KDELR2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KDELR2
Entrez Gene ID	11014
Full Name	KDEL endoplasmic reticulum protein retention receptor 2
Synonyms	ELP-1,ERD2.2
General protein information	Preferred Names KDEL endoplasmic reticulum protein retention receptor 2 Names ER lumen protein-retaining receptor 2 (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 ERD-2-like protein ERD2-like protein 1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 KDEL receptor 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p22.1
Summary	Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:	609024

mRNA and Protein(s)

mRNA	Protein	Name
NM_006854.3	NP_006845.1	ER lumen protein-retaining receptor 2 isoform 1
NM_006854.4	NP_006845.1	ER lumen protein-retaining receptor 2 isoform 1
NM_001100603.2	NP_001094073.1	ER lumen protein-retaining receptor 2 isoform 2
NM_001100603.1	NP_001094073.1	ER lumen protein-retaining receptor 2 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	KDELR2	NP_006845.1
Canis lupus familiaris (dog)	KDELR2	XP_850429.1
Caenorhabditis elegans (roundworm)	erd-2	NP_509703.1
Arabidopsis thaliana (thale cress)	ERD2B	NP_566758.1
Oryza sativa (rice)	Os11g0473000	NP_001067881.1
Xenopus tropicalis (tropical clawed frog)	kdelr1	NP_989381.1
Bos taurus (cattle)	KDELR2	NP_001073247.1
Mus musculus (house mouse)	Kdelr2	NP_080117.1
Danio rerio (zebrafish)	kdelr2a	NP_956397.1
Danio rerio (zebrafish)	kdelr2b	NP_997860.1
Caenorhabditis elegans (roundworm)	C28H8.4	NP_498282.1
	KDELR2	XP_001090796.1
Rattus norvegicus (Norway rat)	Kdelr2	NP_001013140.1
Gallus gallus (chicken)	KDELR2	NP_001153187.1
Oryza sativa (rice)	Os04g0376700	NP_001052584.1

Gene Ontology
Bibliography

Related articles in PubMed

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.
Ek WE, Reznichenko A, Ripke S, Niesler B, Zucchelli M, Rivera NV, Schmidt PT, Pedersen NL, Magnusson P, Talley NJ, Holliday EG, Houghton L, Gazouli M, Karamanolis G, Rappold G, Burwinkel B, Surowy H, Rafter J, Assadi G, Li L, Papadaki E, Gambaccini D, Marchi S, Colucci R, Blandizzi C, Barbaro R, Karling P, Walter S, Ohlsson B, Tornblom H, Bresso F, Andreasson A, Dlugosz A, Simren M, Agreus L, Lindberg G, Boeckxstaens G, Bellini M, Stanghellini V, Barbara G, Daly MJ, Camilleri M, Wouters MM, D'Amato M
Gut64(11)1774-82(2015 Nov)

A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation.
Ruggiero C, Fragassi G, Grossi M, Picciani B, Di Martino R, Capitani M, Buccione R, Luini A, Sallese M
Oncotarget6(5)3375-93(2015 Feb)

Phosphorylation of Elp1 by Hrr25 is required for elongator-dependent tRNA modification in yeast.
Abdel-Fattah W, Jablonowski D, Di Santo R, Th?ring KL, Scheidt V, Hammermeister A, Ten Have S, Helm M, Schaffrath R, Stark MJ
PLoS genetics11(1)e1004931(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A Golgi-based KDELR-dependent signalling pathway controls invadopodia-dependent extracellular matrix degradation.
Title: A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation.

Hrr25 protein kinase directly modifies Elp1 on two sites and we provide evidence that phosphorylation plays a positive role in the tRNA modification
Title: Phosphorylation of Elp1 by Hrr25 is required for elongator-dependent tRNA modification in yeast.

The following KDELR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KDELR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28377	NM_001100603.2 Latest version!	Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28402	NM_006854.4 Latest version!	Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu28402	NM_006854.3	Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu28377	NM_001100603.1	Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KDELR2 ( NM_001100603.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001094073.1 Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28377
Clone ID Related Accession (Same CDS sequence)	NM_001100603.2 , NM_001100603.1
Accession Version	NM_001100603.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	ER lumen protein-retaining receptor 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC071982.1, AC072052.6 and AK124072.1. On May 31, 2019 this sequence version replaced NM_001100603.1. Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.269466.1, SRR1803613.183049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACATTT TCCGGCTGAC TGGGGACCTG TCCCACCTGG CGGCCATCGT CATCCTGCTG 
CTGAAGATCT GGAAGACGCG CTCCTGCGCC GGTATTTCTG GGAAAAGCCA GCTTCTGTTT 
GCACTGGTCT TCACAACTCG TTACCTGGAT CTTTTTACTT CATTTATTTC ATTGTATAAC 
ACATCTATGA AGGTTATCTA CCTTGCCTGC TCCTATGCCA CAGTGTACCT GATCTACCTG 
AAATTTAAGG CAACCTACGA TGGAAATCAT GATACCTTCC GAGTGGAGTT TCTGGTGGTC 
CCTGTGGGAG GCCTCTCATT TTTAGTTAAT CACGATTTCT CTCCTCTTGA GTACTCAAGG 
GAAAGAAGCT CAGTTTGCCA GCATAAGTGC CAAAGACCAT CACCAGCATC TGTCCTTCAG 
GGTGCTCGGA CAGAATTCTT ACCACAGCAA AGGCATAAGA TGCTTGATAC GGAAAATCAG 
AAACTTAACT CTTTTGTTGC AGATAGTCAT CAGTGGCTCT GTAAAAACGC AGAGGAAAAG 
AGCCAGAAGG TTTCTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094073.1
CDS	96..656
Translation	MNIFRLTGDLSHLAAIVILLLKIWKTRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYNTSMKVIYLACSYATVYLIYLKFKATYDGNHDTFRVEFLVVPVGGLSFLVNHDFSPLEYSRERSSVCQHKCQRPSPASVLQGARTEFLPQQRHKMLDTENQKLNSFVADSHQWLCKNAEEKSQKVSV

Target ORF information:

RefSeq Version	NM_001100603.2
Organism	Homo sapiens(human)
Definition	Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100603.2

ORF Insert Sequence:

ATGAACATTT TCCGGCTGAC TGGGGACCTG TCCCACCTGG CGGCCATCGT CATCCTGCTG 
CTGAAGATCT GGAAGACGCG CTCCTGCGCC GGTATTTCTG GGAAAAGCCA GCTTCTGTTT 
GCACTGGTCT TCACAACTCG TTACCTGGAT CTTTTTACTT CATTTATTTC ATTGTATAAC 
ACATCTATGA AGGTTATCTA CCTTGCCTGC TCCTATGCCA CAGTGTACCT GATCTACCTG 
AAATTTAAGG CAACCTACGA TGGAAATCAT GATACCTTCC GAGTGGAGTT TCTGGTGGTC 
CCTGTGGGAG GCCTCTCATT TTTAGTTAAT CACGATTTCT CTCCTCTTGA GTACTCAAGG 
GAAAGAAGCT CAGTTTGCCA GCATAAGTGC CAAAGACCAT CACCAGCATC TGTCCTTCAG 
GGTGCTCGGA CAGAATTCTT ACCACAGCAA AGGCATAAGA TGCTTGATAC GGAAAATCAG 
AAACTTAACT CTTTTGTTGC AGATAGTCAT CAGTGGCTCT GTAAAAACGC AGAGGAAAAG 
AGCCAGAAGG TTTCTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KDELR2 ( NM_001100603.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001094073.1 Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28377
Clone ID Related Accession (Same CDS sequence)	NM_001100603.2 , NM_001100603.1
Accession Version	NM_001100603.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	ER lumen protein-retaining receptor 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA713413.1, BC071982.1, AC072052.6, AK124072.1 and AV660600.1. Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.269466.1, SRR1803613.183049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACATTT TCCGGCTGAC TGGGGACCTG TCCCACCTGG CGGCCATCGT CATCCTGCTG 
CTGAAGATCT GGAAGACGCG CTCCTGCGCC GGTATTTCTG GGAAAAGCCA GCTTCTGTTT 
GCACTGGTCT TCACAACTCG TTACCTGGAT CTTTTTACTT CATTTATTTC ATTGTATAAC 
ACATCTATGA AGGTTATCTA CCTTGCCTGC TCCTATGCCA CAGTGTACCT GATCTACCTG 
AAATTTAAGG CAACCTACGA TGGAAATCAT GATACCTTCC GAGTGGAGTT TCTGGTGGTC 
CCTGTGGGAG GCCTCTCATT TTTAGTTAAT CACGATTTCT CTCCTCTTGA GTACTCAAGG 
GAAAGAAGCT CAGTTTGCCA GCATAAGTGC CAAAGACCAT CACCAGCATC TGTCCTTCAG 
GGTGCTCGGA CAGAATTCTT ACCACAGCAA AGGCATAAGA TGCTTGATAC GGAAAATCAG 
AAACTTAACT CTTTTGTTGC AGATAGTCAT CAGTGGCTCT GTAAAAACGC AGAGGAAAAG 
AGCCAGAAGG TTTCTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094073.1
CDS	162..722
Translation	MNIFRLTGDLSHLAAIVILLLKIWKTRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYNTSMKVIYLACSYATVYLIYLKFKATYDGNHDTFRVEFLVVPVGGLSFLVNHDFSPLEYSRERSSVCQHKCQRPSPASVLQGARTEFLPQQRHKMLDTENQKLNSFVADSHQWLCKNAEEKSQKVSV

Target ORF information:

RefSeq Version	NM_001100603.1
Organism	Homo sapiens(human)
Definition	Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100603.1

ORF Insert Sequence:

ATGAACATTT TCCGGCTGAC TGGGGACCTG TCCCACCTGG CGGCCATCGT CATCCTGCTG 
CTGAAGATCT GGAAGACGCG CTCCTGCGCC GGTATTTCTG GGAAAAGCCA GCTTCTGTTT 
GCACTGGTCT TCACAACTCG TTACCTGGAT CTTTTTACTT CATTTATTTC ATTGTATAAC 
ACATCTATGA AGGTTATCTA CCTTGCCTGC TCCTATGCCA CAGTGTACCT GATCTACCTG 
AAATTTAAGG CAACCTACGA TGGAAATCAT GATACCTTCC GAGTGGAGTT TCTGGTGGTC 
CCTGTGGGAG GCCTCTCATT TTTAGTTAAT CACGATTTCT CTCCTCTTGA GTACTCAAGG 
GAAAGAAGCT CAGTTTGCCA GCATAAGTGC CAAAGACCAT CACCAGCATC TGTCCTTCAG 
GGTGCTCGGA CAGAATTCTT ACCACAGCAA AGGCATAAGA TGCTTGATAC GGAAAATCAG 
AAACTTAACT CTTTTGTTGC AGATAGTCAT CAGTGGCTCT GTAAAAACGC AGAGGAAAAG 
AGCCAGAAGG TTTCTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KDELR2 ( NM_006854.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006845.1 Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28402
Clone ID Related Accession (Same CDS sequence)	NM_006854.3 , NM_006854.4
Accession Version	NM_006854.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ER lumen protein-retaining receptor 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA713413.1, AL547016.3, AC072052.6, AK124072.1 and AV660600.1. On Aug 3, 2007 this sequence version replaced NM_006854.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1803616.114739.1, SRR1803611.78123.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACATTT TCCGGCTGAC TGGGGACCTG TCCCACCTGG CGGCCATCGT CATCCTGCTG 
CTGAAGATCT GGAAGACGCG CTCCTGCGCC GGTATTTCTG GGAAAAGCCA GCTTCTGTTT 
GCACTGGTCT TCACAACTCG TTACCTGGAT CTTTTTACTT CATTTATTTC ATTGTATAAC 
ACATCTATGA AGGTTATCTA CCTTGCCTGC TCCTATGCCA CAGTGTACCT GATCTACCTG 
AAATTTAAGG CAACCTACGA TGGAAATCAT GATACCTTCC GAGTGGAGTT TCTGGTGGTC 
CCTGTGGGAG GCCTCTCATT TTTAGTTAAT CACGATTTCT CTCCTCTTGA GATCCTCTGG 
ACCTTCTCCA TCTACCTGGA GTCCGTGGCT ATCCTTCCGC AGCTATTTAT GATCAGCAAG 
ACTGGGGAGG CCGAGACCAT CACCACCCAC TACCTGTTCT TCCTGGGCCT CTATCGTGCT 
TTGTATCTTG TCAACTGGAT CTGGCGCTTC TACTTTGAGG GCTTCTTTGA CCTCATTGCT 
GTGGTGGCCG GCGTAGTCCA GACCATCCTA TACTGTGACT TCTTCTACTT GTACATTACA 
AAAGTACTCA AGGGAAAGAA GCTCAGTTTG CCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006845.1
CDS	162..800
Translation	MNIFRLTGDLSHLAAIVILLLKIWKTRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYNTSMKVIYLACSYATVYLIYLKFKATYDGNHDTFRVEFLVVPVGGLSFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLVNWIWRFYFEGFFDLIAVVAGVVQTILYCDFFYLYITKVLKGKKLSLPA

Target ORF information:

RefSeq Version	NM_006854.3
Organism	Homo sapiens(human)
Definition	Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006854.3

ORF Insert Sequence:

ATGAACATTT TCCGGCTGAC TGGGGACCTG TCCCACCTGG CGGCCATCGT CATCCTGCTG 
CTGAAGATCT GGAAGACGCG CTCCTGCGCC GGTATTTCTG GGAAAAGCCA GCTTCTGTTT 
GCACTGGTCT TCACAACTCG TTACCTGGAT CTTTTTACTT CATTTATTTC ATTGTATAAC 
ACATCTATGA AGGTTATCTA CCTTGCCTGC TCCTATGCCA CAGTGTACCT GATCTACCTG 
AAATTTAAGG CAACCTACGA TGGAAATCAT GATACCTTCC GAGTGGAGTT TCTGGTGGTC 
CCTGTGGGAG GCCTCTCATT TTTAGTTAAT CACGATTTCT CTCCTCTTGA GATCCTCTGG 
ACCTTCTCCA TCTACCTGGA GTCCGTGGCT ATCCTTCCGC AGCTATTTAT GATCAGCAAG 
ACTGGGGAGG CCGAGACCAT CACCACCCAC TACCTGTTCT TCCTGGGCCT CTATCGTGCT 
TTGTATCTTG TCAACTGGAT CTGGCGCTTC TACTTTGAGG GCTTCTTTGA CCTCATTGCT 
GTGGTGGCCG GCGTAGTCCA GACCATCCTA TACTGTGACT TCTTCTACTT GTACATTACA 
AAAGTACTCA AGGGAAAGAA GCTCAGTTTG CCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KDELR2 ( NM_006854.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006845.1 Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28402
Clone ID Related Accession (Same CDS sequence)	NM_006854.3 , NM_006854.4
Accession Version	NM_006854.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	ER lumen protein-retaining receptor 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA713413.1, AL547016.3, AC072052.6 and AK124072.1. On Nov 22, 2018 this sequence version replaced NM_006854.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR3476690.445187.1, SRR1803615.128608.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000258739.9/ ENSP00000258739.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACATTT TCCGGCTGAC TGGGGACCTG TCCCACCTGG CGGCCATCGT CATCCTGCTG 
CTGAAGATCT GGAAGACGCG CTCCTGCGCC GGTATTTCTG GGAAAAGCCA GCTTCTGTTT 
GCACTGGTCT TCACAACTCG TTACCTGGAT CTTTTTACTT CATTTATTTC ATTGTATAAC 
ACATCTATGA AGGTTATCTA CCTTGCCTGC TCCTATGCCA CAGTGTACCT GATCTACCTG 
AAATTTAAGG CAACCTACGA TGGAAATCAT GATACCTTCC GAGTGGAGTT TCTGGTGGTC 
CCTGTGGGAG GCCTCTCATT TTTAGTTAAT CACGATTTCT CTCCTCTTGA GATCCTCTGG 
ACCTTCTCCA TCTACCTGGA GTCCGTGGCT ATCCTTCCGC AGCTATTTAT GATCAGCAAG 
ACTGGGGAGG CCGAGACCAT CACCACCCAC TACCTGTTCT TCCTGGGCCT CTATCGTGCT 
TTGTATCTTG TCAACTGGAT CTGGCGCTTC TACTTTGAGG GCTTCTTTGA CCTCATTGCT 
GTGGTGGCCG GCGTAGTCCA GACCATCCTA TACTGTGACT TCTTCTACTT GTACATTACA 
AAAGTACTCA AGGGAAAGAA GCTCAGTTTG CCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006845.1
CDS	96..734
Translation	MNIFRLTGDLSHLAAIVILLLKIWKTRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYNTSMKVIYLACSYATVYLIYLKFKATYDGNHDTFRVEFLVVPVGGLSFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLVNWIWRFYFEGFFDLIAVVAGVVQTILYCDFFYLYITKVLKGKKLSLPA

Target ORF information:

RefSeq Version	NM_006854.4
Organism	Homo sapiens(human)
Definition	Homo sapiens KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006854.4

ORF Insert Sequence:

ATGAACATTT TCCGGCTGAC TGGGGACCTG TCCCACCTGG CGGCCATCGT CATCCTGCTG 
CTGAAGATCT GGAAGACGCG CTCCTGCGCC GGTATTTCTG GGAAAAGCCA GCTTCTGTTT 
GCACTGGTCT TCACAACTCG TTACCTGGAT CTTTTTACTT CATTTATTTC ATTGTATAAC 
ACATCTATGA AGGTTATCTA CCTTGCCTGC TCCTATGCCA CAGTGTACCT GATCTACCTG 
AAATTTAAGG CAACCTACGA TGGAAATCAT GATACCTTCC GAGTGGAGTT TCTGGTGGTC 
CCTGTGGGAG GCCTCTCATT TTTAGTTAAT CACGATTTCT CTCCTCTTGA GATCCTCTGG 
ACCTTCTCCA TCTACCTGGA GTCCGTGGCT ATCCTTCCGC AGCTATTTAT GATCAGCAAG 
ACTGGGGAGG CCGAGACCAT CACCACCCAC TACCTGTTCT TCCTGGGCCT CTATCGTGCT 
TTGTATCTTG TCAACTGGAT CTGGCGCTTC TACTTTGAGG GCTTCTTTGA CCTCATTGCT 
GTGGTGGCCG GCGTAGTCCA GACCATCCTA TACTGTGACT TCTTCTACTT GTACATTACA 
AAAGTACTCA AGGGAAAGAA GCTCAGTTTG CCAGCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.
Gut64(11)1774-82(2015 Nov)
Ek WE,Reznichenko A,Ripke S,Niesler B,Zucchelli M,Rivera NV,Schmidt PT,Pedersen NL,Magnusson P,Talley NJ,Holliday EG,Houghton L,Gazouli M,Karamanolis G,Rappold G,Burwinkel B,Surowy H,Rafter J,Assadi G,Li L,Papadaki E,Gambaccini D,Marchi S,Colucci R,Blandizzi C,Barbaro R,Karling P,Walter S,Ohlsson B,Tornblom H,Bresso F,Andreasson A,Dlugosz A,Simren M,Agreus L,Lindberg G,Boeckxstaens G,Bellini M,Stanghellini V,Barbara G,Daly MJ,Camilleri M,Wouters MM,D'Amato M

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Oncotarget6(5)3375-93(2015 Feb)
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Phosphorylation of Elp1 by Hrr25 is required for elongator-dependent tRNA modification in yeast.
PLoS genetics11(1)e1004931(2015 Jan)
Abdel-Fattah W,Jablonowski D,Di Santo R,Th?ring KL,Scheidt V,Hammermeister A,Ten Have S,Helm M,Schaffrath R,Stark MJ

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KDELR2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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