AKAP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AKAP2
Entrez Gene ID	11217
Full Name	A-kinase anchoring protein 2
Synonyms	AKAP-2,AKAPKL,MISP2,PRKA2
General protein information	Preferred Names A-kinase anchoring protein 2 Names A-kinase anchor protein 2 A kinase (PRKA) anchor protein 2 protein kinase A anchoring protein 2 protein kinase A2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q31.3
Summary	The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
Disorder MIM:	604582

mRNA and Protein(s)

mRNA	Protein	Name
NM_001136562.2	NP_001130034.1	A-kinase anchor protein 2 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	AKAP2	XP_003951538.1
Mus musculus (house mouse)	Akap2	NP_001030610.1
Gallus gallus (chicken)	AKAP2	NP_001191146.1
Danio rerio (zebrafish)	akap2	NP_001191129.1
Xenopus tropicalis (tropical clawed frog)	akap2	NP_001123815.1
Homo sapiens (human)	AKAP2	NP_001185585.1
Rattus norvegicus (Norway rat)	Akap2	NP_001011974.1

Gene Ontology
Bibliography

Related articles in PubMed

AKAP2 is upregulated in ovarian cancer, and promotes growth and migration of cancer cells.
Li X, Wang C, Zhang G, Liang M, Zhang B
Molecular medicine reports16(4)5151-5156(2017 Oct)

Lack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population.
Xu L, Xia C, Zhu W, Feng Z, Qin X, Sun W, Qiu Y, Zhu Z
BMC musculoskeletal disorders18(1)368(2017 Aug)

AKAP2 identified as a novel gene mutated in a Chinese family with adolescent idiopathic scoliosis.
Li W, Li Y, Zhang L, Guo H, Tian D, Li Y, Peng Y, Zheng Y, Dai Y, Xia K, Lan X, Wang B, Hu Z
Journal of medical genetics53(7)488-93(2016 Jul)

A-kinase anchoring protein 2 is required for calcitonin-mediated invasion of cancer cells.
Thakkar A, Aljameeli A, Thomas S, Shah GV
Endocrine-related cancer23(1)1-14(2016 Jan)

Is the gene-environment interaction paradigm relevant to genome-wide studies? The case of education and body mass index.
Boardman JD, Domingue BW, Blalock CL, Haberstick BC, Harris KM, McQueen MB
Demography51(1)119-39(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AKAP2 was therefore implicated as a novel gene mutated in a Chinese family with adolescent idiopathic scoliosis.
Title: AKAP2 identified as a novel gene mutated in a Chinese family with adolescent idiopathic scoliosis.

AKAP2 is expressed in human prostates, its expression is elevated in metastatic prostate cancer.
Title: A-kinase anchoring protein 2 is required for calcitonin-mediated invasion of cancer cells.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: A three-stage genome-wide association study of general cognitive ability: hunting the small effects.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Identification of 15 loci influencing height in a Korean population.

Observational study of gene-disease association. (HuGE Navigator)
Title: Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.

The following AKAP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AKAP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu32174	NM_001136562.2 Latest version!	Homo sapiens A-kinase anchoring protein 2 (AKAP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AKAP2 ( NM_001136562.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001130034.1 Homo sapiens A-kinase anchoring protein 2 (AKAP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu32174
Clone ID Related Accession (Same CDS sequence)	NM_001136562.2
Accession Version	NM_001136562.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2580bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	A-kinase anchor protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC422367.1, AK300427.1, AL158823.11, AL353598.12 and BC010513.1. On Oct 30, 2010 this sequence version replaced NM_001136562.1. Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.70530.1, SRR1803615.200173.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAATTG AGGTGTCTGT TGCAGAATGT AAAAGTGTTC CTGGAATCAC CTCTACCCCA 
CATCCCATGG ACCATCCCTC CGCTTTCTAT TCACCCCCGC ATAATGGCCT CCTTACTGAT 
CACCACGAAT CCCTGGATAA TGATGTTGCC AGAGAGATCC GCTATCTAGA TGAGGTGCTA 
GAGGCCAACT GCTGTGATTC TGCTGTGGAT GGAACGTACA ATGGAACATC CTCCCCAGAG 
CCTGGTGCAG TGGTTCTGGT GGGCGGCCTA AGCCCCCCTG TCCACGAGGC GACCCAGCCA 
GAACCCACTG AAAGAACAGC TAGCCGGCAG GCACCTCCTC ACATCGAGCT CAGTAATAGC 
AGCCCTGACC CCATGGCAGA GGCAGAAAGA ACAAATGGCC ATTCCCCCAG CCAGCCTAGA 
GATGCGCTGG GGGACAGCCT GCAGGTGCCT GTCAGCCCCA GCTCCACAAC CAGCTCACGG 
TGTTCTTCCC GAGATGGAGA GTTCACTCTC ACCACACTGA AAAAGGAGGC CAAGTTTGAG 
CTGCGTGCCT TCCATGAGGA CAAGAAGCCC TCCAAGCTCT TTGAGGATGA CGAGCATGAG 
AAAGAACAAT ACTGCATTAG AAAAGTGAGG CCTTCAGAGG AGATGCTGGA GCTGGAAAAG 
GAGAGGAGAG AGCTCATCCG CAGCCAGGCC GTCAAGAAGA ATCCTGGCAT TGCAGCAAAA 
TGGTGGAATC CCCCGCAGGA AAAAACCATC GAGGAGCAGC TGGACGAGGA ACATCTGGAG 
TCGCACAAAA AGTACAAGGA GCGCAAAGAG AGAAGGGCAC AGCAGGAACA GTTGCTGCTG 
CAGAAGCAGT TACAGCAGCA GCAGCAGCAG CCCCCATCGC AGCTCTGCAC AGCCCCTGCC 
TCTTCTCATG AACGCGCAAG CATGATTGAC AAAGCAAAGG AGGACATTGT CACAGAGCAG 
ATAGATTTCT CTGCTGCTCG CAAACAATTT CAGCTGATGG AGAATTCCAG GCAAGCGGTG 
GCCAAGGGCC AGAGTACACC CAGGCTGTTC TCCATCAAGC CTTTCTACAG GCCTCTGGGG 
TCAGTCAACT CAGACAAGCC ACTGACTAAT CCGAGACCAC CTTCTGTCGG GGGACCTCCA 
GAAGACAGTG GTGCCTCAGC CGCCAAGGGA CAGAAATCCC CCGGTGCCCT GGAGACCCCA 
TCGGCAGCAG GAAGCCAGGG CAACACAGCC TCTCAGGGGA AGGAAGGGCC CTACAGCGAG 
CCTTCTAAAC GTGGGCCCTT ATCTAAACTG TGGGCTGAGG ATGGAGAATT TACGAGCGCC 
CGGGCTGTCC TCACTGTGGT CAAGGATGAT GACCATGGGA TTTTGGATCA GTTCTCAAGA 
TCTGTCAATG TCTCCTTGAC CCAAGAGGAG CTTGACTCTG GTCTGGACGA ATTGTCGGTG 
AGGTCTCAGG ATACCACAGT CCTGGAGACC CTATCCAATG ATTTCAGCAT GGACAACATC 
AGTGACAGCG GGGCATCCAA TGAGACAACC AATGCCCTCC AGGAAAATTC ACTGGCTGAT 
TTTTCTCTGC CCCAGACACC ACAAACTGAC AACCCCTCAG AGGGCCGAGG AGAAGGCGTC 
TCCAAGTCAT TTAGTGATCA TGGTTTCTAT TCCCCTTCCT CCACGCTGGG GGACTCTCCG 
TTGGTTGATG ACCCCTTGGA GTATCAGGCT GGCCTCCTGG TGCAGAATGC CATTCAACAA 
GCCATAGCCG AGCAGGTGGA TAAAGCTGTG TCCAAAACCA GCAGGGATGG AGCAGAGCAA 
CAGGGACCTG AAGCGACTGT AGAGGAAGCT GAAGCTGCGG CTTTCGGCTC AGAAAAGCCT 
CAGAGCATGT TTGAGCCACC TCAGGTGTCT TCTCCTGTTC AAGAGAAAAG GGATGTATTA 
CCAAAGATTC TGCCTGCTGA AGACAGGGCG CTCAGGGAAA GGGGGCCCCC CCAGCCACTG 
CCAGCTGTGC AGCCCAGTGG CCCGATTAAC ATGGAGGAGA CCAGGCCCGA AGGAAGCTAT 
TTCAGCAAGT ACTCGGAGGC AGCTGAGCTG AGAAGCACAG CCTCCCTCCT GGCCACTCAA 
GAATCTGACG TGATGGTTGG GCCTTTCAAG CTGAGGTCCA GGAAACAGCG GACTTTGTCC 
ATGATTGAGG AAGAGATCCG AGCAGCTCAG GAAAGGGAAG AGGAGCTGAA GAGGCAGAGA 
CAAGTCTTGC AGAGTACGCA GAGCCCCAGG ACAAAGAATG CCCCATCACT GCCCTCCAGA 
ACATGCTACA AAACTGCTCC AGGGAAAATA GAGAAAGTCA AACCTCCTCC ATCCCCCACC 
ACTGAAGGCC CCAGCTTGCA GCCTGACTTA GCCCCTGAAG AGGCTGCCGG AACCCAGCGG 
CCCAAGAATC TGATGCAGAC CCTCATGGAA GACTATGAGA CACACAAATC TAAAAGGCGC 
GAGAGAATGG ATGATAGTAG TGTCCTCGAG GCCACACGGG TTAATCGAAG AAAGAGCGCA 
CTGGCTTTGC GCTGGGAAGC AGGGATCTAT GCCAACCAGG AGGAAGAAGA CAACGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001130034.1
CDS	208..2787
Translation	MEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSVLEATRVNRRKSALALRWEAGIYANQEEEDNE

Target ORF information:

RefSeq Version	NM_001136562.2
Organism	Homo sapiens(human)
Definition	Homo sapiens A-kinase anchoring protein 2 (AKAP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136562.2

ORF Insert Sequence:

ATGGAAATTG AGGTGTCTGT TGCAGAATGT AAAAGTGTTC CTGGAATCAC CTCTACCCCA 
CATCCCATGG ACCATCCCTC CGCTTTCTAT TCACCCCCGC ATAATGGCCT CCTTACTGAT 
CACCACGAAT CCCTGGATAA TGATGTTGCC AGAGAGATCC GCTATCTAGA TGAGGTGCTA 
GAGGCCAACT GCTGTGATTC TGCTGTGGAT GGAACGTACA ATGGAACATC CTCCCCAGAG 
CCTGGTGCAG TGGTTCTGGT GGGCGGCCTA AGCCCCCCTG TCCACGAGGC GACCCAGCCA 
GAACCCACTG AAAGAACAGC TAGCCGGCAG GCACCTCCTC ACATCGAGCT CAGTAATAGC 
AGCCCTGACC CCATGGCAGA GGCAGAAAGA ACAAATGGCC ATTCCCCCAG CCAGCCTAGA 
GATGCGCTGG GGGACAGCCT GCAGGTGCCT GTCAGCCCCA GCTCCACAAC CAGCTCACGG 
TGTTCTTCCC GAGATGGAGA GTTCACTCTC ACCACACTGA AAAAGGAGGC CAAGTTTGAG 
CTGCGTGCCT TCCATGAGGA CAAGAAGCCC TCCAAGCTCT TTGAGGATGA CGAGCATGAG 
AAAGAACAAT ACTGCATTAG AAAAGTGAGG CCTTCAGAGG AGATGCTGGA GCTGGAAAAG 
GAGAGGAGAG AGCTCATCCG CAGCCAGGCC GTCAAGAAGA ATCCTGGCAT TGCAGCAAAA 
TGGTGGAATC CCCCGCAGGA AAAAACCATC GAGGAGCAGC TGGACGAGGA ACATCTGGAG 
TCGCACAAAA AGTACAAGGA GCGCAAAGAG AGAAGGGCAC AGCAGGAACA GTTGCTGCTG 
CAGAAGCAGT TACAGCAGCA GCAGCAGCAG CCCCCATCGC AGCTCTGCAC AGCCCCTGCC 
TCTTCTCATG AACGCGCAAG CATGATTGAC AAAGCAAAGG AGGACATTGT CACAGAGCAG 
ATAGATTTCT CTGCTGCTCG CAAACAATTT CAGCTGATGG AGAATTCCAG GCAAGCGGTG 
GCCAAGGGCC AGAGTACACC CAGGCTGTTC TCCATCAAGC CTTTCTACAG GCCTCTGGGG 
TCAGTCAACT CAGACAAGCC ACTGACTAAT CCGAGACCAC CTTCTGTCGG GGGACCTCCA 
GAAGACAGTG GTGCCTCAGC CGCCAAGGGA CAGAAATCCC CCGGTGCCCT GGAGACCCCA 
TCGGCAGCAG GAAGCCAGGG CAACACAGCC TCTCAGGGGA AGGAAGGGCC CTACAGCGAG 
CCTTCTAAAC GTGGGCCCTT ATCTAAACTG TGGGCTGAGG ATGGAGAATT TACGAGCGCC 
CGGGCTGTCC TCACTGTGGT CAAGGATGAT GACCATGGGA TTTTGGATCA GTTCTCAAGA 
TCTGTCAATG TCTCCTTGAC CCAAGAGGAG CTTGACTCTG GTCTGGACGA ATTGTCGGTG 
AGGTCTCAGG ATACCACAGT CCTGGAGACC CTATCCAATG ATTTCAGCAT GGACAACATC 
AGTGACAGCG GGGCATCCAA TGAGACAACC AATGCCCTCC AGGAAAATTC ACTGGCTGAT 
TTTTCTCTGC CCCAGACACC ACAAACTGAC AACCCCTCAG AGGGCCGAGG AGAAGGCGTC 
TCCAAGTCAT TTAGTGATCA TGGTTTCTAT TCCCCTTCCT CCACGCTGGG GGACTCTCCG 
TTGGTTGATG ACCCCTTGGA GTATCAGGCT GGCCTCCTGG TGCAGAATGC CATTCAACAA 
GCCATAGCCG AGCAGGTGGA TAAAGCTGTG TCCAAAACCA GCAGGGATGG AGCAGAGCAA 
CAGGGACCTG AAGCGACTGT AGAGGAAGCT GAAGCTGCGG CTTTCGGCTC AGAAAAGCCT 
CAGAGCATGT TTGAGCCACC TCAGGTGTCT TCTCCTGTTC AAGAGAAAAG GGATGTATTA 
CCAAAGATTC TGCCTGCTGA AGACAGGGCG CTCAGGGAAA GGGGGCCCCC CCAGCCACTG 
CCAGCTGTGC AGCCCAGTGG CCCGATTAAC ATGGAGGAGA CCAGGCCCGA AGGAAGCTAT 
TTCAGCAAGT ACTCGGAGGC AGCTGAGCTG AGAAGCACAG CCTCCCTCCT GGCCACTCAA 
GAATCTGACG TGATGGTTGG GCCTTTCAAG CTGAGGTCCA GGAAACAGCG GACTTTGTCC 
ATGATTGAGG AAGAGATCCG AGCAGCTCAG GAAAGGGAAG AGGAGCTGAA GAGGCAGAGA 
CAAGTCTTGC AGAGTACGCA GAGCCCCAGG ACAAAGAATG CCCCATCACT GCCCTCCAGA 
ACATGCTACA AAACTGCTCC AGGGAAAATA GAGAAAGTCA AACCTCCTCC ATCCCCCACC 
ACTGAAGGCC CCAGCTTGCA GCCTGACTTA GCCCCTGAAG AGGCTGCCGG AACCCAGCGG 
CCCAAGAATC TGATGCAGAC CCTCATGGAA GACTATGAGA CACACAAATC TAAAAGGCGC 
GAGAGAATGG ATGATAGTAG TGTCCTCGAG GCCACACGGG TTAATCGAAG AAAGAGCGCA 
CTGGCTTTGC GCTGGGAAGC AGGGATCTAT GCCAACCAGG AGGAAGAAGA CAACGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

AKAP2 is upregulated in ovarian cancer, and promotes growth and migration of cancer cells.
Molecular medicine reports16(4)5151-5156(2017 Oct)
Li X,Wang C,Zhang G,Liang M,Zhang B

Lack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population.
BMC musculoskeletal disorders18(1)368(2017 Aug)
Xu L,Xia C,Zhu W,Feng Z,Qin X,Sun W,Qiu Y,Zhu Z

AKAP2 identified as a novel gene mutated in a Chinese family with adolescent idiopathic scoliosis.
Journal of medical genetics53(7)488-93(2016 Jul)
Li W,Li Y,Zhang L,Guo H,Tian D,Li Y,Peng Y,Zheng Y,Dai Y,Xia K,Lan X,Wang B,Hu Z

A-kinase anchoring protein 2 is required for calcitonin-mediated invasion of cancer cells.
Endocrine-related cancer23(1)1-14(2016 Jan)
Thakkar A,Aljameeli A,Thomas S,Shah GV

Is the gene-environment interaction paradigm relevant to genome-wide studies? The case of education and body mass index.
Demography51(1)119-39(2014 Feb)
Boardman JD,Domingue BW,Blalock CL,Haberstick BC,Harris KM,McQueen MB

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AKAP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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