TXNRD3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TXNRD3
Entrez Gene ID	114112
Full Name	thioredoxin reductase 3
Synonyms	TGR,TR2,TRXR3
General protein information	Preferred Names thioredoxin reductase 3 Names thioredoxin reductase 3 thioredoxin and glutathione reductase thioredoxin glutathione reductase thioredoxin reductase 2 thioredoxin reductase TR2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q21.3
Summary	The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017].
Disorder MIM:	606235

mRNA and Protein(s)

mRNA	Protein	Name
NM_001173513.2	NP_001166984.1	thioredoxin reductase 3 isoform 2
NM_052883.2	NP_443115.1	thioredoxin reductase 3 isoform 1
NM_052883.1	NP_443115.1	thioredoxin reductase 3 isoform 1
NM_001173513.1	NP_001166984.1	thioredoxin reductase 3 isoform 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	txnrd1	NP_898895.2
Bos taurus (cattle)	TXNRD3	XP_005223242.1
Rattus norvegicus (Norway rat)	Txnrd3	NP_001171641.1
Caenorhabditis elegans (roundworm)	trxr-1	NP_501085.3
Homo sapiens (human)	TXNRD3	NP_443115.1
Pan troglodytes (chimpanzee)	TXNRD3	NP_001243146.1
Canis lupus familiaris (dog)	TXNRD3	NP_001116250.1
Mus musculus (house mouse)	Txnrd3	NP_001171529.1
Gallus gallus (chicken)	TXNRD3	NP_001116249.1

Gene Ontology
Bibliography

Related articles in PubMed

Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms.
Brandstaedter C, Fritz-Wolf K, Weder S, Fischer M, Hecker B, Rahlfs S, Becker K
The FEBS journal(2017 Dec)

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium.
Kipp AP, M?ller MF, G?ken EM, Deubel S, Brigelius-Floh? R
Biochimica et biophysica acta1820(10)1588-96(2012 Oct)

CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes.
Gerashchenko MV, Su D, Gladyshev VN
The Journal of biological chemistry285(7)4595-602(2010 Feb)

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ
BMC genetics843(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development.
Title: The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium.

This study pertains to use of non-AUG (CUG) start codon in mouse thioredoxin reductase 3 gene, and conservation of this site in other mammals.
Title: CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes.

Observational study of gene-disease association. (HuGE Navigator)
Title: A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

The following TXNRD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TXNRD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu107698	NM_052883.2 Latest version!	Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu108348	NM_001173513.2 Latest version!	Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu09385	NM_052883.1 Latest version!	Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
OHu09485	NM_001173513.1 Latest version!	Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TXNRD3 ( NM_052883.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_443115.1 Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107698
Clone ID Related Accession (Same CDS sequence)	NM_052883.2
Accession Version	NM_052883.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	thioredoxin reductase 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC024558.21. On Nov 23, 2018 this sequence version replaced NM_052883.1. Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). A non-AUG (CUG) codon is used as translation initiation codon. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.51267.1, SRR1803614.209339.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation protein contains selenocysteine :: PMID: 10455115 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

CTGGAGCGGT CGCCGCCGCA GTCGCCCGGG CCGGGAAAGG CGGGCGATGC CCCCAACCGC 
CGCTCGGGCC ATGTCCGAGG GGCGCGCGTG TTGTCGCCGC CGGGGCGCCG TGCCCGCCTG 
TCGTCCCCCG GGCCCAGCCG CTCGTCCGAG GCCCGCGAGG AGCTGCGCCG CCACCTCGTG 
GGCCTCATCG AGCGCAGCCG GGTGGTGATC TTCAGCAAGA GCTACTGTCC CCATAGTACT 
CGGGTGAAAG AACTCTTTTC TTCTTTGGGA GTCGAATGTA ATGTCTTGGA ACTTGATCAA 
GTTGATGATG GGGCCAGGGT TCAAGAAGTG CTGTCAGAAA TCACTAATCA GAAAACTGTG 
CCCAATATTT TCGTGAATAA AGTGCATGTA GGTGGATGTG ACCAAACTTT CCAGGCATAT 
CAGAGTGGTT TGTTACAGAA GCTCCTTCAG GAAGATTTGG CATATGATTA TGATCTCATC 
ATCATCGGTG GTGGTTCTGG AGGCCTTTCA TGTGCGAAGG AAGCTGCCAT TTTGGGAAAG 
AAAGTTATGG TGCTAGACTT TGTTGTCCCG TCACCTCAGG GCACATCCTG GGGTCTTGGT 
GGCACTTGTG TAAATGTAGG TTGTATTCCT AAGAAATTGA TGCATCAGGC TGCCCTTTTG 
GGGCAGGCAT TATGTGACTC AAGGAAATTT GGCTGGGAAT ATAATCAACA AGTGAGGCAC 
AACTGGGAGA CAATGACAAA AGCGATTCAG AACCACATCA GCTCTCTAAA CTGGGGCTAC 
AGGTTGTCTC TGAGGGAAAA GGCTGTGGCC TATGTCAATT CCTATGGAGA ATTTGTTGAA 
CATCATAAAA TAAAGGCAAC CAATAAAAAA GGACAGGAGA CTTATTATAC TGCTGCACAG 
TTTGTCATAG CAACGGGTGA AAGGCCACGG TATTTAGGAA TCCAAGGAGA TAAAGAATAC 
TGTATTACTA GTGATGACCT TTTTTCTCTG CCTTATTGCC CTGGCAAAAC ATTAGTGGTG 
GGTGCCTCTT ATGTTGCCCT GGAGTGTGCA GGGTTTCTGG CTGGCTTTGG CCTAGATGTC 
ACAGTTATGG TACGCTCAAT CCTTCTCCGT GGCTTCGACC AAGAAATGGC AGAAAAAGTG 
GGTTCCTACA TGGAGCAGCA TGGTGTGAAG TTCCTACGGA AATTCATACC TGTGATGGTT 
CAACAGTTGG AGAAAGGTTC ACCTGGAAAG CTGAAAGTGT TGGCTAAATC CACTGAAGGA 
ACAGAAACAA TTGAAGGAGT CTATAACACA GTTTTGTTAG CTATTGGTCG TGACTCCTGT 
ACAAGGAAAA TAGGCTTGGA GAAGATTGGT GTCAAAATTA ATGAGAAGAG TGGAAAAATA 
CCTGTAAATG ATGTGGAACA GACCAATGTG CCATATGTCT ATGCTGTTGG TGATATTTTG 
GAGGATAAGC CAGAGCTCAC TCCTGTCGCC ATACAGTCAG GCAAGCTGCT AGCTCAGAGA 
CTTTTTGGGG CCTCTTTAGA AAAGTGTGAT TATATTAATG TTCCGACTAC AGTGTTTACT 
CCTCTGGAGT ATGGTTGCTG TGGATTATCT GAAGAGAAAG CTATTGAAGT ATATAAAAAA 
GAGAATCTAG AAATATATCA TACTTTGTTC TGGCCTCTTG AATGGACAGT AGCTGGCAGA 
GAGAACAACA CTTGTTATGC AAAGATAATC TGCAATAAAT TCGACCATGA TCGGGTGATA 
GGATTTCATA TTCTTGGACC AAACGCCGGT GAGGTTACCC AAGGATTTGC AGCTGCAATG 
AAATGTGGGC TCACAAAACA GCTACTTGAT GACACCATTG GAATTCACCC CACATGTGGG 
GAGGTGTTCA CGACTTTGGA AATCACAAAG TCGTCAGGAC TAGACATCAC TCAGAAAGGC 
TGCTGAGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443115.1
CDS	135..2066
Translation	LERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTVPNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGC*G

Target ORF information:

RefSeq Version	NM_052883.2
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052883.2

ORF Insert Sequence:

CTGGAGCGGT CGCCGCCGCA GTCGCCCGGG CCGGGAAAGG CGGGCGATGC CCCCAACCGC 
CGCTCGGGCC ATGTCCGAGG GGCGCGCGTG TTGTCGCCGC CGGGGCGCCG TGCCCGCCTG 
TCGTCCCCCG GGCCCAGCCG CTCGTCCGAG GCCCGCGAGG AGCTGCGCCG CCACCTCGTG 
GGCCTCATCG AGCGCAGCCG GGTGGTGATC TTCAGCAAGA GCTACTGTCC CCATAGTACT 
CGGGTGAAAG AACTCTTTTC TTCTTTGGGA GTCGAATGTA ATGTCTTGGA ACTTGATCAA 
GTTGATGATG GGGCCAGGGT TCAAGAAGTG CTGTCAGAAA TCACTAATCA GAAAACTGTG 
CCCAATATTT TCGTGAATAA AGTGCATGTA GGTGGATGTG ACCAAACTTT CCAGGCATAT 
CAGAGTGGTT TGTTACAGAA GCTCCTTCAG GAAGATTTGG CATATGATTA TGATCTCATC 
ATCATCGGTG GTGGTTCTGG AGGCCTTTCA TGTGCGAAGG AAGCTGCCAT TTTGGGAAAG 
AAAGTTATGG TGCTAGACTT TGTTGTCCCG TCACCTCAGG GCACATCCTG GGGTCTTGGT 
GGCACTTGTG TAAATGTAGG TTGTATTCCT AAGAAATTGA TGCATCAGGC TGCCCTTTTG 
GGGCAGGCAT TATGTGACTC AAGGAAATTT GGCTGGGAAT ATAATCAACA AGTGAGGCAC 
AACTGGGAGA CAATGACAAA AGCGATTCAG AACCACATCA GCTCTCTAAA CTGGGGCTAC 
AGGTTGTCTC TGAGGGAAAA GGCTGTGGCC TATGTCAATT CCTATGGAGA ATTTGTTGAA 
CATCATAAAA TAAAGGCAAC CAATAAAAAA GGACAGGAGA CTTATTATAC TGCTGCACAG 
TTTGTCATAG CAACGGGTGA AAGGCCACGG TATTTAGGAA TCCAAGGAGA TAAAGAATAC 
TGTATTACTA GTGATGACCT TTTTTCTCTG CCTTATTGCC CTGGCAAAAC ATTAGTGGTG 
GGTGCCTCTT ATGTTGCCCT GGAGTGTGCA GGGTTTCTGG CTGGCTTTGG CCTAGATGTC 
ACAGTTATGG TACGCTCAAT CCTTCTCCGT GGCTTCGACC AAGAAATGGC AGAAAAAGTG 
GGTTCCTACA TGGAGCAGCA TGGTGTGAAG TTCCTACGGA AATTCATACC TGTGATGGTT 
CAACAGTTGG AGAAAGGTTC ACCTGGAAAG CTGAAAGTGT TGGCTAAATC CACTGAAGGA 
ACAGAAACAA TTGAAGGAGT CTATAACACA GTTTTGTTAG CTATTGGTCG TGACTCCTGT 
ACAAGGAAAA TAGGCTTGGA GAAGATTGGT GTCAAAATTA ATGAGAAGAG TGGAAAAATA 
CCTGTAAATG ATGTGGAACA GACCAATGTG CCATATGTCT ATGCTGTTGG TGATATTTTG 
GAGGATAAGC CAGAGCTCAC TCCTGTCGCC ATACAGTCAG GCAAGCTGCT AGCTCAGAGA 
CTTTTTGGGG CCTCTTTAGA AAAGTGTGAT TATATTAATG TTCCGACTAC AGTGTTTACT 
CCTCTGGAGT ATGGTTGCTG TGGATTATCT GAAGAGAAAG CTATTGAAGT ATATAAAAAA 
GAGAATCTAG AAATATATCA TACTTTGTTC TGGCCTCTTG AATGGACAGT AGCTGGCAGA 
GAGAACAACA CTTGTTATGC AAAGATAATC TGCAATAAAT TCGACCATGA TCGGGTGATA 
GGATTTCATA TTCTTGGACC AAACGCCGGT GAGGTTACCC AAGGATTTGC AGCTGCAATG 
AAATGTGGGC TCACAAAACA GCTACTTGAT GACACCATTG GAATTCACCC CACATGTGGG 
GAGGTGTTCA CGACTTTGGA AATCACAAAG TCGTCAGGAC TAGACATCAC TCAGAAAGGC 
TGCTGAGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXNRD3 ( NM_001173513.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166984.1 Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu108348
Clone ID Related Accession (Same CDS sequence)	NM_001173513.2
Accession Version	NM_001173513.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	thioredoxin reductase 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC024558.21. On Jun 2, 2019 this sequence version replaced NM_001173513.1. Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, which results in a shorter isoform (2) missing an internal protein segment compared to isoform 1. A non-AUG (CUG) codon is used as translation initiation codon. ##Evidence-Data-START## Transcript exon combination :: AK299502.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation protein contains selenocysteine :: PMID: 10455115 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGGAGCGGT CGCCGCCGCA GTCGCCCGGG CCGGGAAAGG CGGGCGATGC CCCCAACCGC 
CGCTCGGGCC ATGTCCGAGG GGCGCGCGTG TTGTCGCCGC CGGGGCGCCG TGCCCGCCTG 
TCGTCCCCCG GGCCCAGCCG CTCGTCCGAG GCCCGCGAGG AGCTGCGCCG CCACCTCGTG 
GGCCTCATCG AGCGCAGCCG GGTGGTGATC TTCAGCAAGA GCTACTGTCC CCATAGTACT 
CGGGTGAAAG AACTCTTTTC TTCTTTGGGA GTCGAATGTA ATGTCTTGGA ACTTGATCAA 
GTTGATGATG GGGCCAGGGT TCAAGAAGTG CTGTCAGAAA TCACTAATCA GAAAACTGTG 
CCCAATATTT TCGTGAATAA AGTGCATGTA GGTGGATGTG ACCAAACTTT CCAGGCATAT 
CAGAGTGGTT TGTTACAGAA GCTCCTTCAG GAAGATTTGG CATATGATTA TGATCTCATC 
ATCATCGGTG GTGGTTCTGG AGGCCTTTCA TGTGCGAAGG AAGCTGCCAT TTTGGGAAAG 
AAAGTTATGG TGCTAGACTT TGTTGTCCCG TCACCTCAGG GCACATCCTG GGGTCTTGGT 
GGCACTTGTG TAAATGTAGG TTGTATTCCT AAGAAATTGA TGCATCAGGC TGCCCTTTTG 
GGGCAGGCAT TATGTGACTC AAGGAAATTT GGCTGGGAAT ATAATCAACA AGTGAGGCAC 
AACTGGGAGA CAATGACAAA AGCGATTCAG AACCACATCA GCTCTCTAAA CTGGGGCTAC 
AGGTTGTCTC TGAGGGAAAA GGCTGTGGCC TATGTCAATT CCTATGGAGA ATTTGTTGAA 
CATCATAAAA TAAAGGCAAC CAATAAAAAA GGACAGGAGA CTTATTATAC TGCTGCACAG 
TTTGTCATAG CAACGGGTGA AAGGCCACGG TATTTAGGAA TCCAAGGAGA TAAAGAATAC 
TGTATTACTA GTGATGACCT TTTTTCTCTG CCTTATTGCC CTGGCAAAAC ATTAGTGGTG 
GGTGCCTCTT ATGTTGCCCT GGAGTGTGCA GGGTTTCTGG CTGGCTTTGG CCTAGATGTC 
ACAGTTATGG TACGCTCAAT CCTTCTCCGT GGCTTCGACC AAGAAATGGC AGAAAAAGTG 
GGTTCCTACA TGGAGCAGCA TGGTGTGAAG TTCCTACGGA AATTCATACC TGTGATGGTT 
CAACAGTTGG AGAAAGGTTC ACCTGGAAAG CTGAAAGTGT TGGCTAAATC CACTGAAGGA 
ACAGAAACAA TTGAAGGAGT CTATAACACA GTTTTGTTAG CTATTGGTCG TGACTCCTGT 
ACAAGGAAAA TAGGCTTGGA GAAGATTGGT GTCAAAATTA ATGAGAAGAG TGGAAAAATA 
CCTGTAAATG ATGTGGAACA GACCAATGTG CCATATGTCT ATGCTGTTGG TGATATTTTG 
GAGGATAAGC CAGAGCTCAC TCCTGTCGCC ATACAGTCAG GCAAGCTGCT AGCTCAGAGA 
CTTTTTGGGG CCTCTTTAGA AAAGATATAT CATACTTTGT TCTGGCCTCT TGAATGGACA 
GTAGCTGGCA GAGAGAACAA CACTTGTTAT GCAAAGATAA TCTGCAATAA ATTCGACCAT 
GATCGGGTGA TAGGATTTCA TATTCTTGGA CCAAACGCCG GTGAGGTTAC CCAAGGATTT 
GCAGCTGCAA TGAAATGTGG GCTCACAAAA CAGCTACTTG ATGACACCAT TGGAATTCAC 
CCCACATGTG GGGAGGTGTT CACGACTTTG GAAATCACAA AGTCGTCAGG ACTAGACATC 
ACTCAGAAAG GCTGCTGAGG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166984.1
CDS	135..1958
Translation	LERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTVPNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGC*G

Target ORF information:

RefSeq Version	NM_001173513.2
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173513.2

ORF Insert Sequence:

CTGGAGCGGT CGCCGCCGCA GTCGCCCGGG CCGGGAAAGG CGGGCGATGC CCCCAACCGC 
CGCTCGGGCC ATGTCCGAGG GGCGCGCGTG TTGTCGCCGC CGGGGCGCCG TGCCCGCCTG 
TCGTCCCCCG GGCCCAGCCG CTCGTCCGAG GCCCGCGAGG AGCTGCGCCG CCACCTCGTG 
GGCCTCATCG AGCGCAGCCG GGTGGTGATC TTCAGCAAGA GCTACTGTCC CCATAGTACT 
CGGGTGAAAG AACTCTTTTC TTCTTTGGGA GTCGAATGTA ATGTCTTGGA ACTTGATCAA 
GTTGATGATG GGGCCAGGGT TCAAGAAGTG CTGTCAGAAA TCACTAATCA GAAAACTGTG 
CCCAATATTT TCGTGAATAA AGTGCATGTA GGTGGATGTG ACCAAACTTT CCAGGCATAT 
CAGAGTGGTT TGTTACAGAA GCTCCTTCAG GAAGATTTGG CATATGATTA TGATCTCATC 
ATCATCGGTG GTGGTTCTGG AGGCCTTTCA TGTGCGAAGG AAGCTGCCAT TTTGGGAAAG 
AAAGTTATGG TGCTAGACTT TGTTGTCCCG TCACCTCAGG GCACATCCTG GGGTCTTGGT 
GGCACTTGTG TAAATGTAGG TTGTATTCCT AAGAAATTGA TGCATCAGGC TGCCCTTTTG 
GGGCAGGCAT TATGTGACTC AAGGAAATTT GGCTGGGAAT ATAATCAACA AGTGAGGCAC 
AACTGGGAGA CAATGACAAA AGCGATTCAG AACCACATCA GCTCTCTAAA CTGGGGCTAC 
AGGTTGTCTC TGAGGGAAAA GGCTGTGGCC TATGTCAATT CCTATGGAGA ATTTGTTGAA 
CATCATAAAA TAAAGGCAAC CAATAAAAAA GGACAGGAGA CTTATTATAC TGCTGCACAG 
TTTGTCATAG CAACGGGTGA AAGGCCACGG TATTTAGGAA TCCAAGGAGA TAAAGAATAC 
TGTATTACTA GTGATGACCT TTTTTCTCTG CCTTATTGCC CTGGCAAAAC ATTAGTGGTG 
GGTGCCTCTT ATGTTGCCCT GGAGTGTGCA GGGTTTCTGG CTGGCTTTGG CCTAGATGTC 
ACAGTTATGG TACGCTCAAT CCTTCTCCGT GGCTTCGACC AAGAAATGGC AGAAAAAGTG 
GGTTCCTACA TGGAGCAGCA TGGTGTGAAG TTCCTACGGA AATTCATACC TGTGATGGTT 
CAACAGTTGG AGAAAGGTTC ACCTGGAAAG CTGAAAGTGT TGGCTAAATC CACTGAAGGA 
ACAGAAACAA TTGAAGGAGT CTATAACACA GTTTTGTTAG CTATTGGTCG TGACTCCTGT 
ACAAGGAAAA TAGGCTTGGA GAAGATTGGT GTCAAAATTA ATGAGAAGAG TGGAAAAATA 
CCTGTAAATG ATGTGGAACA GACCAATGTG CCATATGTCT ATGCTGTTGG TGATATTTTG 
GAGGATAAGC CAGAGCTCAC TCCTGTCGCC ATACAGTCAG GCAAGCTGCT AGCTCAGAGA 
CTTTTTGGGG CCTCTTTAGA AAAGATATAT CATACTTTGT TCTGGCCTCT TGAATGGACA 
GTAGCTGGCA GAGAGAACAA CACTTGTTAT GCAAAGATAA TCTGCAATAA ATTCGACCAT 
GATCGGGTGA TAGGATTTCA TATTCTTGGA CCAAACGCCG GTGAGGTTAC CCAAGGATTT 
GCAGCTGCAA TGAAATGTGG GCTCACAAAA CAGCTACTTG ATGACACCAT TGGAATTCAC 
CCCACATGTG GGGAGGTGTT CACGACTTTG GAAATCACAA AGTCGTCAGG ACTAGACATC 
ACTCAGAAAG GCTGCTGAGG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXNRD3 ( NM_052883.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_443115.1 Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09385
Clone ID Related Accession (Same CDS sequence)	NM_052883.1
Accession Version	NM_052883.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	thioredoxin reductase 3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ929894.1 and AF171055.1. Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). A non-AUG (CUG) codon is used as translation initiation codon. ##Evidence-Data-START## Transcript exon combination :: AF171055.1, SRR1660807.51267.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation protein contains selenocysteine :: PMID: 10455115 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGGAGCGGT CGCCGCCGCA GTCGCCCGGG CCGGGAAAGG CGGGCGATGC CCCCAACCGC 
CGCTCGGGCC ATGTCCGAGG GGCGCGCGTG TTGTCGCCGC CGGGGCGCCG TGCCCGCCTG 
TCGTCCCCCG GGCCCAGCCG CTCGTCCGAG GCCCGCGAGG AGCTGCGCCG CCACCTCGTG 
GGCCTCATCG AGCGCAGCCG GGTGGTGATC TTCAGCAAGA GCTACTGTCC CCATAGTACT 
CGGGTGAAAG AACTCTTTTC TTCTTTGGGA GTCGAATGTA ATGTCTTGGA ACTTGATCAA 
GTTGATGATG GGGCCAGGGT TCAAGAAGTG CTGTCAGAAA TCACTAATCA GAAAACTGTG 
CCCAATATTT TCGTGAATAA AGTGCATGTA GGTGGATGTG ACCAAACTTT CCAGGCATAT 
CAGAGTGGTT TGTTACAGAA GCTCCTTCAG GAAGATTTGG CATATGATTA TGATCTCATC 
ATCATCGGTG GTGGTTCTGG AGGCCTTTCA TGTGCGAAGG AAGCTGCCAT TTTGGGAAAG 
AAAGTTATGG TGCTAGACTT TGTTGTCCCG TCACCTCAGG GCACATCCTG GGGTCTTGGT 
GGCACTTGTG TAAATGTAGG TTGTATTCCT AAGAAATTGA TGCATCAGGC TGCCCTTTTG 
GGGCAGGCAT TATGTGACTC AAGGAAATTT GGCTGGGAAT ATAATCAACA AGTGAGGCAC 
AACTGGGAGA CAATGACAAA AGCGATTCAG AACCACATCA GCTCTCTAAA CTGGGGCTAC 
AGGTTGTCTC TGAGGGAAAA GGCTGTGGCC TATGTCAATT CCTATGGAGA ATTTGTTGAA 
CATCATAAAA TAAAGGCAAC CAATAAAAAA GGACAGGAGA CTTATTATAC TGCTGCACAG 
TTTGTCATAG CAACGGGTGA AAGGCCACGG TATTTAGGAA TCCAAGGAGA TAAAGAATAC 
TGTATTACTA GTGATGACCT TTTTTCTCTG CCTTATTGCC CTGGCAAAAC ATTAGTGGTG 
GGTGCCTCTT ATGTTGCCCT GGAGTGTGCA GGGTTTCTGG CTGGCTTTGG CCTAGATGTC 
ACAGTTATGG TACGCTCAAT CCTTCTCCGT GGCTTCGACC AAGAAATGGC AGAAAAAGTG 
GGTTCCTACA TGGAGCAGCA TGGTGTGAAG TTCCTACGGA AATTCATACC TGTGATGGTT 
CAACAGTTGG AGAAAGGTTC ACCTGGAAAG CTGAAAGTGT TGGCTAAATC CACTGAAGGA 
ACAGAAACAA TTGAAGGAGT CTATAACACA GTTTTGTTAG CTATTGGTCG TGACTCCTGT 
ACAAGGAAAA TAGGCTTGGA GAAGATTGGT GTCAAAATTA ATGAGAAGAG TGGAAAAATA 
CCTGTAAATG ATGTGGAACA GACCAATGTG CCATATGTCT ATGCTGTTGG TGATATTTTG 
GAGGATAAGC CAGAGCTCAC TCCTGTCGCC ATACAGTCAG GCAAGCTGCT AGCTCAGAGA 
CTTTTTGGGG CCTCTTTAGA AAAGTGTGAT TATATTAATG TTCCGACTAC AGTGTTTACT 
CCTCTGGAGT ATGGTTGCTG TGGATTATCT GAAGAGAAAG CTATTGAAGT ATATAAAAAA 
GAGAATCTAG AAATATATCA TACTTTGTTC TGGCCTCTTG AATGGACAGT AGCTGGCAGA 
GAGAACAACA CTTGTTACGC AAAGATAATC TGCAATAAAT TCGACCATGA TCGGGTGATA 
GGATTTCATA TTCTTGGACC AAACGCCGGT GAGGTTACCC AAGGATTTGC AGCTGCAATG 
AAATGTGGGC TCACAAAACA GCTACTTGAT GACACCATTG GAATTCACCC CACATGTGGG 
GAGGTGTTCA CGACTTTGGA AATCACAAAG TCGTCAGGAC TAGACATCAC TCAGAAAGGC 
TGCTGAGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_443115.1
CDS	135..2066
Translation	LERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTVPNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGC*G

Target ORF information:

RefSeq Version	NM_052883.1
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_052883.1

ORF Insert Sequence:

CTGGAGCGGT CGCCGCCGCA GTCGCCCGGG CCGGGAAAGG CGGGCGATGC CCCCAACCGC 
CGCTCGGGCC ATGTCCGAGG GGCGCGCGTG TTGTCGCCGC CGGGGCGCCG TGCCCGCCTG 
TCGTCCCCCG GGCCCAGCCG CTCGTCCGAG GCCCGCGAGG AGCTGCGCCG CCACCTCGTG 
GGCCTCATCG AGCGCAGCCG GGTGGTGATC TTCAGCAAGA GCTACTGTCC CCATAGTACT 
CGGGTGAAAG AACTCTTTTC TTCTTTGGGA GTCGAATGTA ATGTCTTGGA ACTTGATCAA 
GTTGATGATG GGGCCAGGGT TCAAGAAGTG CTGTCAGAAA TCACTAATCA GAAAACTGTG 
CCCAATATTT TCGTGAATAA AGTGCATGTA GGTGGATGTG ACCAAACTTT CCAGGCATAT 
CAGAGTGGTT TGTTACAGAA GCTCCTTCAG GAAGATTTGG CATATGATTA TGATCTCATC 
ATCATCGGTG GTGGTTCTGG AGGCCTTTCA TGTGCGAAGG AAGCTGCCAT TTTGGGAAAG 
AAAGTTATGG TGCTAGACTT TGTTGTCCCG TCACCTCAGG GCACATCCTG GGGTCTTGGT 
GGCACTTGTG TAAATGTAGG TTGTATTCCT AAGAAATTGA TGCATCAGGC TGCCCTTTTG 
GGGCAGGCAT TATGTGACTC AAGGAAATTT GGCTGGGAAT ATAATCAACA AGTGAGGCAC 
AACTGGGAGA CAATGACAAA AGCGATTCAG AACCACATCA GCTCTCTAAA CTGGGGCTAC 
AGGTTGTCTC TGAGGGAAAA GGCTGTGGCC TATGTCAATT CCTATGGAGA ATTTGTTGAA 
CATCATAAAA TAAAGGCAAC CAATAAAAAA GGACAGGAGA CTTATTATAC TGCTGCACAG 
TTTGTCATAG CAACGGGTGA AAGGCCACGG TATTTAGGAA TCCAAGGAGA TAAAGAATAC 
TGTATTACTA GTGATGACCT TTTTTCTCTG CCTTATTGCC CTGGCAAAAC ATTAGTGGTG 
GGTGCCTCTT ATGTTGCCCT GGAGTGTGCA GGGTTTCTGG CTGGCTTTGG CCTAGATGTC 
ACAGTTATGG TACGCTCAAT CCTTCTCCGT GGCTTCGACC AAGAAATGGC AGAAAAAGTG 
GGTTCCTACA TGGAGCAGCA TGGTGTGAAG TTCCTACGGA AATTCATACC TGTGATGGTT 
CAACAGTTGG AGAAAGGTTC ACCTGGAAAG CTGAAAGTGT TGGCTAAATC CACTGAAGGA 
ACAGAAACAA TTGAAGGAGT CTATAACACA GTTTTGTTAG CTATTGGTCG TGACTCCTGT 
ACAAGGAAAA TAGGCTTGGA GAAGATTGGT GTCAAAATTA ATGAGAAGAG TGGAAAAATA 
CCTGTAAATG ATGTGGAACA GACCAATGTG CCATATGTCT ATGCTGTTGG TGATATTTTG 
GAGGATAAGC CAGAGCTCAC TCCTGTCGCC ATACAGTCAG GCAAGCTGCT AGCTCAGAGA 
CTTTTTGGGG CCTCTTTAGA AAAGTGTGAT TATATTAATG TTCCGACTAC AGTGTTTACT 
CCTCTGGAGT ATGGTTGCTG TGGATTATCT GAAGAGAAAG CTATTGAAGT ATATAAAAAA 
GAGAATCTAG AAATATATCA TACTTTGTTC TGGCCTCTTG AATGGACAGT AGCTGGCAGA 
GAGAACAACA CTTGTTACGC AAAGATAATC TGCAATAAAT TCGACCATGA TCGGGTGATA 
GGATTTCATA TTCTTGGACC AAACGCCGGT GAGGTTACCC AAGGATTTGC AGCTGCAATG 
AAATGTGGGC TCACAAAACA GCTACTTGAT GACACCATTG GAATTCACCC CACATGTGGG 
GAGGTGTTCA CGACTTTGGA AATCACAAAG TCGTCAGGAC TAGACATCAC TCAGAAAGGC 
TGCTGAGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXNRD3 ( NM_001173513.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166984.1 Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09485
Clone ID Related Accession (Same CDS sequence)	NM_001173513.1
Accession Version	NM_001173513.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	thioredoxin reductase 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ929894.1, AK299502.1 and AF171055.1. Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, which results in a shorter isoform (2) missing an internal protein segment compared to isoform 1. A non-AUG (CUG) codon is used as translation initiation codon. ##Evidence-Data-START## Transcript exon combination :: AK299502.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation protein contains selenocysteine :: PMID: 10455115 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGGAGCGGT CGCCGCCGCA GTCGCCCGGG CCGGGAAAGG CGGGCGATGC CCCCAACCGC 
CGCTCGGGCC ATGTCCGAGG GGCGCGCGTG TTGTCGCCGC CGGGGCGCCG TGCCCGCCTG 
TCGTCCCCCG GGCCCAGCCG CTCGTCCGAG GCCCGCGAGG AGCTGCGCCG CCACCTCGTG 
GGCCTCATCG AGCGCAGCCG GGTGGTGATC TTCAGCAAGA GCTACTGTCC CCATAGTACT 
CGGGTGAAAG AACTCTTTTC TTCTTTGGGA GTCGAATGTA ATGTCTTGGA ACTTGATCAA 
GTTGATGATG GGGCCAGGGT TCAAGAAGTG CTGTCAGAAA TCACTAATCA GAAAACTGTG 
CCCAATATTT TCGTGAATAA AGTGCATGTA GGTGGATGTG ACCAAACTTT CCAGGCATAT 
CAGAGTGGTT TGTTACAGAA GCTCCTTCAG GAAGATTTGG CATATGATTA TGATCTCATC 
ATCATCGGTG GTGGTTCTGG AGGCCTTTCA TGTGCGAAGG AAGCTGCCAT TTTGGGAAAG 
AAAGTTATGG TGCTAGACTT TGTTGTCCCG TCACCTCAGG GCACATCCTG GGGTCTTGGT 
GGCACTTGTG TAAATGTAGG TTGTATTCCT AAGAAATTGA TGCATCAGGC TGCCCTTTTG 
GGGCAGGCAT TATGTGACTC AAGGAAATTT GGCTGGGAAT ATAATCAACA AGTGAGGCAC 
AACTGGGAGA CAATGACAAA AGCGATTCAG AACCACATCA GCTCTCTAAA CTGGGGCTAC 
AGGTTGTCTC TGAGGGAAAA GGCTGTGGCC TATGTCAATT CCTATGGAGA ATTTGTTGAA 
CATCATAAAA TAAAGGCAAC CAATAAAAAA GGACAGGAGA CTTATTATAC TGCTGCACAG 
TTTGTCATAG CAACGGGTGA AAGGCCACGG TATTTAGGAA TCCAAGGAGA TAAAGAATAC 
TGTATTACTA GTGATGACCT TTTTTCTCTG CCTTATTGCC CTGGCAAAAC ATTAGTGGTG 
GGTGCCTCTT ATGTTGCCCT GGAGTGTGCA GGGTTTCTGG CTGGCTTTGG CCTAGATGTC 
ACAGTTATGG TACGCTCAAT CCTTCTCCGT GGCTTCGACC AAGAAATGGC AGAAAAAGTG 
GGTTCCTACA TGGAGCAGCA TGGTGTGAAG TTCCTACGGA AATTCATACC TGTGATGGTT 
CAACAGTTGG AGAAAGGTTC ACCTGGAAAG CTGAAAGTGT TGGCTAAATC CACTGAAGGA 
ACAGAAACAA TTGAAGGAGT CTATAACACA GTTTTGTTAG CTATTGGTCG TGACTCCTGT 
ACAAGGAAAA TAGGCTTGGA GAAGATTGGT GTCAAAATTA ATGAGAAGAG TGGAAAAATA 
CCTGTAAATG ATGTGGAACA GACCAATGTG CCATATGTCT ATGCTGTTGG TGATATTTTG 
GAGGATAAGC CAGAGCTCAC TCCTGTCGCC ATACAGTCAG GCAAGCTGCT AGCTCAGAGA 
CTTTTTGGGG CCTCTTTAGA AAAGATATAT CATACTTTGT TCTGGCCTCT TGAATGGACA 
GTAGCTGGCA GAGAGAACAA CACTTGTTAC GCAAAGATAA TCTGCAATAA ATTCGACCAT 
GATCGGGTGA TAGGATTTCA TATTCTTGGA CCAAACGCCG GTGAGGTTAC CCAAGGATTT 
GCAGCTGCAA TGAAATGTGG GCTCACAAAA CAGCTACTTG ATGACACCAT TGGAATTCAC 
CCCACATGTG GGGAGGTGTT CACGACTTTG GAAATCACAA AGTCGTCAGG ACTAGACATC 
ACTCAGAAAG GCTGCTGAGG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166984.1
CDS	135..1958
Translation	LERSPPQSPGPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVVIFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTVPNIFVNKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKIYHTLFWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGC*G

Target ORF information:

RefSeq Version	NM_001173513.1
Organism	Homo sapiens(human)
Definition	Homo sapiens thioredoxin reductase 3 (TXNRD3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173513.1

ORF Insert Sequence:

CTGGAGCGGT CGCCGCCGCA GTCGCCCGGG CCGGGAAAGG CGGGCGATGC CCCCAACCGC 
CGCTCGGGCC ATGTCCGAGG GGCGCGCGTG TTGTCGCCGC CGGGGCGCCG TGCCCGCCTG 
TCGTCCCCCG GGCCCAGCCG CTCGTCCGAG GCCCGCGAGG AGCTGCGCCG CCACCTCGTG 
GGCCTCATCG AGCGCAGCCG GGTGGTGATC TTCAGCAAGA GCTACTGTCC CCATAGTACT 
CGGGTGAAAG AACTCTTTTC TTCTTTGGGA GTCGAATGTA ATGTCTTGGA ACTTGATCAA 
GTTGATGATG GGGCCAGGGT TCAAGAAGTG CTGTCAGAAA TCACTAATCA GAAAACTGTG 
CCCAATATTT TCGTGAATAA AGTGCATGTA GGTGGATGTG ACCAAACTTT CCAGGCATAT 
CAGAGTGGTT TGTTACAGAA GCTCCTTCAG GAAGATTTGG CATATGATTA TGATCTCATC 
ATCATCGGTG GTGGTTCTGG AGGCCTTTCA TGTGCGAAGG AAGCTGCCAT TTTGGGAAAG 
AAAGTTATGG TGCTAGACTT TGTTGTCCCG TCACCTCAGG GCACATCCTG GGGTCTTGGT 
GGCACTTGTG TAAATGTAGG TTGTATTCCT AAGAAATTGA TGCATCAGGC TGCCCTTTTG 
GGGCAGGCAT TATGTGACTC AAGGAAATTT GGCTGGGAAT ATAATCAACA AGTGAGGCAC 
AACTGGGAGA CAATGACAAA AGCGATTCAG AACCACATCA GCTCTCTAAA CTGGGGCTAC 
AGGTTGTCTC TGAGGGAAAA GGCTGTGGCC TATGTCAATT CCTATGGAGA ATTTGTTGAA 
CATCATAAAA TAAAGGCAAC CAATAAAAAA GGACAGGAGA CTTATTATAC TGCTGCACAG 
TTTGTCATAG CAACGGGTGA AAGGCCACGG TATTTAGGAA TCCAAGGAGA TAAAGAATAC 
TGTATTACTA GTGATGACCT TTTTTCTCTG CCTTATTGCC CTGGCAAAAC ATTAGTGGTG 
GGTGCCTCTT ATGTTGCCCT GGAGTGTGCA GGGTTTCTGG CTGGCTTTGG CCTAGATGTC 
ACAGTTATGG TACGCTCAAT CCTTCTCCGT GGCTTCGACC AAGAAATGGC AGAAAAAGTG 
GGTTCCTACA TGGAGCAGCA TGGTGTGAAG TTCCTACGGA AATTCATACC TGTGATGGTT 
CAACAGTTGG AGAAAGGTTC ACCTGGAAAG CTGAAAGTGT TGGCTAAATC CACTGAAGGA 
ACAGAAACAA TTGAAGGAGT CTATAACACA GTTTTGTTAG CTATTGGTCG TGACTCCTGT 
ACAAGGAAAA TAGGCTTGGA GAAGATTGGT GTCAAAATTA ATGAGAAGAG TGGAAAAATA 
CCTGTAAATG ATGTGGAACA GACCAATGTG CCATATGTCT ATGCTGTTGG TGATATTTTG 
GAGGATAAGC CAGAGCTCAC TCCTGTCGCC ATACAGTCAG GCAAGCTGCT AGCTCAGAGA 
CTTTTTGGGG CCTCTTTAGA AAAGATATAT CATACTTTGT TCTGGCCTCT TGAATGGACA 
GTAGCTGGCA GAGAGAACAA CACTTGTTAC GCAAAGATAA TCTGCAATAA ATTCGACCAT 
GATCGGGTGA TAGGATTTCA TATTCTTGGA CCAAACGCCG GTGAGGTTAC CCAAGGATTT 
GCAGCTGCAA TGAAATGTGG GCTCACAAAA CAGCTACTTG ATGACACCAT TGGAATTCAC 
CCCACATGTG GGGAGGTGTT CACGACTTTG GAAATCACAA AGTCGTCAGG ACTAGACATC 
ACTCAGAAAG GCTGCTGAGG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms.
The FEBS journal(2017 Dec)
Brandstaedter C,Fritz-Wolf K,Weder S,Fischer M,Hecker B,Rahlfs S,Becker K

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium.
Biochimica et biophysica acta1820(10)1588-96(2012 Oct)
Kipp AP,M?ller MF,G?ken EM,Deubel S,Brigelius-Floh? R

CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes.
The Journal of biological chemistry285(7)4595-602(2010 Feb)
Gerashchenko MV,Su D,Gladyshev VN

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
BMC genetics843(2007 Jul)
Harris SE,Fox H,Wright AF,Hayward C,Starr JM,Whalley LJ,Deary IJ

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TXNRD3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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電話

FAX

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