FZD10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FZD10
Entrez Gene ID	11211
Full Name	frizzled class receptor 10
Synonyms	CD350,FZ-10,Fz10,FzE7,hFz10
General protein information	Preferred Names frizzled class receptor 10 Names frizzled-10 frizzled 10, seven transmembrane spanning receptor frizzled family receptor 10 frizzled homolog 10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.33
Summary	This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008].
Disorder MIM:	606147

mRNA and Protein(s)

mRNA	Protein	Name
NM_007197.3	NP_009128.1	frizzled-10 precursor

Pathways from BioSystems

Homologies

	FZD10	XP_001109720.1
Bos taurus (cattle)	FZD10	NP_001091502.1
Danio rerio (zebrafish)	fzd10	NP_570992.2
Pan troglodytes (chimpanzee)	FZD10	XP_522560.2
Canis lupus familiaris (dog)	FZD10	XP_543357.3
Rattus norvegicus (Norway rat)	Fzd10	NP_001258121.1
Xenopus tropicalis (tropical clawed frog)	fzd10	NP_001005669.1
Homo sapiens (human)	FZD10	NP_009128.1
Mus musculus (house mouse)	Fzd10	NP_780493.1
Gallus gallus (chicken)	FZD10	NP_989429.1

Gene Ontology
Bibliography

Related articles in PubMed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 Nov)

FZD
Hot B, Valnohova J, Arthofer E, Simon K, Shin J, Uhl?n M, Kostenis E, Mulder J, Schulte G
Cellular signalling3293-103(2017 Apr)

Genome-wide association study of a quantitative disordered gambling trait.
Lind PA, Zhu G, Montgomery GW, Madden PA, Heath AC, Martin NG, Slutske WS
Addiction biology18(3)511-22(2013 May)

Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors.
Carmon KS, Loose DS
Analytical biochemistry401(2)288-94(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the selective expression of FZD10 in brain vascular endothelial cells points at a potential role of FZD10-Galpha13 signalling in central nervous system angiogenesis.
Title: FZD

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

there was a strong inverse correlation between nuclear immunostaining scores for beta-catenin expression and expression patterns of FZD10
Title: Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.

FZD10 transactivation causes the activation of the Dvl-Rac1-JNK pathway and is associated with the development/progression of synovial sarcomas
Title: Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma.

The following FZD10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FZD10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu27510	NM_007197.3 Latest version!	Homo sapiens frizzled class receptor 10 (FZD10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FZD10 ( NM_007197.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009128.1 Homo sapiens frizzled class receptor 10 (FZD10), mRNA.

Price & Availability↑

CloneID	OHu27510
Clone ID Related Accession (Same CDS sequence)	NM_007197.3
Accession Version	NM_007197.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	frizzled-10 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070037.1, AC026336.20, BC074997.2, AB027464.1 and AI697875.1. On Dec 11, 2010 this sequence version replaced NM_007197.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC070037.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCGCC CGGGCCCCCG CCTGTGGCTG GTCCTGCAGG TGATGGGCTC GTGCGCCGCC 
ATCAGCTCCA TGGACATGGA GCGCCCGGGC GACGGCAAAT GCCAGCCCAT CGAGATCCCG 
ATGTGCAAGG ACATCGGCTA CAACATGACT CGTATGCCCA ACCTGATGGG CCACGAGAAC 
CAGCGCGAGG CAGCCATCCA GTTGCACGAG TTCGCGCCGC TGGTGGAGTA CGGCTGCCAC 
GGCCACCTCC GCTTCTTCCT GTGCTCGCTG TACGCGCCGA TGTGCACCGA GCAGGTCTCT 
ACCCCCATCC CCGCCTGCCG GGTCATGTGC GAGCAGGCCC GGCTCAAGTG CTCCCCGATT 
ATGGAGCAGT TCAACTTCAA GTGGCCCGAC TCCCTGGACT GCCGGAAACT CCCCAACAAG 
AACGACCCCA ACTACCTGTG CATGGAGGCG CCCAACAACG GCTCGGACGA GCCCACCCGG 
GGCTCGGGCC TGTTCCCGCC GCTGTTCCGG CCGCAGCGGC CCCACAGCGC GCAGGAGCAC 
CCGCTGAAGG ACGGGGGCCC CGGGCGCGGC GGCTGCGACA ACCCGGGCAA GTTCCACCAC 
GTGGAGAAGA GCGCGTCGTG CGCGCCGCTC TGCACGCCCG GCGTGGACGT GTACTGGAGC 
CGCGAGGACA AGCGCTTCGC AGTGGTCTGG CTGGCCATCT GGGCGGTGCT GTGCTTCTTC 
TCCAGCGCCT TCACCGTGCT CACCTTCCTC ATCGACCCGG CCCGCTTCCG CTACCCCGAG 
CGCCCCATCA TCTTCCTCTC CATGTGCTAC TGCGTCTACT CCGTGGGCTA CCTCATCCGC 
CTCTTCGCCG GCGCCGAGAG CATCGCCTGC GACCGGGACA GCGGCCAGCT CTATGTCATC 
CAGGAGGGAC TGGAGAGCAC CGGCTGCACG CTGGTCTTCC TGGTCCTCTA CTACTTCGGC 
ATGGCCAGCT CGCTGTGGTG GGTGGTCCTC ACGCTCACCT GGTTCCTGGC CGCCGGCAAG 
AAGTGGGGCC ACGAGGCCAT CGAAGCCAAC AGCAGCTACT TCCACCTGGC AGCCTGGGCC 
ATCCCGGCGG TGAAGACCAT CCTGATCCTG GTCATGCGCA GGGTGGCGGG GGACGAGCTC 
ACCGGGGTCT GCTACGTGGG CAGCATGGAC GTCAACGCGC TCACCGGCTT CGTGCTCATT 
CCCCTGGCCT GCTACCTGGT CATCGGCACG TCCTTCATCC TCTCGGGCTT CGTGGCCCTG 
TTCCACATCC GGAGGGTGAT GAAGACGGGC GGCGAGAACA CGGACAAGCT GGAGAAGCTC 
ATGGTGCGTA TCGGGCTCTT CTCTGTGCTG TACACCGTGC CGGCCACCTG TGTGATCGCC 
TGCTACTTTT ACGAACGCCT CAACATGGAT TACTGGAAGA TCCTGGCGGC GCAGCACAAG 
TGCAAAATGA ACAACCAGAC TAAAACGCTG GACTGCCTGA TGGCCGCCTC CATCCCCGCC 
GTGGAGATCT TCATGGTGAA GATCTTTATG CTGCTGGTGG TGGGGATCAC CAGCGGGATG 
TGGATTTGGA CCTCCAAGAC TCTGCAGTCC TGGCAGCAGG TGTGCAGCCG TAGGTTAAAG 
AAGAAGAGCC GGAGAAAACC GGCCAGCGTG ATCACCAGCG GTGGGATTTA CAAAAAAGCC 
CAGCATCCCC AGAAAACTCA CCACGGGAAA TATGAGATCC CTGCCCAGTC GCCCACCTGC 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009128.1
CDS	485..2230
Translation	MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV

Target ORF information:

RefSeq Version	NM_007197.3
Organism	Homo sapiens(human)
Definition	Homo sapiens frizzled class receptor 10 (FZD10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007197.3

ORF Insert Sequence:

ATGCAGCGCC CGGGCCCCCG CCTGTGGCTG GTCCTGCAGG TGATGGGCTC GTGCGCCGCC 
ATCAGCTCCA TGGACATGGA GCGCCCGGGC GACGGCAAAT GCCAGCCCAT CGAGATCCCG 
ATGTGCAAGG ACATCGGCTA CAACATGACT CGTATGCCCA ACCTGATGGG CCACGAGAAC 
CAGCGCGAGG CAGCCATCCA GTTGCACGAG TTCGCGCCGC TGGTGGAGTA CGGCTGCCAC 
GGCCACCTCC GCTTCTTCCT GTGCTCGCTG TACGCGCCGA TGTGCACCGA GCAGGTCTCT 
ACCCCCATCC CCGCCTGCCG GGTCATGTGC GAGCAGGCCC GGCTCAAGTG CTCCCCGATT 
ATGGAGCAGT TCAACTTCAA GTGGCCCGAC TCCCTGGACT GCCGGAAACT CCCCAACAAG 
AACGACCCCA ACTACCTGTG CATGGAGGCG CCCAACAACG GCTCGGACGA GCCCACCCGG 
GGCTCGGGCC TGTTCCCGCC GCTGTTCCGG CCGCAGCGGC CCCACAGCGC GCAGGAGCAC 
CCGCTGAAGG ACGGGGGCCC CGGGCGCGGC GGCTGCGACA ACCCGGGCAA GTTCCACCAC 
GTGGAGAAGA GCGCGTCGTG CGCGCCGCTC TGCACGCCCG GCGTGGACGT GTACTGGAGC 
CGCGAGGACA AGCGCTTCGC AGTGGTCTGG CTGGCCATCT GGGCGGTGCT GTGCTTCTTC 
TCCAGCGCCT TCACCGTGCT CACCTTCCTC ATCGACCCGG CCCGCTTCCG CTACCCCGAG 
CGCCCCATCA TCTTCCTCTC CATGTGCTAC TGCGTCTACT CCGTGGGCTA CCTCATCCGC 
CTCTTCGCCG GCGCCGAGAG CATCGCCTGC GACCGGGACA GCGGCCAGCT CTATGTCATC 
CAGGAGGGAC TGGAGAGCAC CGGCTGCACG CTGGTCTTCC TGGTCCTCTA CTACTTCGGC 
ATGGCCAGCT CGCTGTGGTG GGTGGTCCTC ACGCTCACCT GGTTCCTGGC CGCCGGCAAG 
AAGTGGGGCC ACGAGGCCAT CGAAGCCAAC AGCAGCTACT TCCACCTGGC AGCCTGGGCC 
ATCCCGGCGG TGAAGACCAT CCTGATCCTG GTCATGCGCA GGGTGGCGGG GGACGAGCTC 
ACCGGGGTCT GCTACGTGGG CAGCATGGAC GTCAACGCGC TCACCGGCTT CGTGCTCATT 
CCCCTGGCCT GCTACCTGGT CATCGGCACG TCCTTCATCC TCTCGGGCTT CGTGGCCCTG 
TTCCACATCC GGAGGGTGAT GAAGACGGGC GGCGAGAACA CGGACAAGCT GGAGAAGCTC 
ATGGTGCGTA TCGGGCTCTT CTCTGTGCTG TACACCGTGC CGGCCACCTG TGTGATCGCC 
TGCTACTTTT ACGAACGCCT CAACATGGAT TACTGGAAGA TCCTGGCGGC GCAGCACAAG 
TGCAAAATGA ACAACCAGAC TAAAACGCTG GACTGCCTGA TGGCCGCCTC CATCCCCGCC 
GTGGAGATCT TCATGGTGAA GATCTTTATG CTGCTGGTGG TGGGGATCAC CAGCGGGATG 
TGGATTTGGA CCTCCAAGAC TCTGCAGTCC TGGCAGCAGG TGTGCAGCCG TAGGTTAAAG 
AAGAAGAGCC GGAGAAAACC GGCCAGCGTG ATCACCAGCG GTGGGATTTA CAAAAAAGCC 
CAGCATCCCC AGAAAACTCA CCACGGGAAA TATGAGATCC CTGCCCAGTC GCCCACCTGC 
GTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4832-4844(2017 Nov)
Voloshanenko O,Gmach P,Winter J,Kranz D,Boutros M

FZD
Cellular signalling3293-103(2017 Apr)
Hot B,Valnohova J,Arthofer E,Simon K,Shin J,Uhl?n M,Kostenis E,Mulder J,Schulte G

Genome-wide association study of a quantitative disordered gambling trait.
Addiction biology18(3)511-22(2013 May)
Lind PA,Zhu G,Montgomery GW,Madden PA,Heath AC,Martin NG,Slutske WS

Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors.
Analytical biochemistry401(2)288-94(2010 Jun)
Carmon KS,Loose DS