GADD45G cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GADD45G
Entrez Gene ID	10912
Full Name	growth arrest and DNA damage inducible gamma
Synonyms	CR6,DDIT2,GADD45gamma,GRP17
General protein information	Preferred Names growth arrest and DNA damage inducible gamma Names growth arrest and DNA damage-inducible protein GADD45 gamma DDIT-2 DNA damage-inducible transcript 2 protein GADD45-gamma cytokine-responsive protein CR6 gadd-related protein, 17 kD
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q22.2
Summary	This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008].
Disorder MIM:	604949

mRNA and Protein(s)

mRNA	Protein	Name
XM_011518163.2	XP_011516465.1	growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1
NM_006705.3	NP_006696.1	growth arrest and DNA damage-inducible protein GADD45 gamma
NM_006705.4	NP_006696.1	growth arrest and DNA damage-inducible protein GADD45 gamma

Pathways from BioSystems

Homologies

	GADD45G	XP_001091258.1
Homo sapiens (human)	GADD45G	NP_006696.1
Canis lupus familiaris (dog)	GADD45G	XP_541314.3
Mus musculus (house mouse)	Gadd45g	NP_035947.2
Xenopus tropicalis (tropical clawed frog)	gadd45g	NP_001004986.1
Pan troglodytes (chimpanzee)	GADD45G	XP_001141972.1
Bos taurus (cattle)	GADD45G	NP_001039366.1
Gallus gallus (chicken)	GADD45B	NP_001038131.1
Rattus norvegicus (Norway rat)	Gadd45g	NP_001071108.1
Danio rerio (zebrafish)	gadd45g	NP_991254.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic variants of JNK and p38? pathways and risk of non-small cell lung cancer in an Eastern Chinese population.
Jia M, Zhu M, Zhou F, Wang M, Sun M, Yang Y, Wang X, Wang J, Jin L, Xiang J, Zhang Y, Chang J, Wei Q
International journal of cancer140(4)807-817(2017 02)

Molecular Changes Involving MEK3-p38 MAPK Activation in Chronic Masticatory Myalgia.
Meng H, Gao Y, Kang YF, Zhao YP, Yang GJ, Wang Y, Cao Y, Gan YH, Xie QF
Journal of dental research95(10)1169-75(2016 Sep)

Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering ?-catenin signalling and GADD45G expression.
Zhao L, Li S, Gan L, Li C, Qiu Z, Feng Y, Li J, Li L, Li C, Peng W, Xu C, Wang Z, Hui T, Ren G, Tao Q, Xiang T
Journal of cellular and molecular medicine20(5)842-54(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In an Eastern Chinese population, carriers of GADD45G rs8252T variant genotypes had a significantly lower risk of NSCLC. rs8252 variant CT/TT carriers showed significantly higher levels of GADD45G mRNA expression than CC carriers in the target tissues. There was some evidence of interactions between rs8252 genotypes and sex in NSCLC risk.
Title: Genetic variants of JNK and p38? pathways and risk of non-small cell lung cancer in an Eastern Chinese population.

In addition to changes in MEK3 gene regulation, our study demonstrated upregulation of CACNG2 and GADD45G at the mRNA level in CMM patients.
Title: Molecular Changes Involving MEK3-p38 MAPK Activation in Chronic Masticatory Myalgia.

PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin pathway and up-regulating GADD45G expression.
Title: Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering ?-catenin signalling and GADD45G expression.

GADD45G protein, human
Title: Nuclear spheres modulate the expression of BEST1 and GADD45G.

Results establish that the dowregulation of GADD45G-SIP1 axis may contribute to cellular senescence evasion and HCC development.
Title: SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells.

The following GADD45G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GADD45G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09657	NM_006705.4 Latest version!	Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu64515	XM_011518163.2 Latest version!	Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu09657	NM_006705.3	Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GADD45G ( NM_006705.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006696.1 Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), mRNA.

Price & Availability↑

CloneID	OHu09657
Clone ID Related Accession (Same CDS sequence)	NM_006705.3 , NM_006705.4
Accession Version	NM_006705.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA420966.1 and BC019325.1. On Oct 11, 2008 this sequence version replaced NM_006705.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000465.2, ERR279837.3111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGACTCTGG AAGAAGTCCG CGGCCAGGAC ACAGTTCCGG AAAGCACAGC CAGGATGCAG 
GGTGCCGGGA AAGCGCTGCA TGAGTTGCTG CTGTCGGCGC AGCGTCAGGG CTGCCTCACT 
GCCGGCGTCT ACGAGTCAGC CAAAGTCTTG AACGTGGACC CCGACAATGT GACCTTCTGT 
GTGCTGGCTG CGGGTGAGGA GGACGAGGGC GACATCGCGC TGCAGATCCA TTTTACGCTG 
ATCCAGGCTT TCTGCTGCGA GAACGACATC GACATAGTGC GCGTGGGCGA TGTGCAGCGG 
CTGGCGGCTA TCGTGGGCGC CGGCGAGGAG GCGGGTGCGC CGGGCGACCT GCACTGCATC 
CTCATTTCGA ACCCCAACGA GGACGCCTGG AAGGATCCCG CCTTGGAGAA GCTCAGCCTG 
TTTTGCGAGG AGAGCCGCAG CGTTAACGAC TGGGTGCCCA GCATCACCCT CCCCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006696.1
CDS	111..590
Translation	MTLEEVRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVYESAKVLNVDPDNVTFCVLAAGEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGAGEEAGAPGDLHCILISNPNEDAWKDPALEKLSLFCEESRSVNDWVPSITLPE

Target ORF information:

RefSeq Version	NM_006705.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006705.3

ORF Insert Sequence:

ATGACTCTGG AAGAAGTCCG CGGCCAGGAC ACAGTTCCGG AAAGCACAGC CAGGATGCAG 
GGTGCCGGGA AAGCGCTGCA TGAGTTGCTG CTGTCGGCGC AGCGTCAGGG CTGCCTCACT 
GCCGGCGTCT ACGAGTCAGC CAAAGTCTTG AACGTGGACC CCGACAATGT GACCTTCTGT 
GTGCTGGCTG CGGGTGAGGA GGACGAGGGC GACATCGCGC TGCAGATCCA TTTTACGCTG 
ATCCAGGCTT TCTGCTGCGA GAACGACATC GACATAGTGC GCGTGGGCGA TGTGCAGCGG 
CTGGCGGCTA TCGTGGGCGC CGGCGAGGAG GCGGGTGCGC CGGGCGACCT GCACTGCATC 
CTCATTTCGA ACCCCAACGA GGACGCCTGG AAGGATCCCG CCTTGGAGAA GCTCAGCCTG 
TTTTGCGAGG AGAGCCGCAG CGTTAACGAC TGGGTGCCCA GCATCACCCT CCCCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GADD45G ( NM_006705.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006696.1 Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), mRNA.

Price & Availability↑

CloneID	OHu09657
Clone ID Related Accession (Same CDS sequence)	NM_006705.3 , NM_006705.4
Accession Version	NM_006705.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA420966.1 and BC019325.1. On Nov 23, 2018 this sequence version replaced NM_006705.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF079806.1, SRR1803613.413299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252506.11/ ENSP00000252506.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTCTGG AAGAAGTCCG CGGCCAGGAC ACAGTTCCGG AAAGCACAGC CAGGATGCAG 
GGTGCCGGGA AAGCGCTGCA TGAGTTGCTG CTGTCGGCGC AGCGTCAGGG CTGCCTCACT 
GCCGGCGTCT ACGAGTCAGC CAAAGTCTTG AACGTGGACC CCGACAATGT GACCTTCTGT 
GTGCTGGCTG CGGGTGAGGA GGACGAGGGC GACATCGCGC TGCAGATCCA TTTTACGCTG 
ATCCAGGCTT TCTGCTGCGA GAACGACATC GACATAGTGC GCGTGGGCGA TGTGCAGCGG 
CTGGCGGCTA TCGTGGGCGC CGGCGAGGAG GCGGGTGCGC CGGGCGACCT GCACTGCATC 
CTCATTTCGA ACCCCAACGA GGACGCCTGG AAGGATCCCG CCTTGGAGAA GCTCAGCCTG 
TTTTGCGAGG AGAGCCGCAG CGTTAACGAC TGGGTGCCCA GCATCACCCT CCCCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006696.1
CDS	111..590
Translation	MTLEEVRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVYESAKVLNVDPDNVTFCVLAAGEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGAGEEAGAPGDLHCILISNPNEDAWKDPALEKLSLFCEESRSVNDWVPSITLPE

Target ORF information:

RefSeq Version	NM_006705.4
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006705.4

ORF Insert Sequence:

ATGACTCTGG AAGAAGTCCG CGGCCAGGAC ACAGTTCCGG AAAGCACAGC CAGGATGCAG 
GGTGCCGGGA AAGCGCTGCA TGAGTTGCTG CTGTCGGCGC AGCGTCAGGG CTGCCTCACT 
GCCGGCGTCT ACGAGTCAGC CAAAGTCTTG AACGTGGACC CCGACAATGT GACCTTCTGT 
GTGCTGGCTG CGGGTGAGGA GGACGAGGGC GACATCGCGC TGCAGATCCA TTTTACGCTG 
ATCCAGGCTT TCTGCTGCGA GAACGACATC GACATAGTGC GCGTGGGCGA TGTGCAGCGG 
CTGGCGGCTA TCGTGGGCGC CGGCGAGGAG GCGGGTGCGC CGGGCGACCT GCACTGCATC 
CTCATTTCGA ACCCCAACGA GGACGCCTGG AAGGATCCCG CCTTGGAGAA GCTCAGCCTG 
TTTTGCGAGG AGAGCCGCAG CGTTAACGAC TGGGTGCCCA GCATCACCCT CCCCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GADD45G ( XM_011518163.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011516465.1 Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu64515
Clone ID Related Accession (Same CDS sequence)	XM_011518163.2
Accession Version	XM_011518163.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011518163.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTCTGG AAGAAGTCCG CGGCCAGGAC ACAGTTCCGG AAAGCACAGC CAGGGACCCC 
GACAATGTGA CCTTCTGTGT GCTGGCTGCG GGTGAGGAGG ACGAGGGCGA CATCGCGCTG 
CAGATCCATT TTACGCTGAT CCAGGCTTTC TGCTGCGAGA ACGACATCGA CATAGTGCGC 
GTGGGCGATG TGCAGCGGCT GGCGGCTATC GTGGGCGCCG GCGAGGAGGC GGGTGCGCCG 
GGCGACCTGC ACTGCATCCT CATTTCGAAC CCCAACGAGG ACGCCTGGAA GGATCCCGCC 
TTGGAGAAGC TCAGCCTGTT TTGCGAGGAG AGCCGCAGCG TTAACGACTG GGTGCCCAGC 
ATCACCCTCC CCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011516465.1
CDS	114..491
Translation	MTLEEVRGQDTVPESTARDPDNVTFCVLAAGEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGAGEEAGAPGDLHCILISNPNEDAWKDPALEKLSLFCEESRSVNDWVPSITLPE

Target ORF information:

RefSeq Version	XM_011518163.2
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011518163.2

ORF Insert Sequence:

ATGACTCTGG AAGAAGTCCG CGGCCAGGAC ACAGTTCCGG AAAGCACAGC CAGGGACCCC 
GACAATGTGA CCTTCTGTGT GCTGGCTGCG GGTGAGGAGG ACGAGGGCGA CATCGCGCTG 
CAGATCCATT TTACGCTGAT CCAGGCTTTC TGCTGCGAGA ACGACATCGA CATAGTGCGC 
GTGGGCGATG TGCAGCGGCT GGCGGCTATC GTGGGCGCCG GCGAGGAGGC GGGTGCGCCG 
GGCGACCTGC ACTGCATCCT CATTTCGAAC CCCAACGAGG ACGCCTGGAA GGATCCCGCC 
TTGGAGAAGC TCAGCCTGTT TTGCGAGGAG AGCCGCAGCG TTAACGACTG GGTGCCCAGC 
ATCACCCTCC CCGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic variants of JNK and p38? pathways and risk of non-small cell lung cancer in an Eastern Chinese population.
International journal of cancer140(4)807-817(2017 02)
Jia M,Zhu M,Zhou F,Wang M,Sun M,Yang Y,Wang X,Wang J,Jin L,Xiang J,Zhang Y,Chang J,Wei Q

Molecular Changes Involving MEK3-p38 MAPK Activation in Chronic Masticatory Myalgia.
Journal of dental research95(10)1169-75(2016 Sep)
Meng H,Gao Y,Kang YF,Zhao YP,Yang GJ,Wang Y,Cao Y,Gan YH,Xie QF

Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering ?-catenin signalling and GADD45G expression.
Journal of cellular and molecular medicine20(5)842-54(2016 May)
Zhao L,Li S,Gan L,Li C,Qiu Z,Feng Y,Li J,Li L,Li C,Peng W,Xu C,Wang Z,Hui T,Ren G,Tao Q,Xiang T

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GADD45G cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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