SRSF8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SRSF8
Entrez Gene ID	10929
Full Name	serine and arginine rich splicing factor 8
Synonyms	DSM-1,SFRS2B,SRP46
General protein information	Preferred Names serine and arginine rich splicing factor 8 Names serine/arginine-rich splicing factor 8 SR splicing factor 8 pre-mRNA-splicing factor SRP46 splicing factor, arginine/serine-rich 2B splicing factor, arginine/serine-rich, 46kD
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q21
Summary	This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Disorder MIM:	603269

mRNA and Protein(s)

mRNA	Protein	Name
XM_017017142.1	XP_016872631.1	serine/arginine-rich splicing factor 8 isoform X1
NM_032102.3	NP_115285.1	serine/arginine-rich splicing factor 8

Pathways from BioSystems

Homologies

Homo sapiens (human)	SRSF8	NP_115285.1
Pan troglodytes (chimpanzee)	SRSF8	XP_001139465.2

Gene Ontology
Bibliography

Related articles in PubMed

The protein interaction landscape of the human CMGC kinase group.
Varjosalo M, Keskitalo S, Van Drogen A, Nurkkala H, Vichalkovski A, Aebersold R, Gstaiger M
Cell reports3(4)1306-20(2013 Apr)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).
Manley JL, Krainer AR
Genes & development24(11)1073-4(2010 Jun)

Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients.
Watanuki T, Funato H, Uchida S, Matsubara T, Kobayashi A, Wakabayashi Y, Otsuki K, Nishida A, Watanabe Y
Journal of affective disorders110(1-2)62-9(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SRSF8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SRSF8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu09269	NM_032102.3 Latest version!	Homo sapiens serine and arginine rich splicing factor 8 (SRSF8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu09269	XM_017017142.1 Latest version!	Homo sapiens serine and arginine rich splicing factor 8 (SRSF8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SRSF8 ( NM_032102.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115285.1 Homo sapiens serine and arginine rich splicing factor 8 (SRSF8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09269
Clone ID Related Accession (Same CDS sequence)	XM_017017142.1 , NM_032102.3
Accession Version	NM_032102.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	serine/arginine-rich splicing factor 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA723253.1, AF031166.1, BC057783.1, AK023379.1, AP001264.4 and KF510392.1. On Jun 19, 2013 this sequence version replaced NM_032102.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCTGCG GCCGCCCCCC TCCCGACGTG GACGGCATGA TCACCCTCAA GGTGGACAAC 
CTGACCTACC GCACCTCTCC CGACAGCTTG AGGCGCGTGT TCGAGAAGTA CGGGCGCGTG 
GGCGACGTGT ACATCCCGCG GGAGCCCCAC ACCAAGGCGC CCCGGGGCTT CGCTTTCGTC 
CGCTTTCACG ACCGGCGCGA CGCCCAAGAC GCCGAGGCCG CCATGGACGG GGCGGAGCTG 
GACGGACGCG AGCTGCGGGT GCAGGTGGCG CGCTATGGCC GCCGGGACCT GCCCCGCAGC 
CGCCAGGGAG AGCCACGCGG CAGGTCCAGA GGCGGCGGCT ACGGACGGCG GAGCCGCAGC 
TACGGGCGGC GGAGCCGCAG CCCCAGGCGG CGACACCGCA GCCGATCCCG GGGTCCCAGC 
TGCTCCAGGT CCCGCAGCCG ATCTCGCTAT AGGGGTTCTC GCTATAGCCG GTCTCCCTAC 
AGCCGATCTC CTTACAGCCG GTCGCGCTAC AGCCGCTCTC CCTACAGCAG ATCTCGCTAC 
AGGGAATCTC GCTACGGCGG ATCTCACTAC AGCTCATCTG GTTACAGTAA CTCTCGCTAC 
AGCCGATATC ACAGCAGCCG GTCTCACTCG AAGTCTGGGT CCTCCACTAG CTCTCGCTCT 
GCATCAACCT CCAAATCGAG CTCTGCGCGA CGATCCAAGT CCTCCTCGGT CTCCAGGTCT 
CGCTCGCGGT CCAGGTCTTC ATCTATGACC AGGAGTCCTC CCCGGGTATC CAAGAGGAAA 
TCCAAGTCAA GGTCGCGATC CAAGAGGCCC CCCAAGTCTC CTGAAGAGGA AGGACAGATG 
TCCTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115285.1
CDS	351..1199
Translation	MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPREPHTKAPRGFAFVRFHDRRDAQDAEAAMDGAELDGRELRVQVARYGRRDLPRSRQGEPRGRSRGGGYGRRSRSYGRRSRSPRRRHRSRSRGPSCSRSRSRSRYRGSRYSRSPYSRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNSRYSRYHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSPEEEGQMSS

Target ORF information:

RefSeq Version	NM_032102.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serine and arginine rich splicing factor 8 (SRSF8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032102.3

ORF Insert Sequence:

ATGAGCTGCG GCCGCCCCCC TCCCGACGTG GACGGCATGA TCACCCTCAA GGTGGACAAC 
CTGACCTACC GCACCTCTCC CGACAGCTTG AGGCGCGTGT TCGAGAAGTA CGGGCGCGTG 
GGCGACGTGT ACATCCCGCG GGAGCCCCAC ACCAAGGCGC CCCGGGGCTT CGCTTTCGTC 
CGCTTTCACG ACCGGCGCGA CGCCCAAGAC GCCGAGGCCG CCATGGACGG GGCGGAGCTG 
GACGGACGCG AGCTGCGGGT GCAGGTGGCG CGCTATGGCC GCCGGGACCT GCCCCGCAGC 
CGCCAGGGAG AGCCACGCGG CAGGTCCAGA GGCGGCGGCT ACGGACGGCG GAGCCGCAGC 
TACGGGCGGC GGAGCCGCAG CCCCAGGCGG CGACACCGCA GCCGATCCCG GGGTCCCAGC 
TGCTCCAGGT CCCGCAGCCG ATCTCGCTAT AGGGGTTCTC GCTATAGCCG GTCTCCCTAC 
AGCCGATCTC CTTACAGCCG GTCGCGCTAC AGCCGCTCTC CCTACAGCAG ATCTCGCTAC 
AGGGAATCTC GCTACGGCGG ATCTCACTAC AGCTCATCTG GTTACAGTAA CTCTCGCTAC 
AGCCGATATC ACAGCAGCCG GTCTCACTCG AAGTCTGGGT CCTCCACTAG CTCTCGCTCT 
GCATCAACCT CCAAATCGAG CTCTGCGCGA CGATCCAAGT CCTCCTCGGT CTCCAGGTCT 
CGCTCGCGGT CCAGGTCTTC ATCTATGACC AGGAGTCCTC CCCGGGTATC CAAGAGGAAA 
TCCAAGTCAA GGTCGCGATC CAAGAGGCCC CCCAAGTCTC CTGAAGAGGA AGGACAGATG 
TCCTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SRSF8 ( XM_017017142.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016872631.1 Homo sapiens serine and arginine rich splicing factor 8 (SRSF8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu09269
Clone ID Related Accession (Same CDS sequence)	XM_017017142.1 , NM_032102.3
Accession Version	XM_017017142.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine/arginine-rich splicing factor 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCTGCG GCCGCCCCCC TCCCGACGTG GACGGCATGA TCACCCTCAA GGTGGACAAC 
CTGACCTACC GCACCTCTCC CGACAGCTTG AGGCGCGTGT TCGAGAAGTA CGGGCGCGTG 
GGCGACGTGT ACATCCCGCG GGAGCCCCAC ACCAAGGCGC CCCGGGGCTT CGCTTTCGTC 
CGCTTTCACG ACCGGCGCGA CGCCCAAGAC GCCGAGGCCG CCATGGACGG GGCGGAGCTG 
GACGGACGCG AGCTGCGGGT GCAGGTGGCG CGCTATGGCC GCCGGGACCT GCCCCGCAGC 
CGCCAGGGAG AGCCACGCGG CAGGTCCAGA GGCGGCGGCT ACGGACGGCG GAGCCGCAGC 
TACGGGCGGC GGAGCCGCAG CCCCAGGCGG CGACACCGCA GCCGATCCCG GGGTCCCAGC 
TGCTCCAGGT CCCGCAGCCG ATCTCGCTAT AGGGGTTCTC GCTATAGCCG GTCTCCCTAC 
AGCCGATCTC CTTACAGCCG GTCGCGCTAC AGCCGCTCTC CCTACAGCAG ATCTCGCTAC 
AGGGAATCTC GCTACGGCGG ATCTCACTAC AGCTCATCTG GTTACAGTAA CTCTCGCTAC 
AGCCGATATC ACAGCAGCCG GTCTCACTCG AAGTCTGGGT CCTCCACTAG CTCTCGCTCT 
GCATCAACCT CCAAATCGAG CTCTGCGCGA CGATCCAAGT CCTCCTCGGT CTCCAGGTCT 
CGCTCGCGGT CCAGGTCTTC ATCTATGACC AGGAGTCCTC CCCGGGTATC CAAGAGGAAA 
TCCAAGTCAA GGTCGCGATC CAAGAGGCCC CCCAAGTCTC CTGAAGAGGA AGGACAGATG 
TCCTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016872631.1
CDS	313..1161
Translation	MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPREPHTKAPRGFAFVRFHDRRDAQDAEAAMDGAELDGRELRVQVARYGRRDLPRSRQGEPRGRSRGGGYGRRSRSYGRRSRSPRRRHRSRSRGPSCSRSRSRSRYRGSRYSRSPYSRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNSRYSRYHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSPEEEGQMSS

Target ORF information:

RefSeq Version	XM_017017142.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serine and arginine rich splicing factor 8 (SRSF8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017017142.1

ORF Insert Sequence:

ATGAGCTGCG GCCGCCCCCC TCCCGACGTG GACGGCATGA TCACCCTCAA GGTGGACAAC 
CTGACCTACC GCACCTCTCC CGACAGCTTG AGGCGCGTGT TCGAGAAGTA CGGGCGCGTG 
GGCGACGTGT ACATCCCGCG GGAGCCCCAC ACCAAGGCGC CCCGGGGCTT CGCTTTCGTC 
CGCTTTCACG ACCGGCGCGA CGCCCAAGAC GCCGAGGCCG CCATGGACGG GGCGGAGCTG 
GACGGACGCG AGCTGCGGGT GCAGGTGGCG CGCTATGGCC GCCGGGACCT GCCCCGCAGC 
CGCCAGGGAG AGCCACGCGG CAGGTCCAGA GGCGGCGGCT ACGGACGGCG GAGCCGCAGC 
TACGGGCGGC GGAGCCGCAG CCCCAGGCGG CGACACCGCA GCCGATCCCG GGGTCCCAGC 
TGCTCCAGGT CCCGCAGCCG ATCTCGCTAT AGGGGTTCTC GCTATAGCCG GTCTCCCTAC 
AGCCGATCTC CTTACAGCCG GTCGCGCTAC AGCCGCTCTC CCTACAGCAG ATCTCGCTAC 
AGGGAATCTC GCTACGGCGG ATCTCACTAC AGCTCATCTG GTTACAGTAA CTCTCGCTAC 
AGCCGATATC ACAGCAGCCG GTCTCACTCG AAGTCTGGGT CCTCCACTAG CTCTCGCTCT 
GCATCAACCT CCAAATCGAG CTCTGCGCGA CGATCCAAGT CCTCCTCGGT CTCCAGGTCT 
CGCTCGCGGT CCAGGTCTTC ATCTATGACC AGGAGTCCTC CCCGGGTATC CAAGAGGAAA 
TCCAAGTCAA GGTCGCGATC CAAGAGGCCC CCCAAGTCTC CTGAAGAGGA AGGACAGATG 
TCCTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The protein interaction landscape of the human CMGC kinase group.
Cell reports3(4)1306-20(2013 Apr)
Varjosalo M,Keskitalo S,Van Drogen A,Nurkkala H,Vichalkovski A,Aebersold R,Gstaiger M

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).
Genes & development24(11)1073-4(2010 Jun)
Manley JL,Krainer AR

Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients.
Journal of affective disorders110(1-2)62-9(2008 Sep)
Watanuki T,Funato H,Uchida S,Matsubara T,Kobayashi A,Wakabayashi Y,Otsuki K,Nishida A,Watanabe Y

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SRSF8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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