SNRNP27 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNRNP27
Entrez Gene ID	11017
Full Name	small nuclear ribonucleoprotein U4/U6.U5 subunit 27
Synonyms	27K,RY1
General protein information	Preferred Names small nuclear ribonucleoprotein U4/U6.U5 subunit 27 Names U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein U4/U6.U5 tri-snRNP-associated 27 kDa protein U4/U6.U5 tri-snRNP-associated protein 3 U4/U6.U5-27K putative nucleic acid binding protein RY-1 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) small nuclear ribonucleoprotein, U4/U6.U5 27kDa subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.3
Summary	This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011].

mRNA and Protein(s)

mRNA	Protein	Name
NM_006857.3	NP_006848.1	U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
NM_006857.2	NP_006848.1	U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Snrnp27	NP_001102106.1
Mus musculus (house mouse)	Snrnp27	NP_079941.1
Pan troglodytes (chimpanzee)	SNRNP27	XP_003309132.1
Canis lupus familiaris (dog)	SNRNP27	XP_531856.2
Bos taurus (cattle)	SNRNP27	NP_001091631.1
Homo sapiens (human)	SNRNP27	NP_006848.1
	SNRNP27	XP_001097157.2

Gene Ontology
Bibliography

Related articles in PubMed

The protein interaction landscape of the human CMGC kinase group.
Varjosalo M, Keskitalo S, Van Drogen A, Nurkkala H, Vichalkovski A, Aebersold R, Gstaiger M
Cell reports3(4)1306-20(2013 Apr)

Dynamic protein-protein interaction wiring of the human spliceosome.
Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, L?hrmann R, Stelzl U
Molecular cell45(4)567-80(2012 Feb)

The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.
Liu S, Rauhut R, Vornlocher HP, L?hrmann R
RNA (New York, N.Y.)12(7)1418-30(2006 Jul)

The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase.
Fetzer S, Lauber J, Will CL, L?hrmann R
RNA (New York, N.Y.)3(4)344-55(1997 Apr)

Altered expression of a novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1.
Nakamura Y, Moriuchi R, Nakayama D, Yamashita I, Higashiyama Y, Yamamoto T, Kusano Y, Hino S, Miyamoto T, Katamine S
The Journal of general virology75 ( Pt 10)2625-33(1994 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SNRNP27 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNRNP27 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01247	NM_006857.3 Latest version!	Homo sapiens small nuclear ribonucleoprotein U4/U6.U5 subunit 27 (SNRNP27), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu01247	NM_006857.2	Homo sapiens small nuclear ribonucleoprotein U4/U6.U5 subunit 27 (SNRNP27), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNRNP27 ( NM_006857.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006848.1 Homo sapiens small nuclear ribonucleoprotein U4/U6.U5 subunit 27 (SNRNP27), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01247
Clone ID Related Accession (Same CDS sequence)	NM_006857.3 , NM_006857.2
Accession Version	NM_006857.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC019206.4, BC017890.1, X76302.1 and AW452063.1. On Nov 22, 2018 this sequence version replaced NM_006857.2. Transcript Variant: This variant (1) represents the longer transcript and encodes a functional protein. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.893936.1, SRR3476690.554754.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244227.8/ ENSP00000244227.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGTCGCA GTCGCAGCCG CTCTCCACGG AGGGAACGTA GGCGTTCCCG GTCCACATCC 
CGGGAGAGAG AACGCAGGCG CCGAGAAAGG TCCAGGTCTC GGGAGAGAGA TCGGAGAAGG 
AGCCGCTCGC GATCCCCGCA CCGAAGACGC TCCCGATCTC CAAGACGACA TAGATCCACA 
TCTCCTTCCC CTTCTCGACT GAAAGAAAGA AGAGATGAGG AAAAGAAAGA AACAAAAGAA 
ACAAAGAGCA AAGAACGGCA GATTACTGAG GAAGACTTAG AGGGCAAAAC AGAGGAAGAA 
ATAGAAATGA TGAAGTTAAT GGGATTTGCC TCCTTTGACT CCACAAAAGG TAAGAAGGTG 
GATGGCTCTG TAAATGCCTA TGCCATAAAT GTCTCTCAGA AGAGGAAGTA CAGGCAGTAC 
ATGAATCGAA AAGGTGGATT CAACAGACCT TTGGATTTCA TTGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006848.1
CDS	30..497
Translation	MGRSRSRSPRRERRRSRSTSRERERRRRERSRSRERDRRRSRSRSPHRRRSRSPRRHRSTSPSPSRLKERRDEEKKETKETKSKERQITEEDLEGKTEEEIEMMKLMGFASFDSTKGKKVDGSVNAYAINVSQKRKYRQYMNRKGGFNRPLDFIA

Target ORF information:

RefSeq Version	NM_006857.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear ribonucleoprotein U4/U6.U5 subunit 27 (SNRNP27), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006857.3

ORF Insert Sequence:

ATGGGTCGCA GTCGCAGCCG CTCTCCACGG AGGGAACGTA GGCGTTCCCG GTCCACATCC 
CGGGAGAGAG AACGCAGGCG CCGAGAAAGG TCCAGGTCTC GGGAGAGAGA TCGGAGAAGG 
AGCCGCTCGC GATCCCCGCA CCGAAGACGC TCCCGATCTC CAAGACGACA TAGATCCACA 
TCTCCTTCCC CTTCTCGACT GAAAGAAAGA AGAGATGAGG AAAAGAAAGA AACAAAAGAA 
ACAAAGAGCA AAGAACGGCA GATTACTGAG GAAGACTTAG AGGGCAAAAC AGAGGAAGAA 
ATAGAAATGA TGAAGTTAAT GGGATTTGCC TCCTTTGACT CCACAAAAGG TAAGAAGGTG 
GATGGCTCTG TAAATGCCTA TGCCATAAAT GTCTCTCAGA AGAGGAAGTA CAGGCAGTAC 
ATGAATCGAA AAGGTGGATT CAACAGACCT TTGGATTTCA TTGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNRNP27 ( NM_006857.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006848.1 Homo sapiens small nuclear ribonucleoprotein U4/U6.U5 subunit 27 (SNRNP27), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01247
Clone ID Related Accession (Same CDS sequence)	NM_006857.3 , NM_006857.2
Accession Version	NM_006857.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC019206.4, BC017890.1, X76302.1 and AW452063.1. On Feb 16, 2011 this sequence version replaced NM_006857.1. Transcript Variant: This variant (1) represents the longer transcript and encodes a functional protein. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.286131.1, SRR1660805.199444.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTCGCA GTCGCAGCCG CTCTCCACGG AGGGAACGTA GGCGTTCCCG GTCCACATCC 
CGGGAGAGAG AACGCAGGCG CCGAGAAAGG TCCAGGTCTC GGGAGAGAGA TCGGAGAAGG 
AGCCGCTCGC GATCCCCGCA CCGAAGACGC TCCCGATCTC CAAGACGACA TAGATCCACA 
TCTCCTTCCC CTTCTCGACT GAAAGAAAGA AGAGATGAGG AAAAGAAAGA AACAAAAGAA 
ACAAAGAGCA AAGAACGGCA GATTACTGAG GAAGACTTAG AGGGCAAAAC AGAGGAAGAA 
ATAGAAATGA TGAAGTTAAT GGGATTTGCC TCCTTTGACT CCACAAAAGG TAAGAAGGTG 
GATGGCTCTG TAAATGCCTA TGCCATAAAT GTCTCTCAGA AGAGGAAGTA CAGGCAGTAC 
ATGAATCGAA AAGGTGGATT CAACAGACCT TTGGATTTCA TTGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006848.1
CDS	43..510
Translation	MGRSRSRSPRRERRRSRSTSRERERRRRERSRSRERDRRRSRSRSPHRRRSRSPRRHRSTSPSPSRLKERRDEEKKETKETKSKERQITEEDLEGKTEEEIEMMKLMGFASFDSTKGKKVDGSVNAYAINVSQKRKYRQYMNRKGGFNRPLDFIA

Target ORF information:

RefSeq Version	NM_006857.2
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear ribonucleoprotein U4/U6.U5 subunit 27 (SNRNP27), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006857.2

ORF Insert Sequence:

ATGGGTCGCA GTCGCAGCCG CTCTCCACGG AGGGAACGTA GGCGTTCCCG GTCCACATCC 
CGGGAGAGAG AACGCAGGCG CCGAGAAAGG TCCAGGTCTC GGGAGAGAGA TCGGAGAAGG 
AGCCGCTCGC GATCCCCGCA CCGAAGACGC TCCCGATCTC CAAGACGACA TAGATCCACA 
TCTCCTTCCC CTTCTCGACT GAAAGAAAGA AGAGATGAGG AAAAGAAAGA AACAAAAGAA 
ACAAAGAGCA AAGAACGGCA GATTACTGAG GAAGACTTAG AGGGCAAAAC AGAGGAAGAA 
ATAGAAATGA TGAAGTTAAT GGGATTTGCC TCCTTTGACT CCACAAAAGG TAAGAAGGTG 
GATGGCTCTG TAAATGCCTA TGCCATAAAT GTCTCTCAGA AGAGGAAGTA CAGGCAGTAC 
ATGAATCGAA AAGGTGGATT CAACAGACCT TTGGATTTCA TTGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The protein interaction landscape of the human CMGC kinase group.
Cell reports3(4)1306-20(2013 Apr)
Varjosalo M,Keskitalo S,Van Drogen A,Nurkkala H,Vichalkovski A,Aebersold R,Gstaiger M

Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,L?hrmann R,Stelzl U

The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.
RNA (New York, N.Y.)12(7)1418-30(2006 Jul)
Liu S,Rauhut R,Vornlocher HP,L?hrmann R

The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase.
RNA (New York, N.Y.)3(4)344-55(1997 Apr)
Fetzer S,Lauber J,Will CL,L?hrmann R

Altered expression of a novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1.
The Journal of general virology75 ( Pt 10)2625-33(1994 Oct)
Nakamura Y,Moriuchi R,Nakayama D,Yamashita I,Higashiyama Y,Yamamoto T,Kusano Y,Hino S,Miyamoto T,Katamine S

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SNRNP27 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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