HNRNPA0 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HNRNPA0
Entrez Gene ID	10949
Full Name	heterogeneous nuclear ribonucleoprotein A0
Synonyms	HNRPA0
General protein information	Preferred Names heterogeneous nuclear ribonucleoprotein A0 Names heterogeneous nuclear ribonucleoprotein A0 hnRNA binding protein hnRNP A0
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.2
Summary	This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008].
Disorder MIM:	609409

mRNA and Protein(s)

mRNA	Protein	Name
NM_006805.4	NP_006796.1	heterogeneous nuclear ribonucleoprotein A0
NM_006805.3	NP_006796.1	heterogeneous nuclear ribonucleoprotein A0

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HNRNPA0	XP_002689241.1
Rattus norvegicus (Norway rat)	LOC681410	XP_003751688.1
Mus musculus (house mouse)	Hnrnpa0	NP_084148.1
Xenopus tropicalis (tropical clawed frog)	hnrnpa0	NP_988923.1
Homo sapiens (human)	HNRNPA0	NP_006796.1
Gallus gallus (chicken)	HNRNPA0	XP_414620.2

Gene Ontology
Bibliography

Related articles in PubMed

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB
Cancer cell28(5)623-637(2015 Nov)

Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.
Young DJ, Stoddart A, Nakitandwe J, Chen SC, Qian Z, Downing JR, Le Beau MM
Haematologica99(6)1032-40(2014 Jun)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB
Molecular cell40(1)34-49(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that heterogeneous nuclear ribonucleoprotein A0 (hnRNPA0) drives chemo-resistance of p53-mutant tumor cells via p27Kip1/Gadd45alpha mRNAs.
Title: A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.

Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.
Title: Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.

Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.

The following HNRNPA0 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HNRNPA0 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30849	NM_006805.4 Latest version!	Homo sapiens heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu30849	NM_006805.3	Homo sapiens heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HNRNPA0 ( NM_006805.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006796.1 Homo sapiens heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0), mRNA.

Price & Availability↑

CloneID	OHu30849
Clone ID Related Accession (Same CDS sequence)	NM_006805.4 , NM_006805.3
Accession Version	NM_006805.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	heterogeneous nuclear ribonucleoprotein A0
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC106791.4, BC030249.1, AA081021.1, AA442538.1, BF445078.1 and BM968394.1. On May 17, 2019 this sequence version replaced NM_006805.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR7410570.251898.1, SRR7410570.251905.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000314940.7/ ENSP00000316042.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGAATT CTCAGTTGTG TAAGCTGTTC ATCGGCGGCC TCAATGTGCA GACGAGTGAG 
TCGGGCCTGC GCGGCCACTT TGAGGCCTTT GGGACTCTGA CGGACTGCGT GGTGGTGGTG 
AATCCCCAGA CCAAGCGCTC CCGTTGCTTT GGCTTCGTGA CCTACTCCAA TGTGGAGGAG 
GCGGACGCCG CCATGGCCGC CTCGCCCCAT GCCGTGGACG GCAACACTGT GGAGCTGAAG 
CGGGCGGTGT CCCGGGAGGA TTCGGCGCGG CCCGGTGCCC ACGCCAAGGT TAAGAAGCTC 
TTTGTCGGAG GCCTTAAAGG AGACGTGGCT GAGGGCGACC TGATCGAGCA CTTCTCGCAG 
TTTGGCACCG TGGAAAAGGC CGAGATTATT GCCGACAAGC AGTCCGGCAA GAAGCGTGGA 
TTCGGCTTCG TGTATTTCCA GAATCACGAC GCGGCAGACA AGGCCGCGGT GGTCAAGTTC 
CATCCGATTC AGGGCCATCG CGTGGAGGTG AAGAAAGCAG TCCCCAAGGA GGATATCTAC 
TCCGGTGGGG GTGGAGGCGG CTCCCGATCC TCCCGGGGCG GCCGAGGCGG CCGGGGGCGC 
GGCGGTGGTC GAGACCAGAA CGGCCTTTCC AAGGGCGGCG GCGGCGGTTA CAACAGCTAC 
GGTGGTTACG GCGGCGGCGG AGGCGGCGGC TACAATGCCT ACGGAGGCGG CGGCGGCGGT 
TCGTCCTACG GTGGGAGCGA CTACGGTAAC GGCTTCGGCG GCTTCGGCAG CTACAGCCAG 
CATCAGTCCT CCTATGGGCC CATGAAGAGC GGCGGCGGCG GCGGCGGTGG AGGCAGTAGC 
TGGGGCGGTC GCAGTAATAG TGGACCTTAC AGAGGCGGCT ATGGCGGTGG GGGTGGCTAT 
GGAGGCAGCT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006796.1
CDS	298..1215
Translation	MENSQLCKLFIGGLNVQTSESGLRGHFEAFGTLTDCVVVVNPQTKRSRCFGFVTYSNVEEADAAMAASPHAVDGNTVELKRAVSREDSARPGAHAKVKKLFVGGLKGDVAEGDLIEHFSQFGTVEKAEIIADKQSGKKRGFGFVYFQNHDAADKAAVVKFHPIQGHRVEVKKAVPKEDIYSGGGGGGSRSSRGGRGGRGRGGGRDQNGLSKGGGGGYNSYGGYGGGGGGGYNAYGGGGGGSSYGGSDYGNGFGGFGSYSQHQSSYGPMKSGGGGGGGGSSWGGRSNSGPYRGGYGGGGGYGGSSF

Target ORF information:

RefSeq Version	NM_006805.4
Organism	Homo sapiens(human)
Definition	Homo sapiens heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006805.4

ORF Insert Sequence:

ATGGAGAATT CTCAGTTGTG TAAGCTGTTC ATCGGCGGCC TCAATGTGCA GACGAGTGAG 
TCGGGCCTGC GCGGCCACTT TGAGGCCTTT GGGACTCTGA CGGACTGCGT GGTGGTGGTG 
AATCCCCAGA CCAAGCGCTC CCGTTGCTTT GGCTTCGTGA CCTACTCCAA TGTGGAGGAG 
GCGGACGCCG CCATGGCCGC CTCGCCCCAT GCCGTGGACG GCAACACTGT GGAGCTGAAG 
CGGGCGGTGT CCCGGGAGGA TTCGGCGCGG CCCGGTGCCC ACGCCAAGGT TAAGAAGCTC 
TTTGTCGGAG GCCTTAAAGG AGACGTGGCT GAGGGCGACC TGATCGAGCA CTTCTCGCAG 
TTTGGCACCG TGGAAAAGGC CGAGATTATT GCCGACAAGC AGTCCGGCAA GAAGCGTGGA 
TTCGGCTTCG TGTATTTCCA GAATCACGAC GCGGCAGACA AGGCCGCGGT GGTCAAGTTC 
CATCCGATTC AGGGCCATCG CGTGGAGGTG AAGAAAGCAG TCCCCAAGGA GGATATCTAC 
TCCGGTGGGG GTGGAGGCGG CTCCCGATCC TCCCGGGGCG GCCGAGGCGG CCGGGGGCGC 
GGCGGTGGTC GAGACCAGAA CGGCCTTTCC AAGGGCGGCG GCGGCGGTTA CAACAGCTAC 
GGTGGTTACG GCGGCGGCGG AGGCGGCGGC TACAATGCCT ACGGAGGCGG CGGCGGCGGT 
TCGTCCTACG GTGGGAGCGA CTACGGTAAC GGCTTCGGCG GCTTCGGCAG CTACAGCCAG 
CATCAGTCCT CCTATGGGCC CATGAAGAGC GGCGGCGGCG GCGGCGGTGG AGGCAGTAGC 
TGGGGCGGTC GCAGTAATAG TGGACCTTAC AGAGGCGGCT ATGGCGGTGG GGGTGGCTAT 
GGAGGCAGCT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HNRNPA0 ( NM_006805.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006796.1 Homo sapiens heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0), mRNA.

Price & Availability↑

CloneID	OHu30849
Clone ID Related Accession (Same CDS sequence)	NM_006805.4 , NM_006805.3
Accession Version	NM_006805.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	heterogeneous nuclear ribonucleoprotein A0
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC030249.1, AA081021.1, AA442538.1, BF445078.1 and BM968394.1. On Sep 22, 2004 this sequence version replaced NM_006805.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGAGAATT CTCAGTTGTG TAAGCTGTTC ATCGGCGGCC TCAATGTGCA GACGAGTGAG 
TCGGGCCTGC GCGGCCACTT TGAGGCCTTT GGGACTCTGA CGGACTGCGT GGTGGTGGTG 
AATCCCCAGA CCAAGCGCTC CCGTTGCTTT GGCTTCGTGA CCTACTCCAA TGTGGAGGAG 
GCGGACGCCG CCATGGCCGC CTCGCCCCAT GCCGTGGACG GCAACACTGT GGAGCTGAAG 
CGGGCGGTGT CCCGGGAGGA TTCGGCGCGG CCCGGTGCCC ACGCCAAGGT TAAGAAGCTC 
TTTGTCGGAG GCCTTAAAGG AGACGTGGCT GAGGGCGACC TGATCGAGCA CTTCTCGCAG 
TTTGGCACCG TGGAAAAGGC CGAGATTATT GCCGACAAGC AGTCCGGCAA GAAGCGTGGA 
TTCGGCTTCG TGTATTTCCA GAATCACGAC GCGGCAGACA AGGCCGCGGT GGTCAAGTTC 
CATCCGATTC AGGGCCATCG CGTGGAGGTG AAGAAAGCAG TCCCCAAGGA GGATATCTAC 
TCCGGTGGGG GTGGAGGCGG CTCCCGATCC TCCCGGGGCG GCCGAGGCGG CCGGGGGCGC 
GGCGGTGGTC GAGACCAGAA CGGCCTTTCC AAGGGCGGCG GCGGCGGTTA CAACAGCTAC 
GGTGGTTACG GCGGCGGCGG AGGCGGCGGC TACAATGCCT ACGGAGGCGG CGGCGGCGGT 
TCGTCCTACG GTGGGAGCGA CTACGGTAAC GGCTTCGGCG GCTTCGGCAG CTACAGCCAG 
CATCAGTCCT CCTATGGGCC CATGAAGAGC GGCGGCGGCG GCGGCGGTGG AGGCAGTAGC 
TGGGGCGGTC GCAGTAATAG TGGACCTTAC AGAGGCGGCT ATGGCGGTGG GGGTGGCTAT 
GGAGGCAGCT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006796.1
CDS	285..1202
Translation	MENSQLCKLFIGGLNVQTSESGLRGHFEAFGTLTDCVVVVNPQTKRSRCFGFVTYSNVEEADAAMAASPHAVDGNTVELKRAVSREDSARPGAHAKVKKLFVGGLKGDVAEGDLIEHFSQFGTVEKAEIIADKQSGKKRGFGFVYFQNHDAADKAAVVKFHPIQGHRVEVKKAVPKEDIYSGGGGGGSRSSRGGRGGRGRGGGRDQNGLSKGGGGGYNSYGGYGGGGGGGYNAYGGGGGGSSYGGSDYGNGFGGFGSYSQHQSSYGPMKSGGGGGGGGSSWGGRSNSGPYRGGYGGGGGYGGSSF

Target ORF information:

RefSeq Version	NM_006805.3
Organism	Homo sapiens(human)
Definition	Homo sapiens heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006805.3

ORF Insert Sequence:

ATGGAGAATT CTCAGTTGTG TAAGCTGTTC ATCGGCGGCC TCAATGTGCA GACGAGTGAG 
TCGGGCCTGC GCGGCCACTT TGAGGCCTTT GGGACTCTGA CGGACTGCGT GGTGGTGGTG 
AATCCCCAGA CCAAGCGCTC CCGTTGCTTT GGCTTCGTGA CCTACTCCAA TGTGGAGGAG 
GCGGACGCCG CCATGGCCGC CTCGCCCCAT GCCGTGGACG GCAACACTGT GGAGCTGAAG 
CGGGCGGTGT CCCGGGAGGA TTCGGCGCGG CCCGGTGCCC ACGCCAAGGT TAAGAAGCTC 
TTTGTCGGAG GCCTTAAAGG AGACGTGGCT GAGGGCGACC TGATCGAGCA CTTCTCGCAG 
TTTGGCACCG TGGAAAAGGC CGAGATTATT GCCGACAAGC AGTCCGGCAA GAAGCGTGGA 
TTCGGCTTCG TGTATTTCCA GAATCACGAC GCGGCAGACA AGGCCGCGGT GGTCAAGTTC 
CATCCGATTC AGGGCCATCG CGTGGAGGTG AAGAAAGCAG TCCCCAAGGA GGATATCTAC 
TCCGGTGGGG GTGGAGGCGG CTCCCGATCC TCCCGGGGCG GCCGAGGCGG CCGGGGGCGC 
GGCGGTGGTC GAGACCAGAA CGGCCTTTCC AAGGGCGGCG GCGGCGGTTA CAACAGCTAC 
GGTGGTTACG GCGGCGGCGG AGGCGGCGGC TACAATGCCT ACGGAGGCGG CGGCGGCGGT 
TCGTCCTACG GTGGGAGCGA CTACGGTAAC GGCTTCGGCG GCTTCGGCAG CTACAGCCAG 
CATCAGTCCT CCTATGGGCC CATGAAGAGC GGCGGCGGCG GCGGCGGTGG AGGCAGTAGC 
TGGGGCGGTC GCAGTAATAG TGGACCTTAC AGAGGCGGCT ATGGCGGTGG GGGTGGCTAT 
GGAGGCAGCT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
Cancer cell28(5)623-637(2015 Nov)
Cannell IG,Merrick KA,Morandell S,Zhu CQ,Braun CJ,Grant RA,Cameron ER,Tsao MS,Hemann MT,Yaffe MB

Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.
Haematologica99(6)1032-40(2014 Jun)
Young DJ,Stoddart A,Nakitandwe J,Chen SC,Qian Z,Downing JR,Le Beau MM

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
Molecular cell40(1)34-49(2010 Oct)
Reinhardt HC,Hasskamp P,Schmedding I,Morandell S,van Vugt MA,Wang X,Linding R,Ong SE,Weaver D,Carr SA,Yaffe MB

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HNRNPA0 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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