KCTD12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCTD12
Entrez Gene ID	115207
Full Name	potassium channel tetramerization domain containing 12
Synonyms	C13orf2,PFET1,PFETIN
General protein information	Preferred Names potassium channel tetramerization domain containing 12 Names BTB/POZ domain-containing protein KCTD12 potassium channel tetramerisation domain containing 12 predominantly fetal expressed T1 domain testicular tissue protein Li 100
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q22.3
Disorder MIM:	610521

mRNA and Protein(s)

mRNA	Protein	Name
NM_138444.3	NP_612453.1	BTB/POZ domain-containing protein KCTD12
NM_138444.4	NP_612453.1	BTB/POZ domain-containing protein KCTD12

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCTD12	NP_612453.1
Pan troglodytes (chimpanzee)	KCTD12	XP_001137708.2
Bos taurus (cattle)	KCTD12	XP_005213929.1
Rattus norvegicus (Norway rat)	Kctd12	XP_006252482.1
Danio rerio (zebrafish)	kctd12.1	NP_919386.1
Canis lupus familiaris (dog)	KCTD12	XP_542614.3
	KCTD12	XP_001085454.1
Danio rerio (zebrafish)	kctd12.2	NP_001029191.1
Mus musculus (house mouse)	Kctd12	NP_808383.3
Xenopus tropicalis (tropical clawed frog)	kctd12	NP_001096456.1

Gene Ontology
Bibliography

Related articles in PubMed

KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Zhong Y, Yang J, Xu WW, Wang Y, Zheng CC, Li B, He QY
Oncogene36(44)6177-6189(2017 Nov)

Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells.
Luo L, Cui J, Feng Z, Li Y, Wang M, Cai Y, Wu Y, Jin J
Oncology reports37(2)871-878(2017 Feb)

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
Smaldone G, Pirone L, Pedone E, Marlovits T, Vitagliano L, Ciccarelli L
FEBS letters590(11)1663-71(2016 Jun)

KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.
Li L, Duan T, Wang X, Zhang RH, Zhang M, Wang S, Wang F, Wu Y, Huang H, Kang T
Scientific reports620460(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our study demonstrate that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12. Thus, the KCTD12-CDC25B-CDK1-Aurora A axis has important implications for cancer diagnoses and prognoses.
Title: KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.

Low KCTD12 expression is associated with uveal melanoma.
Title: Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells.

Studies determined that KCTD12 plays an important role in the tumorigenesis of colorectal cancer progression via activation of the ERK signaling pathway.
Title: KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.

N-terminal domain of KCTD12 assumes an alpha/beta structure, whereas the C-terminal domain is predominantly characterized by a beta-structure.
Title: A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABAB2 receptor.

KCTD12 is a useful and reliable biomarker for both the diagnosis and prognosis of gastrointestinal stromal tumor.
Title: Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor.

The following KCTD12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCTD12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10914	NM_138444.4 Latest version!	Homo sapiens potassium channel tetramerization domain containing 12 (KCTD12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu10914	NM_138444.3	Homo sapiens potassium channel tetramerization domain containing 12 (KCTD12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCTD12 ( NM_138444.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_612453.1 Homo sapiens potassium channel tetramerization domain containing 12 (KCTD12), mRNA.

Price & Availability↑

CloneID	OHu10914
Clone ID Related Accession (Same CDS sequence)	NM_138444.3 , NM_138444.4
Accession Version	NM_138444.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB153209.1, AF359381.1, AC000403.1 and BU742274.1. On May 1, 2007 this sequence version replaced NM_138444.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF359381.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTGG CGGACAGCAC ACGTGGATTA CCCAACGGGG GCGGCGGCGG GGGCGGCAGT 
GGCTCCTCGT CGTCCTCCGC GGAGCCACCG CTCTTCCCCG ACATCGTGGA GCTGAACGTG 
GGGGGCCAGG TGTACGTGAC CCGGCGCTGC ACGGTGGTGT CGGTGCCCGA CTCGCTGCTC 
TGGCGCATGT TCACGCAGCA GCAGCCGCAG GAGCTGGCCC GGGACAGCAA AGGCCGCTTC 
TTTCTGGACC GGGACGGCTT CCTCTTCCGC TACATCCTGG ATTACCTGCG GGACTTGCAG 
CTCGTGCTGC CCGACTACTT CCCCGAGCGC AGCCGGCTGC AGCGCGAGGC CGAGTACTTC 
GAGCTGCCAG AGCTCGTGCG CCGCCTCGGG GCGCCCCAGC AGCCCGGCCC GGGGCCGCCG 
CCCTCGCGGC GCGGGGTGCA CAAGGAGGGC TCGCTGGGTG ACGAGCTGCT GCCGCTTGGC 
TACTCGGAGC CCGAACAGCA GGAGGGCGCC TCTGCCGGGG CGCCGTCGCC CACGCTGGAG 
CTGGCTAGCC GCAGTCCGTC CGGGGGCGCG GCGGGCCCGC TGCTCACGCC GTCCCAGTCG 
CTGGACGGCA GCCGGCGCTC GGGCTACATC ACCATCGGCT ACCGCGGCTC CTACACCATC 
GGGCGGGACG CGCAGGCGGA CGCCAAGTTC CGGCGAGTGG CGCGCATCAC CGTTTGCGGA 
AAGACGTCGC TGGCCAAGGA GGTGTTTGGG GACACCCTGA ACGAAAGCCG GGACCCCGAC 
CGTCCCCCGG AGCGCTACAC CTCGCGCTAT TACCTCAAGT TCAACTTCCT GGAGCAGGCC 
TTCGACAAGC TGTCCGAGTC GGGCTTCCAC ATGGTGGCGT GCAGCTCCAC GGGCACCTGC 
GCCTTTGCCA GCAGCACCGA CCAGAGCGAG GACAAGATCT GGACCAGCTA CACCGAGTAC 
GTCTTCTGCA GGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612453.1
CDS	258..1235
Translation	MALADSTRGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPSRRGVHKEGSLGDELLPLGYSEPEQQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE

Target ORF information:

RefSeq Version	NM_138444.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 12 (KCTD12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138444.3

ORF Insert Sequence:

ATGGCTCTGG CGGACAGCAC ACGTGGATTA CCCAACGGGG GCGGCGGCGG GGGCGGCAGT 
GGCTCCTCGT CGTCCTCCGC GGAGCCACCG CTCTTCCCCG ACATCGTGGA GCTGAACGTG 
GGGGGCCAGG TGTACGTGAC CCGGCGCTGC ACGGTGGTGT CGGTGCCCGA CTCGCTGCTC 
TGGCGCATGT TCACGCAGCA GCAGCCGCAG GAGCTGGCCC GGGACAGCAA AGGCCGCTTC 
TTTCTGGACC GGGACGGCTT CCTCTTCCGC TACATCCTGG ATTACCTGCG GGACTTGCAG 
CTCGTGCTGC CCGACTACTT CCCCGAGCGC AGCCGGCTGC AGCGCGAGGC CGAGTACTTC 
GAGCTGCCAG AGCTCGTGCG CCGCCTCGGG GCGCCCCAGC AGCCCGGCCC GGGGCCGCCG 
CCCTCGCGGC GCGGGGTGCA CAAGGAGGGC TCGCTGGGTG ACGAGCTGCT GCCGCTTGGC 
TACTCGGAGC CCGAACAGCA GGAGGGCGCC TCTGCCGGGG CGCCGTCGCC CACGCTGGAG 
CTGGCTAGCC GCAGTCCGTC CGGGGGCGCG GCGGGCCCGC TGCTCACGCC GTCCCAGTCG 
CTGGACGGCA GCCGGCGCTC GGGCTACATC ACCATCGGCT ACCGCGGCTC CTACACCATC 
GGGCGGGACG CGCAGGCGGA CGCCAAGTTC CGGCGAGTGG CGCGCATCAC CGTTTGCGGA 
AAGACGTCGC TGGCCAAGGA GGTGTTTGGG GACACCCTGA ACGAAAGCCG GGACCCCGAC 
CGTCCCCCGG AGCGCTACAC CTCGCGCTAT TACCTCAAGT TCAACTTCCT GGAGCAGGCC 
TTCGACAAGC TGTCCGAGTC GGGCTTCCAC ATGGTGGCGT GCAGCTCCAC GGGCACCTGC 
GCCTTTGCCA GCAGCACCGA CCAGAGCGAG GACAAGATCT GGACCAGCTA CACCGAGTAC 
GTCTTCTGCA GGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCTD12 ( NM_138444.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_612453.1 Homo sapiens potassium channel tetramerization domain containing 12 (KCTD12), mRNA.

Price & Availability↑

CloneID	OHu10914
Clone ID Related Accession (Same CDS sequence)	NM_138444.3 , NM_138444.4
Accession Version	NM_138444.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB153209.1, AF359381.1, AC000403.1 and BU742274.1. On May 17, 2019 this sequence version replaced NM_138444.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF359381.1, BC013764.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000377474.4/ ENSP00000366694.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTGG CGGACAGCAC ACGTGGATTA CCCAACGGGG GCGGCGGCGG GGGCGGCAGT 
GGCTCCTCGT CGTCCTCCGC GGAGCCACCG CTCTTCCCCG ACATCGTGGA GCTGAACGTG 
GGGGGCCAGG TGTACGTGAC CCGGCGCTGC ACGGTGGTGT CGGTGCCCGA CTCGCTGCTC 
TGGCGCATGT TCACGCAGCA GCAGCCGCAG GAGCTGGCCC GGGACAGCAA AGGCCGCTTC 
TTTCTGGACC GGGACGGCTT CCTCTTCCGC TACATCCTGG ATTACCTGCG GGACTTGCAG 
CTCGTGCTGC CCGACTACTT CCCCGAGCGC AGCCGGCTGC AGCGCGAGGC CGAGTACTTC 
GAGCTGCCAG AGCTCGTGCG CCGCCTCGGG GCGCCCCAGC AGCCCGGCCC GGGGCCGCCG 
CCCTCGCGGC GCGGGGTGCA CAAGGAGGGC TCGCTGGGTG ACGAGCTGCT GCCGCTTGGC 
TACTCGGAGC CCGAACAGCA GGAGGGCGCC TCTGCCGGGG CGCCGTCGCC CACGCTGGAG 
CTGGCTAGCC GCAGTCCGTC CGGGGGCGCG GCGGGCCCGC TGCTCACGCC GTCCCAGTCG 
CTGGACGGCA GCCGGCGCTC GGGCTACATC ACCATCGGCT ACCGCGGCTC CTACACCATC 
GGGCGGGACG CGCAGGCGGA CGCCAAGTTC CGGCGAGTGG CGCGCATCAC CGTTTGCGGA 
AAGACGTCGC TGGCCAAGGA GGTGTTTGGG GACACCCTGA ACGAAAGCCG GGACCCCGAC 
CGTCCCCCGG AGCGCTACAC CTCGCGCTAT TACCTCAAGT TCAACTTCCT GGAGCAGGCC 
TTCGACAAGC TGTCCGAGTC GGGCTTCCAC ATGGTGGCGT GCAGCTCCAC GGGCACCTGC 
GCCTTTGCCA GCAGCACCGA CCAGAGCGAG GACAAGATCT GGACCAGCTA CACCGAGTAC 
GTCTTCTGCA GGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612453.1
CDS	258..1235
Translation	MALADSTRGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPSRRGVHKEGSLGDELLPLGYSEPEQQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE

Target ORF information:

RefSeq Version	NM_138444.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 12 (KCTD12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138444.4

ORF Insert Sequence:

ATGGCTCTGG CGGACAGCAC ACGTGGATTA CCCAACGGGG GCGGCGGCGG GGGCGGCAGT 
GGCTCCTCGT CGTCCTCCGC GGAGCCACCG CTCTTCCCCG ACATCGTGGA GCTGAACGTG 
GGGGGCCAGG TGTACGTGAC CCGGCGCTGC ACGGTGGTGT CGGTGCCCGA CTCGCTGCTC 
TGGCGCATGT TCACGCAGCA GCAGCCGCAG GAGCTGGCCC GGGACAGCAA AGGCCGCTTC 
TTTCTGGACC GGGACGGCTT CCTCTTCCGC TACATCCTGG ATTACCTGCG GGACTTGCAG 
CTCGTGCTGC CCGACTACTT CCCCGAGCGC AGCCGGCTGC AGCGCGAGGC CGAGTACTTC 
GAGCTGCCAG AGCTCGTGCG CCGCCTCGGG GCGCCCCAGC AGCCCGGCCC GGGGCCGCCG 
CCCTCGCGGC GCGGGGTGCA CAAGGAGGGC TCGCTGGGTG ACGAGCTGCT GCCGCTTGGC 
TACTCGGAGC CCGAACAGCA GGAGGGCGCC TCTGCCGGGG CGCCGTCGCC CACGCTGGAG 
CTGGCTAGCC GCAGTCCGTC CGGGGGCGCG GCGGGCCCGC TGCTCACGCC GTCCCAGTCG 
CTGGACGGCA GCCGGCGCTC GGGCTACATC ACCATCGGCT ACCGCGGCTC CTACACCATC 
GGGCGGGACG CGCAGGCGGA CGCCAAGTTC CGGCGAGTGG CGCGCATCAC CGTTTGCGGA 
AAGACGTCGC TGGCCAAGGA GGTGTTTGGG GACACCCTGA ACGAAAGCCG GGACCCCGAC 
CGTCCCCCGG AGCGCTACAC CTCGCGCTAT TACCTCAAGT TCAACTTCCT GGAGCAGGCC 
TTCGACAAGC TGTCCGAGTC GGGCTTCCAC ATGGTGGCGT GCAGCTCCAC GGGCACCTGC 
GCCTTTGCCA GCAGCACCGA CCAGAGCGAG GACAAGATCT GGACCAGCTA CACCGAGTAC 
GTCTTCTGCA GGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Oncogene36(44)6177-6189(2017 Nov)
Zhong Y,Yang J,Xu WW,Wang Y,Zheng CC,Li B,He QY

Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells.
Oncology reports37(2)871-878(2017 Feb)
Luo L,Cui J,Feng Z,Li Y,Wang M,Cai Y,Wu Y,Jin J

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
FEBS letters590(11)1663-71(2016 Jun)
Smaldone G,Pirone L,Pedone E,Marlovits T,Vitagliano L,Ciccarelli L

KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.
Scientific reports620460(2016 Feb)
Li L,Duan T,Wang X,Zhang RH,Zhang M,Wang S,Wang F,Wu Y,Huang H,Kang T

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KCTD12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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