TRAFD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRAFD1
Entrez Gene ID	10906
Full Name	TRAF-type zinc finger domain containing 1
Synonyms	FLN29
General protein information	Preferred Names TRAF-type zinc finger domain containing 1 Names TRAF-type zinc finger domain-containing protein 1 FLN29 gene product
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.13
Summary	The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009].
Disorder MIM:	613197

mRNA and Protein(s)

mRNA	Protein	Name
NM_006700.2	NP_006691.1	TRAF-type zinc finger domain-containing protein 1
NM_006700.3	NP_006691.1	TRAF-type zinc finger domain-containing protein 1
NM_001143906.1	NP_001137378.1	TRAF-type zinc finger domain-containing protein 1

Pathways from BioSystems

Homologies

	TRAFD1	XP_001109743.2
Rattus norvegicus (Norway rat)	Trafd1	NP_446212.2
Danio rerio (zebrafish)	zgc:162228	NP_001082984.1
Pan troglodytes (chimpanzee)	TRAFD1	XP_509385.3
Canis lupus familiaris (dog)	TRAFD1	XP_534682.2
Mus musculus (house mouse)	Trafd1	NP_001156942.1
Homo sapiens (human)	TRAFD1	NP_001137378.1
Bos taurus (cattle)	TRAFD1	NP_001014908.1
Gallus gallus (chicken)	TRAFD1	NP_001006191.1

Gene Ontology
Bibliography

Related articles in PubMed

TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption.
Witwicka H, Jia H, Kutikov A, Reyes-Gutierrez P, Li X, Odgren PR
PloS one10(5)e0127537(2015)

Development and application of a DNA microarray-based yeast two-hybrid system.
Suter B, Fontaine JF, Yildirimman R, Rask? T, Schaefer MH, Rasche A, Porras P, V?zquez-?lvarez BM, Russ J, Rau K, Foulle R, Zenkner M, Saar K, Herwig R, Andrade-Navarro MA, Wanker EE
Nucleic acids research41(3)1496-507(2013 Feb)

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
Ganesh SK, Zakai NA, van Rooij FJ, Soranzo N, Smith AV, Nalls MA, Chen MH, Kottgen A, Glazer NL, Dehghan A, Kuhnel B, Aspelund T, Yang Q, Tanaka T, Jaffe A, Bis JC, Verwoert GC, Teumer A, Fox CS, Guralnik JM, Ehret GB, Rice K, Felix JF, Rendon A, Eiriksdottir G, Levy D, Patel KV, Boerwinkle E, Rotter JI, Hofman A, Sambrook JG, Hernandez DG, Zheng G, Bandinelli S, Singleton AB, Coresh J, Lumley T, Uitterlinden AG, Vangils JM, Launer LJ, Cupples LA, Oostra BA, Zwaginga JJ, Ouwehand WH, Thein SL, Meisinger C, Deloukas P, Nauck M, Spector TD, Gieger C, Gudnason V, van Duijn CM, Psaty BM, Ferrucci L, Chakravarti A, Greinacher A, O'Donnell CJ, Witteman JC, Furth S, Cushman M, Harris TB, Lin JP
Nature genetics41(11)1191-8(2009 Nov)

FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A
The Journal of biological chemistry283(49)33858-64(2008 Dec)

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Nature447(7145)661-78(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FLN29, in addition to playing a negative regulatory role in the TLR4 signaling pathway, negatively regulates the RIG-I-like helicase signaling pathway at the level of IPS-1/TRAF6 and IPS-1/TRAF3 complexes
Title: FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.

FLN29 is a new negative feedback regulator of TLR signaling
Title: FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling.

The following TRAFD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRAFD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13830	NM_001143906.1 Latest version!	Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu13830	NM_006700.3 Latest version!	Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu13830	NM_006700.2	Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRAFD1 ( NM_001143906.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001137378.1 Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13830
Clone ID Related Accession (Same CDS sequence)	NM_006700.2 , NM_006700.3 , NM_001143906.1
Accession Version	NM_001143906.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-21
Organism	Homo sapiens(human)
Product	TRAF-type zinc finger domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK312601.1, AK122620.1, BG828961.1, BC003553.2 and CA314188.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.153368.1, AK122620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAAT TTCTAGATGA CCAGGAAACT CGACTGTGTG ACAACTGCAA AAAAGAAATT 
CCTGTGTTTA ACTTTACCAT CCATGAGATC CACTGTCAAA GGAACATTGG TATGTGTCCT 
ACCTGTAAGG AACCATTTCC CAAATCTGAC ATGGAGACTC ACATGGCTGC AGAACACTGT 
CAGGTGACCT GCAAATGTAA CAAGAAGTTG GAGAAGAGGC TGTTAAAGAA GCATGAGGAG 
ACTGAGTGCC CTTTGCGGCT TGCTGTCTGC CAGCACTGTG ATTTAGAACT TTCCATTCTC 
AAACTGAAGG AACATGAAGA TTATTGTGGT GCCCGGACGG AACTATGTGG CAACTGTGGT 
CGCAATGTCC TTGTGAAAGA TCTGAAGACT CACCCTGAAG TTTGTGGGAG AGAGGGGGAG 
GAAAAGAGAA ATGAGGTTGC CATACCTCCT AATGCATATG ATGAATCTTG GGGTCAGGAT 
GGAATCTGGA TTGCATCCCA ACTCCTCAGA CAAATTGAGG CTCTGGACCC ACCCATGAGG 
CTGCCGCGAA GGCCCCTGAG AGCCTTTGAA TCAGATGTTT TCCACAATAG AACTACCAAC 
CAAAGGAACA TTACAGCCCA GGTTTCAATT CAGAATAATC TGTTTGAAGA ACAAGAGAGG 
CAGGAAAGGA ATAGAGGCCA ACAGCCCCCC AAAGAGGGTG GTGAAGAGAG TGCAAACTTG 
GACTTCATGT TGGCCCTAAG TCTGCAAAAT GAAGGCCAAG CCTCCAGTGT GGCAGAGCAG 
GACTTCTGGA GGGCCGTATG TGAGGCCGAC CAGTCTCATG GCGGTCCCAG GTCTCTCAGT 
GACATAAAGG GTGCAGCTGA CGAGATCATG TTGCCTTGTG AATTTTGTGA GGAGCTCTAC 
CCAGAGGAAC TGCTGATTGA CCATCAGACA AGCTGTAACC CTTCACGTGC CTTACCTTCA 
CTCAATACTG GCAGCTCTTC CCCCAGAGGG GTGGAGGAAC CTGATGTCAT CTTCCAGAAC 
TTCTTGCAAC AGGCTGCAAG TAACCAGTTA GACTCTTTGA TGGGCCTGAG CAATTCACAC 
CCTGTGGAGG AGAGCATCAT TATCCCATGT GAATTCTGTG GGGTACAGCT GGAAGAGGAG 
GTGCTGTTCC ATCACCAGGA CCAGTGTGAC CAACGCCCAG CCACTGCAAC CAACCATGTG 
ACAGAGGGGA TTCCTAGACT GGATTCCCAG CCTCAAGAGA CCTCACCAGA GCTGCCCAGG 
AGGCGTGTCA GACACCAGGG AGACCTGTCT TCTGGTTACC TGGATGATAC TAAGCAGGAA 
ACAGCTAATG GGCCCACCTC CTGTCTGCCT CCCAGCCGAC CCATTAACAA TATGACAGCT 
ACCTATAACC AGCTATCGAG ATCAACATCA GGCCCCAGAC CTGGGTGCCA GCCCAGCTCT 
CCTTGTGTGC CGAAGCTCAG CAACTCAGAC AGCCAGGACA TCCAGGGGCG GAATCGAGAC 
AGCCAGAATG GGGCCATAGC CCCTGGGCAC GTTTCAGTGA TTCGCCCTCC TCAAAATCTC 
TACCCAGAAA ACATTGTGCC CTCTTTCTCC CCTGGGCCTT CAGGGAGATA CGGAGCTAGT 
GGTAGGAGTG AAGGTGGCAG GAATTCCCGG GTCACCCCTG CAGCTGCCAA CTACCGCAGC 
AGAACTGCAA AGGCAAAGCC TTCCAAGCAA CAGGGAGCTG GGGATGCAGA AGAGGAAGAG 
GAGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001137378.1
CDS	618..2366
Translation	MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE

Target ORF information:

RefSeq Version	NM_001143906.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001143906.1

ORF Insert Sequence:

ATGGCTGAAT TTCTAGATGA CCAGGAAACT CGACTGTGTG ACAACTGCAA AAAAGAAATT 
CCTGTGTTTA ACTTTACCAT CCATGAGATC CACTGTCAAA GGAACATTGG TATGTGTCCT 
ACCTGTAAGG AACCATTTCC CAAATCTGAC ATGGAGACTC ACATGGCTGC AGAACACTGT 
CAGGTGACCT GCAAATGTAA CAAGAAGTTG GAGAAGAGGC TGTTAAAGAA GCATGAGGAG 
ACTGAGTGCC CTTTGCGGCT TGCTGTCTGC CAGCACTGTG ATTTAGAACT TTCCATTCTC 
AAACTGAAGG AACATGAAGA TTATTGTGGT GCCCGGACGG AACTATGTGG CAACTGTGGT 
CGCAATGTCC TTGTGAAAGA TCTGAAGACT CACCCTGAAG TTTGTGGGAG AGAGGGGGAG 
GAAAAGAGAA ATGAGGTTGC CATACCTCCT AATGCATATG ATGAATCTTG GGGTCAGGAT 
GGAATCTGGA TTGCATCCCA ACTCCTCAGA CAAATTGAGG CTCTGGACCC ACCCATGAGG 
CTGCCGCGAA GGCCCCTGAG AGCCTTTGAA TCAGATGTTT TCCACAATAG AACTACCAAC 
CAAAGGAACA TTACAGCCCA GGTTTCAATT CAGAATAATC TGTTTGAAGA ACAAGAGAGG 
CAGGAAAGGA ATAGAGGCCA ACAGCCCCCC AAAGAGGGTG GTGAAGAGAG TGCAAACTTG 
GACTTCATGT TGGCCCTAAG TCTGCAAAAT GAAGGCCAAG CCTCCAGTGT GGCAGAGCAG 
GACTTCTGGA GGGCCGTATG TGAGGCCGAC CAGTCTCATG GCGGTCCCAG GTCTCTCAGT 
GACATAAAGG GTGCAGCTGA CGAGATCATG TTGCCTTGTG AATTTTGTGA GGAGCTCTAC 
CCAGAGGAAC TGCTGATTGA CCATCAGACA AGCTGTAACC CTTCACGTGC CTTACCTTCA 
CTCAATACTG GCAGCTCTTC CCCCAGAGGG GTGGAGGAAC CTGATGTCAT CTTCCAGAAC 
TTCTTGCAAC AGGCTGCAAG TAACCAGTTA GACTCTTTGA TGGGCCTGAG CAATTCACAC 
CCTGTGGAGG AGAGCATCAT TATCCCATGT GAATTCTGTG GGGTACAGCT GGAAGAGGAG 
GTGCTGTTCC ATCACCAGGA CCAGTGTGAC CAACGCCCAG CCACTGCAAC CAACCATGTG 
ACAGAGGGGA TTCCTAGACT GGATTCCCAG CCTCAAGAGA CCTCACCAGA GCTGCCCAGG 
AGGCGTGTCA GACACCAGGG AGACCTGTCT TCTGGTTACC TGGATGATAC TAAGCAGGAA 
ACAGCTAATG GGCCCACCTC CTGTCTGCCT CCCAGCCGAC CCATTAACAA TATGACAGCT 
ACCTATAACC AGCTATCGAG ATCAACATCA GGCCCCAGAC CTGGGTGCCA GCCCAGCTCT 
CCTTGTGTGC CGAAGCTCAG CAACTCAGAC AGCCAGGACA TCCAGGGGCG GAATCGAGAC 
AGCCAGAATG GGGCCATAGC CCCTGGGCAC GTTTCAGTGA TTCGCCCTCC TCAAAATCTC 
TACCCAGAAA ACATTGTGCC CTCTTTCTCC CCTGGGCCTT CAGGGAGATA CGGAGCTAGT 
GGTAGGAGTG AAGGTGGCAG GAATTCCCGG GTCACCCCTG CAGCTGCCAA CTACCGCAGC 
AGAACTGCAA AGGCAAAGCC TTCCAAGCAA CAGGGAGCTG GGGATGCAGA AGAGGAAGAG 
GAGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRAFD1 ( NM_006700.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006691.1 Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13830
Clone ID Related Accession (Same CDS sequence)	NM_006700.2 , NM_006700.3 , NM_001143906.1
Accession Version	NM_006700.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	TRAF-type zinc finger domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK312601.1, BC003553.2 and CA314188.1. On Jan 9, 2009 this sequence version replaced NM_006700.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.46222.1, SRR1660805.204133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAAT TTCTAGATGA CCAGGAAACT CGACTGTGTG ACAACTGCAA AAAAGAAATT 
CCTGTGTTTA ACTTTACCAT CCATGAGATC CACTGTCAAA GGAACATTGG TATGTGTCCT 
ACCTGTAAGG AACCATTTCC CAAATCTGAC ATGGAGACTC ACATGGCTGC AGAACACTGT 
CAGGTGACCT GCAAATGTAA CAAGAAGTTG GAGAAGAGGC TGTTAAAGAA GCATGAGGAG 
ACTGAGTGCC CTTTGCGGCT TGCTGTCTGC CAGCACTGTG ATTTAGAACT TTCCATTCTC 
AAACTGAAGG AACATGAAGA TTATTGTGGT GCCCGGACGG AACTATGTGG CAACTGTGGT 
CGCAATGTCC TTGTGAAAGA TCTGAAGACT CACCCTGAAG TTTGTGGGAG AGAGGGGGAG 
GAAAAGAGAA ATGAGGTTGC CATACCTCCT AATGCATATG ATGAATCTTG GGGTCAGGAT 
GGAATCTGGA TTGCATCCCA ACTCCTCAGA CAAATTGAGG CTCTGGACCC ACCCATGAGG 
CTGCCGCGAA GGCCCCTGAG AGCCTTTGAA TCAGATGTTT TCCACAATAG AACTACCAAC 
CAAAGGAACA TTACAGCCCA GGTTTCAATT CAGAATAATC TGTTTGAAGA ACAAGAGAGG 
CAGGAAAGGA ATAGAGGCCA ACAGCCCCCC AAAGAGGGTG GTGAAGAGAG TGCAAACTTG 
GACTTCATGT TGGCCCTAAG TCTGCAAAAT GAAGGCCAAG CCTCCAGTGT GGCAGAGCAG 
GACTTCTGGA GGGCCGTATG TGAGGCCGAC CAGTCTCATG GCGGTCCCAG GTCTCTCAGT 
GACATAAAGG GTGCAGCTGA CGAGATCATG TTGCCTTGTG AATTTTGTGA GGAGCTCTAC 
CCAGAGGAAC TGCTGATTGA CCATCAGACA AGCTGTAACC CTTCACGTGC CTTACCTTCA 
CTCAATACTG GCAGCTCTTC CCCCAGAGGG GTGGAGGAAC CTGATGTCAT CTTCCAGAAC 
TTCTTGCAAC AGGCTGCAAG TAACCAGTTA GACTCTTTGA TGGGCCTGAG CAATTCACAC 
CCTGTGGAGG AGAGCATCAT TATCCCATGT GAATTCTGTG GGGTACAGCT GGAAGAGGAG 
GTGCTGTTCC ATCACCAGGA CCAGTGTGAC CAACGCCCAG CCACTGCAAC CAACCATGTG 
ACAGAGGGGA TTCCTAGACT GGATTCCCAG CCTCAAGAGA CCTCACCAGA GCTGCCCAGG 
AGGCGTGTCA GACACCAGGG AGACCTGTCT TCTGGTTACC TGGATGATAC TAAGCAGGAA 
ACAGCTAATG GGCCCACCTC CTGTCTGCCT CCCAGCCGAC CCATTAACAA TATGACAGCT 
ACCTATAACC AGCTATCGAG ATCAACATCA GGCCCCAGAC CTGGGTGCCA GCCCAGCTCT 
CCTTGTGTGC CGAAGCTCAG CAACTCAGAC AGCCAGGACA TCCAGGGGCG GAATCGAGAC 
AGCCAGAATG GGGCCATAGC CCCTGGGCAC GTTTCAGTGA TTCGCCCTCC TCAAAATCTC 
TACCCAGAAA ACATTGTGCC CTCTTTCTCC CCTGGGCCTT CAGGGAGATA CGGAGCTAGT 
GGTAGGAGTG AAGGTGGCAG GAATTCCCGG GTCACCCCTG CAGCTGCCAA CTACCGCAGC 
AGAACTGCAA AGGCAAAGCC TTCCAAGCAA CAGGGAGCTG GGGATGCAGA AGAGGAAGAG 
GAGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006691.1
CDS	87..1835
Translation	MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE

Target ORF information:

RefSeq Version	NM_006700.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006700.2

ORF Insert Sequence:

ATGGCTGAAT TTCTAGATGA CCAGGAAACT CGACTGTGTG ACAACTGCAA AAAAGAAATT 
CCTGTGTTTA ACTTTACCAT CCATGAGATC CACTGTCAAA GGAACATTGG TATGTGTCCT 
ACCTGTAAGG AACCATTTCC CAAATCTGAC ATGGAGACTC ACATGGCTGC AGAACACTGT 
CAGGTGACCT GCAAATGTAA CAAGAAGTTG GAGAAGAGGC TGTTAAAGAA GCATGAGGAG 
ACTGAGTGCC CTTTGCGGCT TGCTGTCTGC CAGCACTGTG ATTTAGAACT TTCCATTCTC 
AAACTGAAGG AACATGAAGA TTATTGTGGT GCCCGGACGG AACTATGTGG CAACTGTGGT 
CGCAATGTCC TTGTGAAAGA TCTGAAGACT CACCCTGAAG TTTGTGGGAG AGAGGGGGAG 
GAAAAGAGAA ATGAGGTTGC CATACCTCCT AATGCATATG ATGAATCTTG GGGTCAGGAT 
GGAATCTGGA TTGCATCCCA ACTCCTCAGA CAAATTGAGG CTCTGGACCC ACCCATGAGG 
CTGCCGCGAA GGCCCCTGAG AGCCTTTGAA TCAGATGTTT TCCACAATAG AACTACCAAC 
CAAAGGAACA TTACAGCCCA GGTTTCAATT CAGAATAATC TGTTTGAAGA ACAAGAGAGG 
CAGGAAAGGA ATAGAGGCCA ACAGCCCCCC AAAGAGGGTG GTGAAGAGAG TGCAAACTTG 
GACTTCATGT TGGCCCTAAG TCTGCAAAAT GAAGGCCAAG CCTCCAGTGT GGCAGAGCAG 
GACTTCTGGA GGGCCGTATG TGAGGCCGAC CAGTCTCATG GCGGTCCCAG GTCTCTCAGT 
GACATAAAGG GTGCAGCTGA CGAGATCATG TTGCCTTGTG AATTTTGTGA GGAGCTCTAC 
CCAGAGGAAC TGCTGATTGA CCATCAGACA AGCTGTAACC CTTCACGTGC CTTACCTTCA 
CTCAATACTG GCAGCTCTTC CCCCAGAGGG GTGGAGGAAC CTGATGTCAT CTTCCAGAAC 
TTCTTGCAAC AGGCTGCAAG TAACCAGTTA GACTCTTTGA TGGGCCTGAG CAATTCACAC 
CCTGTGGAGG AGAGCATCAT TATCCCATGT GAATTCTGTG GGGTACAGCT GGAAGAGGAG 
GTGCTGTTCC ATCACCAGGA CCAGTGTGAC CAACGCCCAG CCACTGCAAC CAACCATGTG 
ACAGAGGGGA TTCCTAGACT GGATTCCCAG CCTCAAGAGA CCTCACCAGA GCTGCCCAGG 
AGGCGTGTCA GACACCAGGG AGACCTGTCT TCTGGTTACC TGGATGATAC TAAGCAGGAA 
ACAGCTAATG GGCCCACCTC CTGTCTGCCT CCCAGCCGAC CCATTAACAA TATGACAGCT 
ACCTATAACC AGCTATCGAG ATCAACATCA GGCCCCAGAC CTGGGTGCCA GCCCAGCTCT 
CCTTGTGTGC CGAAGCTCAG CAACTCAGAC AGCCAGGACA TCCAGGGGCG GAATCGAGAC 
AGCCAGAATG GGGCCATAGC CCCTGGGCAC GTTTCAGTGA TTCGCCCTCC TCAAAATCTC 
TACCCAGAAA ACATTGTGCC CTCTTTCTCC CCTGGGCCTT CAGGGAGATA CGGAGCTAGT 
GGTAGGAGTG AAGGTGGCAG GAATTCCCGG GTCACCCCTG CAGCTGCCAA CTACCGCAGC 
AGAACTGCAA AGGCAAAGCC TTCCAAGCAA CAGGGAGCTG GGGATGCAGA AGAGGAAGAG 
GAGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRAFD1 ( NM_006700.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006691.1 Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13830
Clone ID Related Accession (Same CDS sequence)	NM_006700.2 , NM_006700.3 , NM_001143906.1
Accession Version	NM_006700.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	TRAF-type zinc finger domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK312601.1, BC003553.2 and CA314188.1. On Nov 24, 2018 this sequence version replaced NM_006700.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.46222.1, SRR3476690.536433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000412615.7/ ENSP00000396526.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGAAT TTCTAGATGA CCAGGAAACT CGACTGTGTG ACAACTGCAA AAAAGAAATT 
CCTGTGTTTA ACTTTACCAT CCATGAGATC CACTGTCAAA GGAACATTGG TATGTGTCCT 
ACCTGTAAGG AACCATTTCC CAAATCTGAC ATGGAGACTC ACATGGCTGC AGAACACTGT 
CAGGTGACCT GCAAATGTAA CAAGAAGTTG GAGAAGAGGC TGTTAAAGAA GCATGAGGAG 
ACTGAGTGCC CTTTGCGGCT TGCTGTCTGC CAGCACTGTG ATTTAGAACT TTCCATTCTC 
AAACTGAAGG AACATGAAGA TTATTGTGGT GCCCGGACGG AACTATGTGG CAACTGTGGT 
CGCAATGTCC TTGTGAAAGA TCTGAAGACT CACCCTGAAG TTTGTGGGAG AGAGGGGGAG 
GAAAAGAGAA ATGAGGTTGC CATACCTCCT AATGCATATG ATGAATCTTG GGGTCAGGAT 
GGAATCTGGA TTGCATCCCA ACTCCTCAGA CAAATTGAGG CTCTGGACCC ACCCATGAGG 
CTGCCGCGAA GGCCCCTGAG AGCCTTTGAA TCAGATGTTT TCCACAATAG AACTACCAAC 
CAAAGGAACA TTACAGCCCA GGTTTCAATT CAGAATAATC TGTTTGAAGA ACAAGAGAGG 
CAGGAAAGGA ATAGAGGCCA ACAGCCCCCC AAAGAGGGTG GTGAAGAGAG TGCAAACTTG 
GACTTCATGT TGGCCCTAAG TCTGCAAAAT GAAGGCCAAG CCTCCAGTGT GGCAGAGCAG 
GACTTCTGGA GGGCCGTATG TGAGGCCGAC CAGTCTCATG GCGGTCCCAG GTCTCTCAGT 
GACATAAAGG GTGCAGCTGA CGAGATCATG TTGCCTTGTG AATTTTGTGA GGAGCTCTAC 
CCAGAGGAAC TGCTGATTGA CCATCAGACA AGCTGTAACC CTTCACGTGC CTTACCTTCA 
CTCAATACTG GCAGCTCTTC CCCCAGAGGG GTGGAGGAAC CTGATGTCAT CTTCCAGAAC 
TTCTTGCAAC AGGCTGCAAG TAACCAGTTA GACTCTTTGA TGGGCCTGAG CAATTCACAC 
CCTGTGGAGG AGAGCATCAT TATCCCATGT GAATTCTGTG GGGTACAGCT GGAAGAGGAG 
GTGCTGTTCC ATCACCAGGA CCAGTGTGAC CAACGCCCAG CCACTGCAAC CAACCATGTG 
ACAGAGGGGA TTCCTAGACT GGATTCCCAG CCTCAAGAGA CCTCACCAGA GCTGCCCAGG 
AGGCGTGTCA GACACCAGGG AGACCTGTCT TCTGGTTACC TGGATGATAC TAAGCAGGAA 
ACAGCTAATG GGCCCACCTC CTGTCTGCCT CCCAGCCGAC CCATTAACAA TATGACAGCT 
ACCTATAACC AGCTATCGAG ATCAACATCA GGCCCCAGAC CTGGGTGCCA GCCCAGCTCT 
CCTTGTGTGC CGAAGCTCAG CAACTCAGAC AGCCAGGACA TCCAGGGGCG GAATCGAGAC 
AGCCAGAATG GGGCCATAGC CCCTGGGCAC GTTTCAGTGA TTCGCCCTCC TCAAAATCTC 
TACCCAGAAA ACATTGTGCC CTCTTTCTCC CCTGGGCCTT CAGGGAGATA CGGAGCTAGT 
GGTAGGAGTG AAGGTGGCAG GAATTCCCGG GTCACCCCTG CAGCTGCCAA CTACCGCAGC 
AGAACTGCAA AGGCAAAGCC TTCCAAGCAA CAGGGAGCTG GGGATGCAGA AGAGGAAGAG 
GAGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006691.1
CDS	72..1820
Translation	MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE

Target ORF information:

RefSeq Version	NM_006700.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006700.3

ORF Insert Sequence:

ATGGCTGAAT TTCTAGATGA CCAGGAAACT CGACTGTGTG ACAACTGCAA AAAAGAAATT 
CCTGTGTTTA ACTTTACCAT CCATGAGATC CACTGTCAAA GGAACATTGG TATGTGTCCT 
ACCTGTAAGG AACCATTTCC CAAATCTGAC ATGGAGACTC ACATGGCTGC AGAACACTGT 
CAGGTGACCT GCAAATGTAA CAAGAAGTTG GAGAAGAGGC TGTTAAAGAA GCATGAGGAG 
ACTGAGTGCC CTTTGCGGCT TGCTGTCTGC CAGCACTGTG ATTTAGAACT TTCCATTCTC 
AAACTGAAGG AACATGAAGA TTATTGTGGT GCCCGGACGG AACTATGTGG CAACTGTGGT 
CGCAATGTCC TTGTGAAAGA TCTGAAGACT CACCCTGAAG TTTGTGGGAG AGAGGGGGAG 
GAAAAGAGAA ATGAGGTTGC CATACCTCCT AATGCATATG ATGAATCTTG GGGTCAGGAT 
GGAATCTGGA TTGCATCCCA ACTCCTCAGA CAAATTGAGG CTCTGGACCC ACCCATGAGG 
CTGCCGCGAA GGCCCCTGAG AGCCTTTGAA TCAGATGTTT TCCACAATAG AACTACCAAC 
CAAAGGAACA TTACAGCCCA GGTTTCAATT CAGAATAATC TGTTTGAAGA ACAAGAGAGG 
CAGGAAAGGA ATAGAGGCCA ACAGCCCCCC AAAGAGGGTG GTGAAGAGAG TGCAAACTTG 
GACTTCATGT TGGCCCTAAG TCTGCAAAAT GAAGGCCAAG CCTCCAGTGT GGCAGAGCAG 
GACTTCTGGA GGGCCGTATG TGAGGCCGAC CAGTCTCATG GCGGTCCCAG GTCTCTCAGT 
GACATAAAGG GTGCAGCTGA CGAGATCATG TTGCCTTGTG AATTTTGTGA GGAGCTCTAC 
CCAGAGGAAC TGCTGATTGA CCATCAGACA AGCTGTAACC CTTCACGTGC CTTACCTTCA 
CTCAATACTG GCAGCTCTTC CCCCAGAGGG GTGGAGGAAC CTGATGTCAT CTTCCAGAAC 
TTCTTGCAAC AGGCTGCAAG TAACCAGTTA GACTCTTTGA TGGGCCTGAG CAATTCACAC 
CCTGTGGAGG AGAGCATCAT TATCCCATGT GAATTCTGTG GGGTACAGCT GGAAGAGGAG 
GTGCTGTTCC ATCACCAGGA CCAGTGTGAC CAACGCCCAG CCACTGCAAC CAACCATGTG 
ACAGAGGGGA TTCCTAGACT GGATTCCCAG CCTCAAGAGA CCTCACCAGA GCTGCCCAGG 
AGGCGTGTCA GACACCAGGG AGACCTGTCT TCTGGTTACC TGGATGATAC TAAGCAGGAA 
ACAGCTAATG GGCCCACCTC CTGTCTGCCT CCCAGCCGAC CCATTAACAA TATGACAGCT 
ACCTATAACC AGCTATCGAG ATCAACATCA GGCCCCAGAC CTGGGTGCCA GCCCAGCTCT 
CCTTGTGTGC CGAAGCTCAG CAACTCAGAC AGCCAGGACA TCCAGGGGCG GAATCGAGAC 
AGCCAGAATG GGGCCATAGC CCCTGGGCAC GTTTCAGTGA TTCGCCCTCC TCAAAATCTC 
TACCCAGAAA ACATTGTGCC CTCTTTCTCC CCTGGGCCTT CAGGGAGATA CGGAGCTAGT 
GGTAGGAGTG AAGGTGGCAG GAATTCCCGG GTCACCCCTG CAGCTGCCAA CTACCGCAGC 
AGAACTGCAA AGGCAAAGCC TTCCAAGCAA CAGGGAGCTG GGGATGCAGA AGAGGAAGAG 
GAGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption.
PloS one10(5)e0127537(2015)
Witwicka H,Jia H,Kutikov A,Reyes-Gutierrez P,Li X,Odgren PR

Development and application of a DNA microarray-based yeast two-hybrid system.
Nucleic acids research41(3)1496-507(2013 Feb)
Suter B,Fontaine JF,Yildirimman R,Rask? T,Schaefer MH,Rasche A,Porras P,V?zquez-?lvarez BM,Russ J,Rau K,Foulle R,Zenkner M,Saar K,Herwig R,Andrade-Navarro MA,Wanker EE

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
Nature genetics41(11)1191-8(2009 Nov)
Ganesh SK,Zakai NA,van Rooij FJ,Soranzo N,Smith AV,Nalls MA,Chen MH,Kottgen A,Glazer NL,Dehghan A,Kuhnel B,Aspelund T,Yang Q,Tanaka T,Jaffe A,Bis JC,Verwoert GC,Teumer A,Fox CS,Guralnik JM,Ehret GB,Rice K,Felix JF,Rendon A,Eiriksdottir G,Levy D,Patel KV,Boerwinkle E,Rotter JI,Hofman A,Sambrook JG,Hernandez DG,Zheng G,Bandinelli S,Singleton AB,Coresh J,Lumley T,Uitterlinden AG,Vangils JM,Launer LJ,Cupples LA,Oostra BA,Zwaginga JJ,Ouwehand WH,Thein SL,Meisinger C,Deloukas P,Nauck M,Spector TD,Gieger C,Gudnason V,van Duijn CM,Psaty BM,Ferrucci L,Chakravarti A,Greinacher A,O'Donnell CJ,Witteman JC,Furth S,Cushman M,Harris TB,Lin JP

FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
The Journal of biological chemistry283(49)33858-64(2008 Dec)
Sanada T,Takaesu G,Mashima R,Yoshida R,Kobayashi T,Yoshimura A

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Nature447(7145)661-78(2007 Jun)