LSM6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LSM6
Entrez Gene ID	11157
Full Name	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms	YDR378C
General protein information	Preferred Names LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Names U6 snRNA-associated Sm-like protein LSm6 LSM6 U6 small nuclear RNA and mRNA degradation associated LSM6 homolog, U6 small nuclear RNA associated Sm protein F
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q31.22
Summary	Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004].
Disorder MIM:	607286

mRNA and Protein(s)

mRNA	Protein	Name
XM_017007672.1	XP_016863161.1	U6 snRNA-associated Sm-like protein LSm6 isoform X1
NM_007080.2	NP_009011.1	U6 snRNA-associated Sm-like protein LSm6
XM_017007673.1	XP_016863162.1	U6 snRNA-associated Sm-like protein LSm6 isoform X1
NM_007080.3	NP_009011.1	U6 snRNA-associated Sm-like protein LSm6

Pathways from BioSystems

Homologies

Homo sapiens (human)	LSM6	NP_009011.1
Pan troglodytes (chimpanzee)	LSM6	XP_003950473.1
Canis lupus familiaris (dog)	LSM6	XP_003432092.1
Caenorhabditis elegans (roundworm)	lsm-6	NP_490883.1
Mus musculus (house mouse)	Lsm6	NP_001177933.1
Drosophila melanogaster (fruit fly)	CG9344	NP_611528.1
Oryza sativa (rice)	Os02g0510100	NP_001046930.1
Oryza sativa (rice)	Os04g0388900	NP_001052634.1
Rattus norvegicus (Norway rat)	Lsm6	NP_001119557.1
Gallus gallus (chicken)	LSM6	XP_004941025.1
Danio rerio (zebrafish)	lsm6	NP_001002077.1
Arabidopsis thaliana (thale cress)	AT3G59810	NP_191540.1
	LSM6	XP_001097636.1
Bos taurus (cattle)	LSM6	NP_001107991.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005314	XP_315329.2
Schizosaccharomyces pombe (fission yeast)	lsm6	NP_594380.1
Arabidopsis thaliana (thale cress)	AT2G43810	NP_181909.1
Xenopus tropicalis (tropical clawed frog)	lsm6	NP_001165068.1

Gene Ontology
Bibliography

Related articles in PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, L?hrmann R, Stark H
Cell170(4)701-713.e11(2017 Aug)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H, L?hrmann R, Stark H
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Dynamic protein-protein interaction wiring of the human spliceosome.
Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, L?hrmann R, Stelzl U
Molecular cell45(4)567-80(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci
Title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.

The following LSM6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSM6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31066	NM_007080.3 Latest version!	Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31066	XM_017007673.1 Latest version!	Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu31066	XM_017007672.1 Latest version!	Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31066	NM_007080.2	Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LSM6 ( NM_007080.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_009011.1 Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), mRNA.

Price & Availability↑

CloneID	OHu31066
Clone ID Related Accession (Same CDS sequence)	XM_017007672.1 , NM_007080.2 , XM_017007673.1 , NM_007080.3
Accession Version	NM_007080.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB465201.1, BC016026.1 and AI351504.1. On or before Aug 3, 2007 this sequence version replaced XM_001131191.1, XM_001127900.1, NM_007080.1. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.389387.1, SRR1163655.529270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTCTTC GGAAGCAAAC CCCTAGTGAC TTCTTAAAGC AAATCATCGG ACGACCAGTT 
GTGGTAAAAT TAAATTCTGG AGTGGATTAT CGAGGGGTCC TGGCTTGCCT GGATGGCTAC 
ATGAATATAG CCCTGGAGCA GACAGAAGAA TATGTAAATG GACAACTGAA GAATAAGTAT 
GGGGATGCAT TTATCCGAGG AAACAATGTG TTGTACATCA GTACACAGAA GAGACGGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009011.1
CDS	140..382
Translation	MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRM

Target ORF information:

RefSeq Version	NM_007080.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007080.2

ORF Insert Sequence:

ATGAGTCTTC GGAAGCAAAC CCCTAGTGAC TTCTTAAAGC AAATCATCGG ACGACCAGTT 
GTGGTAAAAT TAAATTCTGG AGTGGATTAT CGAGGGGTCC TGGCTTGCCT GGATGGCTAC 
ATGAATATAG CCCTGGAGCA GACAGAAGAA TATGTAAATG GACAACTGAA GAATAAGTAT 
GGGGATGCAT TTATCCGAGG AAACAATGTG TTGTACATCA GTACACAGAA GAGACGGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM6 ( NM_007080.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009011.1 Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), mRNA.

Price & Availability↑

CloneID	OHu31066
Clone ID Related Accession (Same CDS sequence)	XM_017007672.1 , NM_007080.2 , XM_017007673.1 , NM_007080.3
Accession Version	NM_007080.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB465201.1, BC016026.1, AI351504.1 and AC097372.3. On Nov 23, 2018 this sequence version replaced NM_007080.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.57963.1, SRR1660803.47897.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296581.11/ ENSP00000296581.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTCTTC GGAAGCAAAC CCCTAGTGAC TTCTTAAAGC AAATCATCGG ACGACCAGTT 
GTGGTAAAAT TAAATTCTGG AGTGGATTAT CGAGGGGTCC TGGCTTGCCT GGATGGCTAC 
ATGAATATAG CCCTGGAGCA GACAGAAGAA TATGTAAATG GACAACTGAA GAATAAGTAT 
GGGGATGCAT TTATCCGAGG AAACAATGTG TTGTACATCA GTACACAGAA GAGACGGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009011.1
CDS	105..347
Translation	MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRM

Target ORF information:

RefSeq Version	NM_007080.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007080.3

ORF Insert Sequence:

ATGAGTCTTC GGAAGCAAAC CCCTAGTGAC TTCTTAAAGC AAATCATCGG ACGACCAGTT 
GTGGTAAAAT TAAATTCTGG AGTGGATTAT CGAGGGGTCC TGGCTTGCCT GGATGGCTAC 
ATGAATATAG CCCTGGAGCA GACAGAAGAA TATGTAAATG GACAACTGAA GAATAAGTAT 
GGGGATGCAT TTATCCGAGG AAACAATGTG TTGTACATCA GTACACAGAA GAGACGGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM6 ( XM_017007672.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863161.1 Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu31066
Clone ID Related Accession (Same CDS sequence)	XM_017007672.1 , NM_007080.2 , XM_017007673.1 , NM_007080.3
Accession Version	XM_017007672.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTCTTC GGAAGCAAAC CCCTAGTGAC TTCTTAAAGC AAATCATCGG ACGACCAGTT 
GTGGTAAAAT TAAATTCTGG AGTGGATTAT CGAGGGGTCC TGGCTTGCCT GGATGGCTAC 
ATGAATATAG CCCTGGAGCA GACAGAAGAA TATGTAAATG GACAACTGAA GAATAAGTAT 
GGGGATGCAT TTATCCGAGG AAACAATGTG TTGTACATCA GTACACAGAA GAGACGGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863161.1
CDS	115..357
Translation	MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRM

Target ORF information:

RefSeq Version	XM_017007672.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017007672.1

ORF Insert Sequence:

ATGAGTCTTC GGAAGCAAAC CCCTAGTGAC TTCTTAAAGC AAATCATCGG ACGACCAGTT 
GTGGTAAAAT TAAATTCTGG AGTGGATTAT CGAGGGGTCC TGGCTTGCCT GGATGGCTAC 
ATGAATATAG CCCTGGAGCA GACAGAAGAA TATGTAAATG GACAACTGAA GAATAAGTAT 
GGGGATGCAT TTATCCGAGG AAACAATGTG TTGTACATCA GTACACAGAA GAGACGGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM6 ( XM_017007673.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016863162.1 Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu31066
Clone ID Related Accession (Same CDS sequence)	XM_017007672.1 , NM_007080.2 , XM_017007673.1 , NM_007080.3
Accession Version	XM_017007673.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTCTTC GGAAGCAAAC CCCTAGTGAC TTCTTAAAGC AAATCATCGG ACGACCAGTT 
GTGGTAAAAT TAAATTCTGG AGTGGATTAT CGAGGGGTCC TGGCTTGCCT GGATGGCTAC 
ATGAATATAG CCCTGGAGCA GACAGAAGAA TATGTAAATG GACAACTGAA GAATAAGTAT 
GGGGATGCAT TTATCCGAGG AAACAATGTG TTGTACATCA GTACACAGAA GAGACGGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016863162.1
CDS	440..682
Translation	MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRM

Target ORF information:

RefSeq Version	XM_017007673.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM6), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017007673.1

ORF Insert Sequence:

ATGAGTCTTC GGAAGCAAAC CCCTAGTGAC TTCTTAAAGC AAATCATCGG ACGACCAGTT 
GTGGTAAAAT TAAATTCTGG AGTGGATTAT CGAGGGGTCC TGGCTTGCCT GGATGGCTAC 
ATGAATATAG CCCTGGAGCA GACAGAAGAA TATGTAAATG GACAACTGAA GAATAAGTAT 
GGGGATGCAT TTATCCGAGG AAACAATGTG TTGTACATCA GTACACAGAA GAGACGGATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,L?hrmann R,Stark H

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)
Agafonov DE,Kastner B,Dybkov O,Hofele RV,Liu WT,Urlaub H,L?hrmann R,Stark H

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,L?hrmann R,Stelzl U

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LSM6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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