CAVIN3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CAVIN3
Entrez Gene ID	112464
Full Name	caveolae associated protein 3
Synonyms	HSRBC,PRKCDBP,SRBC,cavin-3
General protein information	Preferred Names caveolae associated protein 3 Names caveolae-associated protein 3 protein kinase C delta binding protein sdr-related gene product that binds to c-kinase serum deprivation response factor-related gene product that binds to C-kinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_145040.2	NP_659477.2	caveolae-associated protein 3
NM_145040.3	NP_659477.2	caveolae-associated protein 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Prkcdbp	NP_604444.1
Canis lupus familiaris (dog)	PRKCDBP	XP_534035.2
Mus musculus (house mouse)	Prkcdbp	NP_082720.1
Homo sapiens (human)	PRKCDBP	NP_659477.2
Bos taurus (cattle)	PRKCDBP	NP_001076870.1
Pan troglodytes (chimpanzee)	PRKCDBP	XP_003951859.1
	LOC712799	XP_002808124.1

Gene Ontology
Bibliography

Related articles in PubMed

PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.
Kovanen L, Donner K, Kaunisto M, Partonen T
Journal of affective disorders207136-140(2017 Jan)

Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.
Mohan J, Mor?n B, Larsson E, Holst MR, Lundmark R
Journal of cell science128(5)979-91(2015 Mar)

Elevation of PRKCDBP, a novel transcriptional target of TNF-?, and its downregulation by infliximab in patients with ulcerative colitis.
Kim JW, Kim HJ, Lee CK, Shim JJ, Jang JY, Dong SH, Kim BH, Chang YW, Chi SG
Digestive diseases and sciences59(12)2947-57(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PRKCDBP variants may be risk factors of major depressive disorder.
Title: PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.

cavin3 is recruited to the caveolae coat by cavin1 to interact with caveolin1 and regulate the duration time of caveolae at the plasma membrane.
Title: Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.

These results demonstrate that mucosal expression of PRKCDBP correlated strongly with TNF-alpha expression in UC patients and that infliximab therapy resulted in profound reductions in both PRKCDBP and TNF-alpha.
Title: Elevation of PRKCDBP, a novel transcriptional target of TNF-?, and its downregulation by infliximab in patients with ulcerative colitis.

in vivo consequences of cavin-3 knockout are increased lactate production and cachexia
Title: Cavin-3 dictates the balance between ERK and Akt signaling.

Rather than forming a single coat complex containing the three cavin family members, single-molecule analysis reveals an exquisite specificity of interactions between cavin1, cavin2 and cavin3.
Title: Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae.

The following CAVIN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CAVIN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31085	NM_145040.3 Latest version!	Homo sapiens caveolae associated protein 3 (CAVIN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu31085	NM_145040.2	Homo sapiens caveolae associated protein 3 (CAVIN3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CAVIN3 ( NM_145040.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_659477.2 Homo sapiens caveolae associated protein 3 (CAVIN3), mRNA.

Price & Availability↑

CloneID	OHu31085
Clone ID Related Accession (Same CDS sequence)	NM_145040.2 , NM_145040.3
Accession Version	NM_145040.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	caveolae-associated protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ434360.1 and BC011585.1. On Nov 22, 2018 this sequence version replaced NM_145040.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011585.1, AF339881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000303927.4/ ENSP00000307292.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGGAGA GTGCGTTGGA GCGGGGGCCT GTGCCCGAGG CGCCGGCGGG GGGTCCCGTG 
CACGCCGTGA CGGTGGTGAC CCTGCTGGAG AAGCTGGCCT CCATGCTGGA GACTCTGCGG 
GAGCGGCAGG GAGGCCTGGC TCGAAGGCAG GGAGGCCTGG CAGGGTCCGT GCGCCGCATC 
CAGAGCGGCC TGGGCGCTCT GAGTCGCAGC CACGACACCA CCAGCAACAC CTTGGCGCAG 
CTGCTGGCCA AGGCGGAGCG CGTGAGCTCG CACGCCAACG CCGCCCAAGA GCGCGCGGTG 
CGCCGCGCAG CCCAGGTGCA GCGGCTGGAG GCCAACCACG GGCTGCTGGT GGCGCGCGGG 
AAGCTCCACG TTCTGCTCTT CAAGGAGGAG GGTGAAGTCC CAGCCAGCGC TTTCCAGAAG 
GCACCAGAGC CCTTGGGCCC GGCGGACCAG TCCGAGCTGG GCCCAGAGCA GCTGGAGGCC 
GAAGTTGGAG AGAGCTCGGA CGAGGAGCCG GTGGAGTCCA GGGCCCAGCG GCTGCGGCGC 
ACCGGATTGC AGAAGGTACA GAGCCTCCGA AGGGCCCTTT CGGGCCGGAA AGGCCCTGCA 
GCGCCACCGC CCACCCCGGT CAAGCCGCCT CGCCTTGGGC CTGGCCGGAG CGCTGAAGCC 
CAGCCGGAAG CCCAGCCTGC GCTGGAGCCC ACGCTGGAGC CAGAGCCTCC GCAGGACACC 
GAGGAAGATC CCGGGAGACC TGGGGCTGCC GAAGAAGCTC TGCTCCAAAT GGAGAGTGTA 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659477.2
CDS	26..811
Translation	MRESALERGPVPEAPAGGPVHAVTVVTLLEKLASMLETLRERQGGLARRQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVSSHANAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEGEVPASAFQKAPEPLGPADQSELGPEQLEAEVGESSDEEPVESRAQRLRRTGLQKVQSLRRALSGRKGPAAPPPTPVKPPRLGPGRSAEAQPEAQPALEPTLEPEPPQDTEEDPGRPGAAEEALLQMESVA

Target ORF information:

RefSeq Version	NM_145040.3
Organism	Homo sapiens(human)
Definition	Homo sapiens caveolae associated protein 3 (CAVIN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145040.3

ORF Insert Sequence:

ATGAGGGAGA GTGCGTTGGA GCGGGGGCCT GTGCCCGAGG CGCCGGCGGG GGGTCCCGTG 
CACGCCGTGA CGGTGGTGAC CCTGCTGGAG AAGCTGGCCT CCATGCTGGA GACTCTGCGG 
GAGCGGCAGG GAGGCCTGGC TCGAAGGCAG GGAGGCCTGG CAGGGTCCGT GCGCCGCATC 
CAGAGCGGCC TGGGCGCTCT GAGTCGCAGC CACGACACCA CCAGCAACAC CTTGGCGCAG 
CTGCTGGCCA AGGCGGAGCG CGTGAGCTCG CACGCCAACG CCGCCCAAGA GCGCGCGGTG 
CGCCGCGCAG CCCAGGTGCA GCGGCTGGAG GCCAACCACG GGCTGCTGGT GGCGCGCGGG 
AAGCTCCACG TTCTGCTCTT CAAGGAGGAG GGTGAAGTCC CAGCCAGCGC TTTCCAGAAG 
GCACCAGAGC CCTTGGGCCC GGCGGACCAG TCCGAGCTGG GCCCAGAGCA GCTGGAGGCC 
GAAGTTGGAG AGAGCTCGGA CGAGGAGCCG GTGGAGTCCA GGGCCCAGCG GCTGCGGCGC 
ACCGGATTGC AGAAGGTACA GAGCCTCCGA AGGGCCCTTT CGGGCCGGAA AGGCCCTGCA 
GCGCCACCGC CCACCCCGGT CAAGCCGCCT CGCCTTGGGC CTGGCCGGAG CGCTGAAGCC 
CAGCCGGAAG CCCAGCCTGC GCTGGAGCCC ACGCTGGAGC CAGAGCCTCC GCAGGACACC 
GAGGAAGATC CCGGGAGACC TGGGGCTGCC GAAGAAGCTC TGCTCCAAAT GGAGAGTGTA 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CAVIN3 ( NM_145040.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_659477.2 Homo sapiens caveolae associated protein 3 (CAVIN3), mRNA.

Price & Availability↑

CloneID	OHu31085
Clone ID Related Accession (Same CDS sequence)	NM_145040.2 , NM_145040.3
Accession Version	NM_145040.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	caveolae-associated protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ434360.1 and BC011585.1. On May 12, 2004 this sequence version replaced NM_145040.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011585.1, AF339881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGAGA GTGCGTTGGA GCGGGGGCCT GTGCCCGAGG CGCCGGCGGG GGGTCCCGTG 
CACGCCGTGA CGGTGGTGAC CCTGCTGGAG AAGCTGGCCT CCATGCTGGA GACTCTGCGG 
GAGCGGCAGG GAGGCCTGGC TCGAAGGCAG GGAGGCCTGG CAGGGTCCGT GCGCCGCATC 
CAGAGCGGCC TGGGCGCTCT GAGTCGCAGC CACGACACCA CCAGCAACAC CTTGGCGCAG 
CTGCTGGCCA AGGCGGAGCG CGTGAGCTCG CACGCCAACG CCGCCCAAGA GCGCGCGGTG 
CGCCGCGCAG CCCAGGTGCA GCGGCTGGAG GCCAACCACG GGCTGCTGGT GGCGCGCGGG 
AAGCTCCACG TTCTGCTCTT CAAGGAGGAG GGTGAAGTCC CAGCCAGCGC TTTCCAGAAG 
GCACCAGAGC CCTTGGGCCC GGCGGACCAG TCCGAGCTGG GCCCAGAGCA GCTGGAGGCC 
GAAGTTGGAG AGAGCTCGGA CGAGGAGCCG GTGGAGTCCA GGGCCCAGCG GCTGCGGCGC 
ACCGGATTGC AGAAGGTACA GAGCCTCCGA AGGGCCCTTT CGGGCCGGAA AGGCCCTGCA 
GCGCCACCGC CCACCCCGGT CAAGCCGCCT CGCCTTGGGC CTGGCCGGAG CGCTGAAGCC 
CAGCCGGAAG CCCAGCCTGC GCTGGAGCCC ACGCTGGAGC CAGAGCCTCC GCAGGACACC 
GAGGAAGATC CCGGGAGACC TGGGGCTGCC GAAGAAGCTC TGCTCCAAAT GGAGAGTGTA 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659477.2
CDS	35..820
Translation	MRESALERGPVPEAPAGGPVHAVTVVTLLEKLASMLETLRERQGGLARRQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVSSHANAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEGEVPASAFQKAPEPLGPADQSELGPEQLEAEVGESSDEEPVESRAQRLRRTGLQKVQSLRRALSGRKGPAAPPPTPVKPPRLGPGRSAEAQPEAQPALEPTLEPEPPQDTEEDPGRPGAAEEALLQMESVA

Target ORF information:

RefSeq Version	NM_145040.2
Organism	Homo sapiens(human)
Definition	Homo sapiens caveolae associated protein 3 (CAVIN3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145040.2

ORF Insert Sequence:

ATGAGGGAGA GTGCGTTGGA GCGGGGGCCT GTGCCCGAGG CGCCGGCGGG GGGTCCCGTG 
CACGCCGTGA CGGTGGTGAC CCTGCTGGAG AAGCTGGCCT CCATGCTGGA GACTCTGCGG 
GAGCGGCAGG GAGGCCTGGC TCGAAGGCAG GGAGGCCTGG CAGGGTCCGT GCGCCGCATC 
CAGAGCGGCC TGGGCGCTCT GAGTCGCAGC CACGACACCA CCAGCAACAC CTTGGCGCAG 
CTGCTGGCCA AGGCGGAGCG CGTGAGCTCG CACGCCAACG CCGCCCAAGA GCGCGCGGTG 
CGCCGCGCAG CCCAGGTGCA GCGGCTGGAG GCCAACCACG GGCTGCTGGT GGCGCGCGGG 
AAGCTCCACG TTCTGCTCTT CAAGGAGGAG GGTGAAGTCC CAGCCAGCGC TTTCCAGAAG 
GCACCAGAGC CCTTGGGCCC GGCGGACCAG TCCGAGCTGG GCCCAGAGCA GCTGGAGGCC 
GAAGTTGGAG AGAGCTCGGA CGAGGAGCCG GTGGAGTCCA GGGCCCAGCG GCTGCGGCGC 
ACCGGATTGC AGAAGGTACA GAGCCTCCGA AGGGCCCTTT CGGGCCGGAA AGGCCCTGCA 
GCGCCACCGC CCACCCCGGT CAAGCCGCCT CGCCTTGGGC CTGGCCGGAG CGCTGAAGCC 
CAGCCGGAAG CCCAGCCTGC GCTGGAGCCC ACGCTGGAGC CAGAGCCTCC GCAGGACACC 
GAGGAAGATC CCGGGAGACC TGGGGCTGCC GAAGAAGCTC TGCTCCAAAT GGAGAGTGTA 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.
Journal of affective disorders207136-140(2017 Jan)
Kovanen L,Donner K,Kaunisto M,Partonen T

Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.
Journal of cell science128(5)979-91(2015 Mar)
Mohan J,Mor?n B,Larsson E,Holst MR,Lundmark R

Elevation of PRKCDBP, a novel transcriptional target of TNF-?, and its downregulation by infliximab in patients with ulcerative colitis.
Digestive diseases and sciences59(12)2947-57(2014 Dec)
Kim JW,Kim HJ,Lee CK,Shim JJ,Jang JY,Dong SH,Kim BH,Chang YW,Chi SG

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CAVIN3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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