HOGA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOGA1
Entrez Gene ID	112817
Full Name	4-hydroxy-2-oxoglutarate aldolase 1
Synonyms	C10orf65,DHDPS2,DHDPSL,HP3,NPL2
General protein information	Preferred Names 4-hydroxy-2-oxoglutarate aldolase 1 Names 4-hydroxy-2-oxoglutarate aldolase, mitochondrial DHDPS-like protein N-acetylneuraminate pyruvate lyase 2 (putative) dihydrodipicolinate synthase-like, mitochondrial dihydrodipicolinate synthetase homolog 2 probable 2-keto-4-hydroxyglutarate aldolase probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial probable KHG-aldolase protein 569272
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.2
Summary	The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010].
Disorder MIM:	613597
Disorder Html:	Hyperoxaluria, primary, type III, 613616 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134670.1	NP_001128142.1	4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 2
NM_138413.3	NP_612422.2	4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 1
NM_138413.4	NP_612422.2	4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	HOGA1	NP_612422.2
Bos taurus (cattle)	HOGA1	NP_001068705.1
Gallus gallus (chicken)	C10ORF65	XP_001233352.2
Magnaporthe oryzae (rice blast fungus)	MGG_07462	XP_003711366.1
Neurospora crassa	NCU09532	XP_957838.1
Pan troglodytes (chimpanzee)	HOGA1	XP_001164461.1
Mus musculus (house mouse)	Hoga1	NP_080428.1
Danio rerio (zebrafish)	hoga1	NP_998035.1
Rattus norvegicus (Norway rat)	Hoga1	NP_001099825.1
Canis lupus familiaris (dog)	HOGA1	XP_850958.1
Xenopus tropicalis (tropical clawed frog)	hoga1	NP_001263607.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ
Molecular cell63(4)621-632(2016 Aug)

Cellular degradation of 4-hydroxy-2-oxoglutarate aldolase leads to absolute deficiency in primary hyperoxaluria type 3.
MacDonald JR, Huang AD, Loomes KM
FEBS letters590(10)1467-76(2016 05)

Renal function can be impaired in children with primary hyperoxaluria type 3.
Allard L, Cochat P, Leclerc AL, Cachat F, Fichtner C, De Souza VC, Garcia CD, Camoin-Schweitzer MC, Macher MA, Acquaviva-Bourdain C, Bacchetta J
Pediatric nephrology (Berlin, Germany)30(10)1807-13(2015 Oct)

Novel findings in patients with primary hyperoxaluria type III and implications for advanced molecular testing strategies.
Beck BB, Baasner A, Buescher A, Habbig S, Reintjes N, Kemper MJ, Sikora P, Mache C, Pohl M, Stahl M, Toenshoff B, Pape L, Fehrenbach H, Jacob DE, Grohe B, Wolf MT, N?rnberg G, Yigit G, Salido EC, Hoppe B
European journal of human genetics : EJHG21(2)162-72(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that HOGA1 harboring mutations found in primary hyperoxaluria is thermally unstable and targeted for proteolytic degradation leading to an absolute loss of function.
Title: Cellular degradation of 4-hydroxy-2-oxoglutarate aldolase leads to absolute deficiency in primary hyperoxaluria type 3.

Among the seven patients identified with HOGA1 mutations the median onset of clinical symptoms was 1.8 years. Five patients initially presented with urolithiasis, and two other patients presented with urinary tract infection.
Title: Renal function can be impaired in children with primary hyperoxaluria type 3.

Our results strongly suggest HOGA1 as a major cause of PH, indicate a greater genetic heterogeneity of hyperoxaluria, and point to a favorable outcome of type III in the context of PH despite incomplete or absent biochemical remission
Title: Novel findings in patients with primary hyperoxaluria type III and implications for advanced molecular testing strategies.

seven different mutations were identified in primary hyperoxaluria type 3
Title: The enzyme 4-hydroxy-2-oxoglutarate aldolase is deficient in primary hyperoxaluria type 3.

Two crystal forms of DHDPSL were obtained, both of which diffracted X-rays to approximately 2.0 A resolution
Title: Purification, crystallization and preliminary crystallographic analysis of human dihydrodipicolinate synthase-like protein (DHDPSL).

The following HOGA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOGA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09103	NM_001134670.1 Latest version!	Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18357	NM_138413.4 Latest version!	Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu18357	NM_138413.3	Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOGA1 ( NM_001134670.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128142.1 Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09103
Clone ID Related Accession (Same CDS sequence)	NM_001134670.1
Accession Version	NM_001134670.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC011916.2. Transcript Variant: This variant (2) lacks multiple consecutive exons in the coding region, compared to variant 1, resulting in a protein (isoform 2) that lacks a large region of the central protein when compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011916.2, BC057821.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGCTGGGTC CCCAAGTCTG GTCTTCTGTG AGGCAGGGGC TAAGCAGGAG CTTGTCCAGG 
AATGTGGGGG TCTGGGCCTC AGGGGAGGGG AAGAAGGTGG ACATTGCGGG TATCTACCCC 
CCTGTGACCA CCCCCTTCAC TGCCACTGCA GAGGTGGACT ATGGGAAACT GGAGGAGAAT 
CTGCACAAAC TGGGCACCTT CCCCTTCCGA GGAGCTGTGG GGGGCGTCTG CGCCCTGGCC 
AATGTCCTGG GGGCTCAGGT GTGCCAGCTG GAGCGACTGT GCTGCACGGG GCAATGGGAA 
GATGCCCAGA AACTGCAGCA CCGCCTCATT GAGCCAAACG CTGCGGTGAC CCGGCGCTTT 
GGGATCCCAG GGCTGAAGAA AATCATGGAC TGGTTTGGCT ACTATGGAGG CCCCTGCCGC 
GCCCCCTTGC AGGAGCTGAG CCCCGCTGAG GAGGAGGCAC TGCGCATGGA TTTCACCAGC 
AACGGCTGGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128142.1
CDS	360..854
Translation	MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGAVGGVCALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGGPCRAPLQELSPAEEEALRMDFTSNGWL

Target ORF information:

RefSeq Version	NM_001134670.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134670.1

ORF Insert Sequence:

ATGCTGGGTC CCCAAGTCTG GTCTTCTGTG AGGCAGGGGC TAAGCAGGAG CTTGTCCAGG 
AATGTGGGGG TCTGGGCCTC AGGGGAGGGG AAGAAGGTGG ACATTGCGGG TATCTACCCC 
CCTGTGACCA CCCCCTTCAC TGCCACTGCA GAGGTGGACT ATGGGAAACT GGAGGAGAAT 
CTGCACAAAC TGGGCACCTT CCCCTTCCGA GGAGCTGTGG GGGGCGTCTG CGCCCTGGCC 
AATGTCCTGG GGGCTCAGGT GTGCCAGCTG GAGCGACTGT GCTGCACGGG GCAATGGGAA 
GATGCCCAGA AACTGCAGCA CCGCCTCATT GAGCCAAACG CTGCGGTGAC CCGGCGCTTT 
GGGATCCCAG GGCTGAAGAA AATCATGGAC TGGTTTGGCT ACTATGGAGG CCCCTGCCGC 
GCCCCCTTGC AGGAGCTGAG CCCCGCTGAG GAGGAGGCAC TGCGCATGGA TTTCACCAGC 
AACGGCTGGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOGA1 ( NM_138413.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_612422.2 Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18357
Clone ID Related Accession (Same CDS sequence)	NM_138413.3 , NM_138413.4
Accession Version	NM_138413.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC011916.2 and BC045550.1. This sequence is a reference standard in the RefSeqGene project. On Sep 5, 2008 this sequence version replaced NM_138413.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC045550.1, SRR1803613.260042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGGGTC CCCAAGTCTG GTCTTCTGTG AGGCAGGGGC TAAGCAGGAG CTTGTCCAGG 
AATGTGGGGG TCTGGGCCTC AGGGGAGGGG AAGAAGGTGG ACATTGCGGG TATCTACCCC 
CCTGTGACCA CCCCCTTCAC TGCCACTGCA GAGGTGGACT ATGGGAAACT GGAGGAGAAT 
CTGCACAAAC TGGGCACCTT CCCCTTCCGA GGCTTCGTGG TCCAGGGCTC CAATGGCGAG 
TTTCCTTTCC TGACCAGCAG TGAGCGCCTC GAGGTGGTGA GCCGTGTGCG CCAGGCCATG 
CCCAAGAACA GGCTCCTGCT AGCTGGCTCC GGATGCGAGT CCACTCAAGC CACAGTGGAG 
ATGACCGTCA GCATGGCCCA GGTCGGGGCT GACGCGGCCA TGGTGGTGAC CCCTTGCTAC 
TATCGTGGCC GCATGAGCAG TGCGGCCCTC ATTCACCACT ACACCAAGGT TGCTGATCTC 
TCTCCAATCC CTGTGGTGCT GTACAGTGTC CCAGCCAACA CAGGGCTGGA CCTGCCTGTG 
GATGCAGTGG TCACGCTTTC CCAGCACCCG AATATTGTGG GCATGAAGGA CAGCGGTGGT 
GATGTGACCA GGATTGGGCT GATTGTTCAC AAGACCAGGA AGCAGGATTT TCAGGTGTTG 
GCTGGATCGG CTGGCTTTCT GATGGCCAGC TATGCCTTGG GAGCTGTGGG GGGCGTCTGC 
GCCCTGGCCA ATGTCCTGGG GGCTCAGGTG TGCCAGCTGG AGCGACTGTG CTGCACGGGG 
CAATGGGAAG ATGCCCAGAA ACTGCAGCAC CGCCTCATTG AGCCAAACGC TGCGGTGACC 
CGGCGCTTTG GGATCCCAGG GCTGAAGAAA ATCATGGACT GGTTTGGCTA CTATGGAGGC 
CCCTGCCGCG CCCCCTTGCA GGAGCTGAGC CCCGCTGAGG AGGAGGCACT GCGCATGGAT 
TTCACCAGCA ACGGCTGGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612422.2
CDS	360..1343
Translation	MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGFVVQGSNGEFPFLTSSERLEVVSRVRQAMPKNRLLLAGSGCESTQATVEMTVSMAQVGADAAMVVTPCYYRGRMSSAALIHHYTKVADLSPIPVVLYSVPANTGLDLPVDAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAGFLMASYALGAVGGVCALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGGPCRAPLQELSPAEEEALRMDFTSNGWL

Target ORF information:

RefSeq Version	NM_138413.3
Organism	Homo sapiens(human)
Definition	Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138413.3

ORF Insert Sequence:

ATGCTGGGTC CCCAAGTCTG GTCTTCTGTG AGGCAGGGGC TAAGCAGGAG CTTGTCCAGG 
AATGTGGGGG TCTGGGCCTC AGGGGAGGGG AAGAAGGTGG ACATTGCGGG TATCTACCCC 
CCTGTGACCA CCCCCTTCAC TGCCACTGCA GAGGTGGACT ATGGGAAACT GGAGGAGAAT 
CTGCACAAAC TGGGCACCTT CCCCTTCCGA GGCTTCGTGG TCCAGGGCTC CAATGGCGAG 
TTTCCTTTCC TGACCAGCAG TGAGCGCCTC GAGGTGGTGA GCCGTGTGCG CCAGGCCATG 
CCCAAGAACA GGCTCCTGCT AGCTGGCTCC GGATGCGAGT CCACTCAAGC CACAGTGGAG 
ATGACCGTCA GCATGGCCCA GGTCGGGGCT GACGCGGCCA TGGTGGTGAC CCCTTGCTAC 
TATCGTGGCC GCATGAGCAG TGCGGCCCTC ATTCACCACT ACACCAAGGT TGCTGATCTC 
TCTCCAATCC CTGTGGTGCT GTACAGTGTC CCAGCCAACA CAGGGCTGGA CCTGCCTGTG 
GATGCAGTGG TCACGCTTTC CCAGCACCCG AATATTGTGG GCATGAAGGA CAGCGGTGGT 
GATGTGACCA GGATTGGGCT GATTGTTCAC AAGACCAGGA AGCAGGATTT TCAGGTGTTG 
GCTGGATCGG CTGGCTTTCT GATGGCCAGC TATGCCTTGG GAGCTGTGGG GGGCGTCTGC 
GCCCTGGCCA ATGTCCTGGG GGCTCAGGTG TGCCAGCTGG AGCGACTGTG CTGCACGGGG 
CAATGGGAAG ATGCCCAGAA ACTGCAGCAC CGCCTCATTG AGCCAAACGC TGCGGTGACC 
CGGCGCTTTG GGATCCCAGG GCTGAAGAAA ATCATGGACT GGTTTGGCTA CTATGGAGGC 
CCCTGCCGCG CCCCCTTGCA GGAGCTGAGC CCCGCTGAGG AGGAGGCACT GCGCATGGAT 
TTCACCAGCA ACGGCTGGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOGA1 ( NM_138413.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_612422.2 Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18357
Clone ID Related Accession (Same CDS sequence)	NM_138413.3 , NM_138413.4
Accession Version	NM_138413.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC011916.2 and BC045550.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_138413.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC045550.1, SRR3476690.742212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000370646.9/ ENSP00000359680.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGGGTC CCCAAGTCTG GTCTTCTGTG AGGCAGGGGC TAAGCAGGAG CTTGTCCAGG 
AATGTGGGGG TCTGGGCCTC AGGGGAGGGG AAGAAGGTGG ACATTGCGGG TATCTACCCC 
CCTGTGACCA CCCCCTTCAC TGCCACTGCA GAGGTGGACT ATGGGAAACT GGAGGAGAAT 
CTGCACAAAC TGGGCACCTT CCCCTTCCGA GGCTTCGTGG TCCAGGGCTC CAATGGCGAG 
TTTCCTTTCC TGACCAGCAG TGAGCGCCTC GAGGTGGTGA GCCGTGTGCG CCAGGCCATG 
CCCAAGAACA GGCTCCTGCT AGCTGGCTCC GGATGCGAGT CCACTCAAGC CACAGTGGAG 
ATGACCGTCA GCATGGCCCA GGTCGGGGCT GACGCGGCCA TGGTGGTGAC CCCTTGCTAC 
TATCGTGGCC GCATGAGCAG TGCGGCCCTC ATTCACCACT ACACCAAGGT TGCTGATCTC 
TCTCCAATCC CTGTGGTGCT GTACAGTGTC CCAGCCAACA CAGGGCTGGA CCTGCCTGTG 
GATGCAGTGG TCACGCTTTC CCAGCACCCG AATATTGTGG GCATGAAGGA CAGCGGTGGT 
GATGTGACCA GGATTGGGCT GATTGTTCAC AAGACCAGGA AGCAGGATTT TCAGGTGTTG 
GCTGGATCGG CTGGCTTTCT GATGGCCAGC TATGCCTTGG GAGCTGTGGG GGGCGTCTGC 
GCCCTGGCCA ATGTCCTGGG GGCTCAGGTG TGCCAGCTGG AGCGACTGTG CTGCACGGGG 
CAATGGGAAG ATGCCCAGAA ACTGCAGCAC CGCCTCATTG AGCCAAACGC TGCGGTGACC 
CGGCGCTTTG GGATCCCAGG GCTGAAGAAA ATCATGGACT GGTTTGGCTA CTATGGAGGC 
CCCTGCCGCG CCCCCTTGCA GGAGCTGAGC CCCGCTGAGG AGGAGGCACT GCGCATGGAT 
TTCACCAGCA ACGGCTGGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612422.2
CDS	316..1299
Translation	MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGFVVQGSNGEFPFLTSSERLEVVSRVRQAMPKNRLLLAGSGCESTQATVEMTVSMAQVGADAAMVVTPCYYRGRMSSAALIHHYTKVADLSPIPVVLYSVPANTGLDLPVDAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAGFLMASYALGAVGGVCALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGGPCRAPLQELSPAEEEALRMDFTSNGWL

Target ORF information:

RefSeq Version	NM_138413.4
Organism	Homo sapiens(human)
Definition	Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138413.4

ORF Insert Sequence:

ATGCTGGGTC CCCAAGTCTG GTCTTCTGTG AGGCAGGGGC TAAGCAGGAG CTTGTCCAGG 
AATGTGGGGG TCTGGGCCTC AGGGGAGGGG AAGAAGGTGG ACATTGCGGG TATCTACCCC 
CCTGTGACCA CCCCCTTCAC TGCCACTGCA GAGGTGGACT ATGGGAAACT GGAGGAGAAT 
CTGCACAAAC TGGGCACCTT CCCCTTCCGA GGCTTCGTGG TCCAGGGCTC CAATGGCGAG 
TTTCCTTTCC TGACCAGCAG TGAGCGCCTC GAGGTGGTGA GCCGTGTGCG CCAGGCCATG 
CCCAAGAACA GGCTCCTGCT AGCTGGCTCC GGATGCGAGT CCACTCAAGC CACAGTGGAG 
ATGACCGTCA GCATGGCCCA GGTCGGGGCT GACGCGGCCA TGGTGGTGAC CCCTTGCTAC 
TATCGTGGCC GCATGAGCAG TGCGGCCCTC ATTCACCACT ACACCAAGGT TGCTGATCTC 
TCTCCAATCC CTGTGGTGCT GTACAGTGTC CCAGCCAACA CAGGGCTGGA CCTGCCTGTG 
GATGCAGTGG TCACGCTTTC CCAGCACCCG AATATTGTGG GCATGAAGGA CAGCGGTGGT 
GATGTGACCA GGATTGGGCT GATTGTTCAC AAGACCAGGA AGCAGGATTT TCAGGTGTTG 
GCTGGATCGG CTGGCTTTCT GATGGCCAGC TATGCCTTGG GAGCTGTGGG GGGCGTCTGC 
GCCCTGGCCA ATGTCCTGGG GGCTCAGGTG TGCCAGCTGG AGCGACTGTG CTGCACGGGG 
CAATGGGAAG ATGCCCAGAA ACTGCAGCAC CGCCTCATTG AGCCAAACGC TGCGGTGACC 
CGGCGCTTTG GGATCCCAGG GCTGAAGAAA ATCATGGACT GGTTTGGCTA CTATGGAGGC 
CCCTGCCGCG CCCCCTTGCA GGAGCTGAGC CCCGCTGAGG AGGAGGCACT GCGCATGGAT 
TTCACCAGCA ACGGCTGGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Molecular cell63(4)621-632(2016 Aug)
Floyd BJ,Wilkerson EM,Veling MT,Minogue CE,Xia C,Beebe ET,Wrobel RL,Cho H,Kremer LS,Alston CL,Gromek KA,Dolan BK,Ulbrich A,Stefely JA,Bohl SL,Werner KM,Jochem A,Westphall MS,Rensvold JW,Taylor RW,Prokisch H,Kim JP,Coon JJ,Pagliarini DJ

Cellular degradation of 4-hydroxy-2-oxoglutarate aldolase leads to absolute deficiency in primary hyperoxaluria type 3.
FEBS letters590(10)1467-76(2016 05)
MacDonald JR,Huang AD,Loomes KM

Renal function can be impaired in children with primary hyperoxaluria type 3.
Pediatric nephrology (Berlin, Germany)30(10)1807-13(2015 Oct)
Allard L,Cochat P,Leclerc AL,Cachat F,Fichtner C,De Souza VC,Garcia CD,Camoin-Schweitzer MC,Macher MA,Acquaviva-Bourdain C,Bacchetta J

Novel findings in patients with primary hyperoxaluria type III and implications for advanced molecular testing strategies.
European journal of human genetics : EJHG21(2)162-72(2013 Feb)
Beck BB,Baasner A,Buescher A,Habbig S,Reintjes N,Kemper MJ,Sikora P,Mache C,Pohl M,Stahl M,Toenshoff B,Pape L,Fehrenbach H,Jacob DE,Grohe B,Wolf MT,N?rnberg G,Yigit G,Salido EC,Hoppe B

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HOGA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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