CIDEA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CIDEA
Entrez Gene ID	1149
Full Name	cell death-inducing DFFA-like effector a
Synonyms	CIDE-A
General protein information	Preferred Names cell death-inducing DFFA-like effector a Names cell death activator CIDE-A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18p11.21\|18
Summary	This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010].
Disorder MIM:	604440

mRNA and Protein(s)

mRNA	Protein	Name
NM_001279.4	NP_001270.1	cell death activator CIDE-A isoform 1
NM_001318383.2	NP_001305312.1	cell death activator CIDE-A isoform 2
NM_001318383.1	NP_001305312.1	cell death activator CIDE-A isoform 2
NM_001279.3	NP_001270.1	cell death activator CIDE-A isoform 1

Pathways from BioSystems

Homologies

	CIDEA	XP_001094509.1
Gallus gallus (chicken)	CIDEA	NP_001182052.1
Pan troglodytes (chimpanzee)	CIDEA	XP_523993.2
Bos taurus (cattle)	CIDEA	NP_001076918.1
Mus musculus (house mouse)	Cidea	NP_031728.2
Rattus norvegicus (Norway rat)	Cidea	NP_001163938.1
Canis lupus familiaris (dog)	CIDEA	XP_547681.3
Danio rerio (zebrafish)	cidea	XP_003201313.1
Homo sapiens (human)	CIDEA	NP_001270.1
Xenopus tropicalis (tropical clawed frog)	cidea	NP_001007987.1

Gene Ontology
Bibliography

Related articles in PubMed

UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment.
Fischer AW, Shabalina IG, Mattsson CL, Abreu-Vieira G, Cannon B, Nedergaard J, Petrovic N
American journal of physiology. Endocrinology and metabolism312(1)E72-E87(2017 Jan)

Cidea improves the metabolic profile through expansion of adipose tissue.
Abreu-Vieira G, Fischer AW, Mattsson C, de Jong JM, Shabalina IG, Ryd?n M, Laurencikiene J, Arner P, Cannon B, Nedergaard J, Petrovic N
Nature communications67433(2015 Jun)

CIDE-A gene expression in patients with obesity qualified for endovascular treatment of abdominal aorta aneurysm.
Feldo M, Kocki J, Feldo J, ?ukasik S, Bogucki J, Skwarzy?ski A, Wro?ski J, K?sik J, Zubilewicz T
Polski przeglad chirurgiczny86(10)473-8(2015 Feb)

CIDE--A gene expression in patients with abdominal obesity and LDL hyperlipoproteinemia qualified for surgical revascularization in chronic limb ischemia.
Feldo M, Kocki J, Lukasik S, Bogucki J, Feldo J, Terlecki P, K?sik J, Wro?ski J, Zubilewicz T
Polski przeglad chirurgiczny85(11)644-8(2013 Nov)

The genetic contribution of CIDEA polymorphisms, haplotypes and loci interaction to obesity in a Han Chinese population.
Wu J, Zhang L, Zhang J, Dai Y, Bian L, Song M, Russell A, Wang W
Molecular biology reports40(10)5691-9(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cidea, unexpectedly, functions molecularly as an indirect inhibitor of thermogenesis via inhibition of UCP1 activity.
Title: UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment.

These data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.
Title: Cidea improves the metabolic profile through expansion of adipose tissue.

The lowest mean relative of the gene expression for CIDE-A was observed in the group of obese patients with aortic aneurysm and lipid disorders
Title: CIDE-A gene expression in patients with obesity qualified for endovascular treatment of abdominal aorta aneurysm.

Since Cide-A protein plays a role in the development of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and their vascular complications, CIDE -A gene and protein are potential therapeutic targets for these diseases.
Title: CIDE--A gene expression in patients with abdominal obesity and LDL hyperlipoproteinemia qualified for surgical revascularization in chronic limb ischemia.

the association of tag-single nucleotide polymorphisms and haplotype structures of the CIDEA gene with obesity in a Han Chinese population, was investigated.
Title: The genetic contribution of CIDEA polymorphisms, haplotypes and loci interaction to obesity in a Han Chinese population.

The following CIDEA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CIDEA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30700	NM_001279.4 Latest version!	Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu82793	NM_001318383.2 Latest version!	Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu82793	NM_001318383.1	Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu30700	NM_001279.3	Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CIDEA ( NM_001279.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001270.1 Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30700
Clone ID Related Accession (Same CDS sequence)	NM_001279.4 , NM_001279.3
Accession Version	NM_001279.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	cell death activator CIDE-A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from R73455.1, BQ718688.1 and BC031896.1. On May 17, 2019 this sequence version replaced NM_001279.3. Transcript Variant: This variant (1) encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG674879.1, AY364639.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000320477.10/ ENSP00000320209.8 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCCG CCCGGGACTA TGCAGGAGCC CTCATCAGGC CCCTGACATT TATGGGATCA 
CAGACTAAGC GAGTCCTGTT CACCCCGCTC ATGCATCCAG CTCGCCCTTT CCGGGTCTCC 
AACCATGACA GGAGCAGCCG GCGTGGGGTG ATGGCAAGCA GCCTGCAGGA GCTCATCAGC 
AAGACTCTGG ATGCCCTCGT CATCGCTACC GGACTGGTCA CTCTGGTGCT GGAGGAAGAT 
GGCACCGTGG TGGACACAGA AGAGTTCTTT CAGACCTTGG GAGACAACAC GCATTTCATG 
ATCTTGGAAA AAGGACAGAA GTGGATGCCG GGCAGCCAGC ACGTCCCCAC TTGCTCGCCG 
CCGAAGAGGT CGGGAATAGC GAGAGTCACC TTCGACTTGT ACAGGCTGAA CCCCAAGGAC 
TTCATCGGCT GCCTTAACGT GAAGGCCACC ATGTATGAGA TGTACTCCGT GTCCTACGAC 
ATCCGGTGCA CGGGACTCAA GGGCCTGCTG AGGAGTCTGC TGCGGTTCCT GTCCTACTCC 
GCCCAGGTGA CGGGACAGTT TCTCATCTAT CTGGGCACAT ACATGCTCCG GGTGCTGGAT 
GACAAGGAAG AGCGGCCATC CCTCCGGTCA CAAGCCAAGG GCAGGTTCAC GTGTGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001270.1
CDS	24..683
Translation	MEAARDYAGALIRPLTFMGSQTKRVLFTPLMHPARPFRVSNHDRSSRRGVMASSLQELISKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMILEKGQKWMPGSQHVPTCSPPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYDIRCTGLKGLLRSLLRFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQAKGRFTCG

Target ORF information:

RefSeq Version	NM_001279.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001279.4

ORF Insert Sequence:

ATGGAGGCCG CCCGGGACTA TGCAGGAGCC CTCATCAGGC CCCTGACATT TATGGGATCA 
CAGACTAAGC GAGTCCTGTT CACCCCGCTC ATGCATCCAG CTCGCCCTTT CCGGGTCTCC 
AACCATGACA GGAGCAGCCG GCGTGGGGTG ATGGCAAGCA GCCTGCAGGA GCTCATCAGC 
AAGACTCTGG ATGCCCTCGT CATCGCTACC GGACTGGTCA CTCTGGTGCT GGAGGAAGAT 
GGCACCGTGG TGGACACAGA AGAGTTCTTT CAGACCTTGG GAGACAACAC GCATTTCATG 
ATCTTGGAAA AAGGACAGAA GTGGATGCCG GGCAGCCAGC ACGTCCCCAC TTGCTCGCCG 
CCGAAGAGGT CGGGAATAGC GAGAGTCACC TTCGACTTGT ACAGGCTGAA CCCCAAGGAC 
TTCATCGGCT GCCTTAACGT GAAGGCCACC ATGTATGAGA TGTACTCCGT GTCCTACGAC 
ATCCGGTGCA CGGGACTCAA GGGCCTGCTG AGGAGTCTGC TGCGGTTCCT GTCCTACTCC 
GCCCAGGTGA CGGGACAGTT TCTCATCTAT CTGGGCACAT ACATGCTCCG GGTGCTGGAT 
GACAAGGAAG AGCGGCCATC CCTCCGGTCA CAAGCCAAGG GCAGGTTCAC GTGTGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CIDEA ( NM_001279.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001270.1 Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30700
Clone ID Related Accession (Same CDS sequence)	NM_001279.4 , NM_001279.3
Accession Version	NM_001279.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	cell death activator CIDE-A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from R73455.1, BQ718688.1 and BC031896.1. On Aug 28, 2007 this sequence version replaced NM_001279.2. Transcript Variant: This variant (1) encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279827.7286.1, ERR279832.833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCCG CCCGGGACTA TGCAGGAGCC CTCATCAGGC CCCTGACATT TATGGGATCA 
CAGACTAAGC GAGTCCTGTT CACCCCGCTC ATGCATCCAG CTCGCCCTTT CCGGGTCTCC 
AACCATGACA GGAGCAGCCG GCGTGGGGTG ATGGCAAGCA GCCTGCAGGA GCTCATCAGC 
AAGACTCTGG ATGCCCTCGT CATCGCTACC GGACTGGTCA CTCTGGTGCT GGAGGAAGAT 
GGCACCGTGG TGGACACAGA AGAGTTCTTT CAGACCTTGG GAGACAACAC GCATTTCATG 
ATCTTGGAAA AAGGACAGAA GTGGATGCCG GGCAGCCAGC ACGTCCCCAC TTGCTCGCCG 
CCGAAGAGGT CGGGAATAGC GAGAGTCACC TTCGACTTGT ACAGGCTGAA CCCCAAGGAC 
TTCATCGGCT GCCTTAACGT GAAGGCCACC ATGTATGAGA TGTACTCCGT GTCCTACGAC 
ATCCGGTGCA CGGGACTCAA GGGCCTGCTG AGGAGTCTGC TGCGGTTCCT GTCCTACTCC 
GCCCAGGTGA CGGGACAGTT TCTCATCTAT CTGGGCACAT ACATGCTCCG GGTGCTGGAT 
GACAAGGAAG AGCGGCCATC CCTCCGGTCA CAAGCCAAGG GCAGGTTCAC GTGTGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001270.1
CDS	66..725
Translation	MEAARDYAGALIRPLTFMGSQTKRVLFTPLMHPARPFRVSNHDRSSRRGVMASSLQELISKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMILEKGQKWMPGSQHVPTCSPPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYDIRCTGLKGLLRSLLRFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQAKGRFTCG

Target ORF information:

RefSeq Version	NM_001279.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001279.3

ORF Insert Sequence:

ATGGAGGCCG CCCGGGACTA TGCAGGAGCC CTCATCAGGC CCCTGACATT TATGGGATCA 
CAGACTAAGC GAGTCCTGTT CACCCCGCTC ATGCATCCAG CTCGCCCTTT CCGGGTCTCC 
AACCATGACA GGAGCAGCCG GCGTGGGGTG ATGGCAAGCA GCCTGCAGGA GCTCATCAGC 
AAGACTCTGG ATGCCCTCGT CATCGCTACC GGACTGGTCA CTCTGGTGCT GGAGGAAGAT 
GGCACCGTGG TGGACACAGA AGAGTTCTTT CAGACCTTGG GAGACAACAC GCATTTCATG 
ATCTTGGAAA AAGGACAGAA GTGGATGCCG GGCAGCCAGC ACGTCCCCAC TTGCTCGCCG 
CCGAAGAGGT CGGGAATAGC GAGAGTCACC TTCGACTTGT ACAGGCTGAA CCCCAAGGAC 
TTCATCGGCT GCCTTAACGT GAAGGCCACC ATGTATGAGA TGTACTCCGT GTCCTACGAC 
ATCCGGTGCA CGGGACTCAA GGGCCTGCTG AGGAGTCTGC TGCGGTTCCT GTCCTACTCC 
GCCCAGGTGA CGGGACAGTT TCTCATCTAT CTGGGCACAT ACATGCTCCG GGTGCTGGAT 
GACAAGGAAG AGCGGCCATC CCTCCGGTCA CAAGCCAAGG GCAGGTTCAC GTGTGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CIDEA ( NM_001318383.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305312.1 Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu82793
Clone ID Related Accession (Same CDS sequence)	NM_001318383.2 , NM_001318383.1
Accession Version	NM_001318383.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	cell death activator CIDE-A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK122762.1, AP005264.3 and BC031896.1. On May 31, 2019 this sequence version replaced NM_001318383.1. Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031896.1, BG697827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGAGGGG ACCGGGCTTC TGGGGGTCCT GGAAATCACA ACGGGAGCTG GGCGCGGGAG 
GGGCCCAGGC TTGGCCCCTC CTGGAAGCGC GGGCTCTGGT CTCCGAGGGG AGGCCCCAAC 
CGTCCGGCGG AGCCCTCCAG GCCCCTGACA TTTATGGGAT CACAGACTAA GCGAGTCCTG 
TTCACCCCGC TCATGCATCC AGCTCGCCCT TTCCGGGTCT CCAACCATGA CAGGAGCAGC 
CGGCGTGGGG TGATGGCAAG CAGCCTGCAG GAGCTCATCA GCAAGACTCT GGATGCCCTC 
GTCATCGCTA CCGGACTGGT CACTCTGGTG CTGGAGGAAG ATGGCACCGT GGTGGACACA 
GAAGAGTTCT TTCAGACCTT GGGAGACAAC ACGCATTTCA TGATCTTGGA AAAAGGACAG 
AAGTGGATGC CGGGCAGCCA GCACGTCCCC ACTTGCTCGC CGCCGAAGAG GTCGGGAATA 
GCGAGAGTCA CCTTCGACTT GTACAGGCTG AACCCCAAGG ACTTCATCGG CTGCCTTAAC 
GTGAAGGCCA CCATGTATGA GATGTACTCC GTGTCCTACG ACATCCGGTG CACGGGACTC 
AAGGGCCTGC TGAGGAGTCT GCTGCGGTTC CTGTCCTACT CCGCCCAGGT GACGGGACAG 
TTTCTCATCT ATCTGGGCAC ATACATGCTC CGGGTGCTGG ATGACAAGGA AGAGCGGCCA 
TCCCTCCGGT CACAAGCCAA GGGCAGGTTC ACGTGTGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305312.1
CDS	457..1218
Translation	MRGDRASGGPGNHNGSWAREGPRLGPSWKRGLWSPRGGPNRPAEPSRPLTFMGSQTKRVLFTPLMHPARPFRVSNHDRSSRRGVMASSLQELISKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMILEKGQKWMPGSQHVPTCSPPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYDIRCTGLKGLLRSLLRFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQAKGRFTCG

Target ORF information:

RefSeq Version	NM_001318383.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318383.2

ORF Insert Sequence:

ATGCGAGGGG ACCGGGCTTC TGGGGGTCCT GGAAATCACA ACGGGAGCTG GGCGCGGGAG 
GGGCCCAGGC TTGGCCCCTC CTGGAAGCGC GGGCTCTGGT CTCCGAGGGG AGGCCCCAAC 
CGTCCGGCGG AGCCCTCCAG GCCCCTGACA TTTATGGGAT CACAGACTAA GCGAGTCCTG 
TTCACCCCGC TCATGCATCC AGCTCGCCCT TTCCGGGTCT CCAACCATGA CAGGAGCAGC 
CGGCGTGGGG TGATGGCAAG CAGCCTGCAG GAGCTCATCA GCAAGACTCT GGATGCCCTC 
GTCATCGCTA CCGGACTGGT CACTCTGGTG CTGGAGGAAG ATGGCACCGT GGTGGACACA 
GAAGAGTTCT TTCAGACCTT GGGAGACAAC ACGCATTTCA TGATCTTGGA AAAAGGACAG 
AAGTGGATGC CGGGCAGCCA GCACGTCCCC ACTTGCTCGC CGCCGAAGAG GTCGGGAATA 
GCGAGAGTCA CCTTCGACTT GTACAGGCTG AACCCCAAGG ACTTCATCGG CTGCCTTAAC 
GTGAAGGCCA CCATGTATGA GATGTACTCC GTGTCCTACG ACATCCGGTG CACGGGACTC 
AAGGGCCTGC TGAGGAGTCT GCTGCGGTTC CTGTCCTACT CCGCCCAGGT GACGGGACAG 
TTTCTCATCT ATCTGGGCAC ATACATGCTC CGGGTGCTGG ATGACAAGGA AGAGCGGCCA 
TCCCTCCGGT CACAAGCCAA GGGCAGGTTC ACGTGTGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CIDEA ( NM_001318383.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305312.1 Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu82793
Clone ID Related Accession (Same CDS sequence)	NM_001318383.2 , NM_001318383.1
Accession Version	NM_001318383.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	cell death activator CIDE-A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK122762.1, AP005264.3 and BC031896.1. On Jan 6, 2016 this sequence version replaced NR_036468.1. Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031896.1, BG698059.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGAGGGG ACCGGGCTTC TGGGGGTCCT GGAAATCACA ACGGGAGCTG GGCGCGGGAG 
GGGCCCAGGC TTGGCCCCTC CTGGAAGCGC GGGCTCTGGT CTCCGAGGGG AGGCCCCAAC 
CGTCCGGCGG AGCCCTCCAG GCCCCTGACA TTTATGGGAT CACAGACTAA GCGAGTCCTG 
TTCACCCCGC TCATGCATCC AGCTCGCCCT TTCCGGGTCT CCAACCATGA CAGGAGCAGC 
CGGCGTGGGG TGATGGCAAG CAGCCTGCAG GAGCTCATCA GCAAGACTCT GGATGCCCTC 
GTCATCGCTA CCGGACTGGT CACTCTGGTG CTGGAGGAAG ATGGCACCGT GGTGGACACA 
GAAGAGTTCT TTCAGACCTT GGGAGACAAC ACGCATTTCA TGATCTTGGA AAAAGGACAG 
AAGTGGATGC CGGGCAGCCA GCACGTCCCC ACTTGCTCGC CGCCGAAGAG GTCGGGAATA 
GCGAGAGTCA CCTTCGACTT GTACAGGCTG AACCCCAAGG ACTTCATCGG CTGCCTTAAC 
GTGAAGGCCA CCATGTATGA GATGTACTCC GTGTCCTACG ACATCCGGTG CACGGGACTC 
AAGGGCCTGC TGAGGAGTCT GCTGCGGTTC CTGTCCTACT CCGCCCAGGT GACGGGACAG 
TTTCTCATCT ATCTGGGCAC ATACATGCTC CGGGTGCTGG ATGACAAGGA AGAGCGGCCA 
TCCCTCCGGT CACAAGCCAA GGGCAGGTTC ACGTGTGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305312.1
CDS	457..1218
Translation	MRGDRASGGPGNHNGSWAREGPRLGPSWKRGLWSPRGGPNRPAEPSRPLTFMGSQTKRVLFTPLMHPARPFRVSNHDRSSRRGVMASSLQELISKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMILEKGQKWMPGSQHVPTCSPPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYDIRCTGLKGLLRSLLRFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQAKGRFTCG

Target ORF information:

RefSeq Version	NM_001318383.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318383.1

ORF Insert Sequence:

ATGCGAGGGG ACCGGGCTTC TGGGGGTCCT GGAAATCACA ACGGGAGCTG GGCGCGGGAG 
GGGCCCAGGC TTGGCCCCTC CTGGAAGCGC GGGCTCTGGT CTCCGAGGGG AGGCCCCAAC 
CGTCCGGCGG AGCCCTCCAG GCCCCTGACA TTTATGGGAT CACAGACTAA GCGAGTCCTG 
TTCACCCCGC TCATGCATCC AGCTCGCCCT TTCCGGGTCT CCAACCATGA CAGGAGCAGC 
CGGCGTGGGG TGATGGCAAG CAGCCTGCAG GAGCTCATCA GCAAGACTCT GGATGCCCTC 
GTCATCGCTA CCGGACTGGT CACTCTGGTG CTGGAGGAAG ATGGCACCGT GGTGGACACA 
GAAGAGTTCT TTCAGACCTT GGGAGACAAC ACGCATTTCA TGATCTTGGA AAAAGGACAG 
AAGTGGATGC CGGGCAGCCA GCACGTCCCC ACTTGCTCGC CGCCGAAGAG GTCGGGAATA 
GCGAGAGTCA CCTTCGACTT GTACAGGCTG AACCCCAAGG ACTTCATCGG CTGCCTTAAC 
GTGAAGGCCA CCATGTATGA GATGTACTCC GTGTCCTACG ACATCCGGTG CACGGGACTC 
AAGGGCCTGC TGAGGAGTCT GCTGCGGTTC CTGTCCTACT CCGCCCAGGT GACGGGACAG 
TTTCTCATCT ATCTGGGCAC ATACATGCTC CGGGTGCTGG ATGACAAGGA AGAGCGGCCA 
TCCCTCCGGT CACAAGCCAA GGGCAGGTTC ACGTGTGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment.
American journal of physiology. Endocrinology and metabolism312(1)E72-E87(2017 Jan)
Fischer AW,Shabalina IG,Mattsson CL,Abreu-Vieira G,Cannon B,Nedergaard J,Petrovic N

Cidea improves the metabolic profile through expansion of adipose tissue.
Nature communications67433(2015 Jun)
Abreu-Vieira G,Fischer AW,Mattsson C,de Jong JM,Shabalina IG,Ryd?n M,Laurencikiene J,Arner P,Cannon B,Nedergaard J,Petrovic N

CIDE-A gene expression in patients with obesity qualified for endovascular treatment of abdominal aorta aneurysm.
Polski przeglad chirurgiczny86(10)473-8(2015 Feb)
Feldo M,Kocki J,Feldo J,?ukasik S,Bogucki J,Skwarzy?ski A,Wro?ski J,K?sik J,Zubilewicz T

CIDE--A gene expression in patients with abdominal obesity and LDL hyperlipoproteinemia qualified for surgical revascularization in chronic limb ischemia.
Polski przeglad chirurgiczny85(11)644-8(2013 Nov)
Feldo M,Kocki J,Lukasik S,Bogucki J,Feldo J,Terlecki P,K?sik J,Wro?ski J,Zubilewicz T

The genetic contribution of CIDEA polymorphisms, haplotypes and loci interaction to obesity in a Han Chinese population.
Molecular biology reports40(10)5691-9(2013 Oct)
Wu J,Zhang L,Zhang J,Dai Y,Bian L,Song M,Russell A,Wang W

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CIDEA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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