COPS8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COPS8
Entrez Gene ID	10920
Full Name	COP9 signalosome subunit 8
Synonyms	COP9,CSN8,SGN8
General protein information	Preferred Names COP9 signalosome subunit 8 Names COP9 signalosome complex subunit 8 COP9 constitutive photomorphogenic homolog subunit 8 COP9 homolog JAB1-containing signalosome subunit 8 hCOP9 signalosome subunit 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.3
Summary	The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Disorder MIM:	616011

mRNA and Protein(s)

mRNA	Protein	Name
NM_198189.2	NP_937832.1	COP9 signalosome complex subunit 8 isoform 2
NM_006710.4	NP_006701.1	COP9 signalosome complex subunit 8 isoform 1
NM_006710.5	NP_006701.1	COP9 signalosome complex subunit 8 isoform 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	cops8	NP_956523.1
Homo sapiens (human)	COPS8	NP_006701.1
Bos taurus (cattle)	COPS8	NP_001076966.1
Drosophila melanogaster (fruit fly)	CSN8	NP_723378.2
Pan troglodytes (chimpanzee)	COPS8	XP_003950051.1
Oryza sativa (rice)	Os04g0428900	NP_001052805.1
Canis lupus familiaris (dog)	COPS8	XP_534612.2
Mus musculus (house mouse)	Cops8	NP_598566.3
Gallus gallus (chicken)	COPS8	NP_001041472.1
Rattus norvegicus (Norway rat)	Cops8	NP_001013245.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008857	XP_319600.4
Arabidopsis thaliana (thale cress)	COP9	NP_193147.1
Xenopus tropicalis (tropical clawed frog)	cops8	NP_989106.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutation screening of ACKR3 and COPS8 in kidney cancer cases from the CONFIRM study.
Mahmoodi M, Nguyen-Dumont T, Hammet F, Pope BJ, Park DJ, Southey MC, Darlow JM, Bruinsma F, Winship I
Familial cancer16(3)411-416(2017 Jul)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thom? NH
Nature531(7596)598-603(2016 Mar)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 impaired proliferation in HeLa cells.
Title: COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase.

miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB.
Title: microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-?B by targeting CARD10 and COPS8 in gastric cancer.

proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu
Title: Purification of the COP9 signalosome complex and binding partners from human T cells.

analysis of the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3
Title: Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.

COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination
Title: The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.

The following COPS8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COPS8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02509	NM_198189.2 Latest version!	Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29262	NM_006710.5 Latest version!	Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29262	NM_006710.4	Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COPS8 ( NM_198189.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_937832.1 Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02509
Clone ID Related Accession (Same CDS sequence)	NM_198189.2
Accession Version	NM_198189.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	COP9 signalosome complex subunit 8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC036499.1, BF979628.1, BC003090.1 and AL038738.1. On Jan 13, 2004 this sequence version replaced NM_198189.1. Transcript Variant: This variant (2) contains an additional exon compared to variant 1, resulting in translation initiation from a downstream start codon and an isoform (2) with a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.56355.1, SRR1803616.61119.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATAATG CAAGATATCT TTGGAAAAGA ATACCACCTG CTATAAAATC TGCAAATTCT 
GAACTTGGGG GAATTTGGTC AGTAGGACAA AGAATCTGGC AGAGAGATTT CCCTGGGATC 
TATACAACCA TCAACGCTCA CCAGTGGTCT GAGACGGTCC AGCCAATTAT GGAAGCACTT 
AGAGATGCAA CAAGGAGACG CGCCTTTGCC CTGGTCTCTC AAGCGTATAC TTCAATCATC 
GCCGATGATT TTGCAGCCTT TGTTGGACTT CCTGTAGAAG AGGCTGTGAA AGGCATATTA 
GAACAAGGAT GGCAAGCTGA TTCCACCACA AGAATGGTTC TGCCCAGAAA GCCAGTTGCA 
GGGGCCCTGG ATGTTTCCTT TAACAAGTTT ATTCCCTTAT CAGAGCCTGC TCCAGTTCCC 
CCAATACCCA ATGAACAGCA GTTAGCCAGA CTGACGGATT ATGTGGCTTT CCTTGAAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_937832.1
CDS	737..1219
Translation	MNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN

Target ORF information:

RefSeq Version	NM_198189.2
Organism	Homo sapiens(human)
Definition	Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198189.2

ORF Insert Sequence:

ATGAATAATG CAAGATATCT TTGGAAAAGA ATACCACCTG CTATAAAATC TGCAAATTCT 
GAACTTGGGG GAATTTGGTC AGTAGGACAA AGAATCTGGC AGAGAGATTT CCCTGGGATC 
TATACAACCA TCAACGCTCA CCAGTGGTCT GAGACGGTCC AGCCAATTAT GGAAGCACTT 
AGAGATGCAA CAAGGAGACG CGCCTTTGCC CTGGTCTCTC AAGCGTATAC TTCAATCATC 
GCCGATGATT TTGCAGCCTT TGTTGGACTT CCTGTAGAAG AGGCTGTGAA AGGCATATTA 
GAACAAGGAT GGCAAGCTGA TTCCACCACA AGAATGGTTC TGCCCAGAAA GCCAGTTGCA 
GGGGCCCTGG ATGTTTCCTT TAACAAGTTT ATTCCCTTAT CAGAGCCTGC TCCAGTTCCC 
CCAATACCCA ATGAACAGCA GTTAGCCAGA CTGACGGATT ATGTGGCTTT CCTTGAAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COPS8 ( NM_006710.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006701.1 Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29262
Clone ID Related Accession (Same CDS sequence)	NM_006710.4 , NM_006710.5
Accession Version	NM_006710.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	COP9 signalosome complex subunit 8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC036499.1, BC003090.1 and AL038738.1. On Jan 13, 2004 this sequence version replaced NM_006710.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036499.1, SRR1803613.5371.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAGTGG CGGTGATGGC GGAAAGCGCC TTTAGTTTCA AAAAGTTGCT GGATCAGTGC 
GAGAACCAGG AGCTCGAGGC CCCTGGAGGA ATTGCTACAC CCCCAGTGTA TGGTCAGCTT 
CTAGCTTTAT ATTTGCTCCA TAATGACATG AATAATGCAA GATATCTTTG GAAAAGAATA 
CCACCTGCTA TAAAATCTGC AAATTCTGAA CTTGGGGGAA TTTGGTCAGT AGGACAAAGA 
ATCTGGCAGA GAGATTTCCC TGGGATCTAT ACAACCATCA ACGCTCACCA GTGGTCTGAG 
ACGGTCCAGC CAATTATGGA AGCACTTAGA GATGCAACAA GGAGACGCGC CTTTGCCCTG 
GTCTCTCAAG CGTATACTTC AATCATCGCC GATGATTTTG CAGCCTTTGT TGGACTTCCT 
GTAGAAGAGG CTGTGAAAGG CATATTAGAA CAAGGATGGC AAGCTGATTC CACCACAAGA 
ATGGTTCTGC CCAGAAAGCC AGTTGCAGGG GCCCTGGATG TTTCCTTTAA CAAGTTTATT 
CCCTTATCAG AGCCTGCTCC AGTTCCCCCA ATACCCAATG AACAGCAGTT AGCCAGACTG 
ACGGATTATG TGGCTTTCCT TGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006701.1
CDS	525..1154
Translation	MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN

Target ORF information:

RefSeq Version	NM_006710.4
Organism	Homo sapiens(human)
Definition	Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006710.4

ORF Insert Sequence:

ATGCCAGTGG CGGTGATGGC GGAAAGCGCC TTTAGTTTCA AAAAGTTGCT GGATCAGTGC 
GAGAACCAGG AGCTCGAGGC CCCTGGAGGA ATTGCTACAC CCCCAGTGTA TGGTCAGCTT 
CTAGCTTTAT ATTTGCTCCA TAATGACATG AATAATGCAA GATATCTTTG GAAAAGAATA 
CCACCTGCTA TAAAATCTGC AAATTCTGAA CTTGGGGGAA TTTGGTCAGT AGGACAAAGA 
ATCTGGCAGA GAGATTTCCC TGGGATCTAT ACAACCATCA ACGCTCACCA GTGGTCTGAG 
ACGGTCCAGC CAATTATGGA AGCACTTAGA GATGCAACAA GGAGACGCGC CTTTGCCCTG 
GTCTCTCAAG CGTATACTTC AATCATCGCC GATGATTTTG CAGCCTTTGT TGGACTTCCT 
GTAGAAGAGG CTGTGAAAGG CATATTAGAA CAAGGATGGC AAGCTGATTC CACCACAAGA 
ATGGTTCTGC CCAGAAAGCC AGTTGCAGGG GCCCTGGATG TTTCCTTTAA CAAGTTTATT 
CCCTTATCAG AGCCTGCTCC AGTTCCCCCA ATACCCAATG AACAGCAGTT AGCCAGACTG 
ACGGATTATG TGGCTTTCCT TGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COPS8 ( NM_006710.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006701.1 Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29262
Clone ID Related Accession (Same CDS sequence)	NM_006710.4 , NM_006710.5
Accession Version	NM_006710.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	COP9 signalosome complex subunit 8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC036499.1, BC003090.1, AL038738.1 and AC105760.3. On Nov 23, 2018 this sequence version replaced NM_006710.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.64047.1, SRR1660803.87842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000354371.7/ ENSP00000346340.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCAGTGG CGGTGATGGC GGAAAGCGCC TTTAGTTTCA AAAAGTTGCT GGATCAGTGC 
GAGAACCAGG AGCTCGAGGC CCCTGGAGGA ATTGCTACAC CCCCAGTGTA TGGTCAGCTT 
CTAGCTTTAT ATTTGCTCCA TAATGACATG AATAATGCAA GATATCTTTG GAAAAGAATA 
CCACCTGCTA TAAAATCTGC AAATTCTGAA CTTGGGGGAA TTTGGTCAGT AGGACAAAGA 
ATCTGGCAGA GAGATTTCCC TGGGATCTAT ACAACCATCA ACGCTCACCA GTGGTCTGAG 
ACGGTCCAGC CAATTATGGA AGCACTTAGA GATGCAACAA GGAGACGCGC CTTTGCCCTG 
GTCTCTCAAG CGTATACTTC AATCATCGCC GATGATTTTG CAGCCTTTGT TGGACTTCCT 
GTAGAAGAGG CTGTGAAAGG CATATTAGAA CAAGGATGGC AAGCTGATTC CACCACAAGA 
ATGGTTCTGC CCAGAAAGCC AGTTGCAGGG GCCCTGGATG TTTCCTTTAA CAAGTTTATT 
CCCTTATCAG AGCCTGCTCC AGTTCCCCCA ATACCCAATG AACAGCAGTT AGCCAGACTG 
ACGGATTATG TGGCTTTCCT TGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006701.1
CDS	77..706
Translation	MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN

Target ORF information:

RefSeq Version	NM_006710.5
Organism	Homo sapiens(human)
Definition	Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006710.5

ORF Insert Sequence:

ATGCCAGTGG CGGTGATGGC GGAAAGCGCC TTTAGTTTCA AAAAGTTGCT GGATCAGTGC 
GAGAACCAGG AGCTCGAGGC CCCTGGAGGA ATTGCTACAC CCCCAGTGTA TGGTCAGCTT 
CTAGCTTTAT ATTTGCTCCA TAATGACATG AATAATGCAA GATATCTTTG GAAAAGAATA 
CCACCTGCTA TAAAATCTGC AAATTCTGAA CTTGGGGGAA TTTGGTCAGT AGGACAAAGA 
ATCTGGCAGA GAGATTTCCC TGGGATCTAT ACAACCATCA ACGCTCACCA GTGGTCTGAG 
ACGGTCCAGC CAATTATGGA AGCACTTAGA GATGCAACAA GGAGACGCGC CTTTGCCCTG 
GTCTCTCAAG CGTATACTTC AATCATCGCC GATGATTTTG CAGCCTTTGT TGGACTTCCT 
GTAGAAGAGG CTGTGAAAGG CATATTAGAA CAAGGATGGC AAGCTGATTC CACCACAAGA 
ATGGTTCTGC CCAGAAAGCC AGTTGCAGGG GCCCTGGATG TTTCCTTTAA CAAGTTTATT 
CCCTTATCAG AGCCTGCTCC AGTTCCCCCA ATACCCAATG AACAGCAGTT AGCCAGACTG 
ACGGATTATG TGGCTTTCCT TGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutation screening of ACKR3 and COPS8 in kidney cancer cases from the CONFIRM study.
Familial cancer16(3)411-416(2017 Jul)
Mahmoodi M,Nguyen-Dumont T,Hammet F,Pope BJ,Park DJ,Southey MC,Darlow JM,Bruinsma F,Winship I

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Nature531(7596)598-603(2016 Mar)
Cavadini S,Fischer ES,Bunker RD,Potenza A,Lingaraju GM,Goldie KN,Mohamed WI,Faty M,Petzold G,Beckwith RE,Tichkule RB,Hassiepen U,Abdulrahman W,Pantelic RS,Matsumoto S,Sugasawa K,Stahlberg H,Thom? NH

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

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COPS8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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