRGASSAEAPDGDKDAPEPLDKVIILSPGISDATAPAWPPPGEDPGTTPPGHSVPVPATELGSTELVTTKTAGPEQQ

Target ORF information:

RefSeq Version	NM_052945.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF receptor superfamily member 13C (TNFRSF13C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052945.3

ORF Insert Sequence:

ATGAGGCGAG GGCCCCGGAG CCTGCGGGGC AGGGACGCGC CAGCCCCCAC GCCCTGCGTC 
CCGGCCGAGT GCTTCGACCT GCTGGTCCGC CACTGCGTGG CCTGCGGGCT CCTGCGCACG 
CCGCGGCCGA AACCGGCCGG GGCCAGCAGC CCTGCGCCCA GGACGGCGCT GCAGCCGCAG 
GAGTCGGTGG GCGCGGGGGC CGGCGAGGCG GCGCTGCCCC TGCCCGGGCT GCTCTTTGGC 
GCCCCCGCGC TGCTGGGCCT GGCACTGGTC CTGGCGCTGG TCCTGGTGGG TCTGGTGAGC 
TGGAGGCGGC GACAGCGGCG GCTTCGCGGC GCGTCCTCCG CAGAGGCCCC CGACGGAGAC 
AAGGACGCCC CAGAGCCCCT GGACAAGGTC ATCATTCTGT CTCCGGGAAT CTCTGATGCC 
ACAGCTCCTG CCTGGCCTCC TCCTGGGGAA GACCCAGGAA CCACCCCACC TGGCCACAGT 
GTCCCTGTGC CAGCCACAGA GCTGGGCTCC ACTGAACTGG TGACCACCAA GACGGCCGGC 
CCTGAGCAAC AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
Journal of immunotherapy (Hagerstown, Md. : 1997)(2018 Jan)
Bloom DD,Reshetylo S,Nytes C,Goodsett CT,Hematti P

B cell activating factor (BAFF) and BAFF receptors: fakes and facts.
Clinical and experimental immunology190(3)291-292(2017 Dec)
Ferraccioli G,Gremese E

B cell phenotypes in patients with rheumatoid arthritis relapsing after rituximab: expression of B cell-activating factor-binding receptors on B cell subsets.
Clinical and experimental immunology190(3)372-383(2017 Dec)
Becerra E,De La Torre I,Leandro MJ,Cambridge G

TNFRSF13C (BAFFR) positive blasts persist after early treatment and at relapse in childhood B-cell precursor acute lymphoblastic leukaemia.
British journal of haematology(2017 Jun)
Fazio G,Turazzi N,Cazzaniga V,Kreuzaler M,Maglia O,Magnani CF,Biagi E,Rolink A,Biondi A,Cazzaniga G

Profile of BAFF and its receptors' expression in lupus nephritis is associated with pathological classes.
Lupus961203317739132(2017 Jan)
Suso JP,Posso-Osorio I,Jim?nez CA,Naranjo-Escobar J,Ospina FE,S?nchez A,Ca?as CA,Tob?n GJ

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TNFRSF13C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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