TREX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TREX2
Entrez Gene ID	11219
Full Name	three prime repair exonuclease 2
General protein information	Preferred Names three prime repair exonuclease 2 Names three prime repair exonuclease 2 3'-5' exonuclease TREX2 long form
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012].
Disorder MIM:	300370

mRNA and Protein(s)

mRNA	Protein	Name
NM_080701.3	NP_542432.2	three prime repair exonuclease 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Trex2	NP_001101050.1
Xenopus tropicalis (tropical clawed frog)	LOC100488944	XP_004916766.1
	TREX1	XP_001083188.2
Homo sapiens (human)	TREX2	NP_542432.2
Canis lupus familiaris (dog)	TREX2	XP_005642045.1
Mus musculus (house mouse)	Trex2	NP_036037.1
Pan troglodytes (chimpanzee)	TREX2	XP_003317815.2

Gene Ontology
Bibliography

Related articles in PubMed

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.
Manils J, G?mez D, Salla-Martret M, Fischer H, Fye JM, Marzo E, Marruecos L, Serrano I, Salgado R, Rodrigo JP, Garcia-Pedrero JM, Serafin AM, Ca?as X, Benito C, Toll A, Forcales SV, Perrino FW, Eckhart L, Soler C
Oncotarget6(26)22375-96(2015 Sep)

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.
Bhatia V, Barroso SI, Garc?a-Rubio ML, Tumini E, Herrera-Moyano E, Aguilera A
Nature511(7509)362-5(2014 Jul)

The human TREX-2 complex is stably associated with the nuclear pore basket.
Umlauf D, Bonnet J, Waharte F, Fournier M, Stierle M, Fischer B, Brino L, Devys D, Tora L
Journal of cell science126(Pt 12)2656-67(2013 Jun)

Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2.
Chen MJ, Ma SM, Dumitrache LC, Hasty P
Nucleic acids research35(8)2682-94(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Altogether, data provide new insights in the molecular mechanisms of TREX2 activity and establish cell autonomous and non-cell autonomous functions of TREX2 in the UVB-induced skin response.
Title: Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.

human TREX-2 complex prevents genome instability, as determined by the accumulation of gamma-H2AX and 53BP1 foci and single-cell electrophoresis in cells depleted of the TREX-2 subunits PCID2, GANP and DSS1
Title: BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

TREX-2 is an NPC-associated complex in mammalian cells.
Title: The human TREX-2 complex is stably associated with the nuclear pore basket.

Trex2 does not enable DSB repair and prompt a new model that posits Trex2 suppresses the formation of broken chromosomes.
Title: Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair.

a model for DNA binding and 3' hydrolysis for the TREX2 dimer.
Title: DNA binding induces active site conformational change in the human TREX2 3'-exonuclease.

The following TREX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TREX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu25613	NM_080701.3 Latest version!	Homo sapiens three prime repair exonuclease 2 (TREX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TREX2 ( NM_080701.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_542432.2 Homo sapiens three prime repair exonuclease 2 (TREX2), mRNA.

Price & Availability↑

CloneID	OHu25613
Clone ID Related Accession (Same CDS sequence)	NM_080701.3
Accession Version	NM_080701.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Homo sapiens(human)
Product	three prime repair exonuclease 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW296654.1, AF319570.1 and AF151107.1. This sequence is a reference standard in the RefSeqGene project. On or before Sep 13, 2012 this sequence version replaced NM_007205.3, NM_080701.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF319570.1, SRR1163657.503826.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTCCGAGG CACCCCGGGC CGAGACCTTT GTCTTCCTGG ACCTGGAAGC CACTGGGCTC 
CCCAGTGTGG AGCCCGAGAT TGCCGAGCTG TCCCTCTTTG CTGTCCACCG CTCCTCCCTG 
GAGAACCCGG AGCACGACGA GTCTGGTGCC CTAGTATTGC CCCGGGTCCT GGACAAGCTC 
ACGCTGTGCA TGTGCCCGGA GCGCCCCTTC ACTGCCAAGG CCAGCGAGAT CACCGGCCTG 
AGCAGTGAGG GCCTGGCGCG ATGCCGGAAG GCTGGCTTTG ATGGCGCCGT GGTGCGGACG 
CTGCAGGCCT TCCTGAGCCG CCAGGCAGGG CCCATCTGCC TTGTGGCCCA CAATGGCTTT 
GATTATGATT TCCCCCTGCT GTGTGCCGAG CTGCGGCGCC TGGGTGCCCG CCTGCCCCGG 
GACACTGTCT GCCTGGACAC GCTGCCGGCC CTGCGGGGCC TGGACCGCGC CCACAGCCAC 
GGCACCCGGG CCCGGGGCCG CCAGGGTTAC AGCCTCGGCA GCCTCTTCCA CCGCTACTTC 
CGGGCAGAGC CAAGCGCAGC CCACTCAGCC GAGGGCGACG TGCACACCCT GCTCCTGATC 
TTCCTGCACC GCGCCGCAGA GCTGCTCGCC TGGGCCGATG AGCAGGCCCG TGGGTGGGCC 
CACATCGAGC CCATGTACTT GCCGCCTGAT GACCCCAGCC TGGAGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542432.2
CDS	545..1255
Translation	MSEAPRAETFVFLDLEATGLPSVEPEIAELSLFAVHRSSLENPEHDESGALVLPRVLDKLTLCMCPERPFTAKASEITGLSSEGLARCRKAGFDGAVVRTLQAFLSRQAGPICLVAHNGFDYDFPLLCAELRRLGARLPRDTVCLDTLPALRGLDRAHSHGTRARGRQGYSLGSLFHRYFRAEPSAAHSAEGDVHTLLLIFLHRAAELLAWADEQARGWAHIEPMYLPPDDPSLEA

Target ORF information:

RefSeq Version	NM_080701.3
Organism	Homo sapiens(human)
Definition	Homo sapiens three prime repair exonuclease 2 (TREX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080701.3

ORF Insert Sequence:

ATGTCCGAGG CACCCCGGGC CGAGACCTTT GTCTTCCTGG ACCTGGAAGC CACTGGGCTC 
CCCAGTGTGG AGCCCGAGAT TGCCGAGCTG TCCCTCTTTG CTGTCCACCG CTCCTCCCTG 
GAGAACCCGG AGCACGACGA GTCTGGTGCC CTAGTATTGC CCCGGGTCCT GGACAAGCTC 
ACGCTGTGCA TGTGCCCGGA GCGCCCCTTC ACTGCCAAGG CCAGCGAGAT CACCGGCCTG 
AGCAGTGAGG GCCTGGCGCG ATGCCGGAAG GCTGGCTTTG ATGGCGCCGT GGTGCGGACG 
CTGCAGGCCT TCCTGAGCCG CCAGGCAGGG CCCATCTGCC TTGTGGCCCA CAATGGCTTT 
GATTATGATT TCCCCCTGCT GTGTGCCGAG CTGCGGCGCC TGGGTGCCCG CCTGCCCCGG 
GACACTGTCT GCCTGGACAC GCTGCCGGCC CTGCGGGGCC TGGACCGCGC CCACAGCCAC 
GGCACCCGGG CCCGGGGCCG CCAGGGTTAC AGCCTCGGCA GCCTCTTCCA CCGCTACTTC 
CGGGCAGAGC CAAGCGCAGC CCACTCAGCC GAGGGCGACG TGCACACCCT GCTCCTGATC 
TTCCTGCACC GCGCCGCAGA GCTGCTCGCC TGGGCCGATG AGCAGGCCCG TGGGTGGGCC 
CACATCGAGC CCATGTACTT GCCGCCTGAT GACCCCAGCC TGGAGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.
Oncotarget6(26)22375-96(2015 Sep)
Manils J,G?mez D,Salla-Martret M,Fischer H,Fye JM,Marzo E,Marruecos L,Serrano I,Salgado R,Rodrigo JP,Garcia-Pedrero JM,Serafin AM,Ca?as X,Benito C,Toll A,Forcales SV,Perrino FW,Eckhart L,Soler C

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.
Nature511(7509)362-5(2014 Jul)
Bhatia V,Barroso SI,Garc?a-Rubio ML,Tumini E,Herrera-Moyano E,Aguilera A

The human TREX-2 complex is stably associated with the nuclear pore basket.
Journal of cell science126(Pt 12)2656-67(2013 Jun)
Umlauf D,Bonnet J,Waharte F,Fournier M,Stierle M,Fischer B,Brino L,Devys D,Tora L

Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2.
Nucleic acids research35(8)2682-94(2007)
Chen MJ,Ma SM,Dumitrache LC,Hasty P

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TREX2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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