GABARAP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GABARAP
Entrez Gene ID	11337
Full Name	GABA type A receptor-associated protein
Synonyms	ATG8A,GABARAP-a,MM46
General protein information	Preferred Names GABA type A receptor-associated protein Names gamma-aminobutyric acid receptor-associated protein GABA(A) receptor-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Summary	Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008].
Disorder MIM:	605125

mRNA and Protein(s)

mRNA	Protein	Name
NM_007278.1	NP_009209.1	gamma-aminobutyric acid receptor-associated protein
NM_007278.2	NP_009209.1	gamma-aminobutyric acid receptor-associated protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	GABARAP	NP_009209.1
Rattus norvegicus (Norway rat)	Gabarap	NP_742033.1
	GABARAP	XP_001107079.1
Mus musculus (house mouse)	Gabarap	NP_062723.1
Danio rerio (zebrafish)	gabarapa	NP_001013278.1
Pan troglodytes (chimpanzee)	GABARAP	XP_003315392.1
Canis lupus familiaris (dog)	GABARAP	XP_536616.2
Bos taurus (cattle)	GABARAP	NP_001029220.1

Gene Ontology
Bibliography

Related articles in PubMed

Control of GABARAP-mediated autophagy by the Golgi complex, centrosome and centriolar satellites.
Joachim J, Tooze SA
Biology of the cell110(1)1-5(2018 Jan)

Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge.
Herv?s JH, Landajuela A, Ant?n Z, Shnyrova AV, Go?i FM, Alonso A
Scientific reports7(1)15614(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GABAergic synapse is proposed as a focus of aging. (Review)
Title: The space where aging acts: focus on the GABAergic synapse.

Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.
Title: Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.

Although neither GABARAPs nor LC3s are required for autophagosome biogenesis, loss of all Atg8s yields smaller autophagosomes and a slowed initial rate of autophagosome formation.
Title: Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.

Cardiolipin interaction with various Atg8 human orthologs, namely LC3B, GABARAPL2 and GABARAP, was investigated.
Title: Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP.

GABRP plays an important role in placentation and this pathway may be a promising molecular target for the development of novel therapeutic strategies for preeclampsia.
Title: GABA A receptor ? subunit promotes apoptosis of HTR-8/SVneo trophoblastic cells: Implications in preeclampsia.

The following GABARAP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GABARAP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05937	NM_007278.2 Latest version!	Homo sapiens GABA type A receptor-associated protein (GABARAP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu05937	NM_007278.1	Homo sapiens GABA type A receptor-associated protein (GABARAP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GABARAP ( NM_007278.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_009209.1 Homo sapiens GABA type A receptor-associated protein (GABARAP), mRNA.

Price & Availability↑

CloneID	OHu05937
Clone ID Related Accession (Same CDS sequence)	NM_007278.1 , NM_007278.2
Accession Version	NM_007278.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	gamma-aminobutyric acid receptor-associated protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF067171.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF067171.1, ERR279827.9606.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTTCG TGTACAAAGA AGAGCATCCG TTCGAGAAGC GCCGCTCTGA GGGCGAGAAG 
ATCCGAAAGA AATACCCGGA CCGGGTGCCG GTGATAGTAG AAAAGGCTCC CAAAGCTCGG 
ATAGGAGACC TGGACAAAAA GAAATACCTG GTGCCTTCTG ATCTCACAGT TGGTCAGTTC 
TACTTCTTGA TCCGGAAGCG AATTCATCTC CGAGCTGAGG ATGCCTTGTT TTTCTTTGTC 
AACAATGTCA TTCCACCCAC CAGTGCCACA ATGGGTCAGC TGTACCAGGA ACACCATGAA 
GAAGACTTCT TTCTCTACAT TGCCTACAGT GACGAAAGTG TCTACGGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009209.1
CDS	105..458
Translation	MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL

Target ORF information:

RefSeq Version	NM_007278.1
Organism	Homo sapiens(human)
Definition	Homo sapiens GABA type A receptor-associated protein (GABARAP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007278.1

ORF Insert Sequence:

ATGAAGTTCG TGTACAAAGA AGAGCATCCG TTCGAGAAGC GCCGCTCTGA GGGCGAGAAG 
ATCCGAAAGA AATACCCGGA CCGGGTGCCG GTGATAGTAG AAAAGGCTCC CAAAGCTCGG 
ATAGGAGACC TGGACAAAAA GAAATACCTG GTGCCTTCTG ATCTCACAGT TGGTCAGTTC 
TACTTCTTGA TCCGGAAGCG AATTCATCTC CGAGCTGAGG ATGCCTTGTT TTTCTTTGTC 
AACAATGTCA TTCCACCCAC CAGTGCCACA ATGGGTCAGC TGTACCAGGA ACACCATGAA 
GAAGACTTCT TTCTCTACAT TGCCTACAGT GACGAAAGTG TCTACGGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GABARAP ( NM_007278.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_009209.1 Homo sapiens GABA type A receptor-associated protein (GABARAP), mRNA.

Price & Availability↑

CloneID	OHu05937
Clone ID Related Accession (Same CDS sequence)	NM_007278.1 , NM_007278.2
Accession Version	NM_007278.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	gamma-aminobutyric acid receptor-associated protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC120057.9 and AF067171.1. On Nov 22, 2018 this sequence version replaced NM_007278.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.187949.1, SRR1660803.379622.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000302386.10/ ENSP00000306866.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGTTCG TGTACAAAGA AGAGCATCCG TTCGAGAAGC GCCGCTCTGA GGGCGAGAAG 
ATCCGAAAGA AATACCCGGA CCGGGTGCCG GTGATAGTAG AAAAGGCTCC CAAAGCTCGG 
ATAGGAGACC TGGACAAAAA GAAATACCTG GTGCCTTCTG ATCTCACAGT TGGTCAGTTC 
TACTTCTTGA TCCGGAAGCG AATTCATCTC CGAGCTGAGG ATGCCTTGTT TTTCTTTGTC 
AACAATGTCA TTCCACCCAC CAGTGCCACA ATGGGTCAGC TGTACCAGGA ACACCATGAA 
GAAGACTTCT TTCTCTACAT TGCCTACAGT GACGAAAGTG TCTACGGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009209.1
CDS	120..473
Translation	MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL

Target ORF information:

RefSeq Version	NM_007278.2
Organism	Homo sapiens(human)
Definition	Homo sapiens GABA type A receptor-associated protein (GABARAP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007278.2

ORF Insert Sequence:

ATGAAGTTCG TGTACAAAGA AGAGCATCCG TTCGAGAAGC GCCGCTCTGA GGGCGAGAAG 
ATCCGAAAGA AATACCCGGA CCGGGTGCCG GTGATAGTAG AAAAGGCTCC CAAAGCTCGG 
ATAGGAGACC TGGACAAAAA GAAATACCTG GTGCCTTCTG ATCTCACAGT TGGTCAGTTC 
TACTTCTTGA TCCGGAAGCG AATTCATCTC CGAGCTGAGG ATGCCTTGTT TTTCTTTGTC 
AACAATGTCA TTCCACCCAC CAGTGCCACA ATGGGTCAGC TGTACCAGGA ACACCATGAA 
GAAGACTTCT TTCTCTACAT TGCCTACAGT GACGAAAGTG TCTACGGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Control of GABARAP-mediated autophagy by the Golgi complex, centrosome and centriolar satellites.
Biology of the cell110(1)1-5(2018 Jan)
Joachim J,Tooze SA

Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge.
Scientific reports7(1)15614(2017 Nov)
Herv?s JH,Landajuela A,Ant?n Z,Shnyrova AV,Go?i FM,Alonso A

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GABARAP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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