SIGLEC11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SIGLEC11
Entrez Gene ID	114132
Full Name	sialic acid binding Ig like lectin 11
General protein information	Preferred Names sialic acid binding Ig like lectin 11 Names sialic acid-binding Ig-like lectin 11 siglec-11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Disorder MIM:	607157

mRNA and Protein(s)

mRNA	Protein	Name
NM_052884.2	NP_443116.2	sialic acid-binding Ig-like lectin 11 isoform 1 precursor
NM_001135163.1	NP_001128635.1	sialic acid-binding Ig-like lectin 11 isoform 2 precursor
XM_005258476.3	XP_005258533.2	sialic acid-binding Ig-like lectin 11 isoform X1
NM_052884.3	NP_443116.2	sialic acid-binding Ig-like lectin 11 isoform 1 precursor
XM_005258477.3	XP_005258534.2	sialic acid-binding Ig-like lectin 11 isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	SIGLEC11	NP_443116.2
Pan troglodytes (chimpanzee)	SIGLEC11	XP_003953616.1
	SIGLEC11	XP_001115795.1

Gene Ontology
Bibliography

Related articles in PubMed

Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.
Schwarz F, Landig CS, Siddiqui S, Secundino I, Olson J, Varki N, Nizet V, Varki A
The EMBO journal36(6)751-760(2017 03)

Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology.
Wang X, Chow R, Deng L, Anderson D, Weidner N, Godwin AK, Bewtra C, Zlotnik A, Bui J, Varki A, Varki N
Glycobiology21(8)1038-48(2011 Aug)

Alleviation of neurotoxicity by microglial human Siglec-11.
Wang Y, Neumann H
The Journal of neuroscience : the official journal of the Society for Neuroscience30(9)3482-8(2010 Mar)

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.
Cao H, Lakner U, de Bono B, Traherne JA, Trowsdale J, Barrow AD
European journal of immunology38(8)2303-15(2008 Aug)

A human-specific gene in microglia.
Hayakawa T, Angata T, Lewis AL, Mikkelsen TS, Varki NM, Varki A
Science (New York, N.Y.)309(5741)1693(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors demonstrated that the human-specific pathogen Escherichia coli K1 uses its polysialic acid capsule as a molecular mimic to engage Siglec-11 and escape killing. In contrast, engagement of the activating counterpart Siglec-16 increases elimination of bacteria.
Title: Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.

The results indicate potential roles for Siglec-11 in ovarian physiology and human evolution.
Title: Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Siglec-11 ectopically expressed on murine microglia interacts with PSA on neurons, reduces LPS-induced gene transcription of proinflammatory mediators, impairs phagocytosis and alleviates microglial neurotoxicity.
Title: Alleviation of neurotoxicity by microglial human Siglec-11.

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.
Title: SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.

The following SIGLEC11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIGLEC11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09155	NM_001135163.1 Latest version!	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu74735	XM_005258477.3 Latest version!	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu19613	NM_052884.3 Latest version!	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu74734	XM_005258476.3 Latest version!	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu19613	NM_052884.2	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SIGLEC11 ( NM_001135163.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128635.1 Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09155
Clone ID Related Accession (Same CDS sequence)	NM_001135163.1
Accession Version	NM_001135163.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1809bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 11 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF337818.1, AY358135.1 and AC011452.6. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY358135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTATGCC CCCAAAGACC TTATTATCAG CATTTCACAT 
GACAACACGT CAGCCCTGGA ACTCCAGGGA AACGTCATAT ATCTGGAAGT TCAGAAAGGC 
CAGTTCCTGC GGCTCCTCTG TGCTGCTGAC AGCCAGCCCC CTGCCACGCT GAGCTGGGTC 
CTGCAGGACA GAGTCCTCTC CTCGTCCCAC CCCTGGGGCC CCAGAACCCT GGGGCTGGAG 
CTGCGTGGGG TAAGGGCCGG GGATTCAGGG CGCTACACCT GCCGAGCGGA GAACAGGCTT 
GGCTCCCAGC AGCAAGCCCT GGACCTCTCT GTGCAGTATC CTCCAGAGAA CCTGAGAGTG 
ATGGTTTCCC AAGCAAACAG GACAGTCCTG GAAAACCTCG GGAACGGCAC ATCCCTCCCG 
GTCCTGGAGG GCCAAAGCCT GCGCCTGGTC TGTGTCACCC ACAGCAGCCC CCCAGCCAGG 
CTGAGCTGGA CCCGGTGGGG ACAGACCGTG GGCCCCTCCC AGCCCTCAGA CCCCGGGGTC 
CTGGAGCTGC CACCCATTCA AATGGAGCAC GAAGGAGAGT TCACCTGCCA CGCTCAGCAC 
CCTCTGGGCT CCCAGCACGT CTCTCTCAGC CTCTCCGTGC ACTGGAAGCT GGAGCATGGG 
GGAGGACTTG GCCTGGGGGC TGCCCTGGGA GCTGGCGTCG CTGCCCTGCT CGCTTTCTGT 
TCCTGCCTTG TCGTCTTCAG GGTGAAGATC TGCAGGAAGG AAGCTCGCAA GAGGGCAGCA 
GCTGAGCAGG ACGTGCCCTC CACCCTGGGA CCCATCTCCC AGGGTCACCA GCATGAATGC 
TCGGCAGGCA GCTCCCAAGA CCACCCGCCC CCAGGTGCAG CCACCTACAC CCCGGGGAAG 
GGGGAAGAGC AGGAGCTCCA CTATGCCTCC CTCAGCTTCC AGGGCCTGAG GCTCTGGGAG 
CCTGCGGACC AGGAGGCCCC CAGCACCACC GAGTACTCGG AGATCAAGAT CCACACAGGA 
CAGCCCCTGA GGGGCCCAGG CTTTGGGCTT CAATTGGAGA GGGAGATGTC AGGGATGGTT 
CCAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128635.1
CDS	92..1900
Translation	MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHWKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAAAEQDVPSTLGPISQGHQHECSAGSSQDHPPPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQEAPSTTEYSEIKIHTGQPLRGPGFGLQLEREMSGMVPK

Target ORF information:

RefSeq Version	NM_001135163.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135163.1

ORF Insert Sequence:

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTATGCC CCCAAAGACC TTATTATCAG CATTTCACAT 
GACAACACGT CAGCCCTGGA ACTCCAGGGA AACGTCATAT ATCTGGAAGT TCAGAAAGGC 
CAGTTCCTGC GGCTCCTCTG TGCTGCTGAC AGCCAGCCCC CTGCCACGCT GAGCTGGGTC 
CTGCAGGACA GAGTCCTCTC CTCGTCCCAC CCCTGGGGCC CCAGAACCCT GGGGCTGGAG 
CTGCGTGGGG TAAGGGCCGG GGATTCAGGG CGCTACACCT GCCGAGCGGA GAACAGGCTT 
GGCTCCCAGC AGCAAGCCCT GGACCTCTCT GTGCAGTATC CTCCAGAGAA CCTGAGAGTG 
ATGGTTTCCC AAGCAAACAG GACAGTCCTG GAAAACCTCG GGAACGGCAC ATCCCTCCCG 
GTCCTGGAGG GCCAAAGCCT GCGCCTGGTC TGTGTCACCC ACAGCAGCCC CCCAGCCAGG 
CTGAGCTGGA CCCGGTGGGG ACAGACCGTG GGCCCCTCCC AGCCCTCAGA CCCCGGGGTC 
CTGGAGCTGC CACCCATTCA AATGGAGCAC GAAGGAGAGT TCACCTGCCA CGCTCAGCAC 
CCTCTGGGCT CCCAGCACGT CTCTCTCAGC CTCTCCGTGC ACTGGAAGCT GGAGCATGGG 
GGAGGACTTG GCCTGGGGGC TGCCCTGGGA GCTGGCGTCG CTGCCCTGCT CGCTTTCTGT 
TCCTGCCTTG TCGTCTTCAG GGTGAAGATC TGCAGGAAGG AAGCTCGCAA GAGGGCAGCA 
GCTGAGCAGG ACGTGCCCTC CACCCTGGGA CCCATCTCCC AGGGTCACCA GCATGAATGC 
TCGGCAGGCA GCTCCCAAGA CCACCCGCCC CCAGGTGCAG CCACCTACAC CCCGGGGAAG 
GGGGAAGAGC AGGAGCTCCA CTATGCCTCC CTCAGCTTCC AGGGCCTGAG GCTCTGGGAG 
CCTGCGGACC AGGAGGCCCC CAGCACCACC GAGTACTCGG AGATCAAGAT CCACACAGGA 
CAGCCCCTGA GGGGCCCAGG CTTTGGGCTT CAATTGGAGA GGGAGATGTC AGGGATGGTT 
CCAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC11 ( XM_005258477.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005258534.2 Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu74735
Clone ID Related Accession (Same CDS sequence)	XM_005258477.3
Accession Version	XM_005258477.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1368bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 11 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005258477.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTATGCC CCCAAAGACC TTATTATCAG CATTTCACAT 
GACAACACGT CAGCCCTGGA ACTCCAGGGA AACGTCATAT ATCTGGAAGT TCAGAAAGGC 
CAGTTCCTGC GGCTCCTCTG TGCTGCTGAC AGCCAGCCCC CTGCCACGCT GAGCTGGGTC 
CTGCAGGACA GAGTCCTCTC CTCGTCCCAC CCCTGGGGCC CCAGAACCCT GGGGCTGGAG 
CTGCGTGGGG TAAGGGCCGG GGATTCAGGG CGCTACACCT GCCGAGCGGA GAACAGGCTT 
GGCTCCCAGC AGCAAGCCCT GGACCTCTCT GTGCAGTATC CTCCAGAGAA CCTGAGAGTG 
ATGGTTTCCC AAGCAAACAG GACAGTCCTG GAAAACCTCG GGAACGGCAC ATCCCTCCCG 
GTCCTGGAGG GCCAAAGCCT GCGCCTGGTC TGTGTCACCC ACAGCAGCCC CCCAGCCAGG 
CTGAGCTGGA CCCGGTGGGG ACAGACCGTG GGCCCCTCCC AGCCCTCAGA CCCCGGGGTC 
CTGGAGCTGC CACCCATTCA AATGGAGCAC GAAGGAGAGT TCACCTGCCA CGCTCAGCAC 
CCTCTGGGCT CCCAGCACGT CTCTCTCAGC CTCTCCGTGC ACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005258534.2
CDS	33..1400
Translation	MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHW

Target ORF information:

RefSeq Version	XM_005258477.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005258477.3

ORF Insert Sequence:

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTATGCC CCCAAAGACC TTATTATCAG CATTTCACAT 
GACAACACGT CAGCCCTGGA ACTCCAGGGA AACGTCATAT ATCTGGAAGT TCAGAAAGGC 
CAGTTCCTGC GGCTCCTCTG TGCTGCTGAC AGCCAGCCCC CTGCCACGCT GAGCTGGGTC 
CTGCAGGACA GAGTCCTCTC CTCGTCCCAC CCCTGGGGCC CCAGAACCCT GGGGCTGGAG 
CTGCGTGGGG TAAGGGCCGG GGATTCAGGG CGCTACACCT GCCGAGCGGA GAACAGGCTT 
GGCTCCCAGC AGCAAGCCCT GGACCTCTCT GTGCAGTATC CTCCAGAGAA CCTGAGAGTG 
ATGGTTTCCC AAGCAAACAG GACAGTCCTG GAAAACCTCG GGAACGGCAC ATCCCTCCCG 
GTCCTGGAGG GCCAAAGCCT GCGCCTGGTC TGTGTCACCC ACAGCAGCCC CCCAGCCAGG 
CTGAGCTGGA CCCGGTGGGG ACAGACCGTG GGCCCCTCCC AGCCCTCAGA CCCCGGGGTC 
CTGGAGCTGC CACCCATTCA AATGGAGCAC GAAGGAGAGT TCACCTGCCA CGCTCAGCAC 
CCTCTGGGCT CCCAGCACGT CTCTCTCAGC CTCTCCGTGC ACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC11 ( NM_052884.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_443116.2 Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19613
Clone ID Related Accession (Same CDS sequence)	NM_052884.2 , NM_052884.3
Accession Version	NM_052884.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2097bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 11 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF337818.1 and AC011452.6. This sequence is a reference standard in the RefSeqGene project. On Sep 23, 2008 this sequence version replaced NM_052884.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF337818.1, AB072038.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTATGCC CCCAAAGACC TTATTATCAG CATTTCACAT 
GACAACACGT CAGCCCTGGA ACTCCAGGGA AACGTCATAT ATCTGGAAGT TCAGAAAGGC 
CAGTTCCTGC GGCTCCTCTG TGCTGCTGAC AGCCAGCCCC CTGCCACGCT GAGCTGGGTC 
CTGCAGGACA GAGTCCTCTC CTCGTCCCAC CCCTGGGGCC CCAGAACCCT GGGGCTGGAG 
CTGCGTGGGG TAAGGGCCGG GGATTCAGGG CGCTACACCT GCCGAGCGGA GAACAGGCTT 
GGCTCCCAGC AGCAAGCCCT GGACCTCTCT GTGCAGTATC CTCCAGAGAA CCTGAGAGTG 
ATGGTTTCCC AAGCAAACAG GACAGTCCTG GAAAACCTCG GGAACGGCAC ATCCCTCCCG 
GTCCTGGAGG GCCAAAGCCT GCGCCTGGTC TGTGTCACCC ACAGCAGCCC CCCAGCCAGG 
CTGAGCTGGA CCCGGTGGGG ACAGACCGTG GGCCCCTCCC AGCCCTCAGA CCCCGGGGTC 
CTGGAGCTGC CACCCATTCA AATGGAGCAC GAAGGAGAGT TCACCTGCCA CGCTCAGCAC 
CCTCTGGGCT CCCAGCACGT CTCTCTCAGC CTCTCCGTGC ACTACCCTCC ACAGCTGCTG 
GGCCCCTCCT GCTCCTGGGA GGCTGAGGGT CTGCACTGCA GCTGCTCCTC CCAGGCCAGC 
CCGGCCCCCT CTCTGCGCTG GTGGCTTGGG GAGGAGCTGC TGGAGGGGAA CAGCAGTCAG 
GGCTCCTTCG AGGTCACCCC CAGCTCAGCC GGGCCCTGGG CCAACAGCTC CCTGAGCCTC 
CATGGAGGGC TCAGCTCCGG CCTCAGGCTC CGCTGTAAGG CCTGGAACGT CCACGGGGCC 
CAGAGTGGCT CTGTCTTCCA GCTGCTACCA GGGAAGCTGG AGCATGGGGG AGGACTTGGC 
CTGGGGGCTG CCCTGGGAGC TGGCGTCGCT GCCCTGCTCG CTTTCTGTTC CTGCCTTGTC 
GTCTTCAGGG TGAAGATCTG CAGGAAGGAA GCTCGCAAGA GGGCAGCAGC TGAGCAGGAC 
GTGCCCTCCA CCCTGGGACC CATCTCCCAG GGTCACCAGC ATGAATGCTC GGCAGGCAGC 
TCCCAAGACC ACCCGCCCCC AGGTGCAGCC ACCTACACCC CGGGGAAGGG GGAAGAGCAG 
GAGCTCCACT ATGCCTCCCT CAGCTTCCAG GGCCTGAGGC TCTGGGAGCC TGCGGACCAG 
GAGGCCCCCA GCACCACCGA GTACTCGGAG ATCAAGATCC ACACAGGACA GCCCCTGAGG 
GGCCCAGGCT TTGGGCTTCA ATTGGAGAGG GAGATGTCAG GGATGGTTCC AAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443116.2
CDS	92..2188
Translation	MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSVFQLLPGKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAAAEQDVPSTLGPISQGHQHECSAGSSQDHPPPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQEAPSTTEYSEIKIHTGQPLRGPGFGLQLEREMSGMVPK

Target ORF information:

RefSeq Version	NM_052884.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052884.2

ORF Insert Sequence:

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTATGCC CCCAAAGACC TTATTATCAG CATTTCACAT 
GACAACACGT CAGCCCTGGA ACTCCAGGGA AACGTCATAT ATCTGGAAGT TCAGAAAGGC 
CAGTTCCTGC GGCTCCTCTG TGCTGCTGAC AGCCAGCCCC CTGCCACGCT GAGCTGGGTC 
CTGCAGGACA GAGTCCTCTC CTCGTCCCAC CCCTGGGGCC CCAGAACCCT GGGGCTGGAG 
CTGCGTGGGG TAAGGGCCGG GGATTCAGGG CGCTACACCT GCCGAGCGGA GAACAGGCTT 
GGCTCCCAGC AGCAAGCCCT GGACCTCTCT GTGCAGTATC CTCCAGAGAA CCTGAGAGTG 
ATGGTTTCCC AAGCAAACAG GACAGTCCTG GAAAACCTCG GGAACGGCAC ATCCCTCCCG 
GTCCTGGAGG GCCAAAGCCT GCGCCTGGTC TGTGTCACCC ACAGCAGCCC CCCAGCCAGG 
CTGAGCTGGA CCCGGTGGGG ACAGACCGTG GGCCCCTCCC AGCCCTCAGA CCCCGGGGTC 
CTGGAGCTGC CACCCATTCA AATGGAGCAC GAAGGAGAGT TCACCTGCCA CGCTCAGCAC 
CCTCTGGGCT CCCAGCACGT CTCTCTCAGC CTCTCCGTGC ACTACCCTCC ACAGCTGCTG 
GGCCCCTCCT GCTCCTGGGA GGCTGAGGGT CTGCACTGCA GCTGCTCCTC CCAGGCCAGC 
CCGGCCCCCT CTCTGCGCTG GTGGCTTGGG GAGGAGCTGC TGGAGGGGAA CAGCAGTCAG 
GGCTCCTTCG AGGTCACCCC CAGCTCAGCC GGGCCCTGGG CCAACAGCTC CCTGAGCCTC 
CATGGAGGGC TCAGCTCCGG CCTCAGGCTC CGCTGTAAGG CCTGGAACGT CCACGGGGCC 
CAGAGTGGCT CTGTCTTCCA GCTGCTACCA GGGAAGCTGG AGCATGGGGG AGGACTTGGC 
CTGGGGGCTG CCCTGGGAGC TGGCGTCGCT GCCCTGCTCG CTTTCTGTTC CTGCCTTGTC 
GTCTTCAGGG TGAAGATCTG CAGGAAGGAA GCTCGCAAGA GGGCAGCAGC TGAGCAGGAC 
GTGCCCTCCA CCCTGGGACC CATCTCCCAG GGTCACCAGC ATGAATGCTC GGCAGGCAGC 
TCCCAAGACC ACCCGCCCCC AGGTGCAGCC ACCTACACCC CGGGGAAGGG GGAAGAGCAG 
GAGCTCCACT ATGCCTCCCT CAGCTTCCAG GGCCTGAGGC TCTGGGAGCC TGCGGACCAG 
GAGGCCCCCA GCACCACCGA GTACTCGGAG ATCAAGATCC ACACAGGACA GCCCCTGAGG 
GGCCCAGGCT TTGGGCTTCA ATTGGAGAGG GAGATGTCAG GGATGGTTCC AAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC11 ( NM_052884.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_443116.2 Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant 1, mRNA.

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CloneID	OHu19613
Clone ID Related Accession (Same CDS sequence)	NM_052884.2 , NM_052884.3
Accession Version	NM_052884.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2097bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 11 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF337818.1 and AC011452.6. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_052884.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF337818.1, AB072038.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal MANE Ensembl match :: ENST00000447370.6/ ENSP00000412361.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTATGCC CCCAAAGACC TTATTATCAG CATTTCACAT 
GACAACACGT CAGCCCTGGA ACTCCAGGGA AACGTCATAT ATCTGGAAGT TCAGAAAGGC 
CAGTTCCTGC GGCTCCTCTG TGCTGCTGAC AGCCAGCCCC CTGCCACGCT GAGCTGGGTC 
CTGCAGGACA GAGTCCTCTC CTCGTCCCAC CCCTGGGGCC CCAGAACCCT GGGGCTGGAG 
CTGCGTGGGG TAAGGGCCGG GGATTCAGGG CGCTACACCT GCCGAGCGGA GAACAGGCTT 
GGCTCCCAGC AGCAAGCCCT GGACCTCTCT GTGCAGTATC CTCCAGAGAA CCTGAGAGTG 
ATGGTTTCCC AAGCAAACAG GACAGTCCTG GAAAACCTCG GGAACGGCAC ATCCCTCCCG 
GTCCTGGAGG GCCAAAGCCT GCGCCTGGTC TGTGTCACCC ACAGCAGCCC CCCAGCCAGG 
CTGAGCTGGA CCCGGTGGGG ACAGACCGTG GGCCCCTCCC AGCCCTCAGA CCCCGGGGTC 
CTGGAGCTGC CACCCATTCA AATGGAGCAC GAAGGAGAGT TCACCTGCCA CGCTCAGCAC 
CCTCTGGGCT CCCAGCACGT CTCTCTCAGC CTCTCCGTGC ACTACCCTCC ACAGCTGCTG 
GGCCCCTCCT GCTCCTGGGA GGCTGAGGGT CTGCACTGCA GCTGCTCCTC CCAGGCCAGC 
CCGGCCCCCT CTCTGCGCTG GTGGCTTGGG GAGGAGCTGC TGGAGGGGAA CAGCAGTCAG 
GGCTCCTTCG AGGTCACCCC CAGCTCAGCC GGGCCCTGGG CCAACAGCTC CCTGAGCCTC 
CATGGAGGGC TCAGCTCCGG CCTCAGGCTC CGCTGTAAGG CCTGGAACGT CCACGGGGCC 
CAGAGTGGCT CTGTCTTCCA GCTGCTACCA GGGAAGCTGG AGCATGGGGG AGGACTTGGC 
CTGGGGGCTG CCCTGGGAGC TGGCGTCGCT GCCCTGCTCG CTTTCTGTTC CTGCCTTGTC 
GTCTTCAGGG TGAAGATCTG CAGGAAGGAA GCTCGCAAGA GGGCAGCAGC TGAGCAGGAC 
GTGCCCTCCA CCCTGGGACC CATCTCCCAG GGTCACCAGC ATGAATGCTC GGCAGGCAGC 
TCCCAAGACC ACCCGCCCCC AGGTGCAGCC ACCTACACCC CGGGGAAGGG GGAAGAGCAG 
GAGCTCCACT ATGCCTCCCT CAGCTTCCAG GGCCTGAGGC TCTGGGAGCC TGCGGACCAG 
GAGGCCCCCA GCACCACCGA GTACTCGGAG ATCAAGATCC ACACAGGACA GCCCCTGAGG 
GGCCCAGGCT TTGGGCTTCA ATTGGAGAGG GAGATGTCAG GGATGGTTCC AAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443116.2
CDS	92..2188
Translation	MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSVFQLLPGKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAAAEQDVPSTLGPISQGHQHECSAGSSQDHPPPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQEAPSTTEYSEIKIHTGQPLRGPGFGLQLEREMSGMVPK

Target ORF information:

RefSeq Version	NM_052884.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052884.3

ORF Insert Sequence:

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTATGCC CCCAAAGACC TTATTATCAG CATTTCACAT 
GACAACACGT CAGCCCTGGA ACTCCAGGGA AACGTCATAT ATCTGGAAGT TCAGAAAGGC 
CAGTTCCTGC GGCTCCTCTG TGCTGCTGAC AGCCAGCCCC CTGCCACGCT GAGCTGGGTC 
CTGCAGGACA GAGTCCTCTC CTCGTCCCAC CCCTGGGGCC CCAGAACCCT GGGGCTGGAG 
CTGCGTGGGG TAAGGGCCGG GGATTCAGGG CGCTACACCT GCCGAGCGGA GAACAGGCTT 
GGCTCCCAGC AGCAAGCCCT GGACCTCTCT GTGCAGTATC CTCCAGAGAA CCTGAGAGTG 
ATGGTTTCCC AAGCAAACAG GACAGTCCTG GAAAACCTCG GGAACGGCAC ATCCCTCCCG 
GTCCTGGAGG GCCAAAGCCT GCGCCTGGTC TGTGTCACCC ACAGCAGCCC CCCAGCCAGG 
CTGAGCTGGA CCCGGTGGGG ACAGACCGTG GGCCCCTCCC AGCCCTCAGA CCCCGGGGTC 
CTGGAGCTGC CACCCATTCA AATGGAGCAC GAAGGAGAGT TCACCTGCCA CGCTCAGCAC 
CCTCTGGGCT CCCAGCACGT CTCTCTCAGC CTCTCCGTGC ACTACCCTCC ACAGCTGCTG 
GGCCCCTCCT GCTCCTGGGA GGCTGAGGGT CTGCACTGCA GCTGCTCCTC CCAGGCCAGC 
CCGGCCCCCT CTCTGCGCTG GTGGCTTGGG GAGGAGCTGC TGGAGGGGAA CAGCAGTCAG 
GGCTCCTTCG AGGTCACCCC CAGCTCAGCC GGGCCCTGGG CCAACAGCTC CCTGAGCCTC 
CATGGAGGGC TCAGCTCCGG CCTCAGGCTC CGCTGTAAGG CCTGGAACGT CCACGGGGCC 
CAGAGTGGCT CTGTCTTCCA GCTGCTACCA GGGAAGCTGG AGCATGGGGG AGGACTTGGC 
CTGGGGGCTG CCCTGGGAGC TGGCGTCGCT GCCCTGCTCG CTTTCTGTTC CTGCCTTGTC 
GTCTTCAGGG TGAAGATCTG CAGGAAGGAA GCTCGCAAGA GGGCAGCAGC TGAGCAGGAC 
GTGCCCTCCA CCCTGGGACC CATCTCCCAG GGTCACCAGC ATGAATGCTC GGCAGGCAGC 
TCCCAAGACC ACCCGCCCCC AGGTGCAGCC ACCTACACCC CGGGGAAGGG GGAAGAGCAG 
GAGCTCCACT ATGCCTCCCT CAGCTTCCAG GGCCTGAGGC TCTGGGAGCC TGCGGACCAG 
GAGGCCCCCA GCACCACCGA GTACTCGGAG ATCAAGATCC ACACAGGACA GCCCCTGAGG 
GGCCCAGGCT TTGGGCTTCA ATTGGAGAGG GAGATGTCAG GGATGGTTCC AAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC11 ( XM_005258476.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005258533.2 Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant X1, mRNA.

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CloneID	OHu74734
Clone ID Related Accession (Same CDS sequence)	XM_005258476.3
Accession Version	XM_005258476.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2049bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 11 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005258476.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTCCCTG GAACTCCAGG GAAACGTCAT ATATCTGGAA 
GTTCAGAAAG GCCAGTTCCT GCGGCTCCTC TGTGCTGCTG ACAGCCAGCC CCCTGCCACG 
CTGAGCTGGG TCCTGCAGGA CAGAGTCCTC TCCTCGTCCC ACCCCTGGGG CCCCAGAACC 
CTGGGGCTGG AGCTGCGTGG GGTAAGGGCC GGGGATTCAG GGCGCTACAC CTGCCGAGCG 
GAGAACAGGC TTGGCTCCCA GCAGCAAGCC CTGGACCTCT CTGTGCAGTA TCCTCCAGAG 
AACCTGAGAG TGATGGTTTC CCAAGCAAAC AGGACAGTCC TGGAAAACCT CGGGAACGGC 
ACATCCCTCC CGGTCCTGGA GGGCCAAAGC CTGCGCCTGG TCTGTGTCAC CCACAGCAGC 
CCCCCAGCCA GGCTGAGCTG GACCCGGTGG GGACAGACCG TGGGCCCCTC CCAGCCCTCA 
GACCCCGGGG TCCTGGAGCT GCCACCCATT CAAATGGAGC ACGAAGGAGA GTTCACCTGC 
CACGCTCAGC ACCCTCTGGG CTCCCAGCAC GTCTCTCTCA GCCTCTCCGT GCACTACCCT 
CCACAGCTGC TGGGCCCCTC CTGCTCCTGG GAGGCTGAGG GTCTGCACTG CAGCTGCTCC 
TCCCAGGCCA GCCCGGCCCC CTCTCTGCGC TGGTGGCTTG GGGAGGAGCT GCTGGAGGGG 
AACAGCAGTC AGGGCTCCTT CGAGGTCACC CCCAGCTCAG CCGGGCCCTG GGCCAACAGC 
TCCCTGAGCC TCCATGGAGG GCTCAGCTCC GGCCTCAGGC TCCGCTGTAA GGCCTGGAAC 
GTCCACGGGG CCCAGAGTGG CTCTGTCTTC CAGCTGCTAC CAGGGAAGCT GGAGCATGGG 
GGAGGACTTG GCCTGGGGGC TGCCCTGGGA GCTGGCGTCG CTGCCCTGCT CGCTTTCTGT 
TCCTGCCTTG TCGTCTTCAG GGTGAAGATC TGCAGGAAGG AAGCTCGCAA GAGGGCAGCA 
GCTGAGCAGG ACGTGCCCTC CACCCTGGGA CCCATCTCCC AGGGTCACCA GCATGAATGC 
TCGGCAGGCA GCTCCCAAGA CCACCCGCCC CCAGGTGCAG CCACCTACAC CCCGGGGAAG 
GGGGAAGAGC AGGAGCTCCA CTATGCCTCC CTCAGCTTCC AGGGCCTGAG GCTCTGGGAG 
CCTGCGGACC AGGAGGCCCC CAGCACCACC GAGTACTCGG AGATCAAGAT CCACACAGGA 
CAGCCCCTGA GGGGCCCAGG CTTTGGGCTT CAATTGGAGA GGGAGATGTC AGGGATGGTT 
CCAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005258533.2
CDS	33..2081
Translation	MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVASLELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSVFQLLPGKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAAAEQDVPSTLGPISQGHQHECSAGSSQDHPPPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQEAPSTTEYSEIKIHTGQPLRGPGFGLQLEREMSGMVPK

Target ORF information:

RefSeq Version	XM_005258476.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005258476.3

ORF Insert Sequence:

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGACG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCC TGAGCAATGC GTTCTTTCTA AAAGTAACAG CCCTGACTAA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTCCCTG GAACTCCAGG GAAACGTCAT ATATCTGGAA 
GTTCAGAAAG GCCAGTTCCT GCGGCTCCTC TGTGCTGCTG ACAGCCAGCC CCCTGCCACG 
CTGAGCTGGG TCCTGCAGGA CAGAGTCCTC TCCTCGTCCC ACCCCTGGGG CCCCAGAACC 
CTGGGGCTGG AGCTGCGTGG GGTAAGGGCC GGGGATTCAG GGCGCTACAC CTGCCGAGCG 
GAGAACAGGC TTGGCTCCCA GCAGCAAGCC CTGGACCTCT CTGTGCAGTA TCCTCCAGAG 
AACCTGAGAG TGATGGTTTC CCAAGCAAAC AGGACAGTCC TGGAAAACCT CGGGAACGGC 
ACATCCCTCC CGGTCCTGGA GGGCCAAAGC CTGCGCCTGG TCTGTGTCAC CCACAGCAGC 
CCCCCAGCCA GGCTGAGCTG GACCCGGTGG GGACAGACCG TGGGCCCCTC CCAGCCCTCA 
GACCCCGGGG TCCTGGAGCT GCCACCCATT CAAATGGAGC ACGAAGGAGA GTTCACCTGC 
CACGCTCAGC ACCCTCTGGG CTCCCAGCAC GTCTCTCTCA GCCTCTCCGT GCACTACCCT 
CCACAGCTGC TGGGCCCCTC CTGCTCCTGG GAGGCTGAGG GTCTGCACTG CAGCTGCTCC 
TCCCAGGCCA GCCCGGCCCC CTCTCTGCGC TGGTGGCTTG GGGAGGAGCT GCTGGAGGGG 
AACAGCAGTC AGGGCTCCTT CGAGGTCACC CCCAGCTCAG CCGGGCCCTG GGCCAACAGC 
TCCCTGAGCC TCCATGGAGG GCTCAGCTCC GGCCTCAGGC TCCGCTGTAA GGCCTGGAAC 
GTCCACGGGG CCCAGAGTGG CTCTGTCTTC CAGCTGCTAC CAGGGAAGCT GGAGCATGGG 
GGAGGACTTG GCCTGGGGGC TGCCCTGGGA GCTGGCGTCG CTGCCCTGCT CGCTTTCTGT 
TCCTGCCTTG TCGTCTTCAG GGTGAAGATC TGCAGGAAGG AAGCTCGCAA GAGGGCAGCA 
GCTGAGCAGG ACGTGCCCTC CACCCTGGGA CCCATCTCCC AGGGTCACCA GCATGAATGC 
TCGGCAGGCA GCTCCCAAGA CCACCCGCCC CCAGGTGCAG CCACCTACAC CCCGGGGAAG 
GGGGAAGAGC AGGAGCTCCA CTATGCCTCC CTCAGCTTCC AGGGCCTGAG GCTCTGGGAG 
CCTGCGGACC AGGAGGCCCC CAGCACCACC GAGTACTCGG AGATCAAGAT CCACACAGGA 
CAGCCCCTGA GGGGCCCAGG CTTTGGGCTT CAATTGGAGA GGGAGATGTC AGGGATGGTT 
CCAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.
The EMBO journal36(6)751-760(2017 03)
Schwarz F,Landig CS,Siddiqui S,Secundino I,Olson J,Varki N,Nizet V,Varki A

Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology.
Glycobiology21(8)1038-48(2011 Aug)
Wang X,Chow R,Deng L,Anderson D,Weidner N,Godwin AK,Bewtra C,Zlotnik A,Bui J,Varki A,Varki N

Alleviation of neurotoxicity by microglial human Siglec-11.
The Journal of neuroscience : the official journal of the Society for Neuroscience30(9)3482-8(2010 Mar)
Wang Y,Neumann H

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.
European journal of immunology38(8)2303-15(2008 Aug)
Cao H,Lakner U,de Bono B,Traherne JA,Trowsdale J,Barrow AD

A human-specific gene in microglia.
Science (New York, N.Y.)309(5741)1693(2005 Sep)
Hayakawa T,Angata T,Lewis AL,Mikkelsen TS,Varki NM,Varki A

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SIGLEC11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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