CHRND cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHRND
Entrez Gene ID	1144
Full Name	cholinergic receptor nicotinic delta subunit
Synonyms	ACHRD,CMS2A,CMS3A,CMS3B,CMS3C,FCCMS,SCCMS
General protein information	Preferred Names cholinergic receptor nicotinic delta subunit Names acetylcholine receptor subunit delta acetylcholine receptor, nicotinic, delta (muscle) cholinergic receptor, nicotinic delta cholinergic receptor, nicotinic, delta (muscle) cholinergic receptor, nicotinic, delta polypeptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.1
Summary	The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015].
Disorder MIM:	100720
Disorder Html:	?Myasthenic syndrome, congenital, 3A, slow-channel, 616321 (3); Myasthenic syndrome, congenital, 3B, fast-channel, 616322 (3); ?Myasthenic syndrome, congenital, 3C, associated with acetylcholine receptor deficiency, 616323 (3); Multiple pterygium syndrome, lethal type, 253290 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011510524.2	XP_011508826.1	acetylcholine receptor subunit delta isoform X1
NM_001311195.1	NP_001298124.1	acetylcholine receptor subunit delta isoform 3
NM_001311196.1	NP_001298125.1	acetylcholine receptor subunit delta isoform 4
NM_000751.3	NP_000742.1	acetylcholine receptor subunit delta isoform 1 precursor
NM_001256657.1	NP_001243586.1	acetylcholine receptor subunit delta isoform 2 precursor
NM_001311196.2	NP_001298125.1	acetylcholine receptor subunit delta isoform 4
NM_001311195.2	NP_001298124.1	acetylcholine receptor subunit delta isoform 3
NM_000751.2	NP_000742.1	acetylcholine receptor subunit delta isoform 1 precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	chrnd	NP_001015814.1
Canis lupus familiaris (dog)	CHRND	XP_543288.2
Gallus gallus (chicken)	CHRND	NP_001026488.1
Bos taurus (cattle)	CHRND	NP_776696.1
Danio rerio (zebrafish)	chrnd	NP_996947.1
Homo sapiens (human)	CHRND	NP_000742.1
Mus musculus (house mouse)	Chrnd	NP_067611.2
Pan troglodytes (chimpanzee)	CHRND	XP_001146467.2
	CHRND	XP_001114108.1
Rattus norvegicus (Norway rat)	Chrnd	NP_062171.1

Gene Ontology
Bibliography

Related articles in PubMed

Investigation of Congenital Myasthenia Reveals Functional Asymmetry of Invariant Acetylcholine Receptor (AChR) Cys-loop Aspartates.
Shen XM, Brengman J, Neubauer D, Sine SM, Engel AG
The Journal of biological chemistry291(7)3291-301(2016 Feb)

A single mutation in the acetylcholine receptor ?-subunit causes distinct effects in two types of neuromuscular synapses.
Park JY, Mott M, Williams T, Ikeda H, Wen H, Linhoff M, Ono F
The Journal of neuroscience : the official journal of the Society for Neuroscience34(31)10211-8(2014 Jul)

Determinants in the ? and ? subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor.
Rudell JC, Borges LS, Rudell JB, Beck KA, Ferns MJ
The Journal of biological chemistry289(1)203-14(2014 Jan)

Clinical phenotype and the lack of mutations in the CHRNG, CHRND, and CHRNA1 genes in two Indian families with Escobar syndrome.
Kodaganur SG, Tontanahal SJ, Sarda A, Shah MH, Bhat V, Kumar A
Clinical dysmorphology22(2)54-8(2013 Apr)

Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.
Johnson EO, Chen LS, Breslau N, Hatsukami D, Robbins T, Saccone NL, Grucza RA, Bierut LJ
Addiction (Abingdon, England)105(11)2014-22(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest mutation in invariant Cys-loop of CHRND (D140N) observed in muscle of one patient (11 y/o girl) with congenital myasthenia (w/ severe muscle weakness) alters conformation of ligand/acetylcholine binding site and receptor functionality.
Title: Investigation of Congenital Myasthenia Reveals Functional Asymmetry of Invariant Acetylcholine Receptor (AChR) Cys-loop Aspartates.

This study showed that a single mutation of the delta subunit, L332P, allows the synapse in slow muscles to function but renders those in fast muscles almost nonfunctional.
Title: A single mutation in the acetylcholine receptor ?-subunit causes distinct effects in two types of neuromuscular synapses.

These findings identify novel Golgi retention signals in the beta and delta subunit loops that regulate surface trafficking of assembled AChR and may help prevent surface expression of unassembled subunits.
Title: Determinants in the ? and ? subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor.

No mutations were found in CHRNG, CHRND and CHRNA1 genes of Indian families with Escobar syndrome.
Title: Clinical phenotype and the lack of mutations in the CHRNG, CHRND, and CHRNA1 genes in two Indian families with Escobar syndrome.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.

The following CHRND gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHRND cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22807	NM_000751.3 Latest version!	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$214.50-$300.30 $429.00
OHu22723	NM_001256657.1 Latest version!	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu56903	NM_001311195.2 Latest version!	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu56904	NM_001311196.2 Latest version!	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu56905	XM_011510524.2 Latest version!	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu56904	NM_001311196.1	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu56903	NM_001311195.1	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu22807	NM_000751.2	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$214.50-$300.30 $429.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHRND ( NM_000751.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000742.1 Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22807
Clone ID Related Accession (Same CDS sequence)	NM_000751.3 , NM_000751.2
Accession Version	NM_000751.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1554bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	acetylcholine receptor subunit delta isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300109.1, X55019.1 and AC092165.4. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000751.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291526.1, X55019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465413 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000258385.8/ ENSP00000258385.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGGGC CAGTGCTGAC ACTGGGGCTG CTGGCTGCCC TGGCGGTGTG TGGCAGCTGG 
GGGCTGAACG AGGAGGAGCG GCTGATCCGG CACCTGTTTC AAGAGAAGGG CTACAACAAG 
GAGCTCCGGC CCGTGGCACA CAAAGAGGAG AGTGTGGACG TTGCCCTGGC CCTCACACTC 
TCCAACCTCA TCTCCCTGAA AGAAGTTGAG GAGACCCTCA CTACCAATGT GTGGATAGAG 
CACGGCTGGA CAGACAACCG GCTGAAGTGG AATGCTGAAG AATTTGGAAA CATCAGTGTC 
CTGCGCCTCC CCCCGGACAT GGTGTGGCTC CCAGAGATTG TGCTGGAGAA CAACAATGAC 
GGCTCCTTCC AGATCTCCTA CTCCTGCAAC GTGCTTGTCT ACCACTACGG CTTCGTGTAC 
TGGCTGCCAC CTGCCATCTT CCGCTCCTCC TGCCCCATCT CTGTCACCTA TTTCCCCTTC 
GACTGGCAGA ACTGCTCCCT CAAGTTCAGT TCCCTCAAGT ATACGGCCAA AGAGATCACC 
CTGAGCCTGA AACAGGATGC CAAGGAGAAC CGCACCTACC CCGTGGAGTG GATCATCATT 
GATCCTGAAG GCTTCACAGA GAACGGGGAG TGGGAGATAG TCCACCGGCC GGCCAGGGTC 
AACGTGGACC CCAGAGCCCC TCTGGACAGC CCCAGCCGCC AGGACATCAC CTTCTACCTC 
ATCATCCGCC GCAAGCCCCT CTTCTACATC ATCAACATCC TGGTGCCCTG CGTGCTCATC 
TCCTTCATGG TCAACCTGGT CTTCTACCTA CCGGCTGACA GTGGTGAGAA GACATCAGTG 
GCCATCTCGG TGCTCCTGGC TCAGTCTGTC TTCCTGCTGC TCATCTCCAA GCGTCTGCCT 
GCCACATCCA TGGCCATCCC CCTTATCGGC AAGTTCCTGC TCTTCGGCAT GGTGCTGGTC 
ACCATGGTTG TGGTGATCTG TGTCATCGTG CTCAACATCC ACTTCCGAAC ACCCAGCACC 
CATGTGCTGT CTGAGGGGGT CAAGAAGCTC TTCCTGGAGA CCCTGCCGGA GCTCCTGCAC 
ATGTCCCGCC CAGCAGAGGA TGGACCCAGC CCTGGGGCCC TGGTGCGGAG GAGCAGCTCC 
CTGGGATACA TCTCCAAGGC CGAGGAGTAC TTCCTGCTCA AGTCCCGCAG TGACCTCATG 
TTCGAGAAGC AGTCAGAGCG GCATGGGCTG GCCAGGCGCC TCACCACTGC ACGCCGGCCC 
CCAGCAAGCT CTGAGCAGGC CCAGCAGGAA CTCTTCAATG AGCTGAAGCC AGCTGTGGAT 
GGGGCAAACT TCATTGTTAA CCACATGAGG GACCAGAACA ATTACAATGA GGAGAAAGAC 
AGCTGGAACC GAGTGGCCCG CACAGTGGAC CGCCTCTGCC TGTTTGTGGT GACGCCTGTC 
ATGGTGGTGG GCACAGCCTG GATCTTCCTG CAGGGCGTTT ACAACCAGCC ACCACCCCAG 
CCTTTTCCTG GGGACCCCTA CTCCTACAAC GTGCAGGACA AGCGCTTCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000742.1
CDS	57..1610
Translation	MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI

Target ORF information:

RefSeq Version	NM_000751.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000751.3

ORF Insert Sequence:

ATGGAGGGGC CAGTGCTGAC ACTGGGGCTG CTGGCTGCCC TGGCGGTGTG TGGCAGCTGG 
GGGCTGAACG AGGAGGAGCG GCTGATCCGG CACCTGTTTC AAGAGAAGGG CTACAACAAG 
GAGCTCCGGC CCGTGGCACA CAAAGAGGAG AGTGTGGACG TTGCCCTGGC CCTCACACTC 
TCCAACCTCA TCTCCCTGAA AGAAGTTGAG GAGACCCTCA CTACCAATGT GTGGATAGAG 
CACGGCTGGA CAGACAACCG GCTGAAGTGG AATGCTGAAG AATTTGGAAA CATCAGTGTC 
CTGCGCCTCC CCCCGGACAT GGTGTGGCTC CCAGAGATTG TGCTGGAGAA CAACAATGAC 
GGCTCCTTCC AGATCTCCTA CTCCTGCAAC GTGCTTGTCT ACCACTACGG CTTCGTGTAC 
TGGCTGCCAC CTGCCATCTT CCGCTCCTCC TGCCCCATCT CTGTCACCTA TTTCCCCTTC 
GACTGGCAGA ACTGCTCCCT CAAGTTCAGT TCCCTCAAGT ATACGGCCAA AGAGATCACC 
CTGAGCCTGA AACAGGATGC CAAGGAGAAC CGCACCTACC CCGTGGAGTG GATCATCATT 
GATCCTGAAG GCTTCACAGA GAACGGGGAG TGGGAGATAG TCCACCGGCC GGCCAGGGTC 
AACGTGGACC CCAGAGCCCC TCTGGACAGC CCCAGCCGCC AGGACATCAC CTTCTACCTC 
ATCATCCGCC GCAAGCCCCT CTTCTACATC ATCAACATCC TGGTGCCCTG CGTGCTCATC 
TCCTTCATGG TCAACCTGGT CTTCTACCTA CCGGCTGACA GTGGTGAGAA GACATCAGTG 
GCCATCTCGG TGCTCCTGGC TCAGTCTGTC TTCCTGCTGC TCATCTCCAA GCGTCTGCCT 
GCCACATCCA TGGCCATCCC CCTTATCGGC AAGTTCCTGC TCTTCGGCAT GGTGCTGGTC 
ACCATGGTTG TGGTGATCTG TGTCATCGTG CTCAACATCC ACTTCCGAAC ACCCAGCACC 
CATGTGCTGT CTGAGGGGGT CAAGAAGCTC TTCCTGGAGA CCCTGCCGGA GCTCCTGCAC 
ATGTCCCGCC CAGCAGAGGA TGGACCCAGC CCTGGGGCCC TGGTGCGGAG GAGCAGCTCC 
CTGGGATACA TCTCCAAGGC CGAGGAGTAC TTCCTGCTCA AGTCCCGCAG TGACCTCATG 
TTCGAGAAGC AGTCAGAGCG GCATGGGCTG GCCAGGCGCC TCACCACTGC ACGCCGGCCC 
CCAGCAAGCT CTGAGCAGGC CCAGCAGGAA CTCTTCAATG AGCTGAAGCC AGCTGTGGAT 
GGGGCAAACT TCATTGTTAA CCACATGAGG GACCAGAACA ATTACAATGA GGAGAAAGAC 
AGCTGGAACC GAGTGGCCCG CACAGTGGAC CGCCTCTGCC TGTTTGTGGT GACGCCTGTC 
ATGGTGGTGG GCACAGCCTG GATCTTCCTG CAGGGCGTTT ACAACCAGCC ACCACCCCAG 
CCTTTTCCTG GGGACCCCTA CTCCTACAAC GTGCAGGACA AGCGCTTCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRND ( NM_000751.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000742.1 Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22807
Clone ID Related Accession (Same CDS sequence)	NM_000751.3 , NM_000751.2
Accession Version	NM_000751.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1554bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	acetylcholine receptor subunit delta isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300109.1, X55019.1 and AC092165.4. This sequence is a reference standard in the RefSeqGene project. On Feb 15, 2012 this sequence version replaced NM_000751.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291526.1, X55019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465413 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGGC CAGTGCTGAC ACTGGGGCTG CTGGCTGCCC TGGCGGTGTG TGGCAGCTGG 
GGGCTGAACG AGGAGGAGCG GCTGATCCGG CACCTGTTTC AAGAGAAGGG CTACAACAAG 
GAGCTCCGGC CCGTGGCACA CAAAGAGGAG AGTGTGGACG TTGCCCTGGC CCTCACACTC 
TCCAACCTCA TCTCCCTGAA AGAAGTTGAG GAGACCCTCA CTACCAATGT GTGGATAGAG 
CACGGCTGGA CAGACAACCG GCTGAAGTGG AATGCTGAAG AATTTGGAAA CATCAGTGTC 
CTGCGCCTCC CCCCGGACAT GGTGTGGCTC CCAGAGATTG TGCTGGAGAA CAACAATGAC 
GGCTCCTTCC AGATCTCCTA CTCCTGCAAC GTGCTTGTCT ACCACTACGG CTTCGTGTAC 
TGGCTGCCAC CTGCCATCTT CCGCTCCTCC TGCCCCATCT CTGTCACCTA TTTCCCCTTC 
GACTGGCAGA ACTGCTCCCT CAAGTTCAGT TCCCTCAAGT ATACGGCCAA AGAGATCACC 
CTGAGCCTGA AACAGGATGC CAAGGAGAAC CGCACCTACC CCGTGGAGTG GATCATCATT 
GATCCTGAAG GCTTCACAGA GAACGGGGAG TGGGAGATAG TCCACCGGCC GGCCAGGGTC 
AACGTGGACC CCAGAGCCCC TCTGGACAGC CCCAGCCGCC AGGACATCAC CTTCTACCTC 
ATCATCCGCC GCAAGCCCCT CTTCTACATC ATCAACATCC TGGTGCCCTG CGTGCTCATC 
TCCTTCATGG TCAACCTGGT CTTCTACCTA CCGGCTGACA GTGGTGAGAA GACATCAGTG 
GCCATCTCGG TGCTCCTGGC TCAGTCTGTC TTCCTGCTGC TCATCTCCAA GCGTCTGCCT 
GCCACATCCA TGGCCATCCC CCTTATCGGC AAGTTCCTGC TCTTCGGCAT GGTGCTGGTC 
ACCATGGTTG TGGTGATCTG TGTCATCGTG CTCAACATCC ACTTCCGAAC ACCCAGCACC 
CATGTGCTGT CTGAGGGGGT CAAGAAGCTC TTCCTGGAGA CCCTGCCGGA GCTCCTGCAC 
ATGTCCCGCC CAGCAGAGGA TGGACCCAGC CCTGGGGCCC TGGTGCGGAG GAGCAGCTCC 
CTGGGATACA TCTCCAAGGC CGAGGAGTAC TTCCTGCTCA AGTCCCGCAG TGACCTCATG 
TTCGAGAAGC AGTCAGAGCG GCATGGGCTG GCCAGGCGCC TCACCACTGC ACGCCGGCCC 
CCAGCAAGCT CTGAGCAGGC CCAGCAGGAA CTCTTCAATG AGCTGAAGCC AGCTGTGGAT 
GGGGCAAACT TCATTGTTAA CCACATGAGG GACCAGAACA ATTACAATGA GGAGAAAGAC 
AGCTGGAACC GAGTGGCCCG CACAGTGGAC CGCCTCTGCC TGTTTGTGGT GACGCCTGTC 
ATGGTGGTGG GCACAGCCTG GATCTTCCTG CAGGGCGTTT ACAACCAGCC ACCACCCCAG 
CCTTTTCCTG GGGACCCCTA CTCCTACAAC GTGCAGGACA AGCGCTTCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000742.1
CDS	57..1610
Translation	MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI

Target ORF information:

RefSeq Version	NM_000751.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000751.2

ORF Insert Sequence:

ATGGAGGGGC CAGTGCTGAC ACTGGGGCTG CTGGCTGCCC TGGCGGTGTG TGGCAGCTGG 
GGGCTGAACG AGGAGGAGCG GCTGATCCGG CACCTGTTTC AAGAGAAGGG CTACAACAAG 
GAGCTCCGGC CCGTGGCACA CAAAGAGGAG AGTGTGGACG TTGCCCTGGC CCTCACACTC 
TCCAACCTCA TCTCCCTGAA AGAAGTTGAG GAGACCCTCA CTACCAATGT GTGGATAGAG 
CACGGCTGGA CAGACAACCG GCTGAAGTGG AATGCTGAAG AATTTGGAAA CATCAGTGTC 
CTGCGCCTCC CCCCGGACAT GGTGTGGCTC CCAGAGATTG TGCTGGAGAA CAACAATGAC 
GGCTCCTTCC AGATCTCCTA CTCCTGCAAC GTGCTTGTCT ACCACTACGG CTTCGTGTAC 
TGGCTGCCAC CTGCCATCTT CCGCTCCTCC TGCCCCATCT CTGTCACCTA TTTCCCCTTC 
GACTGGCAGA ACTGCTCCCT CAAGTTCAGT TCCCTCAAGT ATACGGCCAA AGAGATCACC 
CTGAGCCTGA AACAGGATGC CAAGGAGAAC CGCACCTACC CCGTGGAGTG GATCATCATT 
GATCCTGAAG GCTTCACAGA GAACGGGGAG TGGGAGATAG TCCACCGGCC GGCCAGGGTC 
AACGTGGACC CCAGAGCCCC TCTGGACAGC CCCAGCCGCC AGGACATCAC CTTCTACCTC 
ATCATCCGCC GCAAGCCCCT CTTCTACATC ATCAACATCC TGGTGCCCTG CGTGCTCATC 
TCCTTCATGG TCAACCTGGT CTTCTACCTA CCGGCTGACA GTGGTGAGAA GACATCAGTG 
GCCATCTCGG TGCTCCTGGC TCAGTCTGTC TTCCTGCTGC TCATCTCCAA GCGTCTGCCT 
GCCACATCCA TGGCCATCCC CCTTATCGGC AAGTTCCTGC TCTTCGGCAT GGTGCTGGTC 
ACCATGGTTG TGGTGATCTG TGTCATCGTG CTCAACATCC ACTTCCGAAC ACCCAGCACC 
CATGTGCTGT CTGAGGGGGT CAAGAAGCTC TTCCTGGAGA CCCTGCCGGA GCTCCTGCAC 
ATGTCCCGCC CAGCAGAGGA TGGACCCAGC CCTGGGGCCC TGGTGCGGAG GAGCAGCTCC 
CTGGGATACA TCTCCAAGGC CGAGGAGTAC TTCCTGCTCA AGTCCCGCAG TGACCTCATG 
TTCGAGAAGC AGTCAGAGCG GCATGGGCTG GCCAGGCGCC TCACCACTGC ACGCCGGCCC 
CCAGCAAGCT CTGAGCAGGC CCAGCAGGAA CTCTTCAATG AGCTGAAGCC AGCTGTGGAT 
GGGGCAAACT TCATTGTTAA CCACATGAGG GACCAGAACA ATTACAATGA GGAGAAAGAC 
AGCTGGAACC GAGTGGCCCG CACAGTGGAC CGCCTCTGCC TGTTTGTGGT GACGCCTGTC 
ATGGTGGTGG GCACAGCCTG GATCTTCCTG CAGGGCGTTT ACAACCAGCC ACCACCCCAG 
CCTTTTCCTG GGGACCCCTA CTCCTACAAC GTGCAGGACA AGCGCTTCAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRND ( NM_001256657.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243586.1 Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22723
Clone ID Related Accession (Same CDS sequence)	NM_001256657.1
Accession Version	NM_001256657.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	acetylcholine receptor subunit delta isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300109.1, X55019.1 and AC092165.4. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300109.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465413 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGGC CAGTGCTGAC ACTGGGGCTG CTGGCTGCCC TGGCGGTGTG TGGCAGCTGG 
GGGCTGAACG AGGAGGAGCG GCTGATCCGG CACCTGTTTC AAGAGAAGGG CTACAACAAG 
GAGCTCCGGC CCGTGGCACA CAAAGAGGAG AGTGTGGACG TTGCCCTGGC CCTCACACTC 
TCCAACCTCA TCTCCCTGGG CTGGACAGAC AACCGGCTGA AGTGGAATGC TGAAGAATTT 
GGAAACATCA GTGTCCTGCG CCTCCCCCCG GACATGGTGT GGCTCCCAGA GATTGTGCTG 
GAGAACAACA ATGACGGCTC CTTCCAGATC TCCTACTCCT GCAACGTGCT TGTCTACCAC 
TACGGCTTCG TGTACTGGCT GCCACCTGCC ATCTTCCGCT CCTCCTGCCC CATCTCTGTC 
ACCTATTTCC CCTTCGACTG GCAGAACTGC TCCCTCAAGT TCAGTTCCCT CAAGTATACG 
GCCAAAGAGA TCACCCTGAG CCTGAAACAG GATGCCAAGG AGAACCGCAC CTACCCCGTG 
GAGTGGATCA TCATTGATCC TGAAGGCTTC ACAGAGAACG GGGAGTGGGA GATAGTCCAC 
CGGCCGGCCA GGGTCAACGT GGACCCCAGA GCCCCTCTGG ACAGCCCCAG CCGCCAGGAC 
ATCACCTTCT ACCTCATCAT CCGCCGCAAG CCCCTCTTCT ACATCATCAA CATCCTGGTG 
CCCTGCGTGC TCATCTCCTT CATGGTCAAC CTGGTCTTCT ACCTACCGGC TGACAGTGGT 
GAGAAGACAT CAGTGGCCAT CTCGGTGCTC CTGGCTCAGT CTGTCTTCCT GCTGCTCATC 
TCCAAGCGTC TGCCTGCCAC ATCCATGGCC ATCCCCCTTA TCGGCAAGTT CCTGCTCTTC 
GGCATGGTGC TGGTCACCAT GGTTGTGGTG ATCTGTGTCA TCGTGCTCAA CATCCACTTC 
CGAACACCCA GCACCCATGT GCTGTCTGAG GGGGTCAAGA AGCTCTTCCT GGAGACCCTG 
CCGGAGCTCC TGCACATGTC CCGCCCAGCA GAGGATGGAC CCAGCCCTGG GGCCCTGGTG 
CGGAGGAGCA GCTCCCTGGG ATACATCTCC AAGGCCGAGG AGTACTTCCT GCTCAAGTCC 
CGCAGTGACC TCATGTTCGA GAAGCAGTCA GAGCGGCATG GGCTGGCCAG GCGCCTCACC 
ACTGCACGCC GGCCCCCAGC AAGCTCTGAG CAGGCCCAGC AGGAACTCTT CAATGAGCTG 
AAGCCAGCTG TGGATGGGGC AAACTTCATT GTTAACCACA TGAGGGACCA GAACAATTAC 
AATGAGGAGA AAGACAGCTG GAACCGAGTG GCCCGCACAG TGGACCGCCT CTGCCTGTTT 
GTGGTGACGC CTGTCATGGT GGTGGGCACA GCCTGGATCT TCCTGCAGGG CGTTTACAAC 
CAGCCACCAC CCCAGCCTTT TCCTGGGGAC CCCTACTCCT ACAACGTGCA GGACAAGCGC 
TTCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243586.1
CDS	57..1565
Translation	MEGPVLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI

Target ORF information:

RefSeq Version	NM_001256657.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256657.1

ORF Insert Sequence:

ATGGAGGGGC CAGTGCTGAC ACTGGGGCTG CTGGCTGCCC TGGCGGTGTG TGGCAGCTGG 
GGGCTGAACG AGGAGGAGCG GCTGATCCGG CACCTGTTTC AAGAGAAGGG CTACAACAAG 
GAGCTCCGGC CCGTGGCACA CAAAGAGGAG AGTGTGGACG TTGCCCTGGC CCTCACACTC 
TCCAACCTCA TCTCCCTGGG CTGGACAGAC AACCGGCTGA AGTGGAATGC TGAAGAATTT 
GGAAACATCA GTGTCCTGCG CCTCCCCCCG GACATGGTGT GGCTCCCAGA GATTGTGCTG 
GAGAACAACA ATGACGGCTC CTTCCAGATC TCCTACTCCT GCAACGTGCT TGTCTACCAC 
TACGGCTTCG TGTACTGGCT GCCACCTGCC ATCTTCCGCT CCTCCTGCCC CATCTCTGTC 
ACCTATTTCC CCTTCGACTG GCAGAACTGC TCCCTCAAGT TCAGTTCCCT CAAGTATACG 
GCCAAAGAGA TCACCCTGAG CCTGAAACAG GATGCCAAGG AGAACCGCAC CTACCCCGTG 
GAGTGGATCA TCATTGATCC TGAAGGCTTC ACAGAGAACG GGGAGTGGGA GATAGTCCAC 
CGGCCGGCCA GGGTCAACGT GGACCCCAGA GCCCCTCTGG ACAGCCCCAG CCGCCAGGAC 
ATCACCTTCT ACCTCATCAT CCGCCGCAAG CCCCTCTTCT ACATCATCAA CATCCTGGTG 
CCCTGCGTGC TCATCTCCTT CATGGTCAAC CTGGTCTTCT ACCTACCGGC TGACAGTGGT 
GAGAAGACAT CAGTGGCCAT CTCGGTGCTC CTGGCTCAGT CTGTCTTCCT GCTGCTCATC 
TCCAAGCGTC TGCCTGCCAC ATCCATGGCC ATCCCCCTTA TCGGCAAGTT CCTGCTCTTC 
GGCATGGTGC TGGTCACCAT GGTTGTGGTG ATCTGTGTCA TCGTGCTCAA CATCCACTTC 
CGAACACCCA GCACCCATGT GCTGTCTGAG GGGGTCAAGA AGCTCTTCCT GGAGACCCTG 
CCGGAGCTCC TGCACATGTC CCGCCCAGCA GAGGATGGAC CCAGCCCTGG GGCCCTGGTG 
CGGAGGAGCA GCTCCCTGGG ATACATCTCC AAGGCCGAGG AGTACTTCCT GCTCAAGTCC 
CGCAGTGACC TCATGTTCGA GAAGCAGTCA GAGCGGCATG GGCTGGCCAG GCGCCTCACC 
ACTGCACGCC GGCCCCCAGC AAGCTCTGAG CAGGCCCAGC AGGAACTCTT CAATGAGCTG 
AAGCCAGCTG TGGATGGGGC AAACTTCATT GTTAACCACA TGAGGGACCA GAACAATTAC 
AATGAGGAGA AAGACAGCTG GAACCGAGTG GCCCGCACAG TGGACCGCCT CTGCCTGTTT 
GTGGTGACGC CTGTCATGGT GGTGGGCACA GCCTGGATCT TCCTGCAGGG CGTTTACAAC 
CAGCCACCAC CCCAGCCTTT TCCTGGGGAC CCCTACTCCT ACAACGTGCA GGACAAGCGC 
TTCATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRND ( NM_001311195.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001298124.1 Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 3, mRNA.

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CloneID	OHu56903
Clone ID Related Accession (Same CDS sequence)	NM_001311195.1 , NM_001311195.2
Accession Version	NM_001311195.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	acetylcholine receptor subunit delta isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300109.1, AK304890.1 and AC092165.4. On Aug 1, 2015 this sequence version replaced NR_046333.1. Transcript Variant: This variant (3) lacks two alternate internal exons compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter and distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465413 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG GTGTGGCTCC 
CAGAGATTGT GCTGGAGAAC AACAATGACG GCTCCTTCCA GATCTCCTAC TCCTGCAACG 
TGCTTGTCTA CCACTACGGC TTCGTGTACT GGCTGCCACC TGCCATCTTC CGCTCCTCCT 
GCCCCATCTC TGTCACCTAT TTCCCCTTCG ACTGGCAGAA CTGCTCCCTC AAGTTCAGGT 
GGTGAGAAGA CATCAGTGGC CATCTCGGTG CTCCTGGCTC AGTCTGTCTT CCTGCTGCTC 
ATCTCCAAGC GTCTGCCTGC CACATCCATG GCCATCCCCC TTATCGGCAA GTTCCTGCTC 
TTCGGCATGG TGCTGGTCAC CATGGTTGTG GTGATCTGTG TCATCGTGCT CAACATCCAC 
TTCCGAACAC CCAGCACCCA TGTGCTGTCT GAGGGGGTCA AGAAGCTCTT CCTGGAGACC 
CTGCCGGAGC TCCTGCACAT GTCCCGCCCA GCAGAGGATG GACCCAGCCC TGGGGCCCTG 
GTGCGGAGGA GCAGCTCCCT GGGATACATC TCCAAGGCCG AGGAGTACTT CCTGCTCAAG 
TCCCGCAGTG ACCTCATGTT CGAGAAGCAG TCAGAGCGGC ATGGGCTGGC CAGGCGCCTC 
ACCACTGCAC GCCGGCCCCC AGCAAGCTCT GAGCAGGCCC AGCAGGAACT CTTCAATGAG 
CTGAAGCCAG CTGTGGATGG GGCAAACTTC ATTGTTAACC ACATGAGGGA CCAGAACAAT 
TACAATGAGG AGAAAGACAG CTGGAACCGA GTGGCCCGCA CAGTGGACCG CCTCTGCCTG 
TTTGTGGTGA CGCCTGTCAT GGTGGTGGGC ACAGCCTGGA TCTTCCTGCA GGGCGTTTAC 
AACCAGCCAC CACCCCAGCC TTTTCCTGGG GACCCCTACT CCTACAACGT GCAGGACAAG 
CGCTTCATCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298124.1
CDS	328..1299
Translation	MLKNLETSVSCASPRTWCGSQRLCWRTTMTAPSRSPTPATCLSTTTASCTGCHLPSSAPPAPSLSPISPSTGRTAPSSSGGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI

Target ORF information:

RefSeq Version	NM_001311195.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311195.1

ORF Insert Sequence:

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG GTGTGGCTCC 
CAGAGATTGT GCTGGAGAAC AACAATGACG GCTCCTTCCA GATCTCCTAC TCCTGCAACG 
TGCTTGTCTA CCACTACGGC TTCGTGTACT GGCTGCCACC TGCCATCTTC CGCTCCTCCT 
GCCCCATCTC TGTCACCTAT TTCCCCTTCG ACTGGCAGAA CTGCTCCCTC AAGTTCAGGT 
GGTGAGAAGA CATCAGTGGC CATCTCGGTG CTCCTGGCTC AGTCTGTCTT CCTGCTGCTC 
ATCTCCAAGC GTCTGCCTGC CACATCCATG GCCATCCCCC TTATCGGCAA GTTCCTGCTC 
TTCGGCATGG TGCTGGTCAC CATGGTTGTG GTGATCTGTG TCATCGTGCT CAACATCCAC 
TTCCGAACAC CCAGCACCCA TGTGCTGTCT GAGGGGGTCA AGAAGCTCTT CCTGGAGACC 
CTGCCGGAGC TCCTGCACAT GTCCCGCCCA GCAGAGGATG GACCCAGCCC TGGGGCCCTG 
GTGCGGAGGA GCAGCTCCCT GGGATACATC TCCAAGGCCG AGGAGTACTT CCTGCTCAAG 
TCCCGCAGTG ACCTCATGTT CGAGAAGCAG TCAGAGCGGC ATGGGCTGGC CAGGCGCCTC 
ACCACTGCAC GCCGGCCCCC AGCAAGCTCT GAGCAGGCCC AGCAGGAACT CTTCAATGAG 
CTGAAGCCAG CTGTGGATGG GGCAAACTTC ATTGTTAACC ACATGAGGGA CCAGAACAAT 
TACAATGAGG AGAAAGACAG CTGGAACCGA GTGGCCCGCA CAGTGGACCG CCTCTGCCTG 
TTTGTGGTGA CGCCTGTCAT GGTGGTGGGC ACAGCCTGGA TCTTCCTGCA GGGCGTTTAC 
AACCAGCCAC CACCCCAGCC TTTTCCTGGG GACCCCTACT CCTACAACGT GCAGGACAAG 
CGCTTCATCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRND ( NM_001311195.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001298124.1 Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu56903
Clone ID Related Accession (Same CDS sequence)	NM_001311195.1 , NM_001311195.2
Accession Version	NM_001311195.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-17
Organism	Homo sapiens(human)
Product	acetylcholine receptor subunit delta isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300109.1, AK304890.1 and AC092165.4. On May 31, 2019 this sequence version replaced NM_001311195.1. Transcript Variant: This variant (3) lacks two alternate internal exons compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter and distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465413 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG GTGTGGCTCC 
CAGAGATTGT GCTGGAGAAC AACAATGACG GCTCCTTCCA GATCTCCTAC TCCTGCAACG 
TGCTTGTCTA CCACTACGGC TTCGTGTACT GGCTGCCACC TGCCATCTTC CGCTCCTCCT 
GCCCCATCTC TGTCACCTAT TTCCCCTTCG ACTGGCAGAA CTGCTCCCTC AAGTTCAGGT 
GGTGAGAAGA CATCAGTGGC CATCTCGGTG CTCCTGGCTC AGTCTGTCTT CCTGCTGCTC 
ATCTCCAAGC GTCTGCCTGC CACATCCATG GCCATCCCCC TTATCGGCAA GTTCCTGCTC 
TTCGGCATGG TGCTGGTCAC CATGGTTGTG GTGATCTGTG TCATCGTGCT CAACATCCAC 
TTCCGAACAC CCAGCACCCA TGTGCTGTCT GAGGGGGTCA AGAAGCTCTT CCTGGAGACC 
CTGCCGGAGC TCCTGCACAT GTCCCGCCCA GCAGAGGATG GACCCAGCCC TGGGGCCCTG 
GTGCGGAGGA GCAGCTCCCT GGGATACATC TCCAAGGCCG AGGAGTACTT CCTGCTCAAG 
TCCCGCAGTG ACCTCATGTT CGAGAAGCAG TCAGAGCGGC ATGGGCTGGC CAGGCGCCTC 
ACCACTGCAC GCCGGCCCCC AGCAAGCTCT GAGCAGGCCC AGCAGGAACT CTTCAATGAG 
CTGAAGCCAG CTGTGGATGG GGCAAACTTC ATTGTTAACC ACATGAGGGA CCAGAACAAT 
TACAATGAGG AGAAAGACAG CTGGAACCGA GTGGCCCGCA CAGTGGACCG CCTCTGCCTG 
TTTGTGGTGA CGCCTGTCAT GGTGGTGGGC ACAGCCTGGA TCTTCCTGCA GGGCGTTTAC 
AACCAGCCAC CACCCCAGCC TTTTCCTGGG GACCCCTACT CCTACAACGT GCAGGACAAG 
CGCTTCATCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298124.1
CDS	328..1299
Translation	MLKNLETSVSCASPRTWCGSQRLCWRTTMTAPSRSPTPATCLSTTTASCTGCHLPSSAPPAPSLSPISPSTGRTAPSSSGGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI

Target ORF information:

RefSeq Version	NM_001311195.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311195.2

ORF Insert Sequence:

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG GTGTGGCTCC 
CAGAGATTGT GCTGGAGAAC AACAATGACG GCTCCTTCCA GATCTCCTAC TCCTGCAACG 
TGCTTGTCTA CCACTACGGC TTCGTGTACT GGCTGCCACC TGCCATCTTC CGCTCCTCCT 
GCCCCATCTC TGTCACCTAT TTCCCCTTCG ACTGGCAGAA CTGCTCCCTC AAGTTCAGGT 
GGTGAGAAGA CATCAGTGGC CATCTCGGTG CTCCTGGCTC AGTCTGTCTT CCTGCTGCTC 
ATCTCCAAGC GTCTGCCTGC CACATCCATG GCCATCCCCC TTATCGGCAA GTTCCTGCTC 
TTCGGCATGG TGCTGGTCAC CATGGTTGTG GTGATCTGTG TCATCGTGCT CAACATCCAC 
TTCCGAACAC CCAGCACCCA TGTGCTGTCT GAGGGGGTCA AGAAGCTCTT CCTGGAGACC 
CTGCCGGAGC TCCTGCACAT GTCCCGCCCA GCAGAGGATG GACCCAGCCC TGGGGCCCTG 
GTGCGGAGGA GCAGCTCCCT GGGATACATC TCCAAGGCCG AGGAGTACTT CCTGCTCAAG 
TCCCGCAGTG ACCTCATGTT CGAGAAGCAG TCAGAGCGGC ATGGGCTGGC CAGGCGCCTC 
ACCACTGCAC GCCGGCCCCC AGCAAGCTCT GAGCAGGCCC AGCAGGAACT CTTCAATGAG 
CTGAAGCCAG CTGTGGATGG GGCAAACTTC ATTGTTAACC ACATGAGGGA CCAGAACAAT 
TACAATGAGG AGAAAGACAG CTGGAACCGA GTGGCCCGCA CAGTGGACCG CCTCTGCCTG 
TTTGTGGTGA CGCCTGTCAT GGTGGTGGGC ACAGCCTGGA TCTTCCTGCA GGGCGTTTAC 
AACCAGCCAC CACCCCAGCC TTTTCCTGGG GACCCCTACT CCTACAACGT GCAGGACAAG 
CGCTTCATCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRND ( NM_001311196.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001298125.1 Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu56904
Clone ID Related Accession (Same CDS sequence)	NM_001311196.1 , NM_001311196.2
Accession Version	NM_001311196.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	acetylcholine receptor subunit delta isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300109.1, CD013895.1 and AC092165.4. On Aug 1, 2015 this sequence version replaced NR_046334.1. Transcript Variant: This variant (4) uses an alternate internal splice junction compared to variant 1. This difference causes translation initiation at a downstream start codon and results in an isoform (4) with a shorter and distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD013895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465413 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG CAATGACGGC 
TCCTTCCAGA TCTCCTACTC CTGCAACGTG CTTGTCTACC ACTACGGCTT CGTGTACTGG 
CTGCCACCTG CCATCTTCCG CTCCTCCTGC CCCATCTCTG TCACCTATTT CCCCTTCGAC 
TGGCAGAACT GCTCCCTCAA GTTCAGTTCC CTCAAGTATA CGGCCAAAGA GATCACCCTG 
AGCCTGAAAC AGGATGCCAA GGAGAACCGC ACCTACCCCG TGGAGTGGAT CATCATTGAT 
CCTGAAGGCT TCACAGAGAA CGGGGAGTGG GAGATAGTCC ACCGGCCGGC CAGGGTCAAC 
GTGGACCCCA GAGCCCCTCT GGACAGCCCC AGCCGCCAGG ACATCACCTT CTACCTCATC 
ATCCGCCGCA AGCCCCTCTT CTACATCATC AACATCCTGG TGCCCTGCGT GCTCATCTCC 
TTCATGGTCA ACCTGGTCTT CTACCTACCG GCTGACAGTG GTGAGAAGAC ATCAGTGGCC 
ATCTCGGTGC TCCTGGCTCA GTCTGTCTTC CTGCTGCTCA TCTCCAAGCG TCTGCCTGCC 
ACATCCATGG CCATCCCCCT TATCGGCAAG TTCCTGCTCT TCGGCATGGT GCTGGTCACC 
ATGGTTGTGG TGATCTGTGT CATCGTGCTC AACATCCACT TCCGAACACC CAGCACCCAT 
GTGCTGTCTG AGGGGGTCAA GAAGCTCTTC CTGGAGACCC TGCCGGAGCT CCTGCACATG 
TCCCGCCCAG CAGAGGATGG ACCCAGCCCT GGGGCCCTGG TGCGGAGGAG CAGCTCCCTG 
GGATACATCT CCAAGGCCGA GGAGTACTTC CTGCTCAAGT CCCGCAGTGA CCTCATGTTC 
GAGAAGCAGT CAGAGCGGCA TGGGCTGGCC AGGCGCCTCA CCACTGCACG CCGGCCCCCA 
GCAAGCTCTG AGCAGGCCCA GCAGGAACTC TTCAATGAGC TGAAGCCAGC TGTGGATGGG 
GCAAACTTCA TTGTTAACCA CATGAGGGAC CAGAACAATT ACAATGAGGA GAAAGACAGC 
TGGAACCGAG TGGCCCGCAC AGTGGACCGC CTCTGCCTGT TTGTGGTGAC GCCTGTCATG 
GTGGTGGGCA CAGCCTGGAT CTTCCTGCAG GGCGTTTACA ACCAGCCACC ACCCCAGCCT 
TTTCCTGGGG ACCCCTACTC CTACAACGTG CAGGACAAGC GCTTCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298125.1
CDS	328..1578
Translation	MLKNLETSVSCASPRTCNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI

Target ORF information:

RefSeq Version	NM_001311196.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311196.1

ORF Insert Sequence:

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG CAATGACGGC 
TCCTTCCAGA TCTCCTACTC CTGCAACGTG CTTGTCTACC ACTACGGCTT CGTGTACTGG 
CTGCCACCTG CCATCTTCCG CTCCTCCTGC CCCATCTCTG TCACCTATTT CCCCTTCGAC 
TGGCAGAACT GCTCCCTCAA GTTCAGTTCC CTCAAGTATA CGGCCAAAGA GATCACCCTG 
AGCCTGAAAC AGGATGCCAA GGAGAACCGC ACCTACCCCG TGGAGTGGAT CATCATTGAT 
CCTGAAGGCT TCACAGAGAA CGGGGAGTGG GAGATAGTCC ACCGGCCGGC CAGGGTCAAC 
GTGGACCCCA GAGCCCCTCT GGACAGCCCC AGCCGCCAGG ACATCACCTT CTACCTCATC 
ATCCGCCGCA AGCCCCTCTT CTACATCATC AACATCCTGG TGCCCTGCGT GCTCATCTCC 
TTCATGGTCA ACCTGGTCTT CTACCTACCG GCTGACAGTG GTGAGAAGAC ATCAGTGGCC 
ATCTCGGTGC TCCTGGCTCA GTCTGTCTTC CTGCTGCTCA TCTCCAAGCG TCTGCCTGCC 
ACATCCATGG CCATCCCCCT TATCGGCAAG TTCCTGCTCT TCGGCATGGT GCTGGTCACC 
ATGGTTGTGG TGATCTGTGT CATCGTGCTC AACATCCACT TCCGAACACC CAGCACCCAT 
GTGCTGTCTG AGGGGGTCAA GAAGCTCTTC CTGGAGACCC TGCCGGAGCT CCTGCACATG 
TCCCGCCCAG CAGAGGATGG ACCCAGCCCT GGGGCCCTGG TGCGGAGGAG CAGCTCCCTG 
GGATACATCT CCAAGGCCGA GGAGTACTTC CTGCTCAAGT CCCGCAGTGA CCTCATGTTC 
GAGAAGCAGT CAGAGCGGCA TGGGCTGGCC AGGCGCCTCA CCACTGCACG CCGGCCCCCA 
GCAAGCTCTG AGCAGGCCCA GCAGGAACTC TTCAATGAGC TGAAGCCAGC TGTGGATGGG 
GCAAACTTCA TTGTTAACCA CATGAGGGAC CAGAACAATT ACAATGAGGA GAAAGACAGC 
TGGAACCGAG TGGCCCGCAC AGTGGACCGC CTCTGCCTGT TTGTGGTGAC GCCTGTCATG 
GTGGTGGGCA CAGCCTGGAT CTTCCTGCAG GGCGTTTACA ACCAGCCACC ACCCCAGCCT 
TTTCCTGGGG ACCCCTACTC CTACAACGTG CAGGACAAGC GCTTCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRND ( NM_001311196.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001298125.1 Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 4, mRNA.

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CloneID	OHu56904
Clone ID Related Accession (Same CDS sequence)	NM_001311196.1 , NM_001311196.2
Accession Version	NM_001311196.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-17
Organism	Homo sapiens(human)
Product	acetylcholine receptor subunit delta isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300109.1, CD013895.1 and AC092165.4. On May 31, 2019 this sequence version replaced NM_001311196.1. Transcript Variant: This variant (4) uses an alternate internal splice junction compared to variant 1. This difference causes translation initiation at a downstream start codon and results in an isoform (4) with a shorter and distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD013895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465413 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG CAATGACGGC 
TCCTTCCAGA TCTCCTACTC CTGCAACGTG CTTGTCTACC ACTACGGCTT CGTGTACTGG 
CTGCCACCTG CCATCTTCCG CTCCTCCTGC CCCATCTCTG TCACCTATTT CCCCTTCGAC 
TGGCAGAACT GCTCCCTCAA GTTCAGTTCC CTCAAGTATA CGGCCAAAGA GATCACCCTG 
AGCCTGAAAC AGGATGCCAA GGAGAACCGC ACCTACCCCG TGGAGTGGAT CATCATTGAT 
CCTGAAGGCT TCACAGAGAA CGGGGAGTGG GAGATAGTCC ACCGGCCGGC CAGGGTCAAC 
GTGGACCCCA GAGCCCCTCT GGACAGCCCC AGCCGCCAGG ACATCACCTT CTACCTCATC 
ATCCGCCGCA AGCCCCTCTT CTACATCATC AACATCCTGG TGCCCTGCGT GCTCATCTCC 
TTCATGGTCA ACCTGGTCTT CTACCTACCG GCTGACAGTG GTGAGAAGAC ATCAGTGGCC 
ATCTCGGTGC TCCTGGCTCA GTCTGTCTTC CTGCTGCTCA TCTCCAAGCG TCTGCCTGCC 
ACATCCATGG CCATCCCCCT TATCGGCAAG TTCCTGCTCT TCGGCATGGT GCTGGTCACC 
ATGGTTGTGG TGATCTGTGT CATCGTGCTC AACATCCACT TCCGAACACC CAGCACCCAT 
GTGCTGTCTG AGGGGGTCAA GAAGCTCTTC CTGGAGACCC TGCCGGAGCT CCTGCACATG 
TCCCGCCCAG CAGAGGATGG ACCCAGCCCT GGGGCCCTGG TGCGGAGGAG CAGCTCCCTG 
GGATACATCT CCAAGGCCGA GGAGTACTTC CTGCTCAAGT CCCGCAGTGA CCTCATGTTC 
GAGAAGCAGT CAGAGCGGCA TGGGCTGGCC AGGCGCCTCA CCACTGCACG CCGGCCCCCA 
GCAAGCTCTG AGCAGGCCCA GCAGGAACTC TTCAATGAGC TGAAGCCAGC TGTGGATGGG 
GCAAACTTCA TTGTTAACCA CATGAGGGAC CAGAACAATT ACAATGAGGA GAAAGACAGC 
TGGAACCGAG TGGCCCGCAC AGTGGACCGC CTCTGCCTGT TTGTGGTGAC GCCTGTCATG 
GTGGTGGGCA CAGCCTGGAT CTTCCTGCAG GGCGTTTACA ACCAGCCACC ACCCCAGCCT 
TTTCCTGGGG ACCCCTACTC CTACAACGTG CAGGACAAGC GCTTCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298125.1
CDS	328..1578
Translation	MLKNLETSVSCASPRTCNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI

Target ORF information:

RefSeq Version	NM_001311196.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311196.2

ORF Insert Sequence:

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG CAATGACGGC 
TCCTTCCAGA TCTCCTACTC CTGCAACGTG CTTGTCTACC ACTACGGCTT CGTGTACTGG 
CTGCCACCTG CCATCTTCCG CTCCTCCTGC CCCATCTCTG TCACCTATTT CCCCTTCGAC 
TGGCAGAACT GCTCCCTCAA GTTCAGTTCC CTCAAGTATA CGGCCAAAGA GATCACCCTG 
AGCCTGAAAC AGGATGCCAA GGAGAACCGC ACCTACCCCG TGGAGTGGAT CATCATTGAT 
CCTGAAGGCT TCACAGAGAA CGGGGAGTGG GAGATAGTCC ACCGGCCGGC CAGGGTCAAC 
GTGGACCCCA GAGCCCCTCT GGACAGCCCC AGCCGCCAGG ACATCACCTT CTACCTCATC 
ATCCGCCGCA AGCCCCTCTT CTACATCATC AACATCCTGG TGCCCTGCGT GCTCATCTCC 
TTCATGGTCA ACCTGGTCTT CTACCTACCG GCTGACAGTG GTGAGAAGAC ATCAGTGGCC 
ATCTCGGTGC TCCTGGCTCA GTCTGTCTTC CTGCTGCTCA TCTCCAAGCG TCTGCCTGCC 
ACATCCATGG CCATCCCCCT TATCGGCAAG TTCCTGCTCT TCGGCATGGT GCTGGTCACC 
ATGGTTGTGG TGATCTGTGT CATCGTGCTC AACATCCACT TCCGAACACC CAGCACCCAT 
GTGCTGTCTG AGGGGGTCAA GAAGCTCTTC CTGGAGACCC TGCCGGAGCT CCTGCACATG 
TCCCGCCCAG CAGAGGATGG ACCCAGCCCT GGGGCCCTGG TGCGGAGGAG CAGCTCCCTG 
GGATACATCT CCAAGGCCGA GGAGTACTTC CTGCTCAAGT CCCGCAGTGA CCTCATGTTC 
GAGAAGCAGT CAGAGCGGCA TGGGCTGGCC AGGCGCCTCA CCACTGCACG CCGGCCCCCA 
GCAAGCTCTG AGCAGGCCCA GCAGGAACTC TTCAATGAGC TGAAGCCAGC TGTGGATGGG 
GCAAACTTCA TTGTTAACCA CATGAGGGAC CAGAACAATT ACAATGAGGA GAAAGACAGC 
TGGAACCGAG TGGCCCGCAC AGTGGACCGC CTCTGCCTGT TTGTGGTGAC GCCTGTCATG 
GTGGTGGGCA CAGCCTGGAT CTTCCTGCAG GGCGTTTACA ACCAGCCACC ACCCCAGCCT 
TTTCCTGGGG ACCCCTACTC CTACAACGTG CAGGACAAGC GCTTCATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CHRND ( XM_011510524.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011508826.1 Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant X1, mRNA.

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CloneID	OHu56905
Clone ID Related Accession (Same CDS sequence)	XM_011510524.2
Accession Version	XM_011510524.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	acetylcholine receptor subunit delta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011510524.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG GTGTGGCTCC 
CAGAGATTGT GCTGGAGAAC AACAATGACG GCTCCTTCCA GATCTCCTAC TCCTGCAACG 
TGCTTGTCTA CCACTACGGC TTCGTGTACT GGCTGCCACC TGCCATCTTC CGCTCCTCCT 
GCCCCATCTC TGTCACCTAT TTCCCCTTCG ACTGGCAGAA CTGCTCCCTC AAGTTCAGAG 
AACGGGGAGT GGGAGATAGT CCACCGGCCG GCCAGGGTCA ACGTGGACCC CAGAGCCCCT 
CTGGACAGCC CCAGCCGCCA GGACATCACC TTCTACCTCA TCATCCGCCG CAAGCCCCTC 
TTCTACATCA TCAACATCCT GGTGCCCTGC GTGCTCATCT CCTTCATGGT CAACCTGGTC 
TTCTACCTAC CGGCTGACAG TGGTGAGAAG ACATCAGTGG CCATCTCGGT GCTCCTGGCT 
CAGTCTGTCT TCCTGCTGCT CATCTCCAAG CGTCTGCCTG CCACATCCAT GGCCATCCCC 
CTTATCGGCA AGTTCCTGCT CTTCGGCATG GTGCTGGTCA CCATGGTTGT GGTGATCTGT 
GTCATCGTGC TCAACATCCA CTTCCGAACA CCCAGCACCC ATGTGCTGTC TGAGGGGGTC 
AAGAAGCTCT TCCTGGAGAC CCTGCCGGAG CTCCTGCACA TGTCCCGCCC AGCAGAGGAT 
GGACCCAGCC CTGGGGCCCT GGTGCGGAGG AGCAGCTCCC TGGGATACAT CTCCAAGGCC 
GAGGAGTACT TCCTGCTCAA GTCCCGCAGT GACCTCATGT TCGAGAAGCA GTCAGAGCGG 
CATGGGCTGG CCAGGCGCCT CACCACTGCA CGCCGGCCCC CAGCAAGCTC TGAGCAGGCC 
CAGCAGGAAC TCTTCAATGA GCTGAAGCCA GCTGTGGATG GGGCAAACTT CATTGTTAAC 
CACATGAGGG ACCAGAACAA TTACAATGAG GAGAAAGACA GCTGGAACCG AGTGGCCCGC 
ACAGTGGACC GCCTCTGCCT GTTTGTGGTG ACGCCTGTCA TGGTGGTGGG CACAGCCTGG 
ATCTTCCTGC AGGGCGTTTA CAACCAGCCA CCACCCCAGC CTTTTCCTGG GGACCCCTAC 
TCCTACAACG TGCAGGACAA GCGCTTCATC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011508826.1
CDS	300..1472
Translation	MLKNLETSVSCASPRTWCGSQRLCWRTTMTAPSRSPTPATCLSTTTASCTGCHLPSSAPPAPSLSPISPSTGRTAPSSSENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI

Target ORF information:

RefSeq Version	XM_011510524.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cholinergic receptor nicotinic delta subunit (CHRND), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011510524.2

ORF Insert Sequence:

ATGCTGAAGA ATTTGGAAAC ATCAGTGTCC TGCGCCTCCC CCCGGACATG GTGTGGCTCC 
CAGAGATTGT GCTGGAGAAC AACAATGACG GCTCCTTCCA GATCTCCTAC TCCTGCAACG 
TGCTTGTCTA CCACTACGGC TTCGTGTACT GGCTGCCACC TGCCATCTTC CGCTCCTCCT 
GCCCCATCTC TGTCACCTAT TTCCCCTTCG ACTGGCAGAA CTGCTCCCTC AAGTTCAGAG 
AACGGGGAGT GGGAGATAGT CCACCGGCCG GCCAGGGTCA ACGTGGACCC CAGAGCCCCT 
CTGGACAGCC CCAGCCGCCA GGACATCACC TTCTACCTCA TCATCCGCCG CAAGCCCCTC 
TTCTACATCA TCAACATCCT GGTGCCCTGC GTGCTCATCT CCTTCATGGT CAACCTGGTC 
TTCTACCTAC CGGCTGACAG TGGTGAGAAG ACATCAGTGG CCATCTCGGT GCTCCTGGCT 
CAGTCTGTCT TCCTGCTGCT CATCTCCAAG CGTCTGCCTG CCACATCCAT GGCCATCCCC 
CTTATCGGCA AGTTCCTGCT CTTCGGCATG GTGCTGGTCA CCATGGTTGT GGTGATCTGT 
GTCATCGTGC TCAACATCCA CTTCCGAACA CCCAGCACCC ATGTGCTGTC TGAGGGGGTC 
AAGAAGCTCT TCCTGGAGAC CCTGCCGGAG CTCCTGCACA TGTCCCGCCC AGCAGAGGAT 
GGACCCAGCC CTGGGGCCCT GGTGCGGAGG AGCAGCTCCC TGGGATACAT CTCCAAGGCC 
GAGGAGTACT TCCTGCTCAA GTCCCGCAGT GACCTCATGT TCGAGAAGCA GTCAGAGCGG 
CATGGGCTGG CCAGGCGCCT CACCACTGCA CGCCGGCCCC CAGCAAGCTC TGAGCAGGCC 
CAGCAGGAAC TCTTCAATGA GCTGAAGCCA GCTGTGGATG GGGCAAACTT CATTGTTAAC 
CACATGAGGG ACCAGAACAA TTACAATGAG GAGAAAGACA GCTGGAACCG AGTGGCCCGC 
ACAGTGGACC GCCTCTGCCT GTTTGTGGTG ACGCCTGTCA TGGTGGTGGG CACAGCCTGG 
ATCTTCCTGC AGGGCGTTTA CAACCAGCCA CCACCCCAGC CTTTTCCTGG GGACCCCTAC 
TCCTACAACG TGCAGGACAA GCGCTTCATC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Investigation of Congenital Myasthenia Reveals Functional Asymmetry of Invariant Acetylcholine Receptor (AChR) Cys-loop Aspartates.
The Journal of biological chemistry291(7)3291-301(2016 Feb)
Shen XM,Brengman J,Neubauer D,Sine SM,Engel AG

A single mutation in the acetylcholine receptor ?-subunit causes distinct effects in two types of neuromuscular synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(31)10211-8(2014 Jul)
Park JY,Mott M,Williams T,Ikeda H,Wen H,Linhoff M,Ono F

Determinants in the ? and ? subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor.
The Journal of biological chemistry289(1)203-14(2014 Jan)
Rudell JC,Borges LS,Rudell JB,Beck KA,Ferns MJ

Clinical phenotype and the lack of mutations in the CHRNG, CHRND, and CHRNA1 genes in two Indian families with Escobar syndrome.
Clinical dysmorphology22(2)54-8(2013 Apr)
Kodaganur SG,Tontanahal SJ,Sarda A,Shah MH,Bhat V,Kumar A

Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.
Addiction (Abingdon, England)105(11)2014-22(2010 Nov)
Johnson EO,Chen LS,Breslau N,Hatsukami D,Robbins T,Saccone NL,Grucza RA,Bierut LJ

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CHRND cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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