NUDT3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NUDT3
Entrez Gene ID	11165
Full Name	nudix hydrolase 3
Synonyms	DIPP,DIPP-1,DIPP1
General protein information	Preferred Names nudix hydrolase 3 Names diphosphoinositol polyphosphate phosphohydrolase 1 diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1 nucleoside diphosphate-linked moiety X motif 3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 nudix motif 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.31
Summary	NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011].
Disorder MIM:	609228

mRNA and Protein(s)

mRNA	Protein	Name
NM_006703.3	NP_006694.1	diphosphoinositol polyphosphate phosphohydrolase 1
NM_006703.4	NP_006694.1	diphosphoinositol polyphosphate phosphohydrolase 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	NUDT3	NP_001244227.1
Danio rerio (zebrafish)	nudt3b	NP_001006034.1
Caenorhabditis elegans (roundworm)	Y92H12BL.5	NP_740784.1
Bos taurus (cattle)	NUDT3	NP_001075935.1
Canis lupus familiaris (dog)	NUDT3	NP_001239318.1
Mus musculus (house mouse)	Nudt3	NP_062811.1
Homo sapiens (human)	NUDT3	NP_006694.1
	NUDT3	XP_001116464.1
Rattus norvegicus (Norway rat)	Nudt3	NP_001019414.1
Drosophila melanogaster (fruit fly)	Aps	NP_648421.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009901	XP_319021.3

Gene Ontology
Bibliography

Related articles in PubMed

Nudt3 is an mRNA decapping enzyme that modulates cell migration.
Grudzien-Nogalska E, Jiao X, Song MG, Hart RP, Kiledjian M
RNA (New York, N.Y.)22(5)773-81(2016 May)

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L
Human molecular genetics24(6)1791-800(2015 Mar)

NUDT3 rs206936 is associated with body mass index in obese Japanese women.
Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, So R, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Nakao K, Sekine A, Hotta K
Endocrine journal60(8)991-1000(2013)

Identification of 15 loci influencing height in a Korean population.
Kim JJ, Lee HI, Park T, Kim K, Lee JE, Cho NH, Shin C, Cho YS, Lee JY, Han BG, Yoo HW, Lee JK
Journal of human genetics55(1)27-31(2010 Jan)

Crystal structure of human diphosphoinositol phosphatase 1.
Thorsell AG, Persson C, Gr?slund S, Hammarstr?m M, Busam RD, Hallberg BM
Proteins77(1)242-6(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nudt3 is an mRNA decapping enzyme that orchestrates expression of a subset of mRNAs to modulate cell migration and further substantiates the existence of multiple decapping enzymes functioning in distinct cellular pathways in mammals
Title: Nudt3 is an mRNA decapping enzyme that modulates cell migration.

results suggest that NUDT3 rs206936 is associated with body mass index in Japanese women
Title: NUDT3 rs206936 is associated with body mass index in obese Japanese women.

The following NUDT3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NUDT3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14295	NM_006703.4 Latest version!	Homo sapiens nudix hydrolase 3 (NUDT3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu14295	NM_006703.3	Homo sapiens nudix hydrolase 3 (NUDT3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NUDT3 ( NM_006703.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006694.1 Homo sapiens nudix hydrolase 3 (NUDT3), mRNA.

Price & Availability↑

CloneID	OHu14295
Clone ID Related Accession (Same CDS sequence)	NM_006703.3 , NM_006703.4
Accession Version	NM_006703.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	diphosphoinositol polyphosphate phosphohydrolase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA803962.1, BC007727.2, Z98036.1 and CA430332.1. On Feb 5, 2011 this sequence version replaced NM_006703.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.110154.1, SRR1660807.186334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGAAGC TCAAGTCGAA CCAGACCCGC ACCTACGACG GCGACGGCTA CAAGAAGCGG 
GCCGCATGCC TGTGTTTCCG CAGCGAGAGC GAGGAGGAGG TGCTACTCGT GAGCAGTAGT 
CGCCATCCAG ACAGATGGAT TGTCCCTGGA GGAGGCATGG AGCCCGAGGA GGAGCCAAGT 
GTGGCAGCAG TTCGTGAAGT CTGTGAGGAG GCTGGAGTAA AAGGGACATT GGGAAGATTA 
GTTGGAATTT TTGAGAACCA GGAGAGGAAG CACAGGACGT ATGTCTATGT GCTCATTGTC 
ACTGAAGTGC TGGAAGACTG GGAAGATTCA GTTAACATTG GAAGGAAGAG GGAATGGTTT 
AAAATAGAAG ACGCCATAAA AGTGCTGCAG TATCACAAAC CCGTGCAGGC ATCATATTTT 
GAAACATTGA GGCAAGGCTA CTCAGCCAAC AATGGCACCC CAGTCGTGGC CACCACATAC 
TCGGTTTCTG CTCAGAGCTC GATGTCAGGC ATCAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006694.1
CDS	319..837
Translation	MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR

Target ORF information:

RefSeq Version	NM_006703.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nudix hydrolase 3 (NUDT3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006703.3

ORF Insert Sequence:

ATGATGAAGC TCAAGTCGAA CCAGACCCGC ACCTACGACG GCGACGGCTA CAAGAAGCGG 
GCCGCATGCC TGTGTTTCCG CAGCGAGAGC GAGGAGGAGG TGCTACTCGT GAGCAGTAGT 
CGCCATCCAG ACAGATGGAT TGTCCCTGGA GGAGGCATGG AGCCCGAGGA GGAGCCAAGT 
GTGGCAGCAG TTCGTGAAGT CTGTGAGGAG GCTGGAGTAA AAGGGACATT GGGAAGATTA 
GTTGGAATTT TTGAGAACCA GGAGAGGAAG CACAGGACGT ATGTCTATGT GCTCATTGTC 
ACTGAAGTGC TGGAAGACTG GGAAGATTCA GTTAACATTG GAAGGAAGAG GGAATGGTTT 
AAAATAGAAG ACGCCATAAA AGTGCTGCAG TATCACAAAC CCGTGCAGGC ATCATATTTT 
GAAACATTGA GGCAAGGCTA CTCAGCCAAC AATGGCACCC CAGTCGTGGC CACCACATAC 
TCGGTTTCTG CTCAGAGCTC GATGTCAGGC ATCAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUDT3 ( NM_006703.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006694.1 Homo sapiens nudix hydrolase 3 (NUDT3), mRNA.

Price & Availability↑

CloneID	OHu14295
Clone ID Related Accession (Same CDS sequence)	NM_006703.3 , NM_006703.4
Accession Version	NM_006703.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	diphosphoinositol polyphosphate phosphohydrolase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA803962.1, BC007727.2, Z98036.1, CA430332.1 and AL354740.29. On Nov 23, 2018 this sequence version replaced NM_006703.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.223249.1, SRR1660803.243167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000607016.2/ ENSP00000476119.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGAAGC TCAAGTCGAA CCAGACCCGC ACCTACGACG GCGACGGCTA CAAGAAGCGG 
GCCGCATGCC TGTGTTTCCG CAGCGAGAGC GAGGAGGAGG TGCTACTCGT GAGCAGTAGT 
CGCCATCCAG ACAGATGGAT TGTCCCTGGA GGAGGCATGG AGCCCGAGGA GGAGCCAAGT 
GTGGCAGCAG TTCGTGAAGT CTGTGAGGAG GCTGGAGTAA AAGGGACATT GGGAAGATTA 
GTTGGAATTT TTGAGAACCA GGAGAGGAAG CACAGGACGT ATGTCTATGT GCTCATTGTC 
ACTGAAGTGC TGGAAGACTG GGAAGATTCA GTTAACATTG GAAGGAAGAG GGAATGGTTT 
AAAATAGAAG ACGCCATAAA AGTGCTGCAG TATCACAAAC CCGTGCAGGC ATCATATTTT 
GAAACATTGA GGCAAGGCTA CTCAGCCAAC AATGGCACCC CAGTCGTGGC CACCACATAC 
TCGGTTTCTG CTCAGAGCTC GATGTCAGGC ATCAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006694.1
CDS	308..826
Translation	MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR

Target ORF information:

RefSeq Version	NM_006703.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nudix hydrolase 3 (NUDT3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006703.4

ORF Insert Sequence:

ATGATGAAGC TCAAGTCGAA CCAGACCCGC ACCTACGACG GCGACGGCTA CAAGAAGCGG 
GCCGCATGCC TGTGTTTCCG CAGCGAGAGC GAGGAGGAGG TGCTACTCGT GAGCAGTAGT 
CGCCATCCAG ACAGATGGAT TGTCCCTGGA GGAGGCATGG AGCCCGAGGA GGAGCCAAGT 
GTGGCAGCAG TTCGTGAAGT CTGTGAGGAG GCTGGAGTAA AAGGGACATT GGGAAGATTA 
GTTGGAATTT TTGAGAACCA GGAGAGGAAG CACAGGACGT ATGTCTATGT GCTCATTGTC 
ACTGAAGTGC TGGAAGACTG GGAAGATTCA GTTAACATTG GAAGGAAGAG GGAATGGTTT 
AAAATAGAAG ACGCCATAAA AGTGCTGCAG TATCACAAAC CCGTGCAGGC ATCATATTTT 
GAAACATTGA GGCAAGGCTA CTCAGCCAAC AATGGCACCC CAGTCGTGGC CACCACATAC 
TCGGTTTCTG CTCAGAGCTC GATGTCAGGC ATCAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nudt3 is an mRNA decapping enzyme that modulates cell migration.
RNA (New York, N.Y.)22(5)773-81(2016 May)
Grudzien-Nogalska E,Jiao X,Song MG,Hart RP,Kiledjian M

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
Human molecular genetics24(6)1791-800(2015 Mar)
He M,Xu M,Zhang B,Liang J,Chen P,Lee JY,Johnson TA,Li H,Yang X,Dai J,Liang L,Gui L,Qi Q,Huang J,Li Y,Adair LS,Aung T,Cai Q,Cheng CY,Cho MC,Cho YS,Chu M,Cui B,Gao YT,Go MJ,Gu D,Gu W,Guo H,Hao Y,Hong J,Hu Z,Hu Y,Huang J,Hwang JY,Ikram MK,Jin G,Kang DH,Khor CC,Kim BJ,Kim HT,Kubo M,Lee J,Lee J,Lee NR,Li R,Li J,Liu J,Longe J,Lu W,Lu X,Miao X,Okada Y,Ong RT,Qiu G,Seielstad M,Sim X,Song H,Takeuchi F,Tanaka T,Taylor PR,Wang L,Wang W,Wang Y,Wu C,Wu Y,Xiang YB,Yamamoto K,Yang H,Liao M,Yokota M,Young T,Zhang X,Kato N,Wang QK,Zheng W,Hu FB,Lin D,Shen H,Teo YY,Mo Z,Wong TY,Lin X,Mohlke KL,Ning G,Tsunoda T,Han BG,Shu XO,Tai ES,Wu T,Qi L

NUDT3 rs206936 is associated with body mass index in obese Japanese women.
Endocrine journal60(8)991-1000(2013)
Kitamoto A,Kitamoto T,Mizusawa S,Teranishi H,So R,Matsuo T,Nakata Y,Hyogo H,Ochi H,Nakamura T,Kamohara S,Miyatake N,Kotani K,Komatsu R,Itoh N,Mineo I,Wada J,Yoneda M,Nakajima A,Funahashi T,Miyazaki S,Tokunaga K,Masuzaki H,Ueno T,Chayama K,Hamaguchi K,Yamada K,Hanafusa T,Oikawa S,Sakata T,Tanaka K,Matsuzawa Y,Nakao K,Sekine A,Hotta K

Identification of 15 loci influencing height in a Korean population.
Journal of human genetics55(1)27-31(2010 Jan)
Kim JJ,Lee HI,Park T,Kim K,Lee JE,Cho NH,Shin C,Cho YS,Lee JY,Han BG,Yoo HW,Lee JK

Crystal structure of human diphosphoinositol phosphatase 1.
Proteins77(1)242-6(2009 Oct)
Thorsell AG,Persson C,Gr?slund S,Hammarstr?m M,Busam RD,Hallberg BM

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NUDT3 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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