MAL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAL2
Entrez Gene ID	114569
Full Name	mal, T cell differentiation protein 2 (gene/pseudogene)
General protein information	Preferred Names mal, T cell differentiation protein 2 (gene/pseudogene) Names protein MAL2 MAL proteolipid protein 2 MAL2 proteolipid protein mal, T-cell differentiation protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.12
Summary	This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008].
Disorder MIM:	609684

mRNA and Protein(s)

mRNA	Protein	Name
NM_052886.2	NP_443118.1	protein MAL2
NM_052886.3	NP_443118.1	protein MAL2
XM_011516807.2	XP_011515109.1	protein MAL2 isoform X1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	mal2	NP_001106628.1
Homo sapiens (human)	MAL2	NP_443118.1
Mus musculus (house mouse)	Mal2	NP_849251.1
Danio rerio (zebrafish)	zgc:195265	NP_001129449.1
Canis lupus familiaris (dog)	MAL2	XP_851266.1
Bos taurus (cattle)	MAL2	NP_001075188.1
Pan troglodytes (chimpanzee)	MAL2	XP_001142529.1
	LOC705045	XP_001093414.1
Rattus norvegicus (Norway rat)	Mal2	NP_942081.2
Gallus gallus (chicken)	MAL2	NP_001012573.2
Danio rerio (zebrafish)	LOC100332185	XP_002664850.1

Gene Ontology
Bibliography

Related articles in PubMed

The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis.
Li J, Li Y, Liu H, Liu Y, Cui B
PloS one12(5)e0178515(2017)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggested that MAL2 and TPD52 might be potential biomarkers for clinical prognosis and might be a promising therapeutic target for CRC
Title: The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis.

MAL2 and STK16 function to sort secretory soluble cargo into the constitutive secretory pathway in hepatocytes.
Title: Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells.

Results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.
Title: Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.

MAL2 overexpression was highest in serous carcinomas relative to other histological subtypes of ovarian cancer.
Title: MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome.

after differentiation, murine oligodendrocyte precursor and human oligodendroglioma derived cell lines up-regulate the expression of MAL2 and accumulate it in an intracellular compartment, exhibiting a peri-centrosomal localization.
Title: Characterization of the MAL2-positive compartment in oligodendrocytes.

The following MAL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02098	NM_052886.3 Latest version!	Homo sapiens mal, T cell differentiation protein 2 (gene/pseudogene) (MAL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu74744	XM_011516807.2 Latest version!	Homo sapiens mal, T cell differentiation protein 2 (gene/pseudogene) (MAL2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu02098	NM_052886.2	Homo sapiens mal, T cell differentiation protein 2 (gene/pseudogene) (MAL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAL2 ( NM_052886.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_443118.1 Homo sapiens mal, T cell differentiation protein 2 (gene/pseudogene) (MAL2), mRNA.

Price & Availability↑

CloneID	OHu02098
Clone ID Related Accession (Same CDS sequence)	NM_052886.2 , NM_052886.3
Accession Version	NM_052886.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-13
Organism	Homo sapiens(human)
Product	protein MAL2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CV574204.1 and AY007723.1. On Jun 23, 2006 this sequence version replaced NM_052886.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY007723.1, SRR1803613.258366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGCCG GCGGAGCGTC AGTCCCGCCG CCCCCGAACC CCGCCGTGTC CTTCCCGCCG 
CCCCGGGTCA CCCTGCCCGC CGGCCCCGAC ATCCTGCGGA CCTACTCGGG CGCCTTCGTC 
TGCCTGGAGA TTCTGTTCGG GGGTCTTGTC TGGATTTTGG TTGCCTCCTC CAATGTTCCT 
CTACCTCTAC TACAAGGATG GGTCATGTTT GTGTCCGTGA CAGCGTTTTT CTTTTCGCTC 
CTCTTTCTGG GCATGTTCCT CTCTGGCATG GTGGCTCAAA TTGATGCTAA CTGGAACTTC 
CTGGATTTTG CCTACCATTT TACAGTATTT GTCTTCTATT TTGGAGCCTT TTTATTGGAA 
GCAGCAGCCA CATCCCTGCA TGATTTGCAT TGCAATACAA CCATAACCGG GCAGCCACTC 
CTGAGTGATA ACCAGTATAA CATAAACGTA GCAGCCTCAA TTTTTGCCTT TATGACGACA 
GCTTGTTATG GTTGCAGTTT GGGTCTGGCT TTACGAAGAT GGCGACCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443118.1
CDS	103..633
Translation	MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP

Target ORF information:

RefSeq Version	NM_052886.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mal, T cell differentiation protein 2 (gene/pseudogene) (MAL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052886.2

ORF Insert Sequence:

ATGTCGGCCG GCGGAGCGTC AGTCCCGCCG CCCCCGAACC CCGCCGTGTC CTTCCCGCCG 
CCCCGGGTCA CCCTGCCCGC CGGCCCCGAC ATCCTGCGGA CCTACTCGGG CGCCTTCGTC 
TGCCTGGAGA TTCTGTTCGG GGGTCTTGTC TGGATTTTGG TTGCCTCCTC CAATGTTCCT 
CTACCTCTAC TACAAGGATG GGTCATGTTT GTGTCCGTGA CAGCGTTTTT CTTTTCGCTC 
CTCTTTCTGG GCATGTTCCT CTCTGGCATG GTGGCTCAAA TTGATGCTAA CTGGAACTTC 
CTGGATTTTG CCTACCATTT TACAGTATTT GTCTTCTATT TTGGAGCCTT TTTATTGGAA 
GCAGCAGCCA CATCCCTGCA TGATTTGCAT TGCAATACAA CCATAACCGG GCAGCCACTC 
CTGAGTGATA ACCAGTATAA CATAAACGTA GCAGCCTCAA TTTTTGCCTT TATGACGACA 
GCTTGTTATG GTTGCAGTTT GGGTCTGGCT TTACGAAGAT GGCGACCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAL2 ( NM_052886.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_443118.1 Homo sapiens mal, T cell differentiation protein 2 (gene/pseudogene) (MAL2), mRNA.

Price & Availability↑

CloneID	OHu02098
Clone ID Related Accession (Same CDS sequence)	NM_052886.2 , NM_052886.3
Accession Version	NM_052886.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	protein MAL2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087856.6, CV574204.1 and AY007723.1. On Nov 22, 2018 this sequence version replaced NM_052886.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY007723.1, SRR1803613.258366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000614891.5/ ENSP00000479708.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGCCG GCGGAGCGTC AGTCCCGCCG CCCCCGAACC CCGCCGTGTC CTTCCCGCCG 
CCCCGGGTCA CCCTGCCCGC CGGCCCCGAC ATCCTGCGGA CCTACTCGGG CGCCTTCGTC 
TGCCTGGAGA TTCTGTTCGG GGGTCTTGTC TGGATTTTGG TTGCCTCCTC CAATGTTCCT 
CTACCTCTAC TACAAGGATG GGTCATGTTT GTGTCCGTGA CAGCGTTTTT CTTTTCGCTC 
CTCTTTCTGG GCATGTTCCT CTCTGGCATG GTGGCTCAAA TTGATGCTAA CTGGAACTTC 
CTGGATTTTG CCTACCATTT TACAGTATTT GTCTTCTATT TTGGAGCCTT TTTATTGGAA 
GCAGCAGCCA CATCCCTGCA TGATTTGCAT TGCAATACAA CCATAACCGG GCAGCCACTC 
CTGAGTGATA ACCAGTATAA CATAAACGTA GCAGCCTCAA TTTTTGCCTT TATGACGACA 
GCTTGTTATG GTTGCAGTTT GGGTCTGGCT TTACGAAGAT GGCGACCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443118.1
CDS	111..641
Translation	MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP

Target ORF information:

RefSeq Version	NM_052886.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mal, T cell differentiation protein 2 (gene/pseudogene) (MAL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052886.3

ORF Insert Sequence:

ATGTCGGCCG GCGGAGCGTC AGTCCCGCCG CCCCCGAACC CCGCCGTGTC CTTCCCGCCG 
CCCCGGGTCA CCCTGCCCGC CGGCCCCGAC ATCCTGCGGA CCTACTCGGG CGCCTTCGTC 
TGCCTGGAGA TTCTGTTCGG GGGTCTTGTC TGGATTTTGG TTGCCTCCTC CAATGTTCCT 
CTACCTCTAC TACAAGGATG GGTCATGTTT GTGTCCGTGA CAGCGTTTTT CTTTTCGCTC 
CTCTTTCTGG GCATGTTCCT CTCTGGCATG GTGGCTCAAA TTGATGCTAA CTGGAACTTC 
CTGGATTTTG CCTACCATTT TACAGTATTT GTCTTCTATT TTGGAGCCTT TTTATTGGAA 
GCAGCAGCCA CATCCCTGCA TGATTTGCAT TGCAATACAA CCATAACCGG GCAGCCACTC 
CTGAGTGATA ACCAGTATAA CATAAACGTA GCAGCCTCAA TTTTTGCCTT TATGACGACA 
GCTTGTTATG GTTGCAGTTT GGGTCTGGCT TTACGAAGAT GGCGACCGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAL2 ( XM_011516807.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011515109.1 Homo sapiens mal, T cell differentiation protein 2 (gene/pseudogene) (MAL2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu74744
Clone ID Related Accession (Same CDS sequence)	XM_011516807.2
Accession Version	XM_011516807.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein MAL2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011516807.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGCCG GCGGAGCGTC AGTCCCGCCG CCCCCGAACC CCGCCGTGTC CTTCCCGCCG 
CCCCGGGTCA CCCTGCCCGC CGGCCCCGAC ATCCTGCGGA CCTACTCGGG CGCCTTCGTC 
TGCCTGGAGA TTGATTTTGC CTACCATTTT ACAGTATTTG TCTTCTATTT TGGAGCCTTT 
TTATTGGAAG CAGCAGCCAC ATCCCTGCAT GATTTGCATT GCAATACAAC CATAACCGGG 
CAGCCACTCC TGAGTGATAA CCAGTATAAC ATAAACGTAG CAGCCTCAAT TTTTGCCTTT 
ATGACGACAG CTTGTTATGG TTGCAGTTTG GGTCTGGCTT TACGAAGATG GCGACCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011515109.1
CDS	58..417
Translation	MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEIDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP

Target ORF information:

RefSeq Version	XM_011516807.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mal, T cell differentiation protein 2 (gene/pseudogene) (MAL2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516807.2

ORF Insert Sequence:

ATGTCGGCCG GCGGAGCGTC AGTCCCGCCG CCCCCGAACC CCGCCGTGTC CTTCCCGCCG 
CCCCGGGTCA CCCTGCCCGC CGGCCCCGAC ATCCTGCGGA CCTACTCGGG CGCCTTCGTC 
TGCCTGGAGA TTGATTTTGC CTACCATTTT ACAGTATTTG TCTTCTATTT TGGAGCCTTT 
TTATTGGAAG CAGCAGCCAC ATCCCTGCAT GATTTGCATT GCAATACAAC CATAACCGGG 
CAGCCACTCC TGAGTGATAA CCAGTATAAC ATAAACGTAG CAGCCTCAAT TTTTGCCTTT 
ATGACGACAG CTTGTTATGG TTGCAGTTTG GGTCTGGCTT TACGAAGATG GCGACCGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis.
PloS one12(5)e0178515(2017)
Li J,Li Y,Liu H,Liu Y,Cui B

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

MAL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報