WDR45 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WDR45
Entrez Gene ID	11152
Full Name	WD repeat domain 45
Synonyms	JM5,NBIA4,NBIA5,WDRX1,WIPI-4,WIPI4
General protein information	Preferred Names WD repeat domain 45 Names WD repeat domain phosphoinositide-interacting protein 4 WD repeat domain, X-linked 1 WD repeat-containing protein 45 WD45 repeat protein interacting with phosphoinositides 4 neurodegeneration with brain iron accumulation 4 neurodegeneration with brain iron accumulation 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.23
Summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	300526
Disorder Html:	Neurodegeneration with brain iron accumulation 5, 300894 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001029896.1	NP_001025067.1	WD repeat domain phosphoinositide-interacting protein 4 isoform 2
NM_001029896.2	NP_001025067.1	WD repeat domain phosphoinositide-interacting protein 4 isoform 2
NM_007075.3	NP_009006.2	WD repeat domain phosphoinositide-interacting protein 4 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	WDR45	XP_005641402.1
Mus musculus (house mouse)	Wdr45	NP_758960.1
Homo sapiens (human)	WDR45	NP_009006.2
Bos taurus (cattle)	WDR45	NP_001069619.1
Pan troglodytes (chimpanzee)	WDR45	XP_001141338.2
	WDR45	XP_001105392.1
Schizosaccharomyces pombe (fission yeast)	SPAC458.06	NP_594700.1
Danio rerio (zebrafish)	wdr45	NP_956525.1
Caenorhabditis elegans (roundworm)	epg-6	NP_499335.2
Xenopus tropicalis (tropical clawed frog)	wdr45	NP_001011326.1

Gene Ontology
Bibliography

Related articles in PubMed

Neurodegeneration with brain iron accumulation.
Hayflick SJ, Kurian MA, Hogarth P
Handbook of clinical neurology147293-305(2018)

Severe infantile onset developmental and epileptic encephalopathy caused by mutations in autophagy gene WDR45.
Carvill GL, Liu A, Mandelstam S, Schneider A, Lacroix A, Zemel M, McMahon JM, Bello-Espinosa L, Mackay M, Wallace G, Waak M, Zhang J, Yang X, Malone S, Zhang YH, Mefford HC, Scheffer IE
Epilepsia59(1)e5-e13(2018 Jan)

Early manifestations of epileptic encephalopathy, brain atrophy, and elevation of serum neuron specific enolase in a boy with beta-propeller protein-associated neurodegeneration.
Takano K, Goto K, Motobayashi M, Wakui K, Kawamura R, Yamaguchi T, Fukushima Y, Kosho T
European journal of medical genetics60(10)521-526(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A rare male patient is reported with mutation in WDR45 and early manifestations of epileptic encephalopathy, brain atrophy, and elevation of serum neuron specific enolase.
Title: Early manifestations of epileptic encephalopathy, brain atrophy, and elevation of serum neuron specific enolase in a boy with beta-propeller protein-associated neurodegeneration.

Inherited WDR45 variants are possible, albeit rare. Hemizygous germline variants in males can be viable, but likely result in a more severe NBIA phenotype.
Title: Lessons from a pair of siblings with BPAN.

Our findings indicate that hemizygous WDR45 mutations in males lead to severe epileptic encephalopathy.
Title: WDR45 mutations in three male patients with West syndrome.

Genetic analysis for WDR45 revealed that she had a splice site mutation
Title: [A woman with beta-propeller protein-associated neurodegeneration identified by the WDR45 mutation presenting as Rett-like syndrome in childhood].

It is an autophagy gene and its mutation causes SENDA/BPAN(beta-propeller protein associated neurodegeneration). (review)
Title: [De novo mutations in the autophagy gene WDR45 cause SENDA/BPAN].

The following WDR45 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WDR45 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25740	NM_007075.3 Latest version!	Homo sapiens WD repeat domain 45 (WDR45), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu25803	NM_001029896.2 Latest version!	Homo sapiens WD repeat domain 45 (WDR45), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
View Old Accession Versions >>
OHu25803	NM_001029896.1	Homo sapiens WD repeat domain 45 (WDR45), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WDR45 ( NM_007075.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009006.2 Homo sapiens WD repeat domain 45 (WDR45), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25740
Clone ID Related Accession (Same CDS sequence)	NM_007075.3
Accession Version	NM_007075.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	WD repeat domain phosphoinositide-interacting protein 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069206.1, AF196779.2 and BC035979.1. This sequence is a reference standard in the RefSeqGene project. On Jul 29, 2005 this sequence version replaced NM_007075.2. Transcript Variant: This variant (1) represents a longer transcript and encodes a longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069206.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTCAAC AGCCACTTCG AGGAGTGACC AGCCTGCGTT TCAACCAAGA CCAAAGCTGC 
TTTTGCTGCG CCATGGAGAC AGGTGTGCGC ATCTACAACG TGGAGCCCTT GATGGAGAAG 
GGGCATCTGG ACCACGAGCA GGTGGGCAGC ATGGGCTTGG TGGAGATGCT GCACCGCTCC 
AACCTTCTGG CCTTGGTGGG CGGTGGTAGT AGTCCCAAGT TCTCAGAGAT CTCAGCAGTG 
CTGATCTGGG ACGATGCCCG GGAGGGCAAG GACTCCAAGG AGAAGCTGGT GCTGGAGTTC 
ACCTTCACCA AGCCAGTGCT TTCTGTGCGC ATGCGCCATG ACAAGATCGT GATCGTGCTG 
AAGAACCGCA TCTATGTGTA CTCCTTCCCC GACAATCCCC GAAAGCTGTT TGAGTTTGAT 
ACCCGGGACA ACCCCAAGGG GCTCTGTGAC CTCTGCCCCA GCCTGGAGAA GCAACTGCTA 
GTGTTCCCGG GACACAAGTG TGGGAGTCTG CAACTTGTGG ACCTGGCGAG CACAAAGCCT 
GGCACCTCGT CTGCTCCATT CACGATCAAT GCACATCAGA GTGACATAGC CTGTGTGTCT 
CTAAACCAGC CAGGCACTGT AGTGGCCTCA GCCTCCCAGA AGGGTACCCT TATTCGCCTC 
TTTGACACAC AATCCAAGGA GAAACTGGTG GAGCTGCGCC GAGGCACTGA CCCTGCCACC 
CTCTACTGCA TTAACTTCAG CCACGACTCC TCCTTCCTCT GCGCTTCCAG TGATAAGGGT 
ACTGTCCATA TCTTTGCTCT CAAGGATACC CGCCTCAACC GCCGCTCCGC GCTGGCTCGC 
GTGGGCAAGG TGGGGCCTAT GATTGGGCAG TACGTGGACT CTCAGTGGAG CCTGGCGAGC 
TTCACTGTGC CTGCTGAGTC AGCTTGCATC TGCGCCTTCG GTCGCAATAC TTCCAAGAAC 
GTCAACTCTG TCATTGCCAT CTGCGTAGAT GGGACCTTCC ACAAATATGT CTTCACTCCT 
GATGGAAACT GCAACAGAGA GGCTTTCGAC GTGTACCTTG ACATCTGTGA TGATGATGAC 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009006.2
CDS	440..1525
Translation	MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISAVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF

Target ORF information:

RefSeq Version	NM_007075.3
Organism	Homo sapiens(human)
Definition	Homo sapiens WD repeat domain 45 (WDR45), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007075.3

ORF Insert Sequence:

ATGACTCAAC AGCCACTTCG AGGAGTGACC AGCCTGCGTT TCAACCAAGA CCAAAGCTGC 
TTTTGCTGCG CCATGGAGAC AGGTGTGCGC ATCTACAACG TGGAGCCCTT GATGGAGAAG 
GGGCATCTGG ACCACGAGCA GGTGGGCAGC ATGGGCTTGG TGGAGATGCT GCACCGCTCC 
AACCTTCTGG CCTTGGTGGG CGGTGGTAGT AGTCCCAAGT TCTCAGAGAT CTCAGCAGTG 
CTGATCTGGG ACGATGCCCG GGAGGGCAAG GACTCCAAGG AGAAGCTGGT GCTGGAGTTC 
ACCTTCACCA AGCCAGTGCT TTCTGTGCGC ATGCGCCATG ACAAGATCGT GATCGTGCTG 
AAGAACCGCA TCTATGTGTA CTCCTTCCCC GACAATCCCC GAAAGCTGTT TGAGTTTGAT 
ACCCGGGACA ACCCCAAGGG GCTCTGTGAC CTCTGCCCCA GCCTGGAGAA GCAACTGCTA 
GTGTTCCCGG GACACAAGTG TGGGAGTCTG CAACTTGTGG ACCTGGCGAG CACAAAGCCT 
GGCACCTCGT CTGCTCCATT CACGATCAAT GCACATCAGA GTGACATAGC CTGTGTGTCT 
CTAAACCAGC CAGGCACTGT AGTGGCCTCA GCCTCCCAGA AGGGTACCCT TATTCGCCTC 
TTTGACACAC AATCCAAGGA GAAACTGGTG GAGCTGCGCC GAGGCACTGA CCCTGCCACC 
CTCTACTGCA TTAACTTCAG CCACGACTCC TCCTTCCTCT GCGCTTCCAG TGATAAGGGT 
ACTGTCCATA TCTTTGCTCT CAAGGATACC CGCCTCAACC GCCGCTCCGC GCTGGCTCGC 
GTGGGCAAGG TGGGGCCTAT GATTGGGCAG TACGTGGACT CTCAGTGGAG CCTGGCGAGC 
TTCACTGTGC CTGCTGAGTC AGCTTGCATC TGCGCCTTCG GTCGCAATAC TTCCAAGAAC 
GTCAACTCTG TCATTGCCAT CTGCGTAGAT GGGACCTTCC ACAAATATGT CTTCACTCCT 
GATGGAAACT GCAACAGAGA GGCTTTCGAC GTGTACCTTG ACATCTGTGA TGATGATGAC 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WDR45 ( NM_001029896.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025067.1 Homo sapiens WD repeat domain 45 (WDR45), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25803
Clone ID Related Accession (Same CDS sequence)	NM_001029896.1 , NM_001029896.2
Accession Version	NM_001029896.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	WD repeat domain phosphoinositide-interacting protein 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ068083.1, AJ005897.1 and BC035979.1. Transcript Variant: This variant (2) has an alternate 5' UTR and lacks a 3-nt segment in the CDS, as compared to variant 1. The encoded isoform 2 thus lacks an internal amino acid, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.288490.1, SRR1803611.237167.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTCAAC AGCCACTTCG AGGAGTGACC AGCCTGCGTT TCAACCAAGA CCAAAGCTGC 
TTTTGCTGCG CCATGGAGAC AGGTGTGCGC ATCTACAACG TGGAGCCCTT GATGGAGAAG 
GGGCATCTGG ACCACGAGCA GGTGGGCAGC ATGGGCTTGG TGGAGATGCT GCACCGCTCC 
AACCTTCTGG CCTTGGTGGG CGGTGGTAGT AGTCCCAAGT TCTCAGAGAT CTCAGTGCTG 
ATCTGGGACG ATGCCCGGGA GGGCAAGGAC TCCAAGGAGA AGCTGGTGCT GGAGTTCACC 
TTCACCAAGC CAGTGCTTTC TGTGCGCATG CGCCATGACA AGATCGTGAT CGTGCTGAAG 
AACCGCATCT ATGTGTACTC CTTCCCCGAC AATCCCCGAA AGCTGTTTGA GTTTGATACC 
CGGGACAACC CCAAGGGGCT CTGTGACCTC TGCCCCAGCC TGGAGAAGCA ACTGCTAGTG 
TTCCCGGGAC ACAAGTGTGG GAGTCTGCAA CTTGTGGACC TGGCGAGCAC AAAGCCTGGC 
ACCTCGTCTG CTCCATTCAC GATCAATGCA CATCAGAGTG ACATAGCCTG TGTGTCTCTA 
AACCAGCCAG GCACTGTAGT GGCCTCAGCC TCCCAGAAGG GTACCCTTAT TCGCCTCTTT 
GACACACAAT CCAAGGAGAA ACTGGTGGAG CTGCGCCGAG GCACTGACCC TGCCACCCTC 
TACTGCATTA ACTTCAGCCA CGACTCCTCC TTCCTCTGCG CTTCCAGTGA TAAGGGTACT 
GTCCATATCT TTGCTCTCAA GGATACCCGC CTCAACCGCC GCTCCGCGCT GGCTCGCGTG 
GGCAAGGTGG GGCCTATGAT TGGGCAGTAC GTGGACTCTC AGTGGAGCCT GGCGAGCTTC 
ACTGTGCCTG CTGAGTCAGC TTGCATCTGC GCCTTCGGTC GCAATACTTC CAAGAACGTC 
AACTCTGTCA TTGCCATCTG CGTAGATGGG ACCTTCCACA AATATGTCTT CACTCCTGAT 
GGAAACTGCA ACAGAGAGGC TTTCGACGTG TACCTTGACA TCTGTGATGA TGATGACTTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025067.1
CDS	173..1255
Translation	MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF

Target ORF information:

RefSeq Version	NM_001029896.1
Organism	Homo sapiens(human)
Definition	Homo sapiens WD repeat domain 45 (WDR45), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029896.1

ORF Insert Sequence:

ATGACTCAAC AGCCACTTCG AGGAGTGACC AGCCTGCGTT TCAACCAAGA CCAAAGCTGC 
TTTTGCTGCG CCATGGAGAC AGGTGTGCGC ATCTACAACG TGGAGCCCTT GATGGAGAAG 
GGGCATCTGG ACCACGAGCA GGTGGGCAGC ATGGGCTTGG TGGAGATGCT GCACCGCTCC 
AACCTTCTGG CCTTGGTGGG CGGTGGTAGT AGTCCCAAGT TCTCAGAGAT CTCAGTGCTG 
ATCTGGGACG ATGCCCGGGA GGGCAAGGAC TCCAAGGAGA AGCTGGTGCT GGAGTTCACC 
TTCACCAAGC CAGTGCTTTC TGTGCGCATG CGCCATGACA AGATCGTGAT CGTGCTGAAG 
AACCGCATCT ATGTGTACTC CTTCCCCGAC AATCCCCGAA AGCTGTTTGA GTTTGATACC 
CGGGACAACC CCAAGGGGCT CTGTGACCTC TGCCCCAGCC TGGAGAAGCA ACTGCTAGTG 
TTCCCGGGAC ACAAGTGTGG GAGTCTGCAA CTTGTGGACC TGGCGAGCAC AAAGCCTGGC 
ACCTCGTCTG CTCCATTCAC GATCAATGCA CATCAGAGTG ACATAGCCTG TGTGTCTCTA 
AACCAGCCAG GCACTGTAGT GGCCTCAGCC TCCCAGAAGG GTACCCTTAT TCGCCTCTTT 
GACACACAAT CCAAGGAGAA ACTGGTGGAG CTGCGCCGAG GCACTGACCC TGCCACCCTC 
TACTGCATTA ACTTCAGCCA CGACTCCTCC TTCCTCTGCG CTTCCAGTGA TAAGGGTACT 
GTCCATATCT TTGCTCTCAA GGATACCCGC CTCAACCGCC GCTCCGCGCT GGCTCGCGTG 
GGCAAGGTGG GGCCTATGAT TGGGCAGTAC GTGGACTCTC AGTGGAGCCT GGCGAGCTTC 
ACTGTGCCTG CTGAGTCAGC TTGCATCTGC GCCTTCGGTC GCAATACTTC CAAGAACGTC 
AACTCTGTCA TTGCCATCTG CGTAGATGGG ACCTTCCACA AATATGTCTT CACTCCTGAT 
GGAAACTGCA ACAGAGAGGC TTTCGACGTG TACCTTGACA TCTGTGATGA TGATGACTTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WDR45 ( NM_001029896.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025067.1 Homo sapiens WD repeat domain 45 (WDR45), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25803
Clone ID Related Accession (Same CDS sequence)	NM_001029896.1 , NM_001029896.2
Accession Version	NM_001029896.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	WD repeat domain phosphoinositide-interacting protein 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ068083.1, AJ005897.1 and BC035979.1. On Nov 22, 2018 this sequence version replaced NM_001029896.1. Transcript Variant: This variant (2) has an alternate 5' UTR and lacks a 3-nt segment in the CDS, as compared to variant 1. The encoded isoform 2 thus lacks an internal amino acid, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.981492.1, SRR3476690.14986.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376372.9/ ENSP00000365551.3 RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTCAAC AGCCACTTCG AGGAGTGACC AGCCTGCGTT TCAACCAAGA CCAAAGCTGC 
TTTTGCTGCG CCATGGAGAC AGGTGTGCGC ATCTACAACG TGGAGCCCTT GATGGAGAAG 
GGGCATCTGG ACCACGAGCA GGTGGGCAGC ATGGGCTTGG TGGAGATGCT GCACCGCTCC 
AACCTTCTGG CCTTGGTGGG CGGTGGTAGT AGTCCCAAGT TCTCAGAGAT CTCAGTGCTG 
ATCTGGGACG ATGCCCGGGA GGGCAAGGAC TCCAAGGAGA AGCTGGTGCT GGAGTTCACC 
TTCACCAAGC CAGTGCTTTC TGTGCGCATG CGCCATGACA AGATCGTGAT CGTGCTGAAG 
AACCGCATCT ATGTGTACTC CTTCCCCGAC AATCCCCGAA AGCTGTTTGA GTTTGATACC 
CGGGACAACC CCAAGGGGCT CTGTGACCTC TGCCCCAGCC TGGAGAAGCA ACTGCTAGTG 
TTCCCGGGAC ACAAGTGTGG GAGTCTGCAA CTTGTGGACC TGGCGAGCAC AAAGCCTGGC 
ACCTCGTCTG CTCCATTCAC GATCAATGCA CATCAGAGTG ACATAGCCTG TGTGTCTCTA 
AACCAGCCAG GCACTGTAGT GGCCTCAGCC TCCCAGAAGG GTACCCTTAT TCGCCTCTTT 
GACACACAAT CCAAGGAGAA ACTGGTGGAG CTGCGCCGAG GCACTGACCC TGCCACCCTC 
TACTGCATTA ACTTCAGCCA CGACTCCTCC TTCCTCTGCG CTTCCAGTGA TAAGGGTACT 
GTCCATATCT TTGCTCTCAA GGATACCCGC CTCAACCGCC GCTCCGCGCT GGCTCGCGTG 
GGCAAGGTGG GGCCTATGAT TGGGCAGTAC GTGGACTCTC AGTGGAGCCT GGCGAGCTTC 
ACTGTGCCTG CTGAGTCAGC TTGCATCTGC GCCTTCGGTC GCAATACTTC CAAGAACGTC 
AACTCTGTCA TTGCCATCTG CGTAGATGGG ACCTTCCACA AATATGTCTT CACTCCTGAT 
GGAAACTGCA ACAGAGAGGC TTTCGACGTG TACCTTGACA TCTGTGATGA TGATGACTTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025067.1
CDS	155..1237
Translation	MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF

Target ORF information:

RefSeq Version	NM_001029896.2
Organism	Homo sapiens(human)
Definition	Homo sapiens WD repeat domain 45 (WDR45), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029896.2

ORF Insert Sequence:

ATGACTCAAC AGCCACTTCG AGGAGTGACC AGCCTGCGTT TCAACCAAGA CCAAAGCTGC 
TTTTGCTGCG CCATGGAGAC AGGTGTGCGC ATCTACAACG TGGAGCCCTT GATGGAGAAG 
GGGCATCTGG ACCACGAGCA GGTGGGCAGC ATGGGCTTGG TGGAGATGCT GCACCGCTCC 
AACCTTCTGG CCTTGGTGGG CGGTGGTAGT AGTCCCAAGT TCTCAGAGAT CTCAGTGCTG 
ATCTGGGACG ATGCCCGGGA GGGCAAGGAC TCCAAGGAGA AGCTGGTGCT GGAGTTCACC 
TTCACCAAGC CAGTGCTTTC TGTGCGCATG CGCCATGACA AGATCGTGAT CGTGCTGAAG 
AACCGCATCT ATGTGTACTC CTTCCCCGAC AATCCCCGAA AGCTGTTTGA GTTTGATACC 
CGGGACAACC CCAAGGGGCT CTGTGACCTC TGCCCCAGCC TGGAGAAGCA ACTGCTAGTG 
TTCCCGGGAC ACAAGTGTGG GAGTCTGCAA CTTGTGGACC TGGCGAGCAC AAAGCCTGGC 
ACCTCGTCTG CTCCATTCAC GATCAATGCA CATCAGAGTG ACATAGCCTG TGTGTCTCTA 
AACCAGCCAG GCACTGTAGT GGCCTCAGCC TCCCAGAAGG GTACCCTTAT TCGCCTCTTT 
GACACACAAT CCAAGGAGAA ACTGGTGGAG CTGCGCCGAG GCACTGACCC TGCCACCCTC 
TACTGCATTA ACTTCAGCCA CGACTCCTCC TTCCTCTGCG CTTCCAGTGA TAAGGGTACT 
GTCCATATCT TTGCTCTCAA GGATACCCGC CTCAACCGCC GCTCCGCGCT GGCTCGCGTG 
GGCAAGGTGG GGCCTATGAT TGGGCAGTAC GTGGACTCTC AGTGGAGCCT GGCGAGCTTC 
ACTGTGCCTG CTGAGTCAGC TTGCATCTGC GCCTTCGGTC GCAATACTTC CAAGAACGTC 
AACTCTGTCA TTGCCATCTG CGTAGATGGG ACCTTCCACA AATATGTCTT CACTCCTGAT 
GGAAACTGCA ACAGAGAGGC TTTCGACGTG TACCTTGACA TCTGTGATGA TGATGACTTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neurodegeneration with brain iron accumulation.
Handbook of clinical neurology147293-305(2018)
Hayflick SJ,Kurian MA,Hogarth P

Severe infantile onset developmental and epileptic encephalopathy caused by mutations in autophagy gene WDR45.
Epilepsia59(1)e5-e13(2018 Jan)
Carvill GL,Liu A,Mandelstam S,Schneider A,Lacroix A,Zemel M,McMahon JM,Bello-Espinosa L,Mackay M,Wallace G,Waak M,Zhang J,Yang X,Malone S,Zhang YH,Mefford HC,Scheffer IE

Early manifestations of epileptic encephalopathy, brain atrophy, and elevation of serum neuron specific enolase in a boy with beta-propeller protein-associated neurodegeneration.
European journal of medical genetics60(10)521-526(2017 Oct)
Takano K,Goto K,Motobayashi M,Wakui K,Kawamura R,Yamaguchi T,Fukushima Y,Kosho T

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WDR45 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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