FDX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FDX2
Entrez Gene ID	112812
Full Name	ferredoxin 1 like
Synonyms	FDX2
General protein information	Preferred Names ferredoxin 1 like Names ferredoxin-2, mitochondrial adrenodoxin-like protein, mitochondrial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014].
Disorder MIM:	614585

mRNA and Protein(s)

mRNA	Protein	Name
NM_001031734.3	NP_001026904.2	ferredoxin-2, mitochondrial precursor
NM_001031734.4	NP_001026904.2	ferredoxin-2, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FDX1L	XP_512366.3
Canis lupus familiaris (dog)	FDX1L	XP_542073.1
Bos taurus (cattle)	FDX1L	NP_001073695.1
Drosophila melanogaster (fruit fly)	Fdxh	NP_001189075.1
Kluyveromyces lactis	KLLA0B10307g	XP_451988.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006799	XP_308947.3
Caenorhabditis elegans (roundworm)	CELE_Y73F8A.27	NP_502861.1
Arabidopsis thaliana (thale cress)	MFDX2	NP_193841.2
Oryza sativa (rice)	Os07g0110300	NP_001058731.1
Oryza sativa (rice)	Os09g0437900	NP_001063266.1
Danio rerio (zebrafish)	fdx1l	NP_001070132.1
Magnaporthe oryzae (rice blast fungus)	MGG_05964	XP_003711804.1
Neurospora crassa	NCU07794	XP_958085.1
Xenopus tropicalis (tropical clawed frog)	fdx1l	NP_001120210.1
Homo sapiens (human)	FDX1L	NP_001026904.1
	LOC715203	XP_001105309.2
Mus musculus (house mouse)	Fdx1l	NP_001034913.1
Rattus norvegicus (Norway rat)	Fdx1l	NP_001101472.1
Saccharomyces cerevisiae (baker's yeast)	YAH1	NP_015071.1
Eremothecium gossypii	AGOS_AFL169C	NP_985381.1
Arabidopsis thaliana (thale cress)	MFDX1	NP_192454.1

Gene Ontology
Bibliography

Related articles in PubMed

Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy.
Spiegel R, Saada A, Halvardson J, Soiferman D, Shaag A, Edvardson S, Horovitz Y, Khayat M, Shalev SA, Feuk L, Elpeleg O
European journal of human genetics : EJHG22(7)902-6(2014 Jul)

Human ferredoxin-2 displays a unique conformational change.
Qi W, Li J, Cowan JA
Dalton transactions (Cambridge, England : 2003)42(9)3088-91(2013 Mar)

Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.
Shi Y, Ghosh M, Kovtunovych G, Crooks DR, Rouault TA
Biochimica et biophysica acta1823(2)484-92(2012 Feb)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fdx2 is the second component of the Fe-S cluster biogenesis machinery, the first being IscU that is associated with isolated mitochondrial myopathy.
Title: Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy.

unique conformational change is observed when holo hFd2 is warmed to physiological temperatures, or higher
Title: Human ferredoxin-2 displays a unique conformational change.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following FDX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FDX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu74653	NM_001031734.4 Latest version!	Homo sapiens ferredoxin 2 (FDX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu74653	NM_001031734.3	Homo sapiens ferredoxin 1 like (FDX1L), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FDX2 ( NM_001031734.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001026904.2 Homo sapiens ferredoxin 1 like (FDX1L), mRNA.

Price & Availability↑

CloneID	OHu74653
Clone ID Related Accession (Same CDS sequence)	NM_001031734.3 , NM_001031734.4
Accession Version	NM_001031734.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	ferredoxin-2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA243025.1, BC063460.1 and AI289404.1. This sequence is a reference standard in the RefSeqGene project. On Sep 18, 2014 this sequence version replaced NM_001031734.2. ##Evidence-Data-START## Transcript exon combination :: DA243025.1, BC010155.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCATGTCA TGGCCGCCTC CATGGCCCGG GGAGGCGTGA GTGCCAGGGT TCTACTGCAG 
GCTGCCAGGG GCACCTGGTG GAACAGACCT GGGGGCACTT CCGGGTCGGG GGAGGGGGTG 
GCGCTGGGGA CAACCAGAAA GTTTCAAGCG ACAGGCTCGC GCCCGGCTGG AGAGGAGGAC 
GCGGGCGGCC CGGAGCGGCC CGGGGACGTG GTGAACGTGG TGTTCGTAGA CCGCTCAGGC 
CAGCGGATCC CAGTGAGTGG CAGAGTCGGG GACAATGTTC TTCACCTGGC CCAGCGCCAC 
GGGGTGGACC TGGAAGGGGC CTGTGAAGCC TCCCTGGCCT GCTCCACCTG CCATGTGTAT 
GTGAGTGAAG ACCACCTGGA TCTCCTGCCT CCTCCCGAGG AGAGGGAAGA CGACATGCTA 
GACATGGCCC CCCTCCTCCA GGAGAACTCG CGGCTGGGCT GCCAGATTGT GCTGACACCG 
GAGCTGGAAG GAGCGGAATT CACCCTGCCC AAGATCACCA GGAACTTCTA CGTGGATGGC 
CATGTCCCCA AGCCCCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001026904.2
CDS	11..571
Translation	MHVMAASMARGGVSARVLLQAARGTWWNRPGGTSGSGEGVALGTTRKFQATGSRPAGEEDAGGPERPGDVVNVVFVDRSGQRIPVSGRVGDNVLHLAQRHGVDLEGACEASLACSTCHVYVSEDHLDLLPPPEEREDDMLDMAPLLQENSRLGCQIVLTPELEGAEFTLPKITRNFYVDGHVPKPH

Target ORF information:

RefSeq Version	NM_001031734.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ferredoxin 1 like (FDX1L), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001031734.3

ORF Insert Sequence:

ATGCATGTCA TGGCCGCCTC CATGGCCCGG GGAGGCGTGA GTGCCAGGGT TCTACTGCAG 
GCTGCCAGGG GCACCTGGTG GAACAGACCT GGGGGCACTT CCGGGTCGGG GGAGGGGGTG 
GCGCTGGGGA CAACCAGAAA GTTTCAAGCG ACAGGCTCGC GCCCGGCTGG AGAGGAGGAC 
GCGGGCGGCC CGGAGCGGCC CGGGGACGTG GTGAACGTGG TGTTCGTAGA CCGCTCAGGC 
CAGCGGATCC CAGTGAGTGG CAGAGTCGGG GACAATGTTC TTCACCTGGC CCAGCGCCAC 
GGGGTGGACC TGGAAGGGGC CTGTGAAGCC TCCCTGGCCT GCTCCACCTG CCATGTGTAT 
GTGAGTGAAG ACCACCTGGA TCTCCTGCCT CCTCCCGAGG AGAGGGAAGA CGACATGCTA 
GACATGGCCC CCCTCCTCCA GGAGAACTCG CGGCTGGGCT GCCAGATTGT GCTGACACCG 
GAGCTGGAAG GAGCGGAATT CACCCTGCCC AAGATCACCA GGAACTTCTA CGTGGATGGC 
CATGTCCCCA AGCCCCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FDX2 ( NM_001031734.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001026904.2 Homo sapiens ferredoxin 2 (FDX2), mRNA.

Price & Availability↑

CloneID	OHu74653
Clone ID Related Accession (Same CDS sequence)	NM_001031734.3 , NM_001031734.4
Accession Version	NM_001031734.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	ferredoxin-2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA243025.1, BC063460.1, AI289404.1 and AC011511.12. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001031734.3. ##Evidence-Data-START## Transcript exon combination :: BC063460.1, AK300568.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000393708.3/ ENSP00000377311.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCATGTCA TGGCCGCCTC CATGGCCCGG GGAGGCGTGA GTGCCAGGGT TCTACTGCAG 
GCTGCCAGGG GCACCTGGTG GAACAGACCT GGGGGCACTT CCGGGTCGGG GGAGGGGGTG 
GCGCTGGGGA CAACCAGAAA GTTTCAAGCG ACAGGCTCGC GCCCGGCTGG AGAGGAGGAC 
GCGGGCGGCC CGGAGCGGCC CGGGGACGTG GTGAACGTGG TGTTCGTAGA CCGCTCAGGC 
CAGCGGATCC CAGTGAGTGG CAGAGTCGGG GACAATGTTC TTCACCTGGC CCAGCGCCAC 
GGGGTGGACC TGGAAGGGGC CTGTGAAGCC TCCCTGGCCT GCTCCACCTG CCATGTGTAT 
GTGAGTGAAG ACCACCTGGA TCTCCTGCCT CCTCCCGAGG AGAGGGAAGA CGACATGCTA 
GACATGGCCC CCCTCCTCCA GGAGAACTCG CGGCTGGGCT GCCAGATTGT GCTGACACCG 
GAGCTGGAAG GAGCGGAATT CACCCTGCCC AAGATCACCA GGAACTTCTA CGTGGATGGC 
CATGTCCCCA AGCCCCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001026904.2
CDS	11..571
Translation	MHVMAASMARGGVSARVLLQAARGTWWNRPGGTSGSGEGVALGTTRKFQATGSRPAGEEDAGGPERPGDVVNVVFVDRSGQRIPVSGRVGDNVLHLAQRHGVDLEGACEASLACSTCHVYVSEDHLDLLPPPEEREDDMLDMAPLLQENSRLGCQIVLTPELEGAEFTLPKITRNFYVDGHVPKPH

Target ORF information:

RefSeq Version	NM_001031734.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ferredoxin 2 (FDX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001031734.4

ORF Insert Sequence:

ATGCATGTCA TGGCCGCCTC CATGGCCCGG GGAGGCGTGA GTGCCAGGGT TCTACTGCAG 
GCTGCCAGGG GCACCTGGTG GAACAGACCT GGGGGCACTT CCGGGTCGGG GGAGGGGGTG 
GCGCTGGGGA CAACCAGAAA GTTTCAAGCG ACAGGCTCGC GCCCGGCTGG AGAGGAGGAC 
GCGGGCGGCC CGGAGCGGCC CGGGGACGTG GTGAACGTGG TGTTCGTAGA CCGCTCAGGC 
CAGCGGATCC CAGTGAGTGG CAGAGTCGGG GACAATGTTC TTCACCTGGC CCAGCGCCAC 
GGGGTGGACC TGGAAGGGGC CTGTGAAGCC TCCCTGGCCT GCTCCACCTG CCATGTGTAT 
GTGAGTGAAG ACCACCTGGA TCTCCTGCCT CCTCCCGAGG AGAGGGAAGA CGACATGCTA 
GACATGGCCC CCCTCCTCCA GGAGAACTCG CGGCTGGGCT GCCAGATTGT GCTGACACCG 
GAGCTGGAAG GAGCGGAATT CACCCTGCCC AAGATCACCA GGAACTTCTA CGTGGATGGC 
CATGTCCCCA AGCCCCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy.
European journal of human genetics : EJHG22(7)902-6(2014 Jul)
Spiegel R,Saada A,Halvardson J,Soiferman D,Shaag A,Edvardson S,Horovitz Y,Khayat M,Shalev SA,Feuk L,Elpeleg O

Human ferredoxin-2 displays a unique conformational change.
Dalton transactions (Cambridge, England : 2003)42(9)3088-91(2013 Mar)
Qi W,Li J,Cowan JA

Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.
Biochimica et biophysica acta1823(2)484-92(2012 Feb)
Shi Y,Ghosh M,Kovtunovych G,Crooks DR,Rouault TA

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

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FDX2 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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