CARD16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CARD16
Entrez Gene ID	114769
Full Name	caspase recruitment domain family member 16
Synonyms	COP,COP1,PSEUDO-ICE
General protein information	Preferred Names caspase recruitment domain family member 16 Names caspase recruitment domain-containing protein 16 CARD only domain-containing protein 1 CARD only protein CARD-only protein 1 caspase recruitment domain-only protein 1 caspase-1 dominant-negative inhibitor pseudo-ICE caspase-1 inhibitor COP pseudo interleukin-1 beta converting enzyme pseudo interleukin-1beta converting enzyme pseudo-IL1B-converting enzyme
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q22.3
Disorder MIM:	615680

mRNA and Protein(s)

mRNA	Protein	Name
NM_001017534.1	NP_001017534.1	caspase recruitment domain-containing protein 16 isoform 1
XM_011542583.2	XP_011540885.1	caspase recruitment domain-containing protein 16 isoform X1
NM_001017534.2	NP_001017534.1	caspase recruitment domain-containing protein 16 isoform 1
NM_052889.2	NP_443121.1	caspase recruitment domain-containing protein 16 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CARD16	NP_001017534.1
Pan troglodytes (chimpanzee)	CASP1	XP_003313330.1

Gene Ontology
Bibliography

Related articles in PubMed

IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes.
Rousset F, Hazane-Puch F, Pinosa C, Nguyen MV, Grange L, Soldini A, Rubens-Duval B, Dupuy C, Morel F, Lardy B
Osteoarthritis and cartilage23(11)1972-80(2015 Nov)

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression.
Shelton RC, Claiborne J, Sidoryk-Wegrzynowicz M, Reddy R, Aschner M, Lewis DA, Mirnics K
Molecular psychiatry16(7)751-62(2011 Jul)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.
Wang X, Narayanan M, Bruey JM, Rigamonti D, Cattaneo E, Reed JC, Friedlander RM
Biochimica et biophysica acta1762(8)742-54(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression of NOX4/p22(phox) as well as ROS production is enhanced by IL-1beta. On the other hand, the use of NOX4 inhibitors decreased IL-1beta-induced collagenase synthesis by chondrocytes.
Title: IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Cop inhibition of cell death, at least to a certain extent, results from its interference with the activation of caspase-1 and caspase-4.
Title: Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.

Caspase-1-mediated cell death is regulated, at least in part, by the balance of Rip2 and Cop; alterations of this balance may contribute to aberrant caspase-1-mediated pathogenesis in Huntington's disease.
Title: Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease.

The following CARD16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CARD16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13005	NM_001017534.2 Latest version!	Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu13010	NM_052889.2 Latest version!	Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu74757	XM_011542583.2 Latest version!	Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu13005	NM_001017534.1	Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CARD16 ( NM_001017534.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017534.1 Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13005
Clone ID Related Accession (Same CDS sequence)	NM_001017534.1 , NM_001017534.2
Accession Version	NM_001017534.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	caspase recruitment domain-containing protein 16 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC070196.1 and AY885669.1. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AY885669.1, BQ021083.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END##

ATGGCCGACA AGGTCCTGAA GGAGAAGAGA AAGCTGTTTA TCCATTCCAT GGGTGAAGGT 
ACAATAAATG GCTTACTGGA TGAATTATTA CAGACAAGGG TGCTGAACCA GGAAGAGATG 
GAGAAAGTAA AACGTGAAAA TGCTACAGTT ATGGATAAGA CCCGAGCTTT GATTGACTCC 
GTTATTCCGA AAGGGGCACA GGCATGCCAA ATTTGCATCA CATACATTTG TGAAGAAGAC 
AGTTACCTGG CAGAGACGCT GGGACTCTCA GCAGCTCTTC AGGCAGTGCA GGACAACCCA 
GCTATGCCCA CATGCTCAAG CCCAGAAGGC AGAATCAAGC TTTGCTTTCT AGAAGACGCT 
CAAAGGATAT GGAAACAAAA GTTGCAGAGG TGCCATGTTC AGAATACAAT AATAAAGTGG 
AGTGAAAGAT ATACTTCAGG CAGTTTTGAA ATGCAGTGGC TTTTTCTTAG AACCAATTTT 
ATTGAGCGGT TCTGGAGGAA CATACTTCTG CTCCCCTTGC ATAAAGGATC TCTATATCCT 
AGAATCCCAG GTTTAGGTAA AGAGTTGCAA ACTGGAACTC ATAAATTATC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017534.1
CDS	28..621
Translation	MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYPRIPGLGKELQTGTHKLS

Target ORF information:

RefSeq Version	NM_001017534.1
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017534.1

ORF Insert Sequence:

ATGGCCGACA AGGTCCTGAA GGAGAAGAGA AAGCTGTTTA TCCATTCCAT GGGTGAAGGT 
ACAATAAATG GCTTACTGGA TGAATTATTA CAGACAAGGG TGCTGAACCA GGAAGAGATG 
GAGAAAGTAA AACGTGAAAA TGCTACAGTT ATGGATAAGA CCCGAGCTTT GATTGACTCC 
GTTATTCCGA AAGGGGCACA GGCATGCCAA ATTTGCATCA CATACATTTG TGAAGAAGAC 
AGTTACCTGG CAGAGACGCT GGGACTCTCA GCAGCTCTTC AGGCAGTGCA GGACAACCCA 
GCTATGCCCA CATGCTCAAG CCCAGAAGGC AGAATCAAGC TTTGCTTTCT AGAAGACGCT 
CAAAGGATAT GGAAACAAAA GTTGCAGAGG TGCCATGTTC AGAATACAAT AATAAAGTGG 
AGTGAAAGAT ATACTTCAGG CAGTTTTGAA ATGCAGTGGC TTTTTCTTAG AACCAATTTT 
ATTGAGCGGT TCTGGAGGAA CATACTTCTG CTCCCCTTGC ATAAAGGATC TCTATATCCT 
AGAATCCCAG GTTTAGGTAA AGAGTTGCAA ACTGGAACTC ATAAATTATC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CARD16 ( NM_001017534.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017534.1 Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13005
Clone ID Related Accession (Same CDS sequence)	NM_001017534.1 , NM_001017534.2
Accession Version	NM_001017534.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	caspase recruitment domain-containing protein 16 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP001153.5, BC070196.1 and AY885669.1. On May 17, 2019 this sequence version replaced NM_001017534.1. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AY885669.1, BQ021083.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END##

ATGGCCGACA AGGTCCTGAA GGAGAAGAGA AAGCTGTTTA TCCATTCCAT GGGTGAAGGT 
ACAATAAATG GCTTACTGGA TGAATTATTA CAGACAAGGG TGCTGAACCA GGAAGAGATG 
GAGAAAGTAA AACGTGAAAA TGCTACAGTT ATGGATAAGA CCCGAGCTTT GATTGACTCC 
GTTATTCCGA AAGGGGCACA GGCATGCCAA ATTTGCATCA CATACATTTG TGAAGAAGAC 
AGTTACCTGG CAGAGACGCT GGGACTCTCA GCAGCTCTTC AGGCAGTGCA GGACAACCCA 
GCTATGCCCA CATGCTCAAG CCCAGAAGGC AGAATCAAGC TTTGCTTTCT AGAAGACGCT 
CAAAGGATAT GGAAACAAAA GTTGCAGAGG TGCCATGTTC AGAATACAAT AATAAAGTGG 
AGTGAAAGAT ATACTTCAGG CAGTTTTGAA ATGCAGTGGC TTTTTCTTAG AACCAATTTT 
ATTGAGCGGT TCTGGAGGAA CATACTTCTG CTCCCCTTGC ATAAAGGATC TCTATATCCT 
AGAATCCCAG GTTTAGGTAA AGAGTTGCAA ACTGGAACTC ATAAATTATC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017534.1
CDS	39..632
Translation	MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYPRIPGLGKELQTGTHKLS

Target ORF information:

RefSeq Version	NM_001017534.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017534.2

ORF Insert Sequence:

ATGGCCGACA AGGTCCTGAA GGAGAAGAGA AAGCTGTTTA TCCATTCCAT GGGTGAAGGT 
ACAATAAATG GCTTACTGGA TGAATTATTA CAGACAAGGG TGCTGAACCA GGAAGAGATG 
GAGAAAGTAA AACGTGAAAA TGCTACAGTT ATGGATAAGA CCCGAGCTTT GATTGACTCC 
GTTATTCCGA AAGGGGCACA GGCATGCCAA ATTTGCATCA CATACATTTG TGAAGAAGAC 
AGTTACCTGG CAGAGACGCT GGGACTCTCA GCAGCTCTTC AGGCAGTGCA GGACAACCCA 
GCTATGCCCA CATGCTCAAG CCCAGAAGGC AGAATCAAGC TTTGCTTTCT AGAAGACGCT 
CAAAGGATAT GGAAACAAAA GTTGCAGAGG TGCCATGTTC AGAATACAAT AATAAAGTGG 
AGTGAAAGAT ATACTTCAGG CAGTTTTGAA ATGCAGTGGC TTTTTCTTAG AACCAATTTT 
ATTGAGCGGT TCTGGAGGAA CATACTTCTG CTCCCCTTGC ATAAAGGATC TCTATATCCT 
AGAATCCCAG GTTTAGGTAA AGAGTTGCAA ACTGGAACTC ATAAATTATC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CARD16 ( NM_052889.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_443121.1 Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13010
Clone ID Related Accession (Same CDS sequence)	NM_052889.2
Accession Version	NM_052889.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	caspase recruitment domain-containing protein 16 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC070196.1 and AY885669.1. On Apr 28, 2005 this sequence version replaced NM_052889.1. Transcript Variant: This variant (2) has an additional exon containing a stop codon in the middle region, as compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC070196.1, SRR1660807.150075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2150385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGACA AGGTCCTGAA GGAGAAGAGA AAGCTGTTTA TCCATTCCAT GGGTGAAGGT 
ACAATAAATG GCTTACTGGA TGAATTATTA CAGACAAGGG TGCTGAACCA GGAAGAGATG 
GAGAAAGTAA AACGTGAAAA TGCTACAGTT ATGGATAAGA CCCGAGCTTT GATTGACTCC 
GTTATTCCGA AAGGGGCACA GGCATGCCAA ATTTGCATCA CATACATTTG TGAAGAAGAC 
AGTTACCTGG CAGAGACGCT GGGACTCTCA GCAGGTCCGA TACCTGGAAA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443121.1
CDS	28..321
Translation	MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAGPIPGN

Target ORF information:

RefSeq Version	NM_052889.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052889.2

ORF Insert Sequence:

ATGGCCGACA AGGTCCTGAA GGAGAAGAGA AAGCTGTTTA TCCATTCCAT GGGTGAAGGT 
ACAATAAATG GCTTACTGGA TGAATTATTA CAGACAAGGG TGCTGAACCA GGAAGAGATG 
GAGAAAGTAA AACGTGAAAA TGCTACAGTT ATGGATAAGA CCCGAGCTTT GATTGACTCC 
GTTATTCCGA AAGGGGCACA GGCATGCCAA ATTTGCATCA CATACATTTG TGAAGAAGAC 
AGTTACCTGG CAGAGACGCT GGGACTCTCA GCAGGTCCGA TACCTGGAAA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CARD16 ( XM_011542583.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011540885.1 Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu74757
Clone ID Related Accession (Same CDS sequence)	XM_011542583.2
Accession Version	XM_011542583.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	caspase recruitment domain-containing protein 16 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011542583.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCAGTG GGTGTTTCCC AATATGTGTA CACGCCCTGC CAAAAAGGAA GGCGAAACAT 
ACTTTCAGTT TCAGCCCACA CAAGAAGGGT AGGAGAGAAA AGCCATGGCC GGTGAGTCTT 
TTACTGTTCC AAGAACAGGT CCCTGGGAAG AAAGAGTTGT GGAAAGGGCT GGCTCTTCTG 
GAAGCCATAA TTAGTATCTG TGGAAGTTTA GACAAGGTCC TGAAGGAGAA GAGAAAGCTG 
TTTATCCATT CCATGGGTGA AGGTACAATA AATGGCTTAC TGGATGAATT ATTACAGACA 
AGGGTGCTGA ACCAGGAAGA GATGGAGAAA GTAAAACGTG AAAATGCTAC AGTTATGGAT 
AAGACCCGAG CTTTGATTGA CTCCGTTATT CCGAAAGGGG CACAGGCATG CCAAATTTGC 
ATCACATACA TTTGTGAAGA AGACAGTTAC CTGGCAGAGA CGCTGGGACT CTCAGCAGCT 
CTTCAGGCAG TGCAGGACAA CCCAGCTATG CCCACATGCT CAAGCCCAGA AGGCAGAATC 
AAGCTTTGCT TTCTAGAAGA CGCTCAAAGG ATATGGAAAC AAAAGTTGCA GAGGTGCCAT 
GTTCAGAATA CAATAATAAA GTGGAGTGAA AGATATACTT CAGGCAGTTT TGAAATGCAG 
TGGCTTTTTC TTAGAACCAA TTTTATTGAG CGGTTCTGGA GGAACATACT TCTGCTCCCC 
TTGCATAAAG GATCTCTATA TCCTAGAATC CCAGGTTTAG GTAAAGAGTT GCAAACTGGA 
ACTCATAAAT TATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011540885.1
CDS	16..813
Translation	MCSGCFPICVHALPKRKAKHTFSFSPHKKGRREKPWPVSLLLFQEQVPGKKELWKGLALLEAIISICGSLDKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYPRIPGLGKELQTGTHKLS

Target ORF information:

RefSeq Version	XM_011542583.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542583.2

ORF Insert Sequence:

ATGTGCAGTG GGTGTTTCCC AATATGTGTA CACGCCCTGC CAAAAAGGAA GGCGAAACAT 
ACTTTCAGTT TCAGCCCACA CAAGAAGGGT AGGAGAGAAA AGCCATGGCC GGTGAGTCTT 
TTACTGTTCC AAGAACAGGT CCCTGGGAAG AAAGAGTTGT GGAAAGGGCT GGCTCTTCTG 
GAAGCCATAA TTAGTATCTG TGGAAGTTTA GACAAGGTCC TGAAGGAGAA GAGAAAGCTG 
TTTATCCATT CCATGGGTGA AGGTACAATA AATGGCTTAC TGGATGAATT ATTACAGACA 
AGGGTGCTGA ACCAGGAAGA GATGGAGAAA GTAAAACGTG AAAATGCTAC AGTTATGGAT 
AAGACCCGAG CTTTGATTGA CTCCGTTATT CCGAAAGGGG CACAGGCATG CCAAATTTGC 
ATCACATACA TTTGTGAAGA AGACAGTTAC CTGGCAGAGA CGCTGGGACT CTCAGCAGCT 
CTTCAGGCAG TGCAGGACAA CCCAGCTATG CCCACATGCT CAAGCCCAGA AGGCAGAATC 
AAGCTTTGCT TTCTAGAAGA CGCTCAAAGG ATATGGAAAC AAAAGTTGCA GAGGTGCCAT 
GTTCAGAATA CAATAATAAA GTGGAGTGAA AGATATACTT CAGGCAGTTT TGAAATGCAG 
TGGCTTTTTC TTAGAACCAA TTTTATTGAG CGGTTCTGGA GGAACATACT TCTGCTCCCC 
TTGCATAAAG GATCTCTATA TCCTAGAATC CCAGGTTTAG GTAAAGAGTT GCAAACTGGA 
ACTCATAAAT TATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes.
Osteoarthritis and cartilage23(11)1972-80(2015 Nov)
Rousset F,Hazane-Puch F,Pinosa C,Nguyen MV,Grange L,Soldini A,Rubens-Duval B,Dupuy C,Morel F,Lardy B

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression.
Molecular psychiatry16(7)751-62(2011 Jul)
Shelton RC,Claiborne J,Sidoryk-Wegrzynowicz M,Reddy R,Aschner M,Lewis DA,Mirnics K

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.
Biochimica et biophysica acta1762(8)742-54(2006 Aug)
Wang X,Narayanan M,Bruey JM,Rigamonti D,Cattaneo E,Reed JC,Friedlander RM

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CARD16 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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