CBX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CBX1
Entrez Gene ID	10951
Full Name	chromobox 1
Synonyms	CBX,HP1-BETA,HP1Hs-beta,HP1Hsbeta,M31,MOD1,p25beta
General protein information	Preferred Names chromobox 1 Names chromobox protein homolog 1 HP1 beta homolog chromobox homolog 1 (HP1 beta homolog Drosophila ) heterochromatin protein 1 homolog beta heterochromatin protein 1-beta heterochromatin protein p25 beta modifier 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.32
Summary	This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	604511

mRNA and Protein(s)

mRNA	Protein	Name
NM_001127228.2	NP_001120700.1	chromobox protein homolog 1
NM_001127228.1	NP_001120700.1	chromobox protein homolog 1
NM_006807.4	NP_006798.1	chromobox protein homolog 1
NM_006807.5	NP_006798.1	chromobox protein homolog 1

Pathways from BioSystems

Homologies

	LOC697437	XP_001088037.1
Homo sapiens (human)	CBX1	NP_006798.1
Canis lupus familiaris (dog)	CBX1	XP_548171.1
Bos taurus (cattle)	CBX1	NP_001193344.1
Mus musculus (house mouse)	Cbx1	NP_031648.1
Danio rerio (zebrafish)	cbx1b	NP_001002090.1
Pan troglodytes (chimpanzee)	CBX1	NP_001239487.1
Gallus gallus (chicken)	CBX1	NP_989663.1
Danio rerio (zebrafish)	cbx1a	NP_956040.1
Bos taurus (cattle)	LOC101904753	XP_005210243.1
Rattus norvegicus (Norway rat)	Cbx1	XP_006247297.1
Drosophila melanogaster (fruit fly)	HP1b	NP_001162713.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004723	XP_318105.4
Xenopus tropicalis (tropical clawed frog)	cbx1	NP_001017150.1

Gene Ontology
Bibliography

Related articles in PubMed

Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1.
Liu Y, Qin S, Lei M, Tempel W, Zhang Y, Loppnau P, Li Y, Min J
The Journal of biological chemistry292(14)5655-5664(2017 04)

A High-Density Map for Navigating the Human Polycomb Complexome.
Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C
Cell reports17(2)583-595(2016 10)

Dynamic and flexible H3K9me3 bridging via HP1? dimerization establishes a plastic state of condensed chromatin.
Hiragami-Hamada K, Soeroes S, Nikolov M, Wilkins B, Kreuz S, Chen C, De La Rosa-Vel?zquez IA, Zenn HM, Kost N, Pohl W, Chernev A, Schwarzer D, Jenuwein T, Lorincz M, Zimmermann B, Walla PJ, Neumann H, Baubec T, Urlaub H, Fischle W
Nature communications711310(2016 Apr)

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.
Gilmore JM, Sardiu ME, Groppe BD, Thornton JL, Liu X, Dayebgadoh G, Banks CA, Slaughter BD, Unruh JR, Workman JL, Florens L, Washburn MP
PloS one11(6)e0155492(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the prolyl residue of the PXXVXL motif appears to play a role distinct from that of Pro in the known HP1beta CSD-PXVXL complexes.
Title: Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1.

Data show that heterochromatin protein 1-beta (HP1beta) is a prototypic HP1 protein exemplifying most basal chromatin binding and effects.
Title: Dynamic and flexible H3K9me3 bridging via HP1? dimerization establishes a plastic state of condensed chromatin.

increased HP1beta expression is associated with the poor prognosis in breast cancer
Title: HP1? is a biomarker for breast cancer prognosis and PARP inhibitor therapy.

Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.
Title: Heterochromatin protein 1 expression is reduced in human thyroid malignancy.

In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions.
Title: Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins.

The following CBX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CBX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26641	NM_006807.5 Latest version!	Homo sapiens chromobox 1 (CBX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26641	NM_001127228.2 Latest version!	Homo sapiens chromobox 1 (CBX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu26641	NM_001127228.1	Homo sapiens chromobox 1 (CBX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26641	NM_006807.4	Homo sapiens chromobox 1 (CBX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CBX1 ( NM_001127228.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001120700.1 Homo sapiens chromobox 1 (CBX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26641
Clone ID Related Accession (Same CDS sequence)	NM_001127228.2 , NM_001127228.1 , NM_006807.4 , NM_006807.5
Accession Version	NM_001127228.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	chromobox protein homolog 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA020204.1, DB026977.1, BC002609.1 and BC021302.2. On Nov 24, 2018 this sequence version replaced NM_001127228.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.928687.1, SRR1803613.3220.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000225603.9/ ENSP00000225603.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGAAAA AACAAAACAA GAAGAAAGTG GAGGAGGTGC TAGAAGAGGA GGAAGAGGAA 
TATGTGGTGG AAAAAGTTCT CGACCGTCGA GTGGTAAAGG GCAAAGTGGA GTACCTCCTA 
AAGTGGAAGG GATTCTCAGA TGAGGACAAC ACATGGGAGC CAGAAGAGAA CCTGGATTGC 
CCCGACCTCA TTGCTGAGTT TCTGCAGTCA CAGAAAACAG CACATGAGAC AGATAAATCA 
GAGGGAGGCA AGCGCAAAGC TGATTCTGAT TCTGAAGATA AGGGAGAGGA GAGCAAACCA 
AAGAAGAAGA AAGAAGAGTC AGAAAAGCCA CGAGGCTTTG CTCGAGGTTT GGAGCCGGAG 
CGGATTATTG GAGCTACAGA CTCCAGTGGA GAGCTCATGT TCCTGATGAA ATGGAAAAAC 
TCTGATGAGG CTGACCTGGT CCCTGCCAAG GAAGCCAATG TCAAGTGCCC ACAGGTTGTC 
ATATCCTTCT ATGAGGAAAG GCTGACGTGG CATTCCTACC CCTCGGAGGA TGATGACAAA 
AAAGATGACA AGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001120700.1
CDS	249..806
Translation	MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDKKDDKN

Target ORF information:

RefSeq Version	NM_001127228.2
Organism	Homo sapiens(human)
Definition	Homo sapiens chromobox 1 (CBX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127228.2

ORF Insert Sequence:

ATGGGGAAAA AACAAAACAA GAAGAAAGTG GAGGAGGTGC TAGAAGAGGA GGAAGAGGAA 
TATGTGGTGG AAAAAGTTCT CGACCGTCGA GTGGTAAAGG GCAAAGTGGA GTACCTCCTA 
AAGTGGAAGG GATTCTCAGA TGAGGACAAC ACATGGGAGC CAGAAGAGAA CCTGGATTGC 
CCCGACCTCA TTGCTGAGTT TCTGCAGTCA CAGAAAACAG CACATGAGAC AGATAAATCA 
GAGGGAGGCA AGCGCAAAGC TGATTCTGAT TCTGAAGATA AGGGAGAGGA GAGCAAACCA 
AAGAAGAAGA AAGAAGAGTC AGAAAAGCCA CGAGGCTTTG CTCGAGGTTT GGAGCCGGAG 
CGGATTATTG GAGCTACAGA CTCCAGTGGA GAGCTCATGT TCCTGATGAA ATGGAAAAAC 
TCTGATGAGG CTGACCTGGT CCCTGCCAAG GAAGCCAATG TCAAGTGCCC ACAGGTTGTC 
ATATCCTTCT ATGAGGAAAG GCTGACGTGG CATTCCTACC CCTCGGAGGA TGATGACAAA 
AAAGATGACA AGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CBX1 ( NM_001127228.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001120700.1 Homo sapiens chromobox 1 (CBX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26641
Clone ID Related Accession (Same CDS sequence)	NM_001127228.2 , NM_001127228.1 , NM_006807.4 , NM_006807.5
Accession Version	NM_001127228.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	chromobox protein homolog 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA020204.1, DB026977.1, BC002609.1 and BC021302.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002609.1, SRR1803613.3220.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAAAA AACAAAACAA GAAGAAAGTG GAGGAGGTGC TAGAAGAGGA GGAAGAGGAA 
TATGTGGTGG AAAAAGTTCT CGACCGTCGA GTGGTAAAGG GCAAAGTGGA GTACCTCCTA 
AAGTGGAAGG GATTCTCAGA TGAGGACAAC ACATGGGAGC CAGAAGAGAA CCTGGATTGC 
CCCGACCTCA TTGCTGAGTT TCTGCAGTCA CAGAAAACAG CACATGAGAC AGATAAATCA 
GAGGGAGGCA AGCGCAAAGC TGATTCTGAT TCTGAAGATA AGGGAGAGGA GAGCAAACCA 
AAGAAGAAGA AAGAAGAGTC AGAAAAGCCA CGAGGCTTTG CTCGAGGTTT GGAGCCGGAG 
CGGATTATTG GAGCTACAGA CTCCAGTGGA GAGCTCATGT TCCTGATGAA ATGGAAAAAC 
TCTGATGAGG CTGACCTGGT CCCTGCCAAG GAAGCCAATG TCAAGTGCCC ACAGGTTGTC 
ATATCCTTCT ATGAGGAAAG GCTGACGTGG CATTCCTACC CCTCGGAGGA TGATGACAAA 
AAAGATGACA AGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001120700.1
CDS	292..849
Translation	MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDKKDDKN

Target ORF information:

RefSeq Version	NM_001127228.1
Organism	Homo sapiens(human)
Definition	Homo sapiens chromobox 1 (CBX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127228.1

ORF Insert Sequence:

ATGGGGAAAA AACAAAACAA GAAGAAAGTG GAGGAGGTGC TAGAAGAGGA GGAAGAGGAA 
TATGTGGTGG AAAAAGTTCT CGACCGTCGA GTGGTAAAGG GCAAAGTGGA GTACCTCCTA 
AAGTGGAAGG GATTCTCAGA TGAGGACAAC ACATGGGAGC CAGAAGAGAA CCTGGATTGC 
CCCGACCTCA TTGCTGAGTT TCTGCAGTCA CAGAAAACAG CACATGAGAC AGATAAATCA 
GAGGGAGGCA AGCGCAAAGC TGATTCTGAT TCTGAAGATA AGGGAGAGGA GAGCAAACCA 
AAGAAGAAGA AAGAAGAGTC AGAAAAGCCA CGAGGCTTTG CTCGAGGTTT GGAGCCGGAG 
CGGATTATTG GAGCTACAGA CTCCAGTGGA GAGCTCATGT TCCTGATGAA ATGGAAAAAC 
TCTGATGAGG CTGACCTGGT CCCTGCCAAG GAAGCCAATG TCAAGTGCCC ACAGGTTGTC 
ATATCCTTCT ATGAGGAAAG GCTGACGTGG CATTCCTACC CCTCGGAGGA TGATGACAAA 
AAAGATGACA AGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CBX1 ( NM_006807.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006798.1 Homo sapiens chromobox 1 (CBX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26641
Clone ID Related Accession (Same CDS sequence)	NM_001127228.2 , NM_001127228.1 , NM_006807.4 , NM_006807.5
Accession Version	NM_006807.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	chromobox protein homolog 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA689514.1, BC021302.2, CB053834.1 and BC002609.1. On May 13, 2008 this sequence version replaced NM_006807.3. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.88998.1, SRR1660803.77090.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAAAA AACAAAACAA GAAGAAAGTG GAGGAGGTGC TAGAAGAGGA GGAAGAGGAA 
TATGTGGTGG AAAAAGTTCT CGACCGTCGA GTGGTAAAGG GCAAAGTGGA GTACCTCCTA 
AAGTGGAAGG GATTCTCAGA TGAGGACAAC ACATGGGAGC CAGAAGAGAA CCTGGATTGC 
CCCGACCTCA TTGCTGAGTT TCTGCAGTCA CAGAAAACAG CACATGAGAC AGATAAATCA 
GAGGGAGGCA AGCGCAAAGC TGATTCTGAT TCTGAAGATA AGGGAGAGGA GAGCAAACCA 
AAGAAGAAGA AAGAAGAGTC AGAAAAGCCA CGAGGCTTTG CTCGAGGTTT GGAGCCGGAG 
CGGATTATTG GAGCTACAGA CTCCAGTGGA GAGCTCATGT TCCTGATGAA ATGGAAAAAC 
TCTGATGAGG CTGACCTGGT CCCTGCCAAG GAAGCCAATG TCAAGTGCCC ACAGGTTGTC 
ATATCCTTCT ATGAGGAAAG GCTGACGTGG CATTCCTACC CCTCGGAGGA TGATGACAAA 
AAAGATGACA AGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006798.1
CDS	482..1039
Translation	MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDKKDDKN

Target ORF information:

RefSeq Version	NM_006807.4
Organism	Homo sapiens(human)
Definition	Homo sapiens chromobox 1 (CBX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006807.4

ORF Insert Sequence:

ATGGGGAAAA AACAAAACAA GAAGAAAGTG GAGGAGGTGC TAGAAGAGGA GGAAGAGGAA 
TATGTGGTGG AAAAAGTTCT CGACCGTCGA GTGGTAAAGG GCAAAGTGGA GTACCTCCTA 
AAGTGGAAGG GATTCTCAGA TGAGGACAAC ACATGGGAGC CAGAAGAGAA CCTGGATTGC 
CCCGACCTCA TTGCTGAGTT TCTGCAGTCA CAGAAAACAG CACATGAGAC AGATAAATCA 
GAGGGAGGCA AGCGCAAAGC TGATTCTGAT TCTGAAGATA AGGGAGAGGA GAGCAAACCA 
AAGAAGAAGA AAGAAGAGTC AGAAAAGCCA CGAGGCTTTG CTCGAGGTTT GGAGCCGGAG 
CGGATTATTG GAGCTACAGA CTCCAGTGGA GAGCTCATGT TCCTGATGAA ATGGAAAAAC 
TCTGATGAGG CTGACCTGGT CCCTGCCAAG GAAGCCAATG TCAAGTGCCC ACAGGTTGTC 
ATATCCTTCT ATGAGGAAAG GCTGACGTGG CATTCCTACC CCTCGGAGGA TGATGACAAA 
AAAGATGACA AGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CBX1 ( NM_006807.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006798.1 Homo sapiens chromobox 1 (CBX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26641
Clone ID Related Accession (Same CDS sequence)	NM_001127228.2 , NM_001127228.1 , NM_006807.4 , NM_006807.5
Accession Version	NM_006807.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	chromobox protein homolog 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA689514.1, BC021302.2, CB053834.1 and BC002609.1. On May 31, 2019 this sequence version replaced NM_006807.4. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021302.2, SRR5189667.394753.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAAAA AACAAAACAA GAAGAAAGTG GAGGAGGTGC TAGAAGAGGA GGAAGAGGAA 
TATGTGGTGG AAAAAGTTCT CGACCGTCGA GTGGTAAAGG GCAAAGTGGA GTACCTCCTA 
AAGTGGAAGG GATTCTCAGA TGAGGACAAC ACATGGGAGC CAGAAGAGAA CCTGGATTGC 
CCCGACCTCA TTGCTGAGTT TCTGCAGTCA CAGAAAACAG CACATGAGAC AGATAAATCA 
GAGGGAGGCA AGCGCAAAGC TGATTCTGAT TCTGAAGATA AGGGAGAGGA GAGCAAACCA 
AAGAAGAAGA AAGAAGAGTC AGAAAAGCCA CGAGGCTTTG CTCGAGGTTT GGAGCCGGAG 
CGGATTATTG GAGCTACAGA CTCCAGTGGA GAGCTCATGT TCCTGATGAA ATGGAAAAAC 
TCTGATGAGG CTGACCTGGT CCCTGCCAAG GAAGCCAATG TCAAGTGCCC ACAGGTTGTC 
ATATCCTTCT ATGAGGAAAG GCTGACGTGG CATTCCTACC CCTCGGAGGA TGATGACAAA 
AAAGATGACA AGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006798.1
CDS	470..1027
Translation	MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDKKDDKN

Target ORF information:

RefSeq Version	NM_006807.5
Organism	Homo sapiens(human)
Definition	Homo sapiens chromobox 1 (CBX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006807.5

ORF Insert Sequence:

ATGGGGAAAA AACAAAACAA GAAGAAAGTG GAGGAGGTGC TAGAAGAGGA GGAAGAGGAA 
TATGTGGTGG AAAAAGTTCT CGACCGTCGA GTGGTAAAGG GCAAAGTGGA GTACCTCCTA 
AAGTGGAAGG GATTCTCAGA TGAGGACAAC ACATGGGAGC CAGAAGAGAA CCTGGATTGC 
CCCGACCTCA TTGCTGAGTT TCTGCAGTCA CAGAAAACAG CACATGAGAC AGATAAATCA 
GAGGGAGGCA AGCGCAAAGC TGATTCTGAT TCTGAAGATA AGGGAGAGGA GAGCAAACCA 
AAGAAGAAGA AAGAAGAGTC AGAAAAGCCA CGAGGCTTTG CTCGAGGTTT GGAGCCGGAG 
CGGATTATTG GAGCTACAGA CTCCAGTGGA GAGCTCATGT TCCTGATGAA ATGGAAAAAC 
TCTGATGAGG CTGACCTGGT CCCTGCCAAG GAAGCCAATG TCAAGTGCCC ACAGGTTGTC 
ATATCCTTCT ATGAGGAAAG GCTGACGTGG CATTCCTACC CCTCGGAGGA TGATGACAAA 
AAAGATGACA AGAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1.
The Journal of biological chemistry292(14)5655-5664(2017 04)
Liu Y,Qin S,Lei M,Tempel W,Zhang Y,Loppnau P,Li Y,Min J

A High-Density Map for Navigating the Human Polycomb Complexome.
Cell reports17(2)583-595(2016 10)
Hauri S,Comoglio F,Seimiya M,Gerstung M,Glatter T,Hansen K,Aebersold R,Paro R,Gstaiger M,Beisel C

Dynamic and flexible H3K9me3 bridging via HP1? dimerization establishes a plastic state of condensed chromatin.
Nature communications711310(2016 Apr)
Hiragami-Hamada K,Soeroes S,Nikolov M,Wilkins B,Kreuz S,Chen C,De La Rosa-Vel?zquez IA,Zenn HM,Kost N,Pohl W,Chernev A,Schwarzer D,Jenuwein T,Lorincz M,Zimmermann B,Walla PJ,Neumann H,Baubec T,Urlaub H,Fischle W

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.
PloS one11(6)e0155492(2016)
Gilmore JM,Sardiu ME,Groppe BD,Thornton JL,Liu X,Dayebgadoh G,Banks CA,Slaughter BD,Unruh JR,Workman JL,Florens L,Washburn MP

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

CBX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報