ESCO1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ESCO1
Entrez Gene ID	114799
Full Name	establishment of sister chromatid cohesion N-acetyltransferase 1
Synonyms	A930014I12Rik,CTF,ECO1,EFO1,ESO1
General protein information	Preferred Names establishment of sister chromatid cohesion N-acetyltransferase 1 Names N-acetyltransferase ESCO1 CTF7 homolog 1 ECO1 homolog 1 EFO1p ESO1 homolog 1 N-acetyltransferase ESCO1 variant 2 establishment factor-like protein 1 establishment of cohesion 1 homolog 1 hEFO1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q11.2
Summary	ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]).[supplied by OMIM, Mar 2008].
Disorder MIM:	609674

mRNA and Protein(s)

mRNA	Protein	Name
NM_052911.2	NP_443143.2	N-acetyltransferase ESCO1
XM_011525798.1	XP_011524100.1	N-acetyltransferase ESCO1 isoform X1
XM_011525799.2	XP_011524101.1	N-acetyltransferase ESCO1 isoform X2
XM_011525799.3	XP_011524101.1	N-acetyltransferase ESCO1 isoform X2
NM_052911.3	NP_443143.2	N-acetyltransferase ESCO1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ESCO1	XP_005623075.1
Rattus norvegicus (Norway rat)	RGD1562794	XP_003751278.1
Gallus gallus (chicken)	ESCO1	XP_004939821.1
Bos taurus (cattle)	ESCO1	XP_005224156.1
Rattus norvegicus (Norway rat)	Esco1	NP_001119771.2
Homo sapiens (human)	ESCO1	NP_443143.2
Mus musculus (house mouse)	Esco1	NP_001074691.1
Pan troglodytes (chimpanzee)	ESCO1	XP_523883.3
	ESCO1	XP_001091733.1

Gene Ontology
Bibliography

Related articles in PubMed

Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression.
Alomer RM, da Silva EML, Chen J, Piekarz KM, McDonald K, Sansam CG, Sansam CL, Rankin S
Proceedings of the National Academy of Sciences of the United States of America114(37)9906-9911(2017 Sep)

Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1.
Rivera-Col?n Y, Maguire A, Liszczak GP, Olia AS, Marmorstein R
The Journal of biological chemistry291(51)26468-26477(2016 Dec)

Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
Kouznetsova E, Kanno T, Karlberg T, Thorsell AG, Wisniewska M, Kursula P, Sj?gren C, Sch?ler H
Structure (London, England : 1993)24(5)789-796(2016 05)

Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer.
Zhang S, Li J, Zhou G, Mu D, Yan J, Xing J, Yao Z, Sheng H, Li D, Lv C, Sun B, Hong Q, Guo H
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(4)5165-70(2016 Apr)

Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells.
Rahman S, Jones MJ, Jallepalli PV
Proceedings of the National Academy of Sciences of the United States of America112(36)11270-5(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these studies reveal the molecular basis for SMC3 acetylation by ESCO1 and have broader implications for understanding the structure/function of non-histone acetyltransferases.
Title: Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1.

our findings indicated that ESCO1 may play an important role in human bladder cancer, and ESCO1 might serve as a novel target and prognosis factor for human bladder cancer.
Title: Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer.

Data show that acetyltransferase Esco1 colocalizes with cohesin throughout the cell cycle and down-regulates expression of neighboring genes.
Title: Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells.

By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion.
Title: Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.

This is the first report of somatic mutations within ESCO1 and CHTF18 in endometrial tumors and of MRE11A mutations in microsatellite-stable endometrial tumors.
Title: Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A.

The following ESCO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ESCO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05574	NM_052911.3 Latest version!	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu05574	XM_011525798.1 Latest version!	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu74799	XM_011525799.3 Latest version!	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu74799	XM_011525799.2	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu05574	NM_052911.2	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ESCO1 ( NM_052911.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_443143.2 Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), mRNA.

Price & Availability↑

CloneID	OHu05574
Clone ID Related Accession (Same CDS sequence)	NM_052911.2 , XM_011525798.1 , NM_052911.3
Accession Version	NM_052911.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2523bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	N-acetyltransferase ESCO1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG492713.1, AB067498.1, BC089426.1, AK096746.1 and AC011774.9. On Nov 22, 2018 this sequence version replaced NM_052911.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.252007.1, SRR1660803.110398.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000269214.10/ ENSP00000269214.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGGCTGGA AGAAAGAAAG AATTCTGGCT 
GAATACCCTG ATGGCAGGAT AATAATGGTT CTTCCTGAAG ACCCAAAGTA TGCCCTGAAA 
AAGGTTGACG AGATTAGAGA GATGGTTGAC AATGATTTAG GTTTTCAACA GGCTCCACTA 
ATGTGCTATT CCAGAACTAA AACACTTCTC TTCATTTCCA ATGACAAAAA AGTAGTTGGC 
TGCCTAATTG CGGAACATAT CCAATGGGGC TACAGAGTTA TAGAAGAGAA ACTTCCAGTT 
ATCAGGTCAG AAGAAGAAAA AGTCAGATTT GAAAGGCAAA AAGCCTGGTG CTGCTCAACA 
TTACCAGAGC CTGCAATCTG CGGGATCAGT CGAATATGGG TATTCAGCAT GATGCGTCGG 
AAGAAAATTG CTTCTCGCAT GATTGAATGC CTAAGGAGTA ACTTTATATA TGGCTCATAT 
TTGAGCAAAG AAGAAATTGC TTTCTCAGAT CCCACTCCTG ATGGAAAGCT GTTTGCAACA 
CAGTACTGTG GCACTGGTCA ATTTCTGGTA TATAATTTTA TTAATGGACA GAATAGCACG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443143.2
CDS	907..3429
Translation	MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST

Target ORF information:

RefSeq Version	NM_052911.3
Organism	Homo sapiens(human)
Definition	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052911.3

ORF Insert Sequence:

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGGCTGGA AGAAAGAAAG AATTCTGGCT 
GAATACCCTG ATGGCAGGAT AATAATGGTT CTTCCTGAAG ACCCAAAGTA TGCCCTGAAA 
AAGGTTGACG AGATTAGAGA GATGGTTGAC AATGATTTAG GTTTTCAACA GGCTCCACTA 
ATGTGCTATT CCAGAACTAA AACACTTCTC TTCATTTCCA ATGACAAAAA AGTAGTTGGC 
TGCCTAATTG CGGAACATAT CCAATGGGGC TACAGAGTTA TAGAAGAGAA ACTTCCAGTT 
ATCAGGTCAG AAGAAGAAAA AGTCAGATTT GAAAGGCAAA AAGCCTGGTG CTGCTCAACA 
TTACCAGAGC CTGCAATCTG CGGGATCAGT CGAATATGGG TATTCAGCAT GATGCGTCGG 
AAGAAAATTG CTTCTCGCAT GATTGAATGC CTAAGGAGTA ACTTTATATA TGGCTCATAT 
TTGAGCAAAG AAGAAATTGC TTTCTCAGAT CCCACTCCTG ATGGAAAGCT GTTTGCAACA 
CAGTACTGTG GCACTGGTCA ATTTCTGGTA TATAATTTTA TTAATGGACA GAATAGCACG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESCO1 ( NM_052911.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_443143.2 Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), mRNA.

Price & Availability↑

CloneID	OHu05574
Clone ID Related Accession (Same CDS sequence)	NM_052911.2 , XM_011525798.1 , NM_052911.3
Accession Version	NM_052911.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2523bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-29
Organism	Homo sapiens(human)
Product	N-acetyltransferase ESCO1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG492713.1, AB067498.1, BC089426.1 and AK096746.1. On Oct 17, 2006 this sequence version replaced NM_052911.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB067498.1, SRR1803615.140460.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGGCTGGA AGAAAGAAAG AATTCTGGCT 
GAATACCCTG ATGGCAGGAT AATAATGGTT CTTCCTGAAG ACCCAAAGTA TGCCCTGAAA 
AAGGTTGACG AGATTAGAGA GATGGTTGAC AATGATTTAG GTTTTCAACA GGCTCCACTA 
ATGTGCTATT CCAGAACTAA AACACTTCTC TTCATTTCCA ATGACAAAAA AGTAGTTGGC 
TGCCTAATTG CGGAACATAT CCAATGGGGC TACAGAGTTA TAGAAGAGAA ACTTCCAGTT 
ATCAGGTCAG AAGAAGAAAA AGTCAGATTT GAAAGGCAAA AAGCCTGGTG CTGCTCAACA 
TTACCAGAGC CTGCAATCTG CGGGATCAGT CGAATATGGG TATTCAGCAT GATGCGTCGG 
AAGAAAATTG CTTCTCGCAT GATTGAATGC CTAAGGAGTA ACTTTATATA TGGCTCATAT 
TTGAGCAAAG AAGAAATTGC TTTCTCAGAT CCCACTCCTG ATGGAAAGCT GTTTGCAACA 
CAGTACTGTG GCACTGGTCA ATTTCTGGTA TATAATTTTA TTAATGGACA GAATAGCACG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443143.2
CDS	935..3457
Translation	MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST

Target ORF information:

RefSeq Version	NM_052911.2
Organism	Homo sapiens(human)
Definition	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052911.2

ORF Insert Sequence:

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGGCTGGA AGAAAGAAAG AATTCTGGCT 
GAATACCCTG ATGGCAGGAT AATAATGGTT CTTCCTGAAG ACCCAAAGTA TGCCCTGAAA 
AAGGTTGACG AGATTAGAGA GATGGTTGAC AATGATTTAG GTTTTCAACA GGCTCCACTA 
ATGTGCTATT CCAGAACTAA AACACTTCTC TTCATTTCCA ATGACAAAAA AGTAGTTGGC 
TGCCTAATTG CGGAACATAT CCAATGGGGC TACAGAGTTA TAGAAGAGAA ACTTCCAGTT 
ATCAGGTCAG AAGAAGAAAA AGTCAGATTT GAAAGGCAAA AAGCCTGGTG CTGCTCAACA 
TTACCAGAGC CTGCAATCTG CGGGATCAGT CGAATATGGG TATTCAGCAT GATGCGTCGG 
AAGAAAATTG CTTCTCGCAT GATTGAATGC CTAAGGAGTA ACTTTATATA TGGCTCATAT 
TTGAGCAAAG AAGAAATTGC TTTCTCAGAT CCCACTCCTG ATGGAAAGCT GTTTGCAACA 
CAGTACTGTG GCACTGGTCA ATTTCTGGTA TATAATTTTA TTAATGGACA GAATAGCACG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESCO1 ( XM_011525798.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524100.1 Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu05574
Clone ID Related Accession (Same CDS sequence)	NM_052911.2 , XM_011525798.1 , NM_052911.3
Accession Version	XM_011525798.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2523bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	N-acetyltransferase ESCO1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGGCTGGA AGAAAGAAAG AATTCTGGCT 
GAATACCCTG ATGGCAGGAT AATAATGGTT CTTCCTGAAG ACCCAAAGTA TGCCCTGAAA 
AAGGTTGACG AGATTAGAGA GATGGTTGAC AATGATTTAG GTTTTCAACA GGCTCCACTA 
ATGTGCTATT CCAGAACTAA AACACTTCTC TTCATTTCCA ATGACAAAAA AGTAGTTGGC 
TGCCTAATTG CGGAACATAT CCAATGGGGC TACAGAGTTA TAGAAGAGAA ACTTCCAGTT 
ATCAGGTCAG AAGAAGAAAA AGTCAGATTT GAAAGGCAAA AAGCCTGGTG CTGCTCAACA 
TTACCAGAGC CTGCAATCTG CGGGATCAGT CGAATATGGG TATTCAGCAT GATGCGTCGG 
AAGAAAATTG CTTCTCGCAT GATTGAATGC CTAAGGAGTA ACTTTATATA TGGCTCATAT 
TTGAGCAAAG AAGAAATTGC TTTCTCAGAT CCCACTCCTG ATGGAAAGCT GTTTGCAACA 
CAGTACTGTG GCACTGGTCA ATTTCTGGTA TATAATTTTA TTAATGGACA GAATAGCACG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524100.1
CDS	1065..3587
Translation	MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST

Target ORF information:

RefSeq Version	XM_011525798.1
Organism	Homo sapiens(human)
Definition	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525798.1

ORF Insert Sequence:

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGGCTGGA AGAAAGAAAG AATTCTGGCT 
GAATACCCTG ATGGCAGGAT AATAATGGTT CTTCCTGAAG ACCCAAAGTA TGCCCTGAAA 
AAGGTTGACG AGATTAGAGA GATGGTTGAC AATGATTTAG GTTTTCAACA GGCTCCACTA 
ATGTGCTATT CCAGAACTAA AACACTTCTC TTCATTTCCA ATGACAAAAA AGTAGTTGGC 
TGCCTAATTG CGGAACATAT CCAATGGGGC TACAGAGTTA TAGAAGAGAA ACTTCCAGTT 
ATCAGGTCAG AAGAAGAAAA AGTCAGATTT GAAAGGCAAA AAGCCTGGTG CTGCTCAACA 
TTACCAGAGC CTGCAATCTG CGGGATCAGT CGAATATGGG TATTCAGCAT GATGCGTCGG 
AAGAAAATTG CTTCTCGCAT GATTGAATGC CTAAGGAGTA ACTTTATATA TGGCTCATAT 
TTGAGCAAAG AAGAAATTGC TTTCTCAGAT CCCACTCCTG ATGGAAAGCT GTTTGCAACA 
CAGTACTGTG GCACTGGTCA ATTTCTGGTA TATAATTTTA TTAATGGACA GAATAGCACG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESCO1 ( XM_011525799.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524101.1 Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu74799
Clone ID Related Accession (Same CDS sequence)	XM_011525799.2 , XM_011525799.3
Accession Version	XM_011525799.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2433bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	N-acetyltransferase ESCO1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011525799.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGTTGACG AGATTAGAGA GATGGTTGAC 
AATGATTTAG GTTTTCAACA GGCTCCACTA ATGTGCTATT CCAGAACTAA AACACTTCTC 
TTCATTTCCA ATGACAAAAA AGTAGTTGGC TGCCTAATTG CGGAACATAT CCAATGGGGC 
TACAGAGTTA TAGAAGAGAA ACTTCCAGTT ATCAGGTCAG AAGAAGAAAA AGTCAGATTT 
GAAAGGCAAA AAGCCTGGTG CTGCTCAACA TTACCAGAGC CTGCAATCTG CGGGATCAGT 
CGAATATGGG TATTCAGCAT GATGCGTCGG AAGAAAATTG CTTCTCGCAT GATTGAATGC 
CTAAGGAGTA ACTTTATATA TGGCTCATAT TTGAGCAAAG AAGAAATTGC TTTCTCAGAT 
CCCACTCCTG ATGGAAAGCT GTTTGCAACA CAGTACTGTG GCACTGGTCA ATTTCTGGTA 
TATAATTTTA TTAATGGACA GAATAGCACG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524101.1
CDS	1198..3630
Translation	MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST

Target ORF information:

RefSeq Version	XM_011525799.2
Organism	Homo sapiens(human)
Definition	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525799.2

ORF Insert Sequence:

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGTTGACG AGATTAGAGA GATGGTTGAC 
AATGATTTAG GTTTTCAACA GGCTCCACTA ATGTGCTATT CCAGAACTAA AACACTTCTC 
TTCATTTCCA ATGACAAAAA AGTAGTTGGC TGCCTAATTG CGGAACATAT CCAATGGGGC 
TACAGAGTTA TAGAAGAGAA ACTTCCAGTT ATCAGGTCAG AAGAAGAAAA AGTCAGATTT 
GAAAGGCAAA AAGCCTGGTG CTGCTCAACA TTACCAGAGC CTGCAATCTG CGGGATCAGT 
CGAATATGGG TATTCAGCAT GATGCGTCGG AAGAAAATTG CTTCTCGCAT GATTGAATGC 
CTAAGGAGTA ACTTTATATA TGGCTCATAT TTGAGCAAAG AAGAAATTGC TTTCTCAGAT 
CCCACTCCTG ATGGAAAGCT GTTTGCAACA CAGTACTGTG GCACTGGTCA ATTTCTGGTA 
TATAATTTTA TTAATGGACA GAATAGCACG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESCO1 ( XM_011525799.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524101.1 Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), transcript variant X2, mRNA.

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CloneID	OHu74799
Clone ID Related Accession (Same CDS sequence)	XM_011525799.2 , XM_011525799.3
Accession Version	XM_011525799.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2433bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	N-acetyltransferase ESCO1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011525799.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGTTGACG AGATTAGAGA GATGGTTGAC 
AATGATTTAG GTTTTCAACA GGCTCCACTA ATGTGCTATT CCAGAACTAA AACACTTCTC 
TTCATTTCCA ATGACAAAAA AGTAGTTGGC TGCCTAATTG CGGAACATAT CCAATGGGGC 
TACAGAGTTA TAGAAGAGAA ACTTCCAGTT ATCAGGTCAG AAGAAGAAAA AGTCAGATTT 
GAAAGGCAAA AAGCCTGGTG CTGCTCAACA TTACCAGAGC CTGCAATCTG CGGGATCAGT 
CGAATATGGG TATTCAGCAT GATGCGTCGG AAGAAAATTG CTTCTCGCAT GATTGAATGC 
CTAAGGAGTA ACTTTATATA TGGCTCATAT TTGAGCAAAG AAGAAATTGC TTTCTCAGAT 
CCCACTCCTG ATGGAAAGCT GTTTGCAACA CAGTACTGTG GCACTGGTCA ATTTCTGGTA 
TATAATTTTA TTAATGGACA GAATAGCACG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524101.1
CDS	939..3371
Translation	MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST

Target ORF information:

RefSeq Version	XM_011525799.3
Organism	Homo sapiens(human)
Definition	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525799.3

ORF Insert Sequence:

ATGATGTCCA TTCAGGAGAA ATCAAAAGAG AATTCCTCCA AAGTTACTAA AAAAAGTGAC 
GATAAGAATT CAGAAACAGA AATTCAGGAT TCTCAAAAGA ATCTAGCAAA AAAATCAGGT 
CCAAAGGAGA CTATAAAATC ACAGGCTAAA TCTTCCAGTG AAAGTAAAAT AAATCAGCCA 
GAATTGGAAA CACGCATGAG TACAAGGTCA TCAAAGGCAG CATCTAATGA TAAAGCTACT 
AAATCCATTA ATAAAAATAC GGTGACTGTG AGGGGATATT CACAAGAATC TACAAAAAAG 
AAATTATCTC AGAAAAAATT AGTACATGAA AACCCTAAAG CAAATGAACA GCTTAACCGG 
AGATCACAAA GGCTACAACA ATTAACAGAG GTTTCAAGAA GGTCGTTACG CAGTAGAGAA 
ATTCAGGGTC AAGTTCAAGC AGTTAAACAG AGTTTGCCAC CAACTAAAAA AGAGCAGTGT 
AGCAGTACTC AGAGTAAATC TAATAAAACA AGTCAAAAAC ATGTGAAGAG AAAAGTACTG 
GAAGTAAAGT CTGACTCTAA AGAAGATGAA AATCTAGTAA TTAATGAAGT AATAAATTCT 
CCCAAAGGGA AAAAACGCAA GGTAGAACAT CAGACAGCTT GTGCTTGTAG TTCTCAATGC 
ACGCAAGGAT CTGAAAAGTG TCCTCAGAAG ACTACTAGAA GAGACGAAAC GAAACCTGTG 
CCTGTAACTT CTGAGGTGAA AAGATCAAAA ATGGCTACTT CAGTGGTCCC GAAAAAGAAT 
GAGATGAAGA AGTCGGTTCA TACACAAGTG AATACTAACA CAACACTCCC AAAAAGTCCA 
CAGCCATCAG TGCCTGAACA AAGTGATAAT GAGCTGGAGC AAGCAGGAAA GAGCAAACGA 
GGTAGTATTC TCCAGCTCTG TGAAGAAATT GCTGGTGAAA TTGAGTCAGA TAATGTAGAG 
GTAAAAAAGG AATCTTCACA AATGGAAAGT GTAAAGGAAG AAAAGCCCAC AGAAATAAAA 
TTGGAAGAGA CCAGTGTTGA AAGACAAATA CTTCATCAGA AGGAAACAAA TCAGGATGTG 
CAATGTAATC GTTTTTTCCC AAGTAGAAAA ACAAAGCCTG TGAAATGTAT ACTAAATGGA 
ATAAACAGCT CAGCCAAGAA GAACTCCAAC TGGACTAAAA TTAAACTCTC AAAATTTAAC 
TCTGTGCAGC ACAATAAGTT GGACTCTCAA GTTTCCCCTA AATTAGGCTT ATTACGAACC 
AGTTTTTCAC CACCAGCTTT AGAAATGCAT CATCCAGTGA CTCAAAGTAC GTTTTTAGGG 
ACAAAGCTAC ATGATAGAAA TATAACTTGC CAGCAGGAAA AAATGAAAGA AATTAATTCT 
GAAGAAGTGA AAATTAATGA TATTACAGTA GAAATTAATA AAACCACAGA AAGGGCTCCT 
GAAAATTGTC ATTTGGCCAA TGAGATAAAA CCTTCTGACC CACCATTGGA TAATCAGATG 
AAACATTCTT TTGATTCAGC ATCAAATAAG AATTTCAGCC AATGTTTGGA ATCCAAGCTA 
GAAAACAGTC CAGTGGAAAA TGTTACTGCT GCTTCGACTC TGCTCAGTCA AGCAAAAATT 
GATACAGGAG AGAATAAATT TCCAGGTTCA GCTCCCCAAC AGCATAGTAT TCTCAGTAAC 
CAGACATCTA AAAGCAGTGA TAACAGGGAG ACACCACGAA ATCATTCTTT GCCTAAGTGT 
AATTCCCATT TGGAGATAAC AATTCCAAAG GACTTGAAAC TAAAAGAAGC AGAGAAAACT 
GATGAAAAAC AGTTGATTAT AGATGCAGGA CAAAAAAGAT TTGGAGCAGT TTCTTGTAAT 
GTTTGTGGAA TGCTGTATAC AGCTTCAAAT CCAGAAGATG AAACACAGCA TCTGCTTTTC 
CACAACCAGT TTATAAGTGC TGTTAAATAT GTGGTTGACG AGATTAGAGA GATGGTTGAC 
AATGATTTAG GTTTTCAACA GGCTCCACTA ATGTGCTATT CCAGAACTAA AACACTTCTC 
TTCATTTCCA ATGACAAAAA AGTAGTTGGC TGCCTAATTG CGGAACATAT CCAATGGGGC 
TACAGAGTTA TAGAAGAGAA ACTTCCAGTT ATCAGGTCAG AAGAAGAAAA AGTCAGATTT 
GAAAGGCAAA AAGCCTGGTG CTGCTCAACA TTACCAGAGC CTGCAATCTG CGGGATCAGT 
CGAATATGGG TATTCAGCAT GATGCGTCGG AAGAAAATTG CTTCTCGCAT GATTGAATGC 
CTAAGGAGTA ACTTTATATA TGGCTCATAT TTGAGCAAAG AAGAAATTGC TTTCTCAGAT 
CCCACTCCTG ATGGAAAGCT GTTTGCAACA CAGTACTGTG GCACTGGTCA ATTTCTGGTA 
TATAATTTTA TTAATGGACA GAATAGCACG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression.
Proceedings of the National Academy of Sciences of the United States of America114(37)9906-9911(2017 Sep)
Alomer RM,da Silva EML,Chen J,Piekarz KM,McDonald K,Sansam CG,Sansam CL,Rankin S

Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1.
The Journal of biological chemistry291(51)26468-26477(2016 Dec)
Rivera-Col?n Y,Maguire A,Liszczak GP,Olia AS,Marmorstein R

Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
Structure (London, England : 1993)24(5)789-796(2016 05)
Kouznetsova E,Kanno T,Karlberg T,Thorsell AG,Wisniewska M,Kursula P,Sj?gren C,Sch?ler H

Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(4)5165-70(2016 Apr)
Zhang S,Li J,Zhou G,Mu D,Yan J,Xing J,Yao Z,Sheng H,Li D,Lv C,Sun B,Hong Q,Guo H

Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells.
Proceedings of the National Academy of Sciences of the United States of America112(36)11270-5(2015 Sep)
Rahman S,Jones MJ,Jallepalli PV

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ESCO1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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