UPK1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UPK1A
Entrez Gene ID	11045
Full Name	uroplakin 1A
Synonyms	TSPAN21,UP1A,UPIA,UPKA
General protein information	Preferred Names uroplakin 1A Names uroplakin-1a tetraspanin-21 tspan-21 uroplakin Ia
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.12
Summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
Disorder MIM:	611557

mRNA and Protein(s)

mRNA	Protein	Name
XM_017026225.1	XP_016881714.1	uroplakin-1a isoform X1
NM_001281443.1	NP_001268372.1	uroplakin-1a isoform 2
NM_007000.3	NP_008931.1	uroplakin-1a isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Upk1a	NP_001102381.1
Homo sapiens (human)	UPK1A	NP_008931.1
Mus musculus (house mouse)	Upk1a	NP_081091.1
	UPK1A	XP_001096659.1
Canis lupus familiaris (dog)	UPK1A	XP_541693.1
Bos taurus (cattle)	UPK1A	NP_788784.1
Danio rerio (zebrafish)	upk1a	NP_001035332.1

Gene Ontology
Bibliography

Related articles in PubMed

Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic
Hashimoto J, Takahashi M, Saito A, Murata M, Kurimura Y, Nishitani C, Takamiya R, Uehara Y, Hasegawa Y, Hiyama Y, Sawada N, Takahashi S, Masumori N, Kuroki Y, Ariki S
Journal of immunology (Baltimore, Md. : 1950)198(7)2898-2905(2017 Apr)

Downregulation of UPK1A suppresses proliferation and enhances apoptosis of bladder transitional cell carcinoma cells.
Zhu H, Tang Y, Zhang X, Jiang X, Wang Y, Gan Y, Yang J
Medical oncology (Northwood, London, England)32(3)84(2015 Mar)

Reduced expression of uroplakin 1A is associated with the poor prognosis of gastric adenocarcinoma patients.
Zheng Y, Wang DD, Wang W, Pan K, Huang CY, Li YF, Wang QJ, Yuan SQ, Jiang SS, Qiu HB, Chen YM, Zhang XF, Zhao BW, Mai C, Xia JC, Zhou ZW
PloS one9(4)e93073(2014)

Decreased expression of uroplakin Ia is associated with colorectal cancer progression and poor survival of patients.
He Y, Kong F, Du H, Wu M
International journal of clinical and experimental pathology7(8)5031-7(2014)

Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma.
Kong KL, Kwong DL, Fu L, Chan TH, Chen L, Liu H, Li Y, Zhu YH, Bi J, Qin YR, Law SY, Guan XY
Cancer research70(21)8832-41(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Down-regulation of UPK1A suppresses proliferation and enhances apoptosis of bladder transitional cell carcinoma cells.
Title: Downregulation of UPK1A suppresses proliferation and enhances apoptosis of bladder transitional cell carcinoma cells.

Reduced expression of uroplakin 1A is associated with gastric adenocarcinoma.
Title: Reduced expression of uroplakin 1A is associated with the poor prognosis of gastric adenocarcinoma patients.

expression of UPKIa was a promising predictor for poor outcome of colorectal cancer patients
Title: Decreased expression of uroplakin Ia is associated with colorectal cancer progression and poor survival of patients.

Loss of UPK1A is associated with esophageal squamous cell carcinoma.
Title: Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma.

The authors show by cryo-electron microscopy that FimH binding to the extracellular domain of UP Ia induces global conformational changes in the entire UP receptor complex, including a coordinated movement of the tightly bundled transmembrane helices.
Title: Uropathogenic E. coli adhesin-induced host cell receptor conformational changes: implications in transmembrane signaling transduction.

The following UPK1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UPK1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05265	NM_007000.3 Latest version!	Homo sapiens uroplakin 1A (UPK1A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02007	NM_001281443.1 Latest version!	Homo sapiens uroplakin 1A (UPK1A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu88167	XM_017026225.1 Latest version!	Homo sapiens uroplakin 1A (UPK1A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UPK1A ( NM_007000.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008931.1 Homo sapiens uroplakin 1A (UPK1A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05265
Clone ID Related Accession (Same CDS sequence)	NM_007000.3
Accession Version	NM_007000.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Homo sapiens(human)
Product	uroplakin-1a isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC002115.1, AF085807.1, AA548647.1 and HY263470.1. On Jul 30, 2013 this sequence version replaced NM_007000.2. Transcript Variant: This variant (1) encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC107098.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved inferred exon combination :: PMID: 15913809 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTCTG CGGCAGCAGC GGAGGCCGAG AAGGGATCTC CAGTTGTGGT GGGCCTGCTA 
GTTGTGGGCA ATATCATTAT TCTGCTGTCA GGCCTGTCCC TGTTTGCTGA GACCATATGG 
GTGACAGCCG ACCAGTACCG TGTATACCCA CTGATGGGAG TCTCAGGCAA GGATGACGTC 
TTCGCTGGTG CCTGGATTGC CATCTTCTGC GGCTTCTCCT TCTTCATGGT AGCCAGTTTT 
GGTGTGGGTG CCGCACTCTG CCGCCGCCGG TCCATGGTCC TCACGTACCT GGTGCTCATG 
CTCATCGTCT ACATCTTCGA GTGCGCCTCC TGCATCACGT CCTACACCCA CCGTGACTAC 
ATGGTGTCCA ACCCATCCCT GATCACCAAG CAGATGCTGA CCTTCTACAG CGCGGACACC 
GACCAGGGCC AGGAGCTGAC CCGCCTCTGG GACCGCGTCA TGATTGAGCA AGAATGCTGT 
GGCACATCTG GTCCCATGGA CTGGGTGAAC TTCACGTCAG CCTTCCGGGC GGCCACTCCG 
GAGGTGGTGT TCCCCTGGCC CCCACTGTGC TGTCGCCGGA CGGGAAACTT CATCCCCCTC 
AACGAGGAGG GCTGCCGCCT GGGGCACATG GACTACCTGT TCACCAAGGG CTGCTTCGAA 
CACATCGGCC ACGCCATCGA CAGCTACACG TGGGGTATCT CGTGGTTTGG GTTTGCCATC 
CTGATGTGGA CGCTCCCGGT CATGCTGATA GCCATGTATT TCTACACCAT GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008931.1
CDS	28..804
Translation	MASAAAAEAEKGSPVVVGLLVVGNIIILLSGLSLFAETIWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFMVASFGVGAALCRRRSMVLTYLVLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRVMIEQECCGTSGPMDWVNFTSAFRAATPEVVFPWPPLCCRRTGNFIPLNEEGCRLGHMDYLFTKGCFEHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTML

Target ORF information:

RefSeq Version	NM_007000.3
Organism	Homo sapiens(human)
Definition	Homo sapiens uroplakin 1A (UPK1A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007000.3

ORF Insert Sequence:

ATGGCGTCTG CGGCAGCAGC GGAGGCCGAG AAGGGATCTC CAGTTGTGGT GGGCCTGCTA 
GTTGTGGGCA ATATCATTAT TCTGCTGTCA GGCCTGTCCC TGTTTGCTGA GACCATATGG 
GTGACAGCCG ACCAGTACCG TGTATACCCA CTGATGGGAG TCTCAGGCAA GGATGACGTC 
TTCGCTGGTG CCTGGATTGC CATCTTCTGC GGCTTCTCCT TCTTCATGGT AGCCAGTTTT 
GGTGTGGGTG CCGCACTCTG CCGCCGCCGG TCCATGGTCC TCACGTACCT GGTGCTCATG 
CTCATCGTCT ACATCTTCGA GTGCGCCTCC TGCATCACGT CCTACACCCA CCGTGACTAC 
ATGGTGTCCA ACCCATCCCT GATCACCAAG CAGATGCTGA CCTTCTACAG CGCGGACACC 
GACCAGGGCC AGGAGCTGAC CCGCCTCTGG GACCGCGTCA TGATTGAGCA AGAATGCTGT 
GGCACATCTG GTCCCATGGA CTGGGTGAAC TTCACGTCAG CCTTCCGGGC GGCCACTCCG 
GAGGTGGTGT TCCCCTGGCC CCCACTGTGC TGTCGCCGGA CGGGAAACTT CATCCCCCTC 
AACGAGGAGG GCTGCCGCCT GGGGCACATG GACTACCTGT TCACCAAGGG CTGCTTCGAA 
CACATCGGCC ACGCCATCGA CAGCTACACG TGGGGTATCT CGTGGTTTGG GTTTGCCATC 
CTGATGTGGA CGCTCCCGGT CATGCTGATA GCCATGTATT TCTACACCAT GCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UPK1A ( NM_001281443.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001268372.1 Homo sapiens uroplakin 1A (UPK1A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02007
Clone ID Related Accession (Same CDS sequence)	NM_001281443.1
Accession Version	NM_001281443.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	uroplakin-1a isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC002115.1, BC107097.1, AF085807.1, AA548647.1 and HY263470.1. Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.`. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC107097.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved inferred exon combination :: PMID: 15913809 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTCTG CGGCAGCAGC GGAGGCCGAG AAGGGATCTC CAGTTGTGGT GGGCCTGCTA 
GTTGTGGGCA ATATCATTAT TCTGCTGTCA GGCCTGTCCC TGTTTGCTGA GACCATATGG 
GTGACAGCCG ACCAGTACCG TGTATACCCA CTGATGGGAG TCTCAGGCAA GGATGACGTC 
TTCGCTGGTG CCTGGATTGC CATCTTCTGC GGCTTCTCCT TCTTCATGGT AGCCAGTTTT 
GGTGTGGGTG CCGCACTCTG CCGCCGCCGG TCCATGGTCC TCACGTACCT GGTGCTCATG 
CTCATCGTCT ACATCTTCGA GTGCGCCTCC TGCATCACGT CCTACACCCA CCGTGACTAC 
ATGGTGTCCA ACCCATCCCT GATCACCAAG CAGATGCTGA CCTTCTACAG CGCGGACACC 
GACCAGGGCC AGGAGCTGAC CCGCCTCTGG GACCGCGTCA TGATTGAGCA AGAATGCTGT 
GGCACATCTG GTCCCATGGA CTGGGTGAAC TTCACGTCAG CCTTCCGGGC GGCCACTCCG 
GAGGTGGTGT TCCCCTGGCC CCCACTGTGC TGTCGCCGGA CGGGAAACTT CATCCCCCTC 
AACGAGGAGG GCTGCCGCCT GGGGCACATG GACTACCTGT TCACCAAGGC TGGAGTACAG 
TGGCACAATC TCAGCTCACT GCAGCGTCTG CCTCCCGGGT TCAAGGGATT CTCCCACCTC 
AGCTTCCAGA GCAGCTGGGA TTACAGGGCT GCTTCGAACA CATCGGCCAC GCCATCGACA 
GCTACACGTG GGGTATCTCG TGGTTTGGGT TTGCCATCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001268372.1
CDS	28..849
Translation	MASAAAAEAEKGSPVVVGLLVVGNIIILLSGLSLFAETIWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFMVASFGVGAALCRRRSMVLTYLVLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRVMIEQECCGTSGPMDWVNFTSAFRAATPEVVFPWPPLCCRRTGNFIPLNEEGCRLGHMDYLFTKAGVQWHNLSSLQRLPPGFKGFSHLSFQSSWDYRAASNTSATPSTATRGVSRGLGLPS

Target ORF information:

RefSeq Version	NM_001281443.1
Organism	Homo sapiens(human)
Definition	Homo sapiens uroplakin 1A (UPK1A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001281443.1

ORF Insert Sequence:

ATGGCGTCTG CGGCAGCAGC GGAGGCCGAG AAGGGATCTC CAGTTGTGGT GGGCCTGCTA 
GTTGTGGGCA ATATCATTAT TCTGCTGTCA GGCCTGTCCC TGTTTGCTGA GACCATATGG 
GTGACAGCCG ACCAGTACCG TGTATACCCA CTGATGGGAG TCTCAGGCAA GGATGACGTC 
TTCGCTGGTG CCTGGATTGC CATCTTCTGC GGCTTCTCCT TCTTCATGGT AGCCAGTTTT 
GGTGTGGGTG CCGCACTCTG CCGCCGCCGG TCCATGGTCC TCACGTACCT GGTGCTCATG 
CTCATCGTCT ACATCTTCGA GTGCGCCTCC TGCATCACGT CCTACACCCA CCGTGACTAC 
ATGGTGTCCA ACCCATCCCT GATCACCAAG CAGATGCTGA CCTTCTACAG CGCGGACACC 
GACCAGGGCC AGGAGCTGAC CCGCCTCTGG GACCGCGTCA TGATTGAGCA AGAATGCTGT 
GGCACATCTG GTCCCATGGA CTGGGTGAAC TTCACGTCAG CCTTCCGGGC GGCCACTCCG 
GAGGTGGTGT TCCCCTGGCC CCCACTGTGC TGTCGCCGGA CGGGAAACTT CATCCCCCTC 
AACGAGGAGG GCTGCCGCCT GGGGCACATG GACTACCTGT TCACCAAGGC TGGAGTACAG 
TGGCACAATC TCAGCTCACT GCAGCGTCTG CCTCCCGGGT TCAAGGGATT CTCCCACCTC 
AGCTTCCAGA GCAGCTGGGA TTACAGGGCT GCTTCGAACA CATCGGCCAC GCCATCGACA 
GCTACACGTG GGGTATCTCG TGGTTTGGGT TTGCCATCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UPK1A ( XM_017026225.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881714.1 Homo sapiens uroplakin 1A (UPK1A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88167
Clone ID Related Accession (Same CDS sequence)	XM_017026225.1
Accession Version	XM_017026225.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	uroplakin-1a isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGGCGT CTGCGGCAGC AGCGGAGGCC GAGAAGGGAT CTCCAGTTGT GGTGGGCCTG 
CTAGTTGTGG GCAATATCAT TATTCTGCTG TCAGGCCTGT CCCTGTTTGC TGAGACCATA 
TGGGTGACAG CCGACCAGTA CCGTGTATAC CCACTGATGG GAGTCTCAGG CAAGGATGAC 
GTCTTCGCTG GTGCCTGGAT TGCCATCTTC TGCGGCTTCT CCTTCTTCAT GGTAGCCAGT 
TTTGGTGTGG GTGCCGCACT CTGCCGCCGC CGGTCCATGG TCCTCACGTA CCTGGTGCTC 
ATGCTCATCG TCTACATCTT CGAGTGCGCC TCCTGCATCA CGTCCTACAC CCACCGTGAC 
TACATGGTGT CCAACCCATC CCTGATCACC AAGCAGATGC TGACCTTCTA CAGCGCGGAC 
ACCGACCAGG GCCAGGAGCT GACCCGCCTC TGGGACCGCG TCATGATTGA GCAAGAATGC 
TGTGGCACAT CTGGTCCCAT GGACTGGGTG AACTTCACGT CAGCCTTCCG GGCGGCCACT 
CCGGAGGTGG TGTTCCCCTG GCCCCCACTG TGCTGTCGCC GGACGGGAAA CTTCATCCCC 
CTCAACGAGG AGGGCTGCCG CCTGGGGCAC ATGGACTACC TGTTCACCAA GGGCTGCTTC 
GAACACATCG GCCACGCCAT CGACAGCTAC ACGTGGGGTA TCTCGTGGTT TGGGTTTGCC 
ATCCTGATGT GGACGGAGGG GAAGGCAACA TACACACCCC GGACTCCTCC GCATCCTCCT 
CCTGCTTCCT CCGCTGGGCC TGGATGGCTG CCTCACCTCT CACCTCCCAA CGTCCCTAGC 
CCTTACGTCC TTCCACTTCC AAGATCTTTT TCCAGGTTCC TGAGCCCTAC TGTGTCTCAG 
GTGTGCCCTG AAACCCCAGG GCTTGTGTGC ACATATCCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881714.1
CDS	414..1355
Translation	MMASAAAAEAEKGSPVVVGLLVVGNIIILLSGLSLFAETIWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFMVASFGVGAALCRRRSMVLTYLVLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRVMIEQECCGTSGPMDWVNFTSAFRAATPEVVFPWPPLCCRRTGNFIPLNEEGCRLGHMDYLFTKGCFEHIGHAIDSYTWGISWFGFAILMWTEGKATYTPRTPPHPPPASSAGPGWLPHLSPPNVPSPYVLPLPRSFSRFLSPTVSQVCPETPGLVCTYP

Target ORF information:

RefSeq Version	XM_017026225.1
Organism	Homo sapiens(human)
Definition	Homo sapiens uroplakin 1A (UPK1A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026225.1

ORF Insert Sequence:

ATGATGGCGT CTGCGGCAGC AGCGGAGGCC GAGAAGGGAT CTCCAGTTGT GGTGGGCCTG 
CTAGTTGTGG GCAATATCAT TATTCTGCTG TCAGGCCTGT CCCTGTTTGC TGAGACCATA 
TGGGTGACAG CCGACCAGTA CCGTGTATAC CCACTGATGG GAGTCTCAGG CAAGGATGAC 
GTCTTCGCTG GTGCCTGGAT TGCCATCTTC TGCGGCTTCT CCTTCTTCAT GGTAGCCAGT 
TTTGGTGTGG GTGCCGCACT CTGCCGCCGC CGGTCCATGG TCCTCACGTA CCTGGTGCTC 
ATGCTCATCG TCTACATCTT CGAGTGCGCC TCCTGCATCA CGTCCTACAC CCACCGTGAC 
TACATGGTGT CCAACCCATC CCTGATCACC AAGCAGATGC TGACCTTCTA CAGCGCGGAC 
ACCGACCAGG GCCAGGAGCT GACCCGCCTC TGGGACCGCG TCATGATTGA GCAAGAATGC 
TGTGGCACAT CTGGTCCCAT GGACTGGGTG AACTTCACGT CAGCCTTCCG GGCGGCCACT 
CCGGAGGTGG TGTTCCCCTG GCCCCCACTG TGCTGTCGCC GGACGGGAAA CTTCATCCCC 
CTCAACGAGG AGGGCTGCCG CCTGGGGCAC ATGGACTACC TGTTCACCAA GGGCTGCTTC 
GAACACATCG GCCACGCCAT CGACAGCTAC ACGTGGGGTA TCTCGTGGTT TGGGTTTGCC 
ATCCTGATGT GGACGGAGGG GAAGGCAACA TACACACCCC GGACTCCTCC GCATCCTCCT 
CCTGCTTCCT CCGCTGGGCC TGGATGGCTG CCTCACCTCT CACCTCCCAA CGTCCCTAGC 
CCTTACGTCC TTCCACTTCC AAGATCTTTT TCCAGGTTCC TGAGCCCTAC TGTGTCTCAG 
GTGTGCCCTG AAACCCCAGG GCTTGTGTGC ACATATCCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic
Journal of immunology (Baltimore, Md. : 1950)198(7)2898-2905(2017 Apr)
Hashimoto J,Takahashi M,Saito A,Murata M,Kurimura Y,Nishitani C,Takamiya R,Uehara Y,Hasegawa Y,Hiyama Y,Sawada N,Takahashi S,Masumori N,Kuroki Y,Ariki S

Downregulation of UPK1A suppresses proliferation and enhances apoptosis of bladder transitional cell carcinoma cells.
Medical oncology (Northwood, London, England)32(3)84(2015 Mar)
Zhu H,Tang Y,Zhang X,Jiang X,Wang Y,Gan Y,Yang J

Reduced expression of uroplakin 1A is associated with the poor prognosis of gastric adenocarcinoma patients.
PloS one9(4)e93073(2014)
Zheng Y,Wang DD,Wang W,Pan K,Huang CY,Li YF,Wang QJ,Yuan SQ,Jiang SS,Qiu HB,Chen YM,Zhang XF,Zhao BW,Mai C,Xia JC,Zhou ZW

Decreased expression of uroplakin Ia is associated with colorectal cancer progression and poor survival of patients.
International journal of clinical and experimental pathology7(8)5031-7(2014)
He Y,Kong F,Du H,Wu M

Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma.
Cancer research70(21)8832-41(2010 Nov)
Kong KL,Kwong DL,Fu L,Chan TH,Chen L,Liu H,Li Y,Zhu YH,Bi J,Qin YR,Law SY,Guan XY

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UPK1A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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