B4GAT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	B4GAT1
Entrez Gene ID	11041
Full Name	beta-1,4-glucuronyltransferase 1
Synonyms	B3GN-T1,B3GNT1,B3GNT6,BETA3GNTI,MDDGA13,iGAT,iGNT
General protein information	Preferred Names beta-1,4-glucuronyltransferase 1 Names beta-1,4-glucuronyltransferase 1 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 beta-1,3-N-acetylglucosaminyltransferase bGnT-6 i-beta-1,3-N-acetylglucosaminyltransferase poly-N-acetyllactosamine extension enzyme
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.2
Summary	This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008].
Disorder MIM:	605517
Disorder Html:	Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 13, 615287 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006876.2	NP_006867.1	beta-1,4-glucuronyltransferase 1
NM_006876.3	NP_006867.1	beta-1,4-glucuronyltransferase 1

Pathways from BioSystems

Homologies

	B3GNT1	XP_001110420.1
Danio rerio (zebrafish)	b3gnt1	NP_001265757.1
Homo sapiens (human)	B3GNT1	NP_006867.1
Bos taurus (cattle)	B3GNT1	NP_001029980.1
Mus musculus (house mouse)	B3gnt1	NP_780592.1
Rattus norvegicus (Norway rat)	LOC100911750	XP_003749084.1
Xenopus tropicalis (tropical clawed frog)	b3gnt1	XP_002939368.1
Pan troglodytes (chimpanzee)	B3GNT1	XP_508571.2
Rattus norvegicus (Norway rat)	B3gnt1	NP_001099794.1
Drosophila melanogaster (fruit fly)	CG3253	NP_611886.1
Canis lupus familiaris (dog)	B3GNT1	XP_533222.4

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of ?-dystroglycan.
Praissman JL, Live DH, Wang S, Ramiah A, Chinoy ZS, Boons GJ, Moremen KW, Wells L
eLife3(2014 Oct)

The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated ?-dystroglycan functional glycosylation.
Willer T, Inamori K, Venzke D, Harvey C, Morgensen G, Hara Y, Beltr?n Valero de Bernab? D, Yu L, Wright KM, Campbell KP
eLife3(2014 Oct)

A truncating mutation in B3GNT1 causes severe Walker-Warburg syndrome.
Shaheen R, Faqeih E, Ansari S, Alkuraya FS
Neurogenetics14(3-4)243-5(2013 Nov)

Missense mutations in ?-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker-Warburg syndrome.
Buysse K, Riemersma M, Powell G, van Reeuwijk J, Chitayat D, Roscioli T, Kamsteeg EJ, van den Elzen C, van Beusekom E, Blaser S, Babul-Hirji R, Halliday W, Wright GJ, Stemple DL, Lin YY, Lefeber DJ, van Bokhoven H
Human molecular genetics22(9)1746-54(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

B4GAT1 is involved in the initiation of the LARGE-dependent repeating disaccharide that is necessary for extracellular matrix protein binding to O-mannosylated alpha-dystroglycan.
Title: B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of ?-dystroglycan.

report describes the first truncating mutation in B3GNT1 and confirms that this gene, which plays a role in alphaDG glycosylation, is a bona fide disease gene in Walker-Warburg syndrome
Title: A truncating mutation in B3GNT1 causes severe Walker-Warburg syndrome.

These functional studies identify an important role of B3GNT1 in the synthesis of the uncharacterized laminin-binding glycan of alpha-dystroglycan and implicate B3GNT1 as a novel causative gene for Walker-Warburg syndrome.
Title: Missense mutations in ?-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker-Warburg syndrome.

These results identify a previously undescribed role of carbohydrate-dependent cell-basement membrane interaction in tumor suppression and its control by beta3GnT1 and LARGE.
Title: Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase.

These results demonstrate that B3GNT1 and B4GALT1 physically associate in vitro and in cultured cells, providing insight into possible mechanisms for regulation of polyLacNAc production.
Title: Association of beta-1,3-N-acetylglucosaminyltransferase 1 and beta-1,4-galactosyltransferase 1, trans-Golgi enzymes involved in coupled poly-N-acetyllactosamine synthesis.

The following B4GAT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the B4GAT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18559	NM_006876.3 Latest version!	Homo sapiens beta-1,4-glucuronyltransferase 1 (B4GAT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18559	NM_006876.2	Homo sapiens beta-1,4-glucuronyltransferase 1 (B4GAT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

B4GAT1 ( NM_006876.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006867.1 Homo sapiens beta-1,4-glucuronyltransferase 1 (B4GAT1), mRNA.

Price & Availability↑

CloneID	OHu18559
Clone ID Related Accession (Same CDS sequence)	NM_006876.2 , NM_006876.3
Accession Version	NM_006876.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	beta-1,4-glucuronyltransferase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA169103.1 and AF029893.1. This sequence is a reference standard in the RefSeqGene project. On Apr 14, 2006 this sequence version replaced NM_006876.1. ##Evidence-Data-START## Transcript exon combination :: ERR279825.4412.1, SRR1660805.208667.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGATGT CCTACGCCAT CCGGTGCGCC TTCTACCAGC TGCTGCTGGC CGCGCTCATG 
CTGGTGGCGA TGCTGCAGCT GCTCTACCTG TCGCTGCTGT CCGGACTGCA CGGGCAGGAG 
GAGCAAGACC AATATTTTGA GTTCTTTCCC CCGTCCCCAC GGTCCGTGGA CCAGGTCAAG 
GCGCAGCTCC GCACCGCGCT GGCCTCTGGA GGCGTCCTGG ACGCTAGCGG CGATTACCGC 
GTCTACAGGG GCCTGCTGAA GACCACCATG GACCCCAACG ATGTGATCCT GGCCACGCAC 
GCCAGCGTGG ACAACCTGCT GCACCTGTCG GGTCTGCTGG AGCGCTGGGA GGGCCCGCTG 
TCCGTGTCGG TGTTCGCGGC CACCAAGGAG GAGGCGCAGC TGGCCACGGT GCTGGCCTAC 
GCGCTGAGCA GCCACTGCCC CGACATGCGC GCCAGGGTCG CCATGCACCT CGTGTGCCCC 
TCGCGTTACG AGGCAGCCGT GCCCGACCCC CGGGAGCCGG GGGAGTTTGC CCTGCTGCGG 
TCCTGCCAGG AGGTCTTTGA CAAGCTAGCC AGGGTGGCCC AGCCCGGGAT TAATTATGCG 
CTGGGCACCA ATGTCTCCTA CCCCAATAAC CTGCTGAGGA ATCTGGCTCG TGAGGGGGCC 
AACTATGCCC TGGTGATCGA TGTGGACATG GTGCCCAGCG AGGGGCTGTG GAGAGGCCTG 
CGGGAAATGC TGGATCAGAG CAACCAGTGG GGAGGCACCG CGCTGGTGGT GCCTGCCTTC 
GAAATCCGAA GAGCCCGCCG CATGCCCATG AACAAAAACG AGCTGGTGCA GCTCTACCAG 
GTTGGCGAGG TGCGGCCCTT CTATTATGGG TTGTGCACCC CCTGCCAGGC ACCCACCAAC 
TATTCCCGCT GGGTCAACCT GCCGGAAGAG AGCTTGCTGC GGCCCGCCTA CGTGGTACCT 
TGGCAGGACC CCTGGGAGCC ATTCTACGTG GCAGGAGGCA AGGTGCCCAC CTTCGACGAG 
CGCTTTCGGC AGTACGGCTT CAACCGAATC AGCCAGGCCT GCGAGCTGCA TGTGGCGGGG 
TTTGATTTTG AGGTCCTGAA CGAAGGTTTC TTGGTTCATA AGGGCTTCAA AGAAGCGTTG 
AAGTTCCATC CCCAAAAGGA GGCTGAAAAT CAGCACAATA AGATCCTATA TCGCCAGTTC 
AAACAGGAGT TGAAGGCCAA GTACCCCAAC TCTCCCCGAC GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006867.1
CDS	146..1393
Translation	MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVKAQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPLSVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLRSCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGLREMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTNYSRWVNLPEESLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAGFDFEVLNEGFLVHKGFKEALKFHPQKEAENQHNKILYRQFKQELKAKYPNSPRRC

Target ORF information:

RefSeq Version	NM_006876.2
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-1,4-glucuronyltransferase 1 (B4GAT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006876.2

ORF Insert Sequence:

ATGCAGATGT CCTACGCCAT CCGGTGCGCC TTCTACCAGC TGCTGCTGGC CGCGCTCATG 
CTGGTGGCGA TGCTGCAGCT GCTCTACCTG TCGCTGCTGT CCGGACTGCA CGGGCAGGAG 
GAGCAAGACC AATATTTTGA GTTCTTTCCC CCGTCCCCAC GGTCCGTGGA CCAGGTCAAG 
GCGCAGCTCC GCACCGCGCT GGCCTCTGGA GGCGTCCTGG ACGCTAGCGG CGATTACCGC 
GTCTACAGGG GCCTGCTGAA GACCACCATG GACCCCAACG ATGTGATCCT GGCCACGCAC 
GCCAGCGTGG ACAACCTGCT GCACCTGTCG GGTCTGCTGG AGCGCTGGGA GGGCCCGCTG 
TCCGTGTCGG TGTTCGCGGC CACCAAGGAG GAGGCGCAGC TGGCCACGGT GCTGGCCTAC 
GCGCTGAGCA GCCACTGCCC CGACATGCGC GCCAGGGTCG CCATGCACCT CGTGTGCCCC 
TCGCGTTACG AGGCAGCCGT GCCCGACCCC CGGGAGCCGG GGGAGTTTGC CCTGCTGCGG 
TCCTGCCAGG AGGTCTTTGA CAAGCTAGCC AGGGTGGCCC AGCCCGGGAT TAATTATGCG 
CTGGGCACCA ATGTCTCCTA CCCCAATAAC CTGCTGAGGA ATCTGGCTCG TGAGGGGGCC 
AACTATGCCC TGGTGATCGA TGTGGACATG GTGCCCAGCG AGGGGCTGTG GAGAGGCCTG 
CGGGAAATGC TGGATCAGAG CAACCAGTGG GGAGGCACCG CGCTGGTGGT GCCTGCCTTC 
GAAATCCGAA GAGCCCGCCG CATGCCCATG AACAAAAACG AGCTGGTGCA GCTCTACCAG 
GTTGGCGAGG TGCGGCCCTT CTATTATGGG TTGTGCACCC CCTGCCAGGC ACCCACCAAC 
TATTCCCGCT GGGTCAACCT GCCGGAAGAG AGCTTGCTGC GGCCCGCCTA CGTGGTACCT 
TGGCAGGACC CCTGGGAGCC ATTCTACGTG GCAGGAGGCA AGGTGCCCAC CTTCGACGAG 
CGCTTTCGGC AGTACGGCTT CAACCGAATC AGCCAGGCCT GCGAGCTGCA TGTGGCGGGG 
TTTGATTTTG AGGTCCTGAA CGAAGGTTTC TTGGTTCATA AGGGCTTCAA AGAAGCGTTG 
AAGTTCCATC CCCAAAAGGA GGCTGAAAAT CAGCACAATA AGATCCTATA TCGCCAGTTC 
AAACAGGAGT TGAAGGCCAA GTACCCCAAC TCTCCCCGAC GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

B4GAT1 ( NM_006876.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006867.1 Homo sapiens beta-1,4-glucuronyltransferase 1 (B4GAT1), mRNA.

Price & Availability↑

CloneID	OHu18559
Clone ID Related Accession (Same CDS sequence)	NM_006876.2 , NM_006876.3
Accession Version	NM_006876.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	beta-1,4-glucuronyltransferase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA169103.1 and AF029893.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006876.2. ##Evidence-Data-START## Transcript exon combination :: AK098389.1, SRR3476690.186016.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311181.5/ ENSP00000309096.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGATGT CCTACGCCAT CCGGTGCGCC TTCTACCAGC TGCTGCTGGC CGCGCTCATG 
CTGGTGGCGA TGCTGCAGCT GCTCTACCTG TCGCTGCTGT CCGGACTGCA CGGGCAGGAG 
GAGCAAGACC AATATTTTGA GTTCTTTCCC CCGTCCCCAC GGTCCGTGGA CCAGGTCAAG 
GCGCAGCTCC GCACCGCGCT GGCCTCTGGA GGCGTCCTGG ACGCTAGCGG CGATTACCGC 
GTCTACAGGG GCCTGCTGAA GACCACCATG GACCCCAACG ATGTGATCCT GGCCACGCAC 
GCCAGCGTGG ACAACCTGCT GCACCTGTCG GGTCTGCTGG AGCGCTGGGA GGGCCCGCTG 
TCCGTGTCGG TGTTCGCGGC CACCAAGGAG GAGGCGCAGC TGGCCACGGT GCTGGCCTAC 
GCGCTGAGCA GCCACTGCCC CGACATGCGC GCCAGGGTCG CCATGCACCT CGTGTGCCCC 
TCGCGTTACG AGGCAGCCGT GCCCGACCCC CGGGAGCCGG GGGAGTTTGC CCTGCTGCGG 
TCCTGCCAGG AGGTCTTTGA CAAGCTAGCC AGGGTGGCCC AGCCCGGGAT TAATTATGCG 
CTGGGCACCA ATGTCTCCTA CCCCAATAAC CTGCTGAGGA ATCTGGCTCG TGAGGGGGCC 
AACTATGCCC TGGTGATCGA TGTGGACATG GTGCCCAGCG AGGGGCTGTG GAGAGGCCTG 
CGGGAAATGC TGGATCAGAG CAACCAGTGG GGAGGCACCG CGCTGGTGGT GCCTGCCTTC 
GAAATCCGAA GAGCCCGCCG CATGCCCATG AACAAAAACG AGCTGGTGCA GCTCTACCAG 
GTTGGCGAGG TGCGGCCCTT CTATTATGGG TTGTGCACCC CCTGCCAGGC ACCCACCAAC 
TATTCCCGCT GGGTCAACCT GCCGGAAGAG AGCTTGCTGC GGCCCGCCTA CGTGGTACCT 
TGGCAGGACC CCTGGGAGCC ATTCTACGTG GCAGGAGGCA AGGTGCCCAC CTTCGACGAG 
CGCTTTCGGC AGTACGGCTT CAACCGAATC AGCCAGGCCT GCGAGCTGCA TGTGGCGGGG 
TTTGATTTTG AGGTCCTGAA CGAAGGTTTC TTGGTTCATA AGGGCTTCAA AGAAGCGTTG 
AAGTTCCATC CCCAAAAGGA GGCTGAAAAT CAGCACAATA AGATCCTATA TCGCCAGTTC 
AAACAGGAGT TGAAGGCCAA GTACCCCAAC TCTCCCCGAC GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006867.1
CDS	85..1332
Translation	MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVKAQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPLSVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLRSCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGLREMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTNYSRWVNLPEESLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAGFDFEVLNEGFLVHKGFKEALKFHPQKEAENQHNKILYRQFKQELKAKYPNSPRRC

Target ORF information:

RefSeq Version	NM_006876.3
Organism	Homo sapiens(human)
Definition	Homo sapiens beta-1,4-glucuronyltransferase 1 (B4GAT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006876.3

ORF Insert Sequence:

ATGCAGATGT CCTACGCCAT CCGGTGCGCC TTCTACCAGC TGCTGCTGGC CGCGCTCATG 
CTGGTGGCGA TGCTGCAGCT GCTCTACCTG TCGCTGCTGT CCGGACTGCA CGGGCAGGAG 
GAGCAAGACC AATATTTTGA GTTCTTTCCC CCGTCCCCAC GGTCCGTGGA CCAGGTCAAG 
GCGCAGCTCC GCACCGCGCT GGCCTCTGGA GGCGTCCTGG ACGCTAGCGG CGATTACCGC 
GTCTACAGGG GCCTGCTGAA GACCACCATG GACCCCAACG ATGTGATCCT GGCCACGCAC 
GCCAGCGTGG ACAACCTGCT GCACCTGTCG GGTCTGCTGG AGCGCTGGGA GGGCCCGCTG 
TCCGTGTCGG TGTTCGCGGC CACCAAGGAG GAGGCGCAGC TGGCCACGGT GCTGGCCTAC 
GCGCTGAGCA GCCACTGCCC CGACATGCGC GCCAGGGTCG CCATGCACCT CGTGTGCCCC 
TCGCGTTACG AGGCAGCCGT GCCCGACCCC CGGGAGCCGG GGGAGTTTGC CCTGCTGCGG 
TCCTGCCAGG AGGTCTTTGA CAAGCTAGCC AGGGTGGCCC AGCCCGGGAT TAATTATGCG 
CTGGGCACCA ATGTCTCCTA CCCCAATAAC CTGCTGAGGA ATCTGGCTCG TGAGGGGGCC 
AACTATGCCC TGGTGATCGA TGTGGACATG GTGCCCAGCG AGGGGCTGTG GAGAGGCCTG 
CGGGAAATGC TGGATCAGAG CAACCAGTGG GGAGGCACCG CGCTGGTGGT GCCTGCCTTC 
GAAATCCGAA GAGCCCGCCG CATGCCCATG AACAAAAACG AGCTGGTGCA GCTCTACCAG 
GTTGGCGAGG TGCGGCCCTT CTATTATGGG TTGTGCACCC CCTGCCAGGC ACCCACCAAC 
TATTCCCGCT GGGTCAACCT GCCGGAAGAG AGCTTGCTGC GGCCCGCCTA CGTGGTACCT 
TGGCAGGACC CCTGGGAGCC ATTCTACGTG GCAGGAGGCA AGGTGCCCAC CTTCGACGAG 
CGCTTTCGGC AGTACGGCTT CAACCGAATC AGCCAGGCCT GCGAGCTGCA TGTGGCGGGG 
TTTGATTTTG AGGTCCTGAA CGAAGGTTTC TTGGTTCATA AGGGCTTCAA AGAAGCGTTG 
AAGTTCCATC CCCAAAAGGA GGCTGAAAAT CAGCACAATA AGATCCTATA TCGCCAGTTC 
AAACAGGAGT TGAAGGCCAA GTACCCCAAC TCTCCCCGAC GCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of ?-dystroglycan.
eLife3(2014 Oct)
Praissman JL,Live DH,Wang S,Ramiah A,Chinoy ZS,Boons GJ,Moremen KW,Wells L

The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated ?-dystroglycan functional glycosylation.
eLife3(2014 Oct)
Willer T,Inamori K,Venzke D,Harvey C,Morgensen G,Hara Y,Beltr?n Valero de Bernab? D,Yu L,Wright KM,Campbell KP

A truncating mutation in B3GNT1 causes severe Walker-Warburg syndrome.
Neurogenetics14(3-4)243-5(2013 Nov)
Shaheen R,Faqeih E,Ansari S,Alkuraya FS

Missense mutations in ?-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker-Warburg syndrome.
Human molecular genetics22(9)1746-54(2013 May)
Buysse K,Riemersma M,Powell G,van Reeuwijk J,Chitayat D,Roscioli T,Kamsteeg EJ,van den Elzen C,van Beusekom E,Blaser S,Babul-Hirji R,Halliday W,Wright GJ,Stemple DL,Lin YY,Lefeber DJ,van Bokhoven H

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B4GAT1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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