EMILIN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EMILIN1
Entrez Gene ID	11117
Full Name	elastin microfibril interfacer 1
Synonyms	EMI,EMILIN,gp115
General protein information	Preferred Names elastin microfibril interfacer 1 Names EMILIN-1 elastin microfibril interface-located protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p23.3
Summary	This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung. [provided by RefSeq, Sep 2009].
Disorder MIM:	130660

mRNA and Protein(s)

mRNA	Protein	Name
NM_007046.4	NP_008977.1	EMILIN-1 precursor
NM_007046.3	NP_008977.1	EMILIN-1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	EMILIN1	NP_001179363.1
Mus musculus (house mouse)	Emilin1	NP_598679.1
Pan troglodytes (chimpanzee)	EMILIN1	XP_515351.2
	EMILIN1	XP_001089257.1
Rattus norvegicus (Norway rat)	Emilin1	NP_001100180.1
Homo sapiens (human)	EMILIN1	NP_008977.1
Canis lupus familiaris (dog)	EMILIN1	XP_003432201.1
Danio rerio (zebrafish)	emilin1a	NP_001025378.1
Xenopus tropicalis (tropical clawed frog)	emilin1	NP_001090870.1

Gene Ontology
Bibliography

Related articles in PubMed

The ?4?1/EMILIN1 interaction discloses a novel and unique integrin-ligand type of engagement.
Capuano A, Fogolari F, Bucciotti F, Spessotto P, Nicolosi PA, Mucignat MT, Cervi M, Esposito G, Colombatti A, Doliana R
Matrix biology : journal of the International Society for Matrix Biology(2017 Oct)

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO
Journal of proteome research16(8)3083-3091(2017 Aug)

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Ragelle H, Naba A, Larson BL, Zhou F, Priji? M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG
Biomaterials128147-159(2017 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study is the first to identify EMILIN-1 and ILK as prospective markers of islet regenerative function in human mesenchymal stem cells.
Title: Brief Report: Elastin Microfibril Interface 1 and Integrin-Linked Protein Kinase Are Novel Markers of Islet Regenerative Function in Human Multipotent Mesenchymal Stromal Cells.

These findings collectively suggest that EMILIN1 may represent a new disease gene associated with an autosomal-dominant connective tissue disorder.
Title: Diagnostic Exome Sequencing Identifies a Novel Gene, EMILIN1, Associated with Autosomal-Dominant Hereditary Connective Tissue Disease.

Data suggested mechanisms for homo- and hetero-typic EMILINs multimers formation: EMILIN1 or EMILIN2 alone can form trimers and multimers in the absence of each other or they can co-polymerize in a head-to-tail fashion to form hetero-typic multimers.
Title: Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains.

The present findings highlight the peculiar activity of PMN elastase in disabling EMILIN1 suppressor function.
Title: Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1.

Emilin-1 produced by vascular smooth muscle cells acts as a main regulator of resting blood pressure levels by controlling the myogenic response in resistance arteries through TGF-beta.
Title: Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure.

The following EMILIN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EMILIN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12682	NM_007046.4 Latest version!	Homo sapiens elastin microfibril interfacer 1 (EMILIN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$384.30 $549.00
View Old Accession Versions >>
OHu12682	NM_007046.3	Homo sapiens elastin microfibril interfacer 1 (EMILIN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$384.30 $549.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EMILIN1 ( NM_007046.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_008977.1 Homo sapiens elastin microfibril interfacer 1 (EMILIN1), mRNA.

Price & Availability↑

CloneID	OHu12682
Clone ID Related Accession (Same CDS sequence)	NM_007046.4 , NM_007046.3
Accession Version	NM_007046.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3051bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	EMILIN-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL552691.3 and BC142688.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_007046.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC142688.1, AL050138.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380320.9/ ENSP00000369677.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCCC GCACCCTCTG GAGCTGCTAC CTCTGCTGCC TGCTGACGGC AGCTGCAGGG 
GCCGCCAGCT ACCCTCCTCG AGGTTTCAGC CTCTACACAG GTTCCAGTGG GGCCCTCAGC 
CCCGGGGGGC CCCAGGCCCA GATTGCCCCC CGGCCAGCCA GCCGCCACAG GAACTGGTGT 
GCCTACGTGG TGACCCGGAC AGTGAGCTGT GTCCTTGAGG ATGGAGTGGA GACATATGTC 
AAGTACCAGC CTTGTGCCTG GGGCCAGCCC CAGTGTCCCC AAAGCATCAT GTACCGCCGC 
TTCCTCCGCC CTCGCTACCG TGTGGCCTAC AAGACAGTGA CCGACATGGA GTGGAGGTGC 
TGTCAGGGTT ATGGGGGCGA TGACTGTGCT GAGAGTCCCG CTCCAGCGCT GGGGCCTGCG 
TCTTCCACAC CACGGCCCCT GGCCCGGCCT GCCCGCCCCA ACCTCTCTGG CTCCAGTGCA 
GGCAGCCCCC TCAGTGGACT GGGGGGAGAA GGTCCTGGGG AGTCAGAGAA GGTGCAGCAG 
CTGGAGGAAC AGGTGCAGAG CCTGACCAAG GAGCTGCAAG GCCTGCGGGG CGTCCTGCAA 
GGACTGAGCG GGCGCCTGGC AGAGGATGTG CAGAGGGCTG TGGAGACGGC CTTCAACGGG 
AGGCAGCAGC CAGCTGACGC GGCTGCCCGC CCTGGGGTGC ATGAAACCCT CAATGAGATC 
CAGCACCAGC TGCAGCTCCT GGACACCCGC GTCTCCACCC ACGACCAGGA GCTGGGTCAC 
CTCAACAACC ATCATGGCGG CAGCAGCAGC AGTGGGGGCA GCAGGGCCCC AGCCCCAGCC 
TCAGCCCCTC CGGGCCCCAG TGAGGAGCTG CTGCGGCAGC TGGAGCAGCG GTTGCAGGAG 
TCCTGCTCCG TGTGCCTGGC CGGGCTAGAT GGCTTCCGCC GGCAGCAGCA GGAGGACAGG 
GAGCGGCTGC GAGCGATGGA GAAGCTGCTG GCCTCGGTGG AGGAGCGGCA ACGGCACCTC 
GCAGGGCTGG CGGTGGGCCG CAGGCCCCCT CAGGAATGCT GCTCTCCAGA GCTGGGCCGG 
CGACTGGCAG AGCTGGAGCG CAGGCTGGAT GTCGTGGCCG GCTCAGTGAC AGTGCTGAGT 
GGGCGGCGAG GCACAGAGCT GGGAGGAGCC GCGGGGCAGG GAGGCCACCC CCCAGGCTAC 
ACCAGCTTGG CCTCCCGCCT GTCTCGCCTG GAGGACCGCT TCAACTCCAC CCTGGGCCCT 
TCGGAGGAGC AGGAGGAGAG CTGGCCTGGG GCTCCTGGGG GGCTGAGCCA CTGGCTGCCT 
GCTGCCCGGG GCCGACTAGA GCAGTTGGGG GGGCTGCTGG CCAATGTGAG CGGGGAGCTG 
GGGGGGCGGT TGGATCTGTT GGAGGAGCAG GTGGCAGGGG CCATGCAGGC ATGCGGGCAG 
CTCTGCTCTG GGGCCCCTGG GGAGCAGGAC TCTCAAGTCA GCGAGATCCT CAGTGCCTTG 
GAGCGCAGGG TGCTGGACAG TGAGGGGCAG CTGCGGCTGG TGGGCTCCGG CCTGCACACG 
GTGGAAGCAG CGGGGGAGGC CCGGCAGGCC ACGCTGGAGG GATTACAAGA GGTTGTGGGC 
CGGCTCCAGG ATCGTGTGGA TGCCCAGGAT GAGACAGCTG CAGAGTTCAC ACTACGGCTG 
AATCTCACTG CGGCCCGGCT AGGCCAACTG GAGGGGCTGC TGCAGGCCCA TGGGGATGAG 
GGCTGTGGGG CCTGTGGCGG AGTCCAAGAG GAACTAGGCC GCCTTCGGGA TGGTGTGGAG 
CGCTGCTCCT GCCCCCTGTT GCCTCCTCGG GGTCCTGGGG CTGGTCCAGG TGTTGGGGGC 
CCAAGCCGTG GGCCCCTGGA CGGCTTCAGC GTGTTTGGGG GCAGCTCAGG CTCAGCCCTG 
CAGGCCCTGC AAGGAGAGCT CTCTGAGGTT ATTCTCAGCT TCAGCTCCCT CAATGACTCA 
CTGAATGAGC TCCAGACCAC TGTGGAGGGC CAGGGCGCTG ATCTGGCTGA CCTGGGGGCA 
ACCAAGGACC GTATCATTTC TGAGATTAAC AGGCTGCAGC AGGAGGCCAC AGAGCATGCT 
ACAGAGAGTG AAGAGCGCTT CCGAGGCCTA GAGGAGGGAC AAGCACAGGC CGGCCAGTGC 
CCCAGCTTAG AGGGGCGATT GGGCCGTCTT GAGGGTGTCT GTGAACGGTT GGACACTGTG 
GCTGGGGGAC TGCAGGGCCT GCGCGAGGGC CTTTCCAGAC ACGTGGCTGG GCTCTGGGCT 
GGGCTCCGGG AAACCAACAC CACCAGCCAG ATGCAGGCAG CCCTGCTGGA GAAGCTGGTC 
GGGGGACAGG CGGGCCTGGG CAGGCGGCTG GGTGCCCTTA ACAGCTCCCT GCAGCTCCTG 
GAGGACCGTC TGCACCAGCT CAGCCTGAAG GACCTCACTG GGCCTGCAGG AGAGGCTGGG 
CCCCCAGGGC CTCCTGGGCT GCAGGGACCC CCAGGCCCTG CTGGACCTCC AGGATCACCA 
GGCAAGGACG GGCAAGAGGG CCCCATCGGG CCACCAGGTC CTCAAGGTGA ACAGGGAGTG 
GAGGGGGCAC CAGCAGCCCC TGTGCCCCAA GTGGCATTTT CAGCTGCTCT GAGTTTGCCC 
CGGTCTGAAC CAGGCACGGT CCCCTTCGAC AGAGTCCTGC TCAATGATGG AGGCTATTAT 
GATCCAGAGA CAGGCGTGTT CACAGCGCCA CTGGCTGGAC GCTACTTGCT GAGCGCGGTG 
CTGACTGGGC ACCGGCACGA GAAAGTGGAG GCCGTGCTGT CCCGCTCCAA CCAGGGCGTG 
GCCCGCGTAG ACTCCGGTGG CTACGAGCCT GAGGGCCTGG AGAATAAGCC GGTGGCCGAG 
AGCCAGCCCA GCCCGGGCAC CCTGGGCGTC TTCAGCCTCA TCCTGCCGCT GCAGGCCGGG 
GACACGGTCT GCGTCGACCT GGTCATGGGG CAGCTGGCGC ACTCGGAGGA GCCGCTCACC 
ATCTTCAGCG GGGCCCTGCT CTATGGGGAC CCAGAGCTTG AACACGCGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008977.1
CDS	452..3502
Translation	MAPRTLWSCYLCCLLTAAAGAASYPPRGFSLYTGSSGALSPGGPQAQIAPRPASRHRNWCAYVVTRTVSCVLEDGVETYVKYQPCAWGQPQCPQSIMYRRFLRPRYRVAYKTVTDMEWRCCQGYGGDDCAESPAPALGPASSTPRPLARPARPNLSGSSAGSPLSGLGGEGPGESEKVQQLEEQVQSLTKELQGLRGVLQGLSGRLAEDVQRAVETAFNGRQQPADAAARPGVHETLNEIQHQLQLLDTRVSTHDQELGHLNNHHGGSSSSGGSRAPAPASAPPGPSEELLRQLEQRLQESCSVCLAGLDGFRRQQQEDRERLRAMEKLLASVEERQRHLAGLAVGRRPPQECCSPELGRRLAELERRLDVVAGSVTVLSGRRGTELGGAAGQGGHPPGYTSLASRLSRLEDRFNSTLGPSEEQEESWPGAPGGLSHWLPAARGRLEQLGGLLANVSGELGGRLDLLEEQVAGAMQACGQLCSGAPGEQDSQVSEILSALERRVLDSEGQLRLVGSGLHTVEAAGEARQATLEGLQEVVGRLQDRVDAQDETAAEFTLRLNLTAARLGQLEGLLQAHGDEGCGACGGVQEELGRLRDGVERCSCPLLPPRGPGAGPGVGGPSRGPLDGFSVFGGSSGSALQALQGELSEVILSFSSLNDSLNELQTTVEGQGADLADLGATKDRIISEINRLQQEATEHATESEERFRGLEEGQAQAGQCPSLEGRLGRLEGVCERLDTVAGGLQGLREGLSRHVAGLWAGLRETNTTSQMQAALLEKLVGGQAGLGRRLGALNSSLQLLEDRLHQLSLKDLTGPAGEAGPPGPPGLQGPPGPAGPPGSPGKDGQEGPIGPPGPQGEQGVEGAPAAPVPQVAFSAALSLPRSEPGTVPFDRVLLNDGGYYDPETGVFTAPLAGRYLLSAVLTGHRHEKVEAVLSRSNQGVARVDSGGYEPEGLENKPVAESQPSPGTLGVFSLILPLQAGDTVCVDLVMGQLAHSEEPLTIFSGALLYGDPELEHA

Target ORF information:

RefSeq Version	NM_007046.4
Organism	Homo sapiens(human)
Definition	Homo sapiens elastin microfibril interfacer 1 (EMILIN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007046.4

ORF Insert Sequence:

ATGGCCCCCC GCACCCTCTG GAGCTGCTAC CTCTGCTGCC TGCTGACGGC AGCTGCAGGG 
GCCGCCAGCT ACCCTCCTCG AGGTTTCAGC CTCTACACAG GTTCCAGTGG GGCCCTCAGC 
CCCGGGGGGC CCCAGGCCCA GATTGCCCCC CGGCCAGCCA GCCGCCACAG GAACTGGTGT 
GCCTACGTGG TGACCCGGAC AGTGAGCTGT GTCCTTGAGG ATGGAGTGGA GACATATGTC 
AAGTACCAGC CTTGTGCCTG GGGCCAGCCC CAGTGTCCCC AAAGCATCAT GTACCGCCGC 
TTCCTCCGCC CTCGCTACCG TGTGGCCTAC AAGACAGTGA CCGACATGGA GTGGAGGTGC 
TGTCAGGGTT ATGGGGGCGA TGACTGTGCT GAGAGTCCCG CTCCAGCGCT GGGGCCTGCG 
TCTTCCACAC CACGGCCCCT GGCCCGGCCT GCCCGCCCCA ACCTCTCTGG CTCCAGTGCA 
GGCAGCCCCC TCAGTGGACT GGGGGGAGAA GGTCCTGGGG AGTCAGAGAA GGTGCAGCAG 
CTGGAGGAAC AGGTGCAGAG CCTGACCAAG GAGCTGCAAG GCCTGCGGGG CGTCCTGCAA 
GGACTGAGCG GGCGCCTGGC AGAGGATGTG CAGAGGGCTG TGGAGACGGC CTTCAACGGG 
AGGCAGCAGC CAGCTGACGC GGCTGCCCGC CCTGGGGTGC ATGAAACCCT CAATGAGATC 
CAGCACCAGC TGCAGCTCCT GGACACCCGC GTCTCCACCC ACGACCAGGA GCTGGGTCAC 
CTCAACAACC ATCATGGCGG CAGCAGCAGC AGTGGGGGCA GCAGGGCCCC AGCCCCAGCC 
TCAGCCCCTC CGGGCCCCAG TGAGGAGCTG CTGCGGCAGC TGGAGCAGCG GTTGCAGGAG 
TCCTGCTCCG TGTGCCTGGC CGGGCTAGAT GGCTTCCGCC GGCAGCAGCA GGAGGACAGG 
GAGCGGCTGC GAGCGATGGA GAAGCTGCTG GCCTCGGTGG AGGAGCGGCA ACGGCACCTC 
GCAGGGCTGG CGGTGGGCCG CAGGCCCCCT CAGGAATGCT GCTCTCCAGA GCTGGGCCGG 
CGACTGGCAG AGCTGGAGCG CAGGCTGGAT GTCGTGGCCG GCTCAGTGAC AGTGCTGAGT 
GGGCGGCGAG GCACAGAGCT GGGAGGAGCC GCGGGGCAGG GAGGCCACCC CCCAGGCTAC 
ACCAGCTTGG CCTCCCGCCT GTCTCGCCTG GAGGACCGCT TCAACTCCAC CCTGGGCCCT 
TCGGAGGAGC AGGAGGAGAG CTGGCCTGGG GCTCCTGGGG GGCTGAGCCA CTGGCTGCCT 
GCTGCCCGGG GCCGACTAGA GCAGTTGGGG GGGCTGCTGG CCAATGTGAG CGGGGAGCTG 
GGGGGGCGGT TGGATCTGTT GGAGGAGCAG GTGGCAGGGG CCATGCAGGC ATGCGGGCAG 
CTCTGCTCTG GGGCCCCTGG GGAGCAGGAC TCTCAAGTCA GCGAGATCCT CAGTGCCTTG 
GAGCGCAGGG TGCTGGACAG TGAGGGGCAG CTGCGGCTGG TGGGCTCCGG CCTGCACACG 
GTGGAAGCAG CGGGGGAGGC CCGGCAGGCC ACGCTGGAGG GATTACAAGA GGTTGTGGGC 
CGGCTCCAGG ATCGTGTGGA TGCCCAGGAT GAGACAGCTG CAGAGTTCAC ACTACGGCTG 
AATCTCACTG CGGCCCGGCT AGGCCAACTG GAGGGGCTGC TGCAGGCCCA TGGGGATGAG 
GGCTGTGGGG CCTGTGGCGG AGTCCAAGAG GAACTAGGCC GCCTTCGGGA TGGTGTGGAG 
CGCTGCTCCT GCCCCCTGTT GCCTCCTCGG GGTCCTGGGG CTGGTCCAGG TGTTGGGGGC 
CCAAGCCGTG GGCCCCTGGA CGGCTTCAGC GTGTTTGGGG GCAGCTCAGG CTCAGCCCTG 
CAGGCCCTGC AAGGAGAGCT CTCTGAGGTT ATTCTCAGCT TCAGCTCCCT CAATGACTCA 
CTGAATGAGC TCCAGACCAC TGTGGAGGGC CAGGGCGCTG ATCTGGCTGA CCTGGGGGCA 
ACCAAGGACC GTATCATTTC TGAGATTAAC AGGCTGCAGC AGGAGGCCAC AGAGCATGCT 
ACAGAGAGTG AAGAGCGCTT CCGAGGCCTA GAGGAGGGAC AAGCACAGGC CGGCCAGTGC 
CCCAGCTTAG AGGGGCGATT GGGCCGTCTT GAGGGTGTCT GTGAACGGTT GGACACTGTG 
GCTGGGGGAC TGCAGGGCCT GCGCGAGGGC CTTTCCAGAC ACGTGGCTGG GCTCTGGGCT 
GGGCTCCGGG AAACCAACAC CACCAGCCAG ATGCAGGCAG CCCTGCTGGA GAAGCTGGTC 
GGGGGACAGG CGGGCCTGGG CAGGCGGCTG GGTGCCCTTA ACAGCTCCCT GCAGCTCCTG 
GAGGACCGTC TGCACCAGCT CAGCCTGAAG GACCTCACTG GGCCTGCAGG AGAGGCTGGG 
CCCCCAGGGC CTCCTGGGCT GCAGGGACCC CCAGGCCCTG CTGGACCTCC AGGATCACCA 
GGCAAGGACG GGCAAGAGGG CCCCATCGGG CCACCAGGTC CTCAAGGTGA ACAGGGAGTG 
GAGGGGGCAC CAGCAGCCCC TGTGCCCCAA GTGGCATTTT CAGCTGCTCT GAGTTTGCCC 
CGGTCTGAAC CAGGCACGGT CCCCTTCGAC AGAGTCCTGC TCAATGATGG AGGCTATTAT 
GATCCAGAGA CAGGCGTGTT CACAGCGCCA CTGGCTGGAC GCTACTTGCT GAGCGCGGTG 
CTGACTGGGC ACCGGCACGA GAAAGTGGAG GCCGTGCTGT CCCGCTCCAA CCAGGGCGTG 
GCCCGCGTAG ACTCCGGTGG CTACGAGCCT GAGGGCCTGG AGAATAAGCC GGTGGCCGAG 
AGCCAGCCCA GCCCGGGCAC CCTGGGCGTC TTCAGCCTCA TCCTGCCGCT GCAGGCCGGG 
GACACGGTCT GCGTCGACCT GGTCATGGGG CAGCTGGCGC ACTCGGAGGA GCCGCTCACC 
ATCTTCAGCG GGGCCCTGCT CTATGGGGAC CCAGAGCTTG AACACGCGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EMILIN1 ( NM_007046.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008977.1 Homo sapiens elastin microfibril interfacer 1 (EMILIN1), mRNA.

Price & Availability↑

CloneID	OHu12682
Clone ID Related Accession (Same CDS sequence)	NM_007046.4 , NM_007046.3
Accession Version	NM_007046.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3051bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	EMILIN-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC013403.9, AL552691.3 and BC142688.1. This sequence is a reference standard in the RefSeqGene project. On Oct 8, 2009 this sequence version replaced NM_007046.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC142688.1, AF088916.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCCC GCACCCTCTG GAGCTGCTAC CTCTGCTGCC TGCTGACGGC AGCTGCAGGG 
GCCGCCAGCT ACCCTCCTCG AGGTTTCAGC CTCTACACAG GTTCCAGTGG GGCCCTCAGC 
CCCGGGGGGC CCCAGGCCCA GATTGCCCCC CGGCCAGCCA GCCGCCACAG GAACTGGTGT 
GCCTACGTGG TGACCCGGAC AGTGAGCTGT GTCCTTGAGG ATGGAGTGGA GACATATGTC 
AAGTACCAGC CTTGTGCCTG GGGCCAGCCC CAGTGTCCCC AAAGCATCAT GTACCGCCGC 
TTCCTCCGCC CTCGCTACCG TGTGGCCTAC AAGACAGTGA CCGACATGGA GTGGAGGTGC 
TGTCAGGGTT ATGGGGGCGA TGACTGTGCT GAGAGTCCCG CTCCAGCGCT GGGGCCTGCG 
TCTTCCACAC CACGGCCCCT GGCCCGGCCT GCCCGCCCCA ACCTCTCTGG CTCCAGTGCA 
GGCAGCCCCC TCAGTGGACT GGGGGGAGAA GGTCCTGGGG AGTCAGAGAA GGTGCAGCAG 
CTGGAGGAAC AGGTGCAGAG CCTGACCAAG GAGCTGCAAG GCCTGCGGGG CGTCCTGCAA 
GGACTGAGCG GGCGCCTGGC AGAGGATGTG CAGAGGGCTG TGGAGACGGC CTTCAACGGG 
AGGCAGCAGC CAGCTGACGC GGCTGCCCGC CCTGGGGTGC ATGAAACCCT CAATGAGATC 
CAGCACCAGC TGCAGCTCCT GGACACCCGC GTCTCCACCC ACGACCAGGA GCTGGGTCAC 
CTCAACAACC ATCATGGCGG CAGCAGCAGC AGTGGGGGCA GCAGGGCCCC AGCCCCAGCC 
TCAGCCCCTC CGGGCCCCAG TGAGGAGCTG CTGCGGCAGC TGGAGCAGCG GTTGCAGGAG 
TCCTGCTCCG TGTGCCTGGC CGGGCTAGAT GGCTTCCGCC GGCAGCAGCA GGAGGACAGG 
GAGCGGCTGC GAGCGATGGA GAAGCTGCTG GCCTCGGTGG AGGAGCGGCA ACGGCACCTC 
GCAGGGCTGG CGGTGGGCCG CAGGCCCCCT CAGGAATGCT GCTCTCCAGA GCTGGGCCGG 
CGACTGGCAG AGCTGGAGCG CAGGCTGGAT GTCGTGGCCG GCTCAGTGAC AGTGCTGAGT 
GGGCGGCGAG GCACAGAGCT GGGAGGAGCC GCGGGGCAGG GAGGCCACCC CCCAGGCTAC 
ACCAGCTTGG CCTCCCGCCT GTCTCGCCTG GAGGACCGCT TCAACTCCAC CCTGGGCCCT 
TCGGAGGAGC AGGAGGAGAG CTGGCCTGGG GCTCCTGGGG GGCTGAGCCA CTGGCTGCCT 
GCTGCCCGGG GCCGACTAGA GCAGTTGGGG GGGCTGCTGG CCAATGTGAG CGGGGAGCTG 
GGGGGGCGGT TGGATCTGTT GGAGGAGCAG GTGGCAGGGG CCATGCAGGC ATGCGGGCAG 
CTCTGCTCTG GGGCCCCTGG GGAGCAGGAC TCTCAAGTCA GCGAGATCCT CAGTGCCTTG 
GAGCGCAGGG TGCTGGACAG TGAGGGGCAG CTGCGGCTGG TGGGCTCCGG CCTGCACACG 
GTGGAAGCAG CGGGGGAGGC CCGGCAGGCC ACGCTGGAGG GATTACAAGA GGTTGTGGGC 
CGGCTCCAGG ATCGTGTGGA TGCCCAGGAT GAGACAGCTG CAGAGTTCAC ACTACGGCTG 
AATCTCACTG CGGCCCGGCT AGGCCAACTG GAGGGGCTGC TGCAGGCCCA TGGGGATGAG 
GGCTGTGGGG CCTGTGGCGG AGTCCAAGAG GAACTAGGCC GCCTTCGGGA TGGTGTGGAG 
CGCTGCTCCT GCCCCCTGTT GCCTCCTCGG GGTCCTGGGG CTGGTCCAGG TGTTGGGGGC 
CCAAGCCGTG GGCCCCTGGA CGGCTTCAGC GTGTTTGGGG GCAGCTCAGG CTCAGCCCTG 
CAGGCCCTGC AAGGAGAGCT CTCTGAGGTT ATTCTCAGCT TCAGCTCCCT CAATGACTCA 
CTGAATGAGC TCCAGACCAC TGTGGAGGGC CAGGGCGCTG ATCTGGCTGA CCTGGGGGCA 
ACCAAGGACC GTATCATTTC TGAGATTAAC AGGCTGCAGC AGGAGGCCAC AGAGCATGCT 
ACAGAGAGTG AAGAGCGCTT CCGAGGCCTA GAGGAGGGAC AAGCACAGGC CGGCCAGTGC 
CCCAGCTTAG AGGGGCGATT GGGCCGTCTT GAGGGTGTCT GTGAACGGTT GGACACTGTG 
GCTGGGGGAC TGCAGGGCCT GCGCGAGGGC CTTTCCAGAC ACGTGGCTGG GCTCTGGGCT 
GGGCTCCGGG AAACCAACAC CACCAGCCAG ATGCAGGCAG CCCTGCTGGA GAAGCTGGTC 
GGGGGACAGG CGGGCCTGGG CAGGCGGCTG GGTGCCCTTA ACAGCTCCCT GCAGCTCCTG 
GAGGACCGTC TGCACCAGCT CAGCCTGAAG GACCTCACTG GGCCTGCAGG AGAGGCTGGG 
CCCCCAGGGC CTCCTGGGCT GCAGGGACCC CCAGGCCCTG CTGGACCTCC AGGATCACCA 
GGCAAGGACG GGCAAGAGGG CCCCATCGGG CCACCAGGTC CTCAAGGTGA ACAGGGAGTG 
GAGGGGGCAC CAGCAGCCCC TGTGCCCCAA GTGGCATTTT CAGCTGCTCT GAGTTTGCCC 
CGGTCTGAAC CAGGCACGGT CCCCTTCGAC AGAGTCCTGC TCAATGATGG AGGCTATTAT 
GATCCAGAGA CAGGCGTGTT CACAGCGCCA CTGGCTGGAC GCTACTTGCT GAGCGCGGTG 
CTGACTGGGC ACCGGCACGA GAAAGTGGAG GCCGTGCTGT CCCGCTCCAA CCAGGGCGTG 
GCCCGCGTAG ACTCCGGTGG CTACGAGCCT GAGGGCCTGG AGAATAAGCC GGTGGCCGAG 
AGCCAGCCCA GCCCGGGCAC CCTGGGCGTC TTCAGCCTCA TCCTGCCGCT GCAGGCCGGG 
GACACGGTCT GCGTCGACCT GGTCATGGGG CAGCTGGCGC ACTCGGAGGA GCCGCTCACC 
ATCTTCAGCG GGGCCCTGCT CTATGGGGAC CCAGAGCTTG AACACGCGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008977.1
CDS	500..3550
Translation	MAPRTLWSCYLCCLLTAAAGAASYPPRGFSLYTGSSGALSPGGPQAQIAPRPASRHRNWCAYVVTRTVSCVLEDGVETYVKYQPCAWGQPQCPQSIMYRRFLRPRYRVAYKTVTDMEWRCCQGYGGDDCAESPAPALGPASSTPRPLARPARPNLSGSSAGSPLSGLGGEGPGESEKVQQLEEQVQSLTKELQGLRGVLQGLSGRLAEDVQRAVETAFNGRQQPADAAARPGVHETLNEIQHQLQLLDTRVSTHDQELGHLNNHHGGSSSSGGSRAPAPASAPPGPSEELLRQLEQRLQESCSVCLAGLDGFRRQQQEDRERLRAMEKLLASVEERQRHLAGLAVGRRPPQECCSPELGRRLAELERRLDVVAGSVTVLSGRRGTELGGAAGQGGHPPGYTSLASRLSRLEDRFNSTLGPSEEQEESWPGAPGGLSHWLPAARGRLEQLGGLLANVSGELGGRLDLLEEQVAGAMQACGQLCSGAPGEQDSQVSEILSALERRVLDSEGQLRLVGSGLHTVEAAGEARQATLEGLQEVVGRLQDRVDAQDETAAEFTLRLNLTAARLGQLEGLLQAHGDEGCGACGGVQEELGRLRDGVERCSCPLLPPRGPGAGPGVGGPSRGPLDGFSVFGGSSGSALQALQGELSEVILSFSSLNDSLNELQTTVEGQGADLADLGATKDRIISEINRLQQEATEHATESEERFRGLEEGQAQAGQCPSLEGRLGRLEGVCERLDTVAGGLQGLREGLSRHVAGLWAGLRETNTTSQMQAALLEKLVGGQAGLGRRLGALNSSLQLLEDRLHQLSLKDLTGPAGEAGPPGPPGLQGPPGPAGPPGSPGKDGQEGPIGPPGPQGEQGVEGAPAAPVPQVAFSAALSLPRSEPGTVPFDRVLLNDGGYYDPETGVFTAPLAGRYLLSAVLTGHRHEKVEAVLSRSNQGVARVDSGGYEPEGLENKPVAESQPSPGTLGVFSLILPLQAGDTVCVDLVMGQLAHSEEPLTIFSGALLYGDPELEHA

Target ORF information:

RefSeq Version	NM_007046.3
Organism	Homo sapiens(human)
Definition	Homo sapiens elastin microfibril interfacer 1 (EMILIN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007046.3

ORF Insert Sequence:

ATGGCCCCCC GCACCCTCTG GAGCTGCTAC CTCTGCTGCC TGCTGACGGC AGCTGCAGGG 
GCCGCCAGCT ACCCTCCTCG AGGTTTCAGC CTCTACACAG GTTCCAGTGG GGCCCTCAGC 
CCCGGGGGGC CCCAGGCCCA GATTGCCCCC CGGCCAGCCA GCCGCCACAG GAACTGGTGT 
GCCTACGTGG TGACCCGGAC AGTGAGCTGT GTCCTTGAGG ATGGAGTGGA GACATATGTC 
AAGTACCAGC CTTGTGCCTG GGGCCAGCCC CAGTGTCCCC AAAGCATCAT GTACCGCCGC 
TTCCTCCGCC CTCGCTACCG TGTGGCCTAC AAGACAGTGA CCGACATGGA GTGGAGGTGC 
TGTCAGGGTT ATGGGGGCGA TGACTGTGCT GAGAGTCCCG CTCCAGCGCT GGGGCCTGCG 
TCTTCCACAC CACGGCCCCT GGCCCGGCCT GCCCGCCCCA ACCTCTCTGG CTCCAGTGCA 
GGCAGCCCCC TCAGTGGACT GGGGGGAGAA GGTCCTGGGG AGTCAGAGAA GGTGCAGCAG 
CTGGAGGAAC AGGTGCAGAG CCTGACCAAG GAGCTGCAAG GCCTGCGGGG CGTCCTGCAA 
GGACTGAGCG GGCGCCTGGC AGAGGATGTG CAGAGGGCTG TGGAGACGGC CTTCAACGGG 
AGGCAGCAGC CAGCTGACGC GGCTGCCCGC CCTGGGGTGC ATGAAACCCT CAATGAGATC 
CAGCACCAGC TGCAGCTCCT GGACACCCGC GTCTCCACCC ACGACCAGGA GCTGGGTCAC 
CTCAACAACC ATCATGGCGG CAGCAGCAGC AGTGGGGGCA GCAGGGCCCC AGCCCCAGCC 
TCAGCCCCTC CGGGCCCCAG TGAGGAGCTG CTGCGGCAGC TGGAGCAGCG GTTGCAGGAG 
TCCTGCTCCG TGTGCCTGGC CGGGCTAGAT GGCTTCCGCC GGCAGCAGCA GGAGGACAGG 
GAGCGGCTGC GAGCGATGGA GAAGCTGCTG GCCTCGGTGG AGGAGCGGCA ACGGCACCTC 
GCAGGGCTGG CGGTGGGCCG CAGGCCCCCT CAGGAATGCT GCTCTCCAGA GCTGGGCCGG 
CGACTGGCAG AGCTGGAGCG CAGGCTGGAT GTCGTGGCCG GCTCAGTGAC AGTGCTGAGT 
GGGCGGCGAG GCACAGAGCT GGGAGGAGCC GCGGGGCAGG GAGGCCACCC CCCAGGCTAC 
ACCAGCTTGG CCTCCCGCCT GTCTCGCCTG GAGGACCGCT TCAACTCCAC CCTGGGCCCT 
TCGGAGGAGC AGGAGGAGAG CTGGCCTGGG GCTCCTGGGG GGCTGAGCCA CTGGCTGCCT 
GCTGCCCGGG GCCGACTAGA GCAGTTGGGG GGGCTGCTGG CCAATGTGAG CGGGGAGCTG 
GGGGGGCGGT TGGATCTGTT GGAGGAGCAG GTGGCAGGGG CCATGCAGGC ATGCGGGCAG 
CTCTGCTCTG GGGCCCCTGG GGAGCAGGAC TCTCAAGTCA GCGAGATCCT CAGTGCCTTG 
GAGCGCAGGG TGCTGGACAG TGAGGGGCAG CTGCGGCTGG TGGGCTCCGG CCTGCACACG 
GTGGAAGCAG CGGGGGAGGC CCGGCAGGCC ACGCTGGAGG GATTACAAGA GGTTGTGGGC 
CGGCTCCAGG ATCGTGTGGA TGCCCAGGAT GAGACAGCTG CAGAGTTCAC ACTACGGCTG 
AATCTCACTG CGGCCCGGCT AGGCCAACTG GAGGGGCTGC TGCAGGCCCA TGGGGATGAG 
GGCTGTGGGG CCTGTGGCGG AGTCCAAGAG GAACTAGGCC GCCTTCGGGA TGGTGTGGAG 
CGCTGCTCCT GCCCCCTGTT GCCTCCTCGG GGTCCTGGGG CTGGTCCAGG TGTTGGGGGC 
CCAAGCCGTG GGCCCCTGGA CGGCTTCAGC GTGTTTGGGG GCAGCTCAGG CTCAGCCCTG 
CAGGCCCTGC AAGGAGAGCT CTCTGAGGTT ATTCTCAGCT TCAGCTCCCT CAATGACTCA 
CTGAATGAGC TCCAGACCAC TGTGGAGGGC CAGGGCGCTG ATCTGGCTGA CCTGGGGGCA 
ACCAAGGACC GTATCATTTC TGAGATTAAC AGGCTGCAGC AGGAGGCCAC AGAGCATGCT 
ACAGAGAGTG AAGAGCGCTT CCGAGGCCTA GAGGAGGGAC AAGCACAGGC CGGCCAGTGC 
CCCAGCTTAG AGGGGCGATT GGGCCGTCTT GAGGGTGTCT GTGAACGGTT GGACACTGTG 
GCTGGGGGAC TGCAGGGCCT GCGCGAGGGC CTTTCCAGAC ACGTGGCTGG GCTCTGGGCT 
GGGCTCCGGG AAACCAACAC CACCAGCCAG ATGCAGGCAG CCCTGCTGGA GAAGCTGGTC 
GGGGGACAGG CGGGCCTGGG CAGGCGGCTG GGTGCCCTTA ACAGCTCCCT GCAGCTCCTG 
GAGGACCGTC TGCACCAGCT CAGCCTGAAG GACCTCACTG GGCCTGCAGG AGAGGCTGGG 
CCCCCAGGGC CTCCTGGGCT GCAGGGACCC CCAGGCCCTG CTGGACCTCC AGGATCACCA 
GGCAAGGACG GGCAAGAGGG CCCCATCGGG CCACCAGGTC CTCAAGGTGA ACAGGGAGTG 
GAGGGGGCAC CAGCAGCCCC TGTGCCCCAA GTGGCATTTT CAGCTGCTCT GAGTTTGCCC 
CGGTCTGAAC CAGGCACGGT CCCCTTCGAC AGAGTCCTGC TCAATGATGG AGGCTATTAT 
GATCCAGAGA CAGGCGTGTT CACAGCGCCA CTGGCTGGAC GCTACTTGCT GAGCGCGGTG 
CTGACTGGGC ACCGGCACGA GAAAGTGGAG GCCGTGCTGT CCCGCTCCAA CCAGGGCGTG 
GCCCGCGTAG ACTCCGGTGG CTACGAGCCT GAGGGCCTGG AGAATAAGCC GGTGGCCGAG 
AGCCAGCCCA GCCCGGGCAC CCTGGGCGTC TTCAGCCTCA TCCTGCCGCT GCAGGCCGGG 
GACACGGTCT GCGTCGACCT GGTCATGGGG CAGCTGGCGC ACTCGGAGGA GCCGCTCACC 
ATCTTCAGCG GGGCCCTGCT CTATGGGGAC CCAGAGCTTG AACACGCGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The ?4?1/EMILIN1 interaction discloses a novel and unique integrin-ligand type of engagement.
Matrix biology : journal of the International Society for Matrix Biology(2017 Oct)
Capuano A,Fogolari F,Bucciotti F,Spessotto P,Nicolosi PA,Mucignat MT,Cervi M,Esposito G,Colombatti A,Doliana R

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Journal of proteome research16(8)3083-3091(2017 Aug)
Naba A,Pearce OMT,Del Rosario A,Ma D,Ding H,Rajeeve V,Cutillas PR,Balkwill FR,Hynes RO

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Biomaterials128147-159(2017 06)
Ragelle H,Naba A,Larson BL,Zhou F,Priji? M,Whittaker CA,Del Rosario A,Langer R,Hynes RO,Anderson DG

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EMILIN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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