DUSP10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DUSP10
Entrez Gene ID	11221
Full Name	dual specificity phosphatase 10
Synonyms	MKP-5,MKP5
General protein information	Preferred Names dual specificity phosphatase 10 Names dual specificity protein phosphatase 10 dual specificity phosphatase MKP-5 map kinase phosphatase 5 mitogen-activated protein kinase phosphatase 5 serine/threonine specific protein phosphatase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q41
Summary	Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Disorder MIM:	608867

mRNA and Protein(s)

mRNA	Protein	Name
NM_007207.5	NP_009138.1	dual specificity protein phosphatase 10
XM_017000147.1	XP_016855636.1	dual specificity protein phosphatase 10 isoform X1
XM_017000147.2	XP_016855636.1	dual specificity protein phosphatase 10 isoform X1
NM_007207.6	NP_009138.1	dual specificity protein phosphatase 10

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100497288	XP_002940746.2
Rattus norvegicus (Norway rat)	Dusp10	NP_001099204.1
Danio rerio (zebrafish)	si:ch211-180b22.4	XP_003200822.1
Homo sapiens (human)	DUSP10	NP_009138.1
	DUSP10	XP_001101834.1
Bos taurus (cattle)	DUSP10	NP_001029897.2
Canis lupus familiaris (dog)	DUSP10	XP_545790.2
Gallus gallus (chicken)	DUSP10	NP_001026215.1
Pan troglodytes (chimpanzee)	DUSP10	XP_001173001.1
Mus musculus (house mouse)	Dusp10	NP_071302.2

Gene Ontology
Bibliography

Related articles in PubMed

TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma.
Ng KY, Chan LH, Chai S, Tong M, Guan XY, Lee NP, Yuan Y, Xie D, Lee TK, Dusetti NJ, Carrier A, Ma S
Cancer research77(17)4602-4612(2017 Sep)

AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway.
Hrstka R, Bouchalova P, Michalova E, Matoulkova E, Muller P, Coates PJ, Vojtesek B
Molecular oncology10(5)652-62(2016 05)

Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population.
Duan X, Gao Y, Yang H, Feng T, Jin T, Long Y, Chen C
International journal of clinical and experimental pathology8(2)2018-25(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High DUSP10 expression is associated with Metastasis of Hepatocellular Carcinoma.
Title: TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma.

This study demonstrates that AGR2, which is overexpressed in a variety of human cancers and provides a poor prognosis, up-regulates DUSP10 which subsequently inhibits p38 MAPK and prevents p53 activation by phosphorylation.
Title: AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway.

Increased Dusp10 expression is associated with better survival rate in colorectal cancer patients.
Title: DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis.

In females, three SNPs were associated with decreased colorectal cancer risk: rs11118838, rs12724393, and rs908858. However, in males, only one SNP, rs908858, was associated with decreased colorectal cancer risk.
Title: Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population.

Data suggest that vitamin D receptor target genes (DUSP10; THBD, thrombomodulin; NRIP1, nuclear receptor interacting protein 1; TRAK1, trafficking protein kinesin binding 1) can be used as markers for individual's response to vitamin D3 supplements.
Title: Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals.

The following DUSP10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DUSP10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23930	NM_007207.6 Latest version!	Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu83058	XM_017000147.2 Latest version!	Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu83058	XM_017000147.1	Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu23930	NM_007207.5	Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DUSP10 ( NM_007207.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_009138.1 Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23930
Clone ID Related Accession (Same CDS sequence)	NM_007207.5 , NM_007207.6
Accession Version	NM_007207.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1449bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	dual specificity protein phosphatase 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG720911.1, BC031405.1, BC063826.1 and AI261880.1. On Apr 5, 2014 this sequence version replaced NM_007207.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031405.1, SRR1163657.397229.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147920, SAMEA2153031 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCCGT CTCCTTTAGA CGACAGGGTA GTAGTGGCAC TATCTAGGCC CGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCTAGT TACCTTGGCT CTGCCAACCC AGGCAGTAAC 
AGCCACCCTC CTGTCATCGC CACCACCGTT GTGTCCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCG CTGAATTGTG GATGCAGCAG TGCCAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGACAAT CAGGCCCAAA CCCAAGCCAT TGCCGCTGGC 
ACCACCACCA CTGCCATCGG AACCTCTACC ACCTGCCCTG CTAACCAGAT GGTCAACAAT 
AATGAGAATA CAGGCTCTCT AAGTCCATCA AGTGGGGTGG GCAGCCCTGT GTCAGGGACC 
CCCAAGCAGC TAGCCAGCAT CAAAATAATC TACCCCAATG ACTTGGCAAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCGAGTCAG GGCCCTGTCA TCATTGACTG CAGGCCCTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC CGATAAGATC 
AGCCGGCGGA GACTGCAGCA GGGCAAGATC ACTGTCCTAG ACTTGATTTC CTGTAGGGAA 
GGCAAGGACT CTTTCAAGAG GATCTTTTCC AAAGAAATTA TAGTTTATGA TGAGAATACC 
AATGAACCAA GCCGAGTGAT GCCCTCCCAG CCACTTCACA TAGTCCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCTCT GGTGTTGAAA GGTGGACTTA GTAGTTTTAA GCAGAACCAT 
GAAAACCTCT GTGACAACTC CCTCCAGCTC CAAGAGTGCC GGGAGGTGGG GGGCGGCGCA 
TCCGCGGCCT CGAGCTTGCT ACCTCAGCCC ATCCCCACCA CCCCTGACAT CGAGAACGCT 
GAGCTCACCC CCATCTTGCC CTTCCTGTTC CTTGGCAATG AGCAGGATGC TCAGGACCTG 
GACACCATGC AGCGGCTGAA CATCGGCTAC GTCATCAACG TCACCACTCA TCTTCCCCTC 
TACCACTATG AGAAAGGCCT GTTCAACTAC AAGCGGCTGC CAGCCACTGA CAGCAACAAG 
CAGAACCTGC GGCAGTACTT TGAAGAGGCT TTTGAGTTCA TTGAGGAAGC TCACCAGTGT 
GGGAAGGGGC TTCTCATCCA CTGCCAGGCT GGGGTGTCCC GCTCCGCCAC CATCGTCATC 
GCTTACTTGA TGAAGCACAC TCGGATGACC ATGACTGATG CTTATAAATT TGTCAAAGGC 
AAACGACCAA TTATCTCCCC AAACCTTAAC TTCATGGGGC AGTTGCTAGA GTTCGAGGAA 
GACCTAAACA ACGGTGTGAC ACCGAGAATC CTTACACCAA AGCTGATGGG CGTGGAGACG 
GTTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009138.1
CDS	240..1688
Translation	MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGASAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV

Target ORF information:

RefSeq Version	NM_007207.5
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007207.5

ORF Insert Sequence:

ATGCCTCCGT CTCCTTTAGA CGACAGGGTA GTAGTGGCAC TATCTAGGCC CGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCTAGT TACCTTGGCT CTGCCAACCC AGGCAGTAAC 
AGCCACCCTC CTGTCATCGC CACCACCGTT GTGTCCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCG CTGAATTGTG GATGCAGCAG TGCCAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGACAAT CAGGCCCAAA CCCAAGCCAT TGCCGCTGGC 
ACCACCACCA CTGCCATCGG AACCTCTACC ACCTGCCCTG CTAACCAGAT GGTCAACAAT 
AATGAGAATA CAGGCTCTCT AAGTCCATCA AGTGGGGTGG GCAGCCCTGT GTCAGGGACC 
CCCAAGCAGC TAGCCAGCAT CAAAATAATC TACCCCAATG ACTTGGCAAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCGAGTCAG GGCCCTGTCA TCATTGACTG CAGGCCCTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC CGATAAGATC 
AGCCGGCGGA GACTGCAGCA GGGCAAGATC ACTGTCCTAG ACTTGATTTC CTGTAGGGAA 
GGCAAGGACT CTTTCAAGAG GATCTTTTCC AAAGAAATTA TAGTTTATGA TGAGAATACC 
AATGAACCAA GCCGAGTGAT GCCCTCCCAG CCACTTCACA TAGTCCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCTCT GGTGTTGAAA GGTGGACTTA GTAGTTTTAA GCAGAACCAT 
GAAAACCTCT GTGACAACTC CCTCCAGCTC CAAGAGTGCC GGGAGGTGGG GGGCGGCGCA 
TCCGCGGCCT CGAGCTTGCT ACCTCAGCCC ATCCCCACCA CCCCTGACAT CGAGAACGCT 
GAGCTCACCC CCATCTTGCC CTTCCTGTTC CTTGGCAATG AGCAGGATGC TCAGGACCTG 
GACACCATGC AGCGGCTGAA CATCGGCTAC GTCATCAACG TCACCACTCA TCTTCCCCTC 
TACCACTATG AGAAAGGCCT GTTCAACTAC AAGCGGCTGC CAGCCACTGA CAGCAACAAG 
CAGAACCTGC GGCAGTACTT TGAAGAGGCT TTTGAGTTCA TTGAGGAAGC TCACCAGTGT 
GGGAAGGGGC TTCTCATCCA CTGCCAGGCT GGGGTGTCCC GCTCCGCCAC CATCGTCATC 
GCTTACTTGA TGAAGCACAC TCGGATGACC ATGACTGATG CTTATAAATT TGTCAAAGGC 
AAACGACCAA TTATCTCCCC AAACCTTAAC TTCATGGGGC AGTTGCTAGA GTTCGAGGAA 
GACCTAAACA ACGGTGTGAC ACCGAGAATC CTTACACCAA AGCTGATGGG CGTGGAGACG 
GTTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUSP10 ( NM_007207.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_009138.1 Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23930
Clone ID Related Accession (Same CDS sequence)	NM_007207.5 , NM_007207.6
Accession Version	NM_007207.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1449bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	dual specificity protein phosphatase 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG720911.1, BC031405.1, BC063826.1 and AI261880.1. On Nov 23, 2018 this sequence version replaced NM_007207.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031405.1, BC063826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147920, SAMN01820693 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000366899.4/ ENSP00000355866.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTCCGT CTCCTTTAGA CGACAGGGTA GTAGTGGCAC TATCTAGGCC CGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCTAGT TACCTTGGCT CTGCCAACCC AGGCAGTAAC 
AGCCACCCTC CTGTCATCGC CACCACCGTT GTGTCCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCG CTGAATTGTG GATGCAGCAG TGCCAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGACAAT CAGGCCCAAA CCCAAGCCAT TGCCGCTGGC 
ACCACCACCA CTGCCATCGG AACCTCTACC ACCTGCCCTG CTAACCAGAT GGTCAACAAT 
AATGAGAATA CAGGCTCTCT AAGTCCATCA AGTGGGGTGG GCAGCCCTGT GTCAGGGACC 
CCCAAGCAGC TAGCCAGCAT CAAAATAATC TACCCCAATG ACTTGGCAAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCGAGTCAG GGCCCTGTCA TCATTGACTG CAGGCCCTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC CGATAAGATC 
AGCCGGCGGA GACTGCAGCA GGGCAAGATC ACTGTCCTAG ACTTGATTTC CTGTAGGGAA 
GGCAAGGACT CTTTCAAGAG GATCTTTTCC AAAGAAATTA TAGTTTATGA TGAGAATACC 
AATGAACCAA GCCGAGTGAT GCCCTCCCAG CCACTTCACA TAGTCCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCTCT GGTGTTGAAA GGTGGACTTA GTAGTTTTAA GCAGAACCAT 
GAAAACCTCT GTGACAACTC CCTCCAGCTC CAAGAGTGCC GGGAGGTGGG GGGCGGCGCA 
TCCGCGGCCT CGAGCTTGCT ACCTCAGCCC ATCCCCACCA CCCCTGACAT CGAGAACGCT 
GAGCTCACCC CCATCTTGCC CTTCCTGTTC CTTGGCAATG AGCAGGATGC TCAGGACCTG 
GACACCATGC AGCGGCTGAA CATCGGCTAC GTCATCAACG TCACCACTCA TCTTCCCCTC 
TACCACTATG AGAAAGGCCT GTTCAACTAC AAGCGGCTGC CAGCCACTGA CAGCAACAAG 
CAGAACCTGC GGCAGTACTT TGAAGAGGCT TTTGAGTTCA TTGAGGAAGC TCACCAGTGT 
GGGAAGGGGC TTCTCATCCA CTGCCAGGCT GGGGTGTCCC GCTCCGCCAC CATCGTCATC 
GCTTACTTGA TGAAGCACAC TCGGATGACC ATGACTGATG CTTATAAATT TGTCAAAGGC 
AAACGACCAA TTATCTCCCC AAACCTTAAC TTCATGGGGC AGTTGCTAGA GTTCGAGGAA 
GACCTAAACA ACGGTGTGAC ACCGAGAATC CTTACACCAA AGCTGATGGG CGTGGAGACG 
GTTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009138.1
CDS	153..1601
Translation	MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGASAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV

Target ORF information:

RefSeq Version	NM_007207.6
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007207.6

ORF Insert Sequence:

ATGCCTCCGT CTCCTTTAGA CGACAGGGTA GTAGTGGCAC TATCTAGGCC CGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCTAGT TACCTTGGCT CTGCCAACCC AGGCAGTAAC 
AGCCACCCTC CTGTCATCGC CACCACCGTT GTGTCCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCG CTGAATTGTG GATGCAGCAG TGCCAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGACAAT CAGGCCCAAA CCCAAGCCAT TGCCGCTGGC 
ACCACCACCA CTGCCATCGG AACCTCTACC ACCTGCCCTG CTAACCAGAT GGTCAACAAT 
AATGAGAATA CAGGCTCTCT AAGTCCATCA AGTGGGGTGG GCAGCCCTGT GTCAGGGACC 
CCCAAGCAGC TAGCCAGCAT CAAAATAATC TACCCCAATG ACTTGGCAAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCGAGTCAG GGCCCTGTCA TCATTGACTG CAGGCCCTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC CGATAAGATC 
AGCCGGCGGA GACTGCAGCA GGGCAAGATC ACTGTCCTAG ACTTGATTTC CTGTAGGGAA 
GGCAAGGACT CTTTCAAGAG GATCTTTTCC AAAGAAATTA TAGTTTATGA TGAGAATACC 
AATGAACCAA GCCGAGTGAT GCCCTCCCAG CCACTTCACA TAGTCCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCTCT GGTGTTGAAA GGTGGACTTA GTAGTTTTAA GCAGAACCAT 
GAAAACCTCT GTGACAACTC CCTCCAGCTC CAAGAGTGCC GGGAGGTGGG GGGCGGCGCA 
TCCGCGGCCT CGAGCTTGCT ACCTCAGCCC ATCCCCACCA CCCCTGACAT CGAGAACGCT 
GAGCTCACCC CCATCTTGCC CTTCCTGTTC CTTGGCAATG AGCAGGATGC TCAGGACCTG 
GACACCATGC AGCGGCTGAA CATCGGCTAC GTCATCAACG TCACCACTCA TCTTCCCCTC 
TACCACTATG AGAAAGGCCT GTTCAACTAC AAGCGGCTGC CAGCCACTGA CAGCAACAAG 
CAGAACCTGC GGCAGTACTT TGAAGAGGCT TTTGAGTTCA TTGAGGAAGC TCACCAGTGT 
GGGAAGGGGC TTCTCATCCA CTGCCAGGCT GGGGTGTCCC GCTCCGCCAC CATCGTCATC 
GCTTACTTGA TGAAGCACAC TCGGATGACC ATGACTGATG CTTATAAATT TGTCAAAGGC 
AAACGACCAA TTATCTCCCC AAACCTTAAC TTCATGGGGC AGTTGCTAGA GTTCGAGGAA 
GACCTAAACA ACGGTGTGAC ACCGAGAATC CTTACACCAA AGCTGATGGG CGTGGAGACG 
GTTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUSP10 ( XM_017000147.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016855636.1 Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu83058
Clone ID Related Accession (Same CDS sequence)	XM_017000147.1 , XM_017000147.2
Accession Version	XM_017000147.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	dual specificity protein phosphatase 10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTCCGT CTCCTTTAGA CGACAGGGTA GTAGTGGCAC TATCTAGGCC CGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCTAGT TACCTTGGCT CTGCCAACCC AGGCAGTAAC 
AGCCACCCTC CTGTCATCGC CACCACCGTT GTGTCCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCG CTGAATTGTG GATGCAGCAG TGCCAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGACAAT CAGGCCCAAA CCCAAGCCAT TGCCGCTGGC 
ACCACCACCA CTGCCATCGG AACCTCTACC ACCTGCCCTG CTAACCAGAT GGTCAACAAT 
AATGAGAATA CAGGCTCTCT AAGTCCATCA AGTGGGGTGG GCAGCCCTGT GTCAGGGACC 
CCCAAGCAGC TAGCCAGCAT CAAAATAATC TACCCCAATG ACTTGGCAAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCGAGTCAG GGCCCTGTCA TCATTGACTG CAGGCCCTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC CGATAAGATC 
AGCCGGCGGA GACTGCAGCA GGGCAAGATC ACTGTCCTAG ACTTGATTTC CTGTAGGGAA 
GGCAAGGACT CTTTCAAGAG GATCTTTTCC AAAGAAATTA TAGTTTATGA TGAGAATACC 
AATGAACCAA GCCGAGTGAT GCCCTCCCAG CCACTTCACA TAGTCCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCTCT GGTGTTGAAA GGTGTTCATG ATAAAAAGCA AGTCTTTTGT 
GTCTTCATGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016855636.1
CDS	17..871
Translation	MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGVHDKKQVFCVFMI

Target ORF information:

RefSeq Version	XM_017000147.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017000147.1

ORF Insert Sequence:

ATGCCTCCGT CTCCTTTAGA CGACAGGGTA GTAGTGGCAC TATCTAGGCC CGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCTAGT TACCTTGGCT CTGCCAACCC AGGCAGTAAC 
AGCCACCCTC CTGTCATCGC CACCACCGTT GTGTCCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCG CTGAATTGTG GATGCAGCAG TGCCAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGACAAT CAGGCCCAAA CCCAAGCCAT TGCCGCTGGC 
ACCACCACCA CTGCCATCGG AACCTCTACC ACCTGCCCTG CTAACCAGAT GGTCAACAAT 
AATGAGAATA CAGGCTCTCT AAGTCCATCA AGTGGGGTGG GCAGCCCTGT GTCAGGGACC 
CCCAAGCAGC TAGCCAGCAT CAAAATAATC TACCCCAATG ACTTGGCAAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCGAGTCAG GGCCCTGTCA TCATTGACTG CAGGCCCTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC CGATAAGATC 
AGCCGGCGGA GACTGCAGCA GGGCAAGATC ACTGTCCTAG ACTTGATTTC CTGTAGGGAA 
GGCAAGGACT CTTTCAAGAG GATCTTTTCC AAAGAAATTA TAGTTTATGA TGAGAATACC 
AATGAACCAA GCCGAGTGAT GCCCTCCCAG CCACTTCACA TAGTCCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCTCT GGTGTTGAAA GGTGTTCATG ATAAAAAGCA AGTCTTTTGT 
GTCTTCATGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUSP10 ( XM_017000147.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016855636.1 Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant X1, mRNA.

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CloneID	OHu83058
Clone ID Related Accession (Same CDS sequence)	XM_017000147.1 , XM_017000147.2
Accession Version	XM_017000147.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dual specificity protein phosphatase 10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017000147.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTCCGT CTCCTTTAGA CGACAGGGTA GTAGTGGCAC TATCTAGGCC CGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCTAGT TACCTTGGCT CTGCCAACCC AGGCAGTAAC 
AGCCACCCTC CTGTCATCGC CACCACCGTT GTGTCCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCG CTGAATTGTG GATGCAGCAG TGCCAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGACAAT CAGGCCCAAA CCCAAGCCAT TGCCGCTGGC 
ACCACCACCA CTGCCATCGG AACCTCTACC ACCTGCCCTG CTAACCAGAT GGTCAACAAT 
AATGAGAATA CAGGCTCTCT AAGTCCATCA AGTGGGGTGG GCAGCCCTGT GTCAGGGACC 
CCCAAGCAGC TAGCCAGCAT CAAAATAATC TACCCCAATG ACTTGGCAAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCGAGTCAG GGCCCTGTCA TCATTGACTG CAGGCCCTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC CGATAAGATC 
AGCCGGCGGA GACTGCAGCA GGGCAAGATC ACTGTCCTAG ACTTGATTTC CTGTAGGGAA 
GGCAAGGACT CTTTCAAGAG GATCTTTTCC AAAGAAATTA TAGTTTATGA TGAGAATACC 
AATGAACCAA GCCGAGTGAT GCCCTCCCAG CCACTTCACA TAGTCCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCTCT GGTGTTGAAA GGTGTTCATG ATAAAAAGCA AGTCTTTTGT 
GTCTTCATGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016855636.1
CDS	155..1009
Translation	MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTYMPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNNNENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGVHDKKQVFCVFMI

Target ORF information:

RefSeq Version	XM_017000147.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 10 (DUSP10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017000147.2

ORF Insert Sequence:

ATGCCTCCGT CTCCTTTAGA CGACAGGGTA GTAGTGGCAC TATCTAGGCC CGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCTAGT TACCTTGGCT CTGCCAACCC AGGCAGTAAC 
AGCCACCCTC CTGTCATCGC CACCACCGTT GTGTCCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCG CTGAATTGTG GATGCAGCAG TGCCAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGACAAT CAGGCCCAAA CCCAAGCCAT TGCCGCTGGC 
ACCACCACCA CTGCCATCGG AACCTCTACC ACCTGCCCTG CTAACCAGAT GGTCAACAAT 
AATGAGAATA CAGGCTCTCT AAGTCCATCA AGTGGGGTGG GCAGCCCTGT GTCAGGGACC 
CCCAAGCAGC TAGCCAGCAT CAAAATAATC TACCCCAATG ACTTGGCAAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCGAGTCAG GGCCCTGTCA TCATTGACTG CAGGCCCTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC CGATAAGATC 
AGCCGGCGGA GACTGCAGCA GGGCAAGATC ACTGTCCTAG ACTTGATTTC CTGTAGGGAA 
GGCAAGGACT CTTTCAAGAG GATCTTTTCC AAAGAAATTA TAGTTTATGA TGAGAATACC 
AATGAACCAA GCCGAGTGAT GCCCTCCCAG CCACTTCACA TAGTCCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCTCT GGTGTTGAAA GGTGTTCATG ATAAAAAGCA AGTCTTTTGT 
GTCTTCATGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma.
Cancer research77(17)4602-4612(2017 Sep)
Ng KY,Chan LH,Chai S,Tong M,Guan XY,Lee NP,Yuan Y,Xie D,Lee TK,Dusetti NJ,Carrier A,Ma S

AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway.
Molecular oncology10(5)652-62(2016 05)
Hrstka R,Bouchalova P,Michalova E,Matoulkova E,Muller P,Coates PJ,Vojtesek B

Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population.
International journal of clinical and experimental pathology8(2)2018-25(2015)
Duan X,Gao Y,Yang H,Feng T,Jin T,Long Y,Chen C

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DUSP10 cDNA ORF clone, Homo sapiens(human)

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Clones

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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