UCN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UCN3
Entrez Gene ID	114131
Full Name	urocortin 3
Synonyms	SCP,SPC,UCNIII
General protein information	Preferred Names urocortin 3 Names urocortin-3 prepro-urocortin 3 stresscopin ucn III urocortin III
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p15.1
Summary	This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016].
Disorder MIM:	605901

mRNA and Protein(s)

mRNA	Protein	Name
NM_053049.3	NP_444277.2	urocortin-3 preproprotein
NM_053049.4	NP_444277.2	urocortin-3 preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	UCN3	NP_001069995.1
Danio rerio (zebrafish)	ucn3l	NP_001076423.1
Xenopus tropicalis (tropical clawed frog)	LOC100488336	XP_002931892.1
Homo sapiens (human)	UCN3	NP_444277.2
Rattus norvegicus (Norway rat)	Ucn3	NP_001073677.1
Pan troglodytes (chimpanzee)	UCN3	XP_507632.2
	UCN3	XP_001104616.1
Canis lupus familiaris (dog)	UCN3	XP_003638933.1
Mus musculus (house mouse)	Ucn3	NP_112540.2
Gallus gallus (chicken)	UCN3	XP_001231711.1

Gene Ontology
Bibliography

Related articles in PubMed

Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.
Pilbrow AP, Lewis KA, Perrin MH, Sweet WE, Moravec CS, Tang WH, Huising MO, Troughton RW, Cameron VA
Endocrinology157(12)4865-4874(2016 Dec)

Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.
Stirrat CG, Venkatasubramanian S, Pawade T, Mitchell AJ, Shah AS, Lang NN, Newby DE
British journal of clinical pharmacology82(4)974-82(2016 Oct)

Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3.
Telegdy G, Kov?cs AK, R?kosi K, Zar?ndi M, T?th GK
Amino acids48(9)2261-6(2016 Sep)

Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome.
Temur M, Yilmaz ?, Aksun S, ?z?n ?zbay P, Calan M, K?me T, Karakulak M, Korkmaz HA
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology32(3)218-22(2016)

Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway.
Rhee SH, Ma EL, Lee Y, Tach? Y, Pothoulakis C, Im E
The Journal of biological chemistry290(43)26194-203(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients.
Title: Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.

examination of the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 in healthy subjects and patients with heart failure
Title: Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.

Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3
Title: Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3.

circulating levels elevated and positively correlated with C-reactive protein in polycystic ovary syndrome
Title: Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome.

results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway
Title: Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway.

The following UCN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UCN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31078	NM_053049.4 Latest version!	Homo sapiens urocortin 3 (UCN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu31078	NM_053049.3	Homo sapiens urocortin 3 (UCN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UCN3 ( NM_053049.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_444277.2 Homo sapiens urocortin 3 (UCN3), mRNA.

Price & Availability↑

CloneID	OHu31078
Clone ID Related Accession (Same CDS sequence)	NM_053049.3 , NM_053049.4
Accession Version	NM_053049.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	urocortin-3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ777111.1, BQ776877.1, BQ778217.1, AY026949.1, AL683826.14 and CK821206.1. On May 12, 2016 this sequence version replaced NM_053049.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100867.2, BQ777111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGATGC CGGTCCACTT CCTGCTGCTC CTGCTGCTGC TCCTGGGGGG CCCCAGGACA 
GGCCTCCCCC ACAAGTTCTA CAAAGCCAAG CCCATCTTCA GCTGCCTCAA CACCGCCCTG 
TCTGAGGCTG AGAAGGGCCA GTGGGAGGAT GCATCCCTGC TGAGCAAGAG GAGCTTCCAC 
TACCTGCGCA GCAGAGACGC CTCTTCGGGA GAGGAGGAGG AGGGCAAAGA GAAAAAGACT 
TTCCCCATCT CTGGGGCCAG GGGTGGAGCC AGAGGCACCC GGTACAGATA CGTGTCCCAA 
GCACAGCCCA GGGGAAAGCC ACGCCAGGAC ACGGCCAAGA GTCCCCACCG CACCAAGTTC 
ACCCTGTCCC TCGACGTCCC CACCAACATC ATGAACCTCC TCTTCAACAT CGCCAAGGCC 
AAGAACCTGC GTGCCCAGGC GGCCGCCAAT GCCCACCTGA TGGCGCAAAT TGGGAGGAAG 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444277.2
CDS	229..714
Translation	MLMPVHFLLLLLLLLGGPRTGLPHKFYKAKPIFSCLNTALSEAEKGQWEDASLLSKRSFHYLRSRDASSGEEEEGKEKKTFPISGARGGARGTRYRYVSQAQPRGKPRQDTAKSPHRTKFTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQIGRKK

Target ORF information:

RefSeq Version	NM_053049.3
Organism	Homo sapiens(human)
Definition	Homo sapiens urocortin 3 (UCN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053049.3

ORF Insert Sequence:

ATGCTGATGC CGGTCCACTT CCTGCTGCTC CTGCTGCTGC TCCTGGGGGG CCCCAGGACA 
GGCCTCCCCC ACAAGTTCTA CAAAGCCAAG CCCATCTTCA GCTGCCTCAA CACCGCCCTG 
TCTGAGGCTG AGAAGGGCCA GTGGGAGGAT GCATCCCTGC TGAGCAAGAG GAGCTTCCAC 
TACCTGCGCA GCAGAGACGC CTCTTCGGGA GAGGAGGAGG AGGGCAAAGA GAAAAAGACT 
TTCCCCATCT CTGGGGCCAG GGGTGGAGCC AGAGGCACCC GGTACAGATA CGTGTCCCAA 
GCACAGCCCA GGGGAAAGCC ACGCCAGGAC ACGGCCAAGA GTCCCCACCG CACCAAGTTC 
ACCCTGTCCC TCGACGTCCC CACCAACATC ATGAACCTCC TCTTCAACAT CGCCAAGGCC 
AAGAACCTGC GTGCCCAGGC GGCCGCCAAT GCCCACCTGA TGGCGCAAAT TGGGAGGAAG 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCN3 ( NM_053049.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_444277.2 Homo sapiens urocortin 3 (UCN3), mRNA.

Price & Availability↑

CloneID	OHu31078
Clone ID Related Accession (Same CDS sequence)	NM_053049.3 , NM_053049.4
Accession Version	NM_053049.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	urocortin-3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL683826.14, BQ777111.1, BQ776877.1, BQ778217.1, AY026949.1 and CK821206.1. On Nov 23, 2018 this sequence version replaced NM_053049.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100867.2, BQ777111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380433.5/ ENSP00000369798.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGATGC CGGTCCACTT CCTGCTGCTC CTGCTGCTGC TCCTGGGGGG CCCCAGGACA 
GGCCTCCCCC ACAAGTTCTA CAAAGCCAAG CCCATCTTCA GCTGCCTCAA CACCGCCCTG 
TCTGAGGCTG AGAAGGGCCA GTGGGAGGAT GCATCCCTGC TGAGCAAGAG GAGCTTCCAC 
TACCTGCGCA GCAGAGACGC CTCTTCGGGA GAGGAGGAGG AGGGCAAAGA GAAAAAGACT 
TTCCCCATCT CTGGGGCCAG GGGTGGAGCC AGAGGCACCC GGTACAGATA CGTGTCCCAA 
GCACAGCCCA GGGGAAAGCC ACGCCAGGAC ACGGCCAAGA GTCCCCACCG CACCAAGTTC 
ACCCTGTCCC TCGACGTCCC CACCAACATC ATGAACCTCC TCTTCAACAT CGCCAAGGCC 
AAGAACCTGC GTGCCCAGGC GGCCGCCAAT GCCCACCTGA TGGCGCAAAT TGGGAGGAAG 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444277.2
CDS	272..757
Translation	MLMPVHFLLLLLLLLGGPRTGLPHKFYKAKPIFSCLNTALSEAEKGQWEDASLLSKRSFHYLRSRDASSGEEEEGKEKKTFPISGARGGARGTRYRYVSQAQPRGKPRQDTAKSPHRTKFTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQIGRKK

Target ORF information:

RefSeq Version	NM_053049.4
Organism	Homo sapiens(human)
Definition	Homo sapiens urocortin 3 (UCN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053049.4

ORF Insert Sequence:

ATGCTGATGC CGGTCCACTT CCTGCTGCTC CTGCTGCTGC TCCTGGGGGG CCCCAGGACA 
GGCCTCCCCC ACAAGTTCTA CAAAGCCAAG CCCATCTTCA GCTGCCTCAA CACCGCCCTG 
TCTGAGGCTG AGAAGGGCCA GTGGGAGGAT GCATCCCTGC TGAGCAAGAG GAGCTTCCAC 
TACCTGCGCA GCAGAGACGC CTCTTCGGGA GAGGAGGAGG AGGGCAAAGA GAAAAAGACT 
TTCCCCATCT CTGGGGCCAG GGGTGGAGCC AGAGGCACCC GGTACAGATA CGTGTCCCAA 
GCACAGCCCA GGGGAAAGCC ACGCCAGGAC ACGGCCAAGA GTCCCCACCG CACCAAGTTC 
ACCCTGTCCC TCGACGTCCC CACCAACATC ATGAACCTCC TCTTCAACAT CGCCAAGGCC 
AAGAACCTGC GTGCCCAGGC GGCCGCCAAT GCCCACCTGA TGGCGCAAAT TGGGAGGAAG 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.
Endocrinology157(12)4865-4874(2016 Dec)
Pilbrow AP,Lewis KA,Perrin MH,Sweet WE,Moravec CS,Tang WH,Huising MO,Troughton RW,Cameron VA

Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.
British journal of clinical pharmacology82(4)974-82(2016 Oct)
Stirrat CG,Venkatasubramanian S,Pawade T,Mitchell AJ,Shah AS,Lang NN,Newby DE

Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3.
Amino acids48(9)2261-6(2016 Sep)
Telegdy G,Kov?cs AK,R?kosi K,Zar?ndi M,T?th GK

Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology32(3)218-22(2016)
Temur M,Yilmaz ?,Aksun S,?z?n ?zbay P,Calan M,K?me T,Karakulak M,Korkmaz HA

Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway.
The Journal of biological chemistry290(43)26194-203(2015 Oct)
Rhee SH,Ma EL,Lee Y,Tach? Y,Pothoulakis C,Im E

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UCN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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