PDAP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDAP1
Entrez Gene ID	11333
Full Name	PDGFA associated protein 1
Synonyms	HASPP28,PAP,PAP1
General protein information	Preferred Names PDGFA associated protein 1 Names 28 kDa heat- and acid-stable phosphoprotein PDGF-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010].
Disorder MIM:	607075

mRNA and Protein(s)

mRNA	Protein	Name
NM_014891.6	NP_055706.1	28 kDa heat- and acid-stable phosphoprotein
NM_014891.7	NP_055706.1	28 kDa heat- and acid-stable phosphoprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PDAP1	XP_002698262.1
Rattus norvegicus (Norway rat)	Pdap1	NP_072117.1
Gallus gallus (chicken)	PDAP1	XP_414797.1
Pan troglodytes (chimpanzee)	PDAP1	XP_001137719.2
Canis lupus familiaris (dog)	PDAP1	XP_546979.2
Mus musculus (house mouse)	Pdap1	NP_001028485.1
Xenopus tropicalis (tropical clawed frog)	LOC100135404	NP_001107539.1
	PDAP1	XP_001094158.1
Danio rerio (zebrafish)	pdap1b	NP_956504.1
Homo sapiens (human)	PDAP1	NP_055706.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased expression of platelet-derived growth factor associated protein-1 is associated with PDGF-B mediated glioma progression.
Sharma VK, Singh A, Srivastava SK, Kumar V, Gardi NL, Nalwa A, Dinda AK, Chattopadhyay P, Yadav S
The international journal of biochemistry & cell biology78194-205(2016 09)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Vill?n J, Li J, Cohn MA, Cantley LC, Gygi SP
Proceedings of the National Academy of Sciences of the United States of America101(33)12130-5(2004 Aug)

PDGF-D, a new protease-activated growth factor.
LaRochelle WJ, Jeffers M, McDonald WF, Chillakuru RA, Giese NA, Lokker NA, Sullivan C, Boldog FL, Yang M, Vernet C, Burgess CE, Fernandes E, Deegler LL, Rittman B, Shimkets J, Shimkets RA, Rothberg JM, Lichenstein HS
Nature cell biology3(5)517-21(2001 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PDAP-1 as an effecter of PDGF signaling in glioma cells
Title: Increased expression of platelet-derived growth factor associated protein-1 is associated with PDGF-B mediated glioma progression.

The following PDAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21145	NM_014891.7 Latest version!	Homo sapiens PDGFA associated protein 1 (PDAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21145	NM_014891.6	Homo sapiens PDGFA associated protein 1 (PDAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDAP1 ( NM_014891.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_055706.1 Homo sapiens PDGFA associated protein 1 (PDAP1), mRNA.

Price & Availability↑

CloneID	OHu21145
Clone ID Related Accession (Same CDS sequence)	NM_014891.6 , NM_014891.7
Accession Version	NM_014891.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	28 kDa heat- and acid-stable phosphoprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG281467.1, BI460344.1, BC000684.2, AC004922.2 and BC001578.1. This sequence is a reference standard in the RefSeqGene project. On Dec 24, 2010 this sequence version replaced NM_014891.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.313130.1, SRR1163655.33997.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155751 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTAAAG GAGGAAGAAA GGGAGGCCAC AAAGGCCGGG CGAGGCAGTA TACAAGCCCT 
GAGGAGATCG ACGCGCAGCT GCAGGCTGAG AAGCAGAAGG CCAGGGAAGA AGAGGAGCAA 
AAAGAAGGTG GAGATGGGGC TGCAGGTGAC CCCAAAAAGG AGAAGAAATC TCTAGACTCA 
GATGAGAGTG AGGATGAAGA AGATGACTAC CAGCAAAAGC GCAAAGGCGT TGAAGGGCTC 
ATCGACATCG AGAACCCCAA CCGGGTGGCA CAGACAACCA AAAAGGTCAC ACAACTGGAT 
CTGGACGGGC CAAAGGAGCT TTCGAGGAGA GAACGAGAAG AGATTGAGAA GCAGAAGGCA 
AAAGAGCGTT ACATGAAAAT GCACTTGGCC GGGAAGACAG AGCAAGCCAA GGCTGACCTG 
GCCCGGCTGG CCATCATCCG GAAACAGCGG GAGGAGGCTG CCCGGAAGAA GGAAGAGGAA 
AGGAAAGCAA AAGACGATGC CACATTGTCA GGAAAACGAA TGCAGTCACT CTCCCTGAAT 
AAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055706.1
CDS	135..680
Translation	MPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQKEGGDGAAGDPKKEKKSLDSDESEDEEDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDDATLSGKRMQSLSLNK

Target ORF information:

RefSeq Version	NM_014891.6
Organism	Homo sapiens(human)
Definition	Homo sapiens PDGFA associated protein 1 (PDAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014891.6

ORF Insert Sequence:

ATGCCTAAAG GAGGAAGAAA GGGAGGCCAC AAAGGCCGGG CGAGGCAGTA TACAAGCCCT 
GAGGAGATCG ACGCGCAGCT GCAGGCTGAG AAGCAGAAGG CCAGGGAAGA AGAGGAGCAA 
AAAGAAGGTG GAGATGGGGC TGCAGGTGAC CCCAAAAAGG AGAAGAAATC TCTAGACTCA 
GATGAGAGTG AGGATGAAGA AGATGACTAC CAGCAAAAGC GCAAAGGCGT TGAAGGGCTC 
ATCGACATCG AGAACCCCAA CCGGGTGGCA CAGACAACCA AAAAGGTCAC ACAACTGGAT 
CTGGACGGGC CAAAGGAGCT TTCGAGGAGA GAACGAGAAG AGATTGAGAA GCAGAAGGCA 
AAAGAGCGTT ACATGAAAAT GCACTTGGCC GGGAAGACAG AGCAAGCCAA GGCTGACCTG 
GCCCGGCTGG CCATCATCCG GAAACAGCGG GAGGAGGCTG CCCGGAAGAA GGAAGAGGAA 
AGGAAAGCAA AAGACGATGC CACATTGTCA GGAAAACGAA TGCAGTCACT CTCCCTGAAT 
AAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDAP1 ( NM_014891.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_055706.1 Homo sapiens PDGFA associated protein 1 (PDAP1), mRNA.

Price & Availability↑

CloneID	OHu21145
Clone ID Related Accession (Same CDS sequence)	NM_014891.6 , NM_014891.7
Accession Version	NM_014891.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	28 kDa heat- and acid-stable phosphoprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI460344.1, BC000684.2, AC004922.2 and BC001578.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_014891.6. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.482920.1, SRR3476690.121608.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2155751 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000350498.8/ ENSP00000222968.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTAAAG GAGGAAGAAA GGGAGGCCAC AAAGGCCGGG CGAGGCAGTA TACAAGCCCT 
GAGGAGATCG ACGCGCAGCT GCAGGCTGAG AAGCAGAAGG CCAGGGAAGA AGAGGAGCAA 
AAAGAAGGTG GAGATGGGGC TGCAGGTGAC CCCAAAAAGG AGAAGAAATC TCTAGACTCA 
GATGAGAGTG AGGATGAAGA AGATGACTAC CAGCAAAAGC GCAAAGGCGT TGAAGGGCTC 
ATCGACATCG AGAACCCCAA CCGGGTGGCA CAGACAACCA AAAAGGTCAC ACAACTGGAT 
CTGGACGGGC CAAAGGAGCT TTCGAGGAGA GAACGAGAAG AGATTGAGAA GCAGAAGGCA 
AAAGAGCGTT ACATGAAAAT GCACTTGGCC GGGAAGACAG AGCAAGCCAA GGCTGACCTG 
GCCCGGCTGG CCATCATCCG GAAACAGCGG GAGGAGGCTG CCCGGAAGAA GGAAGAGGAA 
AGGAAAGCAA AAGACGATGC CACATTGTCA GGAAAACGAA TGCAGTCACT CTCCCTGAAT 
AAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055706.1
CDS	50..595
Translation	MPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQKEGGDGAAGDPKKEKKSLDSDESEDEEDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDDATLSGKRMQSLSLNK

Target ORF information:

RefSeq Version	NM_014891.7
Organism	Homo sapiens(human)
Definition	Homo sapiens PDGFA associated protein 1 (PDAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014891.7

ORF Insert Sequence:

ATGCCTAAAG GAGGAAGAAA GGGAGGCCAC AAAGGCCGGG CGAGGCAGTA TACAAGCCCT 
GAGGAGATCG ACGCGCAGCT GCAGGCTGAG AAGCAGAAGG CCAGGGAAGA AGAGGAGCAA 
AAAGAAGGTG GAGATGGGGC TGCAGGTGAC CCCAAAAAGG AGAAGAAATC TCTAGACTCA 
GATGAGAGTG AGGATGAAGA AGATGACTAC CAGCAAAAGC GCAAAGGCGT TGAAGGGCTC 
ATCGACATCG AGAACCCCAA CCGGGTGGCA CAGACAACCA AAAAGGTCAC ACAACTGGAT 
CTGGACGGGC CAAAGGAGCT TTCGAGGAGA GAACGAGAAG AGATTGAGAA GCAGAAGGCA 
AAAGAGCGTT ACATGAAAAT GCACTTGGCC GGGAAGACAG AGCAAGCCAA GGCTGACCTG 
GCCCGGCTGG CCATCATCCG GAAACAGCGG GAGGAGGCTG CCCGGAAGAA GGAAGAGGAA 
AGGAAAGCAA AAGACGATGC CACATTGTCA GGAAAACGAA TGCAGTCACT CTCCCTGAAT 
AAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased expression of platelet-derived growth factor associated protein-1 is associated with PDGF-B mediated glioma progression.
The international journal of biochemistry & cell biology78194-205(2016 09)
Sharma VK,Singh A,Srivastava SK,Kumar V,Gardi NL,Nalwa A,Dinda AK,Chattopadhyay P,Yadav S

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Large-scale characterization of HeLa cell nuclear phosphoproteins.
Proceedings of the National Academy of Sciences of the United States of America101(33)12130-5(2004 Aug)
Beausoleil SA,Jedrychowski M,Schwartz D,Elias JE,Vill?n J,Li J,Cohn MA,Cantley LC,Gygi SP

PDGF-D, a new protease-activated growth factor.
Nature cell biology3(5)517-21(2001 May)
LaRochelle WJ,Jeffers M,McDonald WF,Chillakuru RA,Giese NA,Lokker NA,Sullivan C,Boldog FL,Yang M,Vernet C,Burgess CE,Fernandes E,Deegler LL,Rittman B,Shimkets J,Shimkets RA,Rothberg JM,Lichenstein HS

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PDAP1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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