WDR3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WDR3
Entrez Gene ID	10885
Full Name	WD repeat domain 3
Synonyms	DIP2,UTP12
General protein information	Preferred Names WD repeat domain 3 Names WD repeat-containing protein 3 dJ776P7.2 (WD repeat domain 3)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p12
Summary	This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008].
Disorder MIM:	604737

mRNA and Protein(s)

mRNA	Protein	Name
NM_006784.3	NP_006775.1	WD repeat-containing protein 3
NM_006784.2	NP_006775.1	WD repeat-containing protein 3

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	WDR3	NP_001026656.1
Drosophila melanogaster (fruit fly)	CG8064	NP_650705.1
Caenorhabditis elegans (roundworm)	F13H8.2	NP_495256.1
Eremothecium gossypii	AGOS_AGL196C	NP_986471.2
Saccharomyces cerevisiae (baker's yeast)	DIP2	NP_013230.1
Neurospora crassa	NCU03051	XP_963715.1
Pan troglodytes (chimpanzee)	WDR3	XP_524820.3
Magnaporthe oryzae (rice blast fungus)	MGG_04746	XP_003713707.1
Xenopus tropicalis (tropical clawed frog)	wdr3	NP_989242.1
Homo sapiens (human)	WDR3	NP_006775.1
	WDR3	XP_001113399.1
Bos taurus (cattle)	WDR3	NP_001179317.1
Mus musculus (house mouse)	Wdr3	NP_780761.1
Rattus norvegicus (Norway rat)	Wdr3	NP_001101175.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001146	XP_322015.3
Schizosaccharomyces pombe (fission yeast)	SPBC3D6.12	NP_595524.1
Canis lupus familiaris (dog)	WDR3	XP_540261.2
Danio rerio (zebrafish)	wdr3	NP_942574.1
Kluyveromyces lactis	KLLA0D16390g	XP_453783.1
Arabidopsis thaliana (thale cress)	AT3G21540	NP_188791.3
Oryza sativa (rice)	Os03g0151700	NP_001048986.1

Gene Ontology
Bibliography

Related articles in PubMed

Association studies of WD repeat domain 3 and chitobiosyldiphosphodolichol beta-mannosyltransferase genes with schizophrenia in a Japanese population.
Kobayashi M, Jitoku D, Iwayama Y, Yamamoto N, Toyota T, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Kurumaji A, Yoshikawa T, Nishikawa T
PloS one13(1)e0190991(2018)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

Possible role of the WDR3 gene on genome stability in thyroid cancer patients.
Garc?a-Quispes WA, Pastor S, Galofr? P, Biarn?s J, Castell J, Vel?zquez A, Marcos R
PloS one7(9)e44288(2012)

WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population.
Akdi A, Gim?nez EM, Garc?a-Quispes W, Pastor S, Castell J, Biarn?s J, Marcos R, Vel?zquez A
Thyroid : official journal of the American Thyroid Association20(7)803-9(2010 Jul)

Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.
McMahon M, Ayll?n V, Panov KI, O'Connor R
The Journal of biological chemistry285(24)18309-18(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

WDR3 can modulate genome stability in thyroid cancer patients.
Title: Possible role of the WDR3 gene on genome stability in thyroid cancer patients.

Observational study of gene-disease association. (HuGE Navigator)
Title: WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population.

WDR3 has an essential function in 40 S ribosomal subunit synthesis and in ribosomal stress signaling to p53-mediated regulation of cell cycle progression in cancer cells
Title: Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

The following WDR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WDR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05794	NM_006784.3 Latest version!	Homo sapiens WD repeat domain 3 (WDR3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$657.30 $939.00
View Old Accession Versions >>
OHu05794	NM_006784.2	Homo sapiens WD repeat domain 3 (WDR3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$657.30 $939.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WDR3 ( NM_006784.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006775.1 Homo sapiens WD repeat domain 3 (WDR3), mRNA.

Price & Availability↑

CloneID	OHu05794
Clone ID Related Accession (Same CDS sequence)	NM_006784.3 , NM_006784.2
Accession Version	NM_006784.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2832bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	WD repeat-containing protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121993.7, BP281064.1, AK292438.1, AF083217.1, BU685597.1 and AA258068.1. On Nov 22, 2018 this sequence version replaced NM_006784.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.27264.1, SRR1660807.233060.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000349139.6/ ENSP00000308179.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGCTCA CCAAGCAGTA CCTACGCTAT GTTGCTAGTG CGGTCTTTGG CGTTATCGGC 
AGCCAAAAAG GTAATATTGT CTTTGTGACA CTTCGTGGTG AGAAAGGACG TTATGTGGCA 
GTACCAGCTT GTGAACACGT TTTCATCTGG GACTTAAGGA AAGGAGAGAA GATTCTTATC 
CTTCAGGGGC TTAAACAAGA AGTTACTTGC TTATGCCCCT CCCCAGATGG GCTACACTTA 
GCTGTTGGGT ATGAGGATGG GTCGATCCGA ATCTTCAGTC TCCTGAGTGG GGAAGGAAAT 
GTGACCTTCA ATGGTCACAA AGCAGCTATC ACTACCTTGA AGTATGATCA GCTAGGAGGC 
AGACTGGCAT CTGGGTCCAA GGACACAGAT ATTATTGTAT GGGATGTGAT CAATGAAAGT 
GGTCTGTACC GTCTAAAGGG GCACAAGGAT GCCATCACAC AAGCATTGTT TCTACGAGAA 
AAGAACCTGC TAGTTACTAG TGGGAAAGAT ACCATGGTGA AATGGTGGGA CCTTGATACT 
CAGCACTGCT TTAAAACAAT GGTTGGCCAC CGGACTGAGG TATGGGGGTT GGTTCTGTTG 
TCAGAAGAAA AGCGACTCAT CACTGGGGCC TCAGACAGTG AACTGAGGGT ATGGGACATA 
GCTTATCTGC AAGAGATTGA AGACCCGGAA GAACCAGACC CCAAGAAAAT CAAAGGATCT 
TCTCCTGGAA TACAAGATAC TCTTGAGGCA GAGGATGGTG CCTTTGAGAC GGATGAAGCC 
CCTGAGGATC GAATCCTTTC ATGCAGAAAA GCTGGTTCCA TAATGCGGGA AGGAAGAGAC 
AGAGTTGTAA ACCTTGCAGT CGACAAGACA GGCAGGATTC TTGCTTGCCA TGGAACTGAC 
TCTGTGCTAG AATTGTTTTG TATCCTTTCC AAAAAGGAAA TTCAGAAGAA AATGGATAAG 
AAGATGAAGA AAGCTAGAAA GAAAGCAAAA TTACATTCTA GCAAAGGAGA GGAGGAAGAT 
CCTGAGGTTA ATGTTGAAAT GAGTCTGCAA GATGAAATCC AGCGGGTGAC TAATATAAAA 
ACTTCTGCCA AAATCAAGTC CTTTGACTTG ATTCATTCAC CTCACGGAGA GTTAAAGGCT 
GTCTTCCTGC TGCAGAACAA CCTGGTGGAA TTGTATTCAC TGAATCCATC CTTGCCTACT 
CCTCAGCCTG TCAGGACAAG CAGAATCACT ATTGGGGGTC ATCGCAGTGA TGTGCGGACT 
TTGTCATTCA GCTCAGACAA TATTGCTGTT CTTTCAGCTG CAGCTGATTC CATTAAAATA 
TGGAACAGGT CTACACTGCA GTGTATTCGC ACAATGACCT GTGAATATGC ACTTTGCTCA 
TTCTTTGTAC CTGGTGATAG ACAGGTAGTC ATAGGAACAA AGACAGGGAA GCTGCAGCTT 
TATGACTTGG CTTCAGGGAA TCTGCTGGAG ACAATAGATG CACATGATGG AGCTTTGTGG 
TCCATGTCCC TCTCTCCAGA TCAGCGTGGC TTTGTGACAG GTGGTGCAGA TAAATCTGTC 
AAATTCTGGG ATTTTGAGTT AGTGAAAGAT GAAAATAGTA CCCAAAAGAG ACTTTCTGTG 
AAGCAAACCC GAACTTTGCA ACTAGATGAA GATGTTCTGT GTGTCAGTTA CTCTCCCAAT 
CAAAAGCTAT TGGCTGTGTC TTTGCTGGAC TGTACTGTGA AAATTTTCTA CGTTGATACT 
TTAAAGTTTT TTCTGTCACT GTATGGACAC AAACTGCCTG TTATATGCAT GGACATCTCT 
CATGATGGAG CACTCATAGC AACTGGCTCC GCTGATAGGA ATGTGAAAAT CTGGGGTTTG 
GACTTTGGGG ACTGCCACAA GTCTCTCTTT GCACATGATG ACAGTGTGAT GTACCTACAG 
TTTGTACCCA AGTCTCACCT CTTCTTCACT GCCGGAAAAG ATCATAAGAT TAAACAGTGG 
GATGCAGACA AATTTGAACA CATACAGACT CTGGAGGGTC ATCACCAGGA AATATGGTGT 
TTGGCTGTAA GCCCCAGTGG AGACTATGTT GTATCATCGT CCCATGACAA ATCTCTGAGA 
CTTTGGGAGA GAACAAGGGA GCCTCTTATT CTTGAGGAAG AAAGGGAGAT GGAAAGAGAA 
GCAGAATATG AGGAGAGTGT GGCCAAAGAA GACCAACCAG CAGTTCCAGG AGAGACTCAA 
GGTGACAGTT ACTTTACTGG AAAGAAAACT ATTGAAACAG TGAAAGCAGC TGAGAGGATT 
ATGGAGGCTA TTGAGTTGTA CCGAGAAGAA ACTGCAAAAA TGAAGGAACA CAAAGCCATT 
TGTAAAGCTG CAGGGAAAGA GGTTCCACTT CCCAGCAACC CCATCCTAAT GGCTTATGGC 
AGTATCTCAC CTTCAGCTTA TGTATTAGAG ATTTTTAAAG GGATCAAGTC GAGTGAGCTG 
GAAGAATCTC TACTTGTGCT GCCTTTCTCT TATGTCCCAG ACATTCTTAA ACTCTTTAAC 
GAATTCATTC AGCTGGGCTC TGATGTTGAA CTTATATGCC GGTGCCTCTT CTTCCTCCTT 
AGGATTCACT TTGGACAGAT CACTAGCAAT CAAATGCTTG TGCCAGTGAT AGAAAAATTA 
AGGGAAACAA CTATTTCAAA AGTCAGCCAA GTCCGGGATG TTATCGGCTT CAATATGGCT 
GGTCTTGATT ATCTCAAGAG GGAATGCGAG GCAAAAAGTG AAGTTATGTT TTTTGCTGAT 
GCTACTAGCC ACTTGGAAGA GAAGAAGAGG AAGAGGAAAA AGAGGGAGAA GTTGATTCTA 
ACGTTGACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006775.1
CDS	77..2908
Translation	MGLTKQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMEREAEYEESVAKEDQPAVPGETQGDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT

Target ORF information:

RefSeq Version	NM_006784.3
Organism	Homo sapiens(human)
Definition	Homo sapiens WD repeat domain 3 (WDR3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006784.3

ORF Insert Sequence:

ATGGGGCTCA CCAAGCAGTA CCTACGCTAT GTTGCTAGTG CGGTCTTTGG CGTTATCGGC 
AGCCAAAAAG GTAATATTGT CTTTGTGACA CTTCGTGGTG AGAAAGGACG TTATGTGGCA 
GTACCAGCTT GTGAACACGT TTTCATCTGG GACTTAAGGA AAGGAGAGAA GATTCTTATC 
CTTCAGGGGC TTAAACAAGA AGTTACTTGC TTATGCCCCT CCCCAGATGG GCTACACTTA 
GCTGTTGGGT ATGAGGATGG GTCGATCCGA ATCTTCAGTC TCCTGAGTGG GGAAGGAAAT 
GTGACCTTCA ATGGTCACAA AGCAGCTATC ACTACCTTGA AGTATGATCA GCTAGGAGGC 
AGACTGGCAT CTGGGTCCAA GGACACAGAT ATTATTGTAT GGGATGTGAT CAATGAAAGT 
GGTCTGTACC GTCTAAAGGG GCACAAGGAT GCCATCACAC AAGCATTGTT TCTACGAGAA 
AAGAACCTGC TAGTTACTAG TGGGAAAGAT ACCATGGTGA AATGGTGGGA CCTTGATACT 
CAGCACTGCT TTAAAACAAT GGTTGGCCAC CGGACTGAGG TATGGGGGTT GGTTCTGTTG 
TCAGAAGAAA AGCGACTCAT CACTGGGGCC TCAGACAGTG AACTGAGGGT ATGGGACATA 
GCTTATCTGC AAGAGATTGA AGACCCGGAA GAACCAGACC CCAAGAAAAT CAAAGGATCT 
TCTCCTGGAA TACAAGATAC TCTTGAGGCA GAGGATGGTG CCTTTGAGAC GGATGAAGCC 
CCTGAGGATC GAATCCTTTC ATGCAGAAAA GCTGGTTCCA TAATGCGGGA AGGAAGAGAC 
AGAGTTGTAA ACCTTGCAGT CGACAAGACA GGCAGGATTC TTGCTTGCCA TGGAACTGAC 
TCTGTGCTAG AATTGTTTTG TATCCTTTCC AAAAAGGAAA TTCAGAAGAA AATGGATAAG 
AAGATGAAGA AAGCTAGAAA GAAAGCAAAA TTACATTCTA GCAAAGGAGA GGAGGAAGAT 
CCTGAGGTTA ATGTTGAAAT GAGTCTGCAA GATGAAATCC AGCGGGTGAC TAATATAAAA 
ACTTCTGCCA AAATCAAGTC CTTTGACTTG ATTCATTCAC CTCACGGAGA GTTAAAGGCT 
GTCTTCCTGC TGCAGAACAA CCTGGTGGAA TTGTATTCAC TGAATCCATC CTTGCCTACT 
CCTCAGCCTG TCAGGACAAG CAGAATCACT ATTGGGGGTC ATCGCAGTGA TGTGCGGACT 
TTGTCATTCA GCTCAGACAA TATTGCTGTT CTTTCAGCTG CAGCTGATTC CATTAAAATA 
TGGAACAGGT CTACACTGCA GTGTATTCGC ACAATGACCT GTGAATATGC ACTTTGCTCA 
TTCTTTGTAC CTGGTGATAG ACAGGTAGTC ATAGGAACAA AGACAGGGAA GCTGCAGCTT 
TATGACTTGG CTTCAGGGAA TCTGCTGGAG ACAATAGATG CACATGATGG AGCTTTGTGG 
TCCATGTCCC TCTCTCCAGA TCAGCGTGGC TTTGTGACAG GTGGTGCAGA TAAATCTGTC 
AAATTCTGGG ATTTTGAGTT AGTGAAAGAT GAAAATAGTA CCCAAAAGAG ACTTTCTGTG 
AAGCAAACCC GAACTTTGCA ACTAGATGAA GATGTTCTGT GTGTCAGTTA CTCTCCCAAT 
CAAAAGCTAT TGGCTGTGTC TTTGCTGGAC TGTACTGTGA AAATTTTCTA CGTTGATACT 
TTAAAGTTTT TTCTGTCACT GTATGGACAC AAACTGCCTG TTATATGCAT GGACATCTCT 
CATGATGGAG CACTCATAGC AACTGGCTCC GCTGATAGGA ATGTGAAAAT CTGGGGTTTG 
GACTTTGGGG ACTGCCACAA GTCTCTCTTT GCACATGATG ACAGTGTGAT GTACCTACAG 
TTTGTACCCA AGTCTCACCT CTTCTTCACT GCCGGAAAAG ATCATAAGAT TAAACAGTGG 
GATGCAGACA AATTTGAACA CATACAGACT CTGGAGGGTC ATCACCAGGA AATATGGTGT 
TTGGCTGTAA GCCCCAGTGG AGACTATGTT GTATCATCGT CCCATGACAA ATCTCTGAGA 
CTTTGGGAGA GAACAAGGGA GCCTCTTATT CTTGAGGAAG AAAGGGAGAT GGAAAGAGAA 
GCAGAATATG AGGAGAGTGT GGCCAAAGAA GACCAACCAG CAGTTCCAGG AGAGACTCAA 
GGTGACAGTT ACTTTACTGG AAAGAAAACT ATTGAAACAG TGAAAGCAGC TGAGAGGATT 
ATGGAGGCTA TTGAGTTGTA CCGAGAAGAA ACTGCAAAAA TGAAGGAACA CAAAGCCATT 
TGTAAAGCTG CAGGGAAAGA GGTTCCACTT CCCAGCAACC CCATCCTAAT GGCTTATGGC 
AGTATCTCAC CTTCAGCTTA TGTATTAGAG ATTTTTAAAG GGATCAAGTC GAGTGAGCTG 
GAAGAATCTC TACTTGTGCT GCCTTTCTCT TATGTCCCAG ACATTCTTAA ACTCTTTAAC 
GAATTCATTC AGCTGGGCTC TGATGTTGAA CTTATATGCC GGTGCCTCTT CTTCCTCCTT 
AGGATTCACT TTGGACAGAT CACTAGCAAT CAAATGCTTG TGCCAGTGAT AGAAAAATTA 
AGGGAAACAA CTATTTCAAA AGTCAGCCAA GTCCGGGATG TTATCGGCTT CAATATGGCT 
GGTCTTGATT ATCTCAAGAG GGAATGCGAG GCAAAAAGTG AAGTTATGTT TTTTGCTGAT 
GCTACTAGCC ACTTGGAAGA GAAGAAGAGG AAGAGGAAAA AGAGGGAGAA GTTGATTCTA 
ACGTTGACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WDR3 ( NM_006784.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006775.1 Homo sapiens WD repeat domain 3 (WDR3), mRNA.

Price & Availability↑

CloneID	OHu05794
Clone ID Related Accession (Same CDS sequence)	NM_006784.3 , NM_006784.2
Accession Version	NM_006784.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2832bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	WD repeat-containing protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP281064.1, AK292438.1, AF083217.1, BU685597.1 and AA258068.1. On Aug 27, 2008 this sequence version replaced NM_006784.1. ##Evidence-Data-START## Transcript exon combination :: AF083217.1, SRR1803614.144149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGGGCTCA CCAAGCAGTA CCTACGCTAT GTTGCTAGTG CGGTCTTTGG CGTTATCGGC 
AGCCAAAAAG GTAATATTGT CTTTGTGACA CTTCGTGGTG AGAAAGGACG TTATGTGGCA 
GTACCAGCTT GTGAACACGT TTTCATCTGG GACTTAAGGA AAGGAGAGAA GATTCTTATC 
CTTCAGGGGC TTAAACAAGA AGTTACTTGC TTATGCCCCT CCCCAGATGG GCTACACTTA 
GCTGTTGGGT ATGAGGATGG GTCGATCCGA ATCTTCAGTC TCCTGAGTGG GGAAGGAAAT 
GTGACCTTCA ATGGTCACAA AGCAGCTATC ACTACCTTGA AGTATGATCA GCTAGGAGGC 
AGACTGGCAT CTGGGTCCAA GGACACAGAT ATTATTGTAT GGGATGTGAT CAATGAAAGT 
GGTCTGTACC GTCTAAAGGG GCACAAGGAT GCCATCACAC AAGCATTGTT TCTACGAGAA 
AAGAACCTGC TAGTTACTAG TGGGAAAGAT ACCATGGTGA AATGGTGGGA CCTTGATACT 
CAGCACTGCT TTAAAACAAT GGTTGGCCAC CGGACTGAGG TATGGGGGTT GGTTCTGTTG 
TCAGAAGAAA AGCGACTCAT CACTGGGGCC TCAGACAGTG AACTGAGGGT ATGGGACATA 
GCTTATCTGC AAGAGATTGA AGACCCGGAA GAACCAGACC CCAAGAAAAT CAAAGGATCT 
TCTCCTGGAA TACAAGATAC TCTTGAGGCA GAGGATGGTG CCTTTGAGAC GGATGAAGCC 
CCTGAGGATC GAATCCTTTC ATGCAGAAAA GCTGGTTCCA TAATGCGGGA AGGAAGAGAC 
AGAGTTGTAA ACCTTGCAGT CGACAAGACA GGCAGGATTC TTGCTTGCCA TGGAACTGAC 
TCTGTGCTAG AATTGTTTTG TATCCTTTCC AAAAAGGAAA TTCAGAAGAA AATGGATAAG 
AAGATGAAGA AAGCTAGAAA GAAAGCAAAA TTACATTCTA GCAAAGGAGA GGAGGAAGAT 
CCTGAGGTTA ATGTTGAAAT GAGTCTGCAA GATGAAATCC AGCGGGTGAC TAATATAAAA 
ACTTCTGCCA AAATCAAGTC CTTTGACTTG ATTCATTCAC CTCACGGAGA GTTAAAGGCT 
GTCTTCCTGC TGCAGAACAA CCTGGTGGAA TTGTATTCAC TGAATCCATC CTTGCCTACT 
CCTCAGCCTG TCAGGACAAG CAGAATCACT ATTGGGGGTC ATCGCAGTGA TGTGCGGACT 
TTGTCATTCA GCTCAGACAA TATTGCTGTT CTTTCAGCTG CAGCTGATTC CATTAAAATA 
TGGAACAGGT CTACACTGCA GTGTATTCGC ACAATGACCT GTGAATATGC ACTTTGCTCA 
TTCTTTGTAC CTGGTGATAG ACAGGTAGTC ATAGGAACAA AGACAGGGAA GCTGCAGCTT 
TATGACTTGG CTTCAGGGAA TCTGCTGGAG ACAATAGATG CACATGATGG AGCTTTGTGG 
TCCATGTCCC TCTCTCCAGA TCAGCGTGGC TTTGTGACAG GTGGTGCAGA TAAATCTGTC 
AAATTCTGGG ATTTTGAGTT AGTGAAAGAT GAAAATAGTA CCCAAAAGAG ACTTTCTGTG 
AAGCAAACCC GAACTTTGCA ACTAGATGAA GATGTTCTGT GTGTCAGTTA CTCTCCCAAT 
CAAAAGCTAT TGGCTGTGTC TTTGCTGGAC TGTACTGTGA AAATTTTCTA CGTTGATACT 
TTAAAGTTTT TTCTGTCACT GTATGGACAC AAACTGCCTG TTATATGCAT GGACATCTCT 
CATGATGGAG CACTCATAGC AACTGGCTCC GCTGATAGGA ATGTGAAAAT CTGGGGTTTG 
GACTTTGGGG ACTGCCACAA GTCTCTCTTT GCACATGATG ACAGTGTGAT GTACCTACAG 
TTTGTACCCA AGTCTCACCT CTTCTTCACT GCCGGAAAAG ATCATAAGAT TAAACAGTGG 
GATGCAGACA AATTTGAACA CATACAGACT CTGGAGGGTC ATCACCAGGA AATATGGTGT 
TTGGCTGTAA GCCCCAGTGG AGACTATGTT GTATCATCGT CCCATGACAA ATCTCTGAGA 
CTTTGGGAGA GAACAAGGGA GCCTCTTATT CTTGAGGAAG AAAGGGAGAT GGAAAGAGAA 
GCAGAATATG AGGAGAGTGT GGCCAAAGAA GACCAACCAG CAGTTCCAGG AGAGACTCAA 
GGTGACAGTT ACTTTACTGG AAAGAAAACT ATTGAAACAG TGAAAGCAGC TGAGAGGATT 
ATGGAGGCTA TTGAGTTGTA CCGAGAAGAA ACTGCAAAAA TGAAGGAACA CAAAGCCATT 
TGTAAAGCTG CAGGGAAAGA GGTTCCACTT CCCAGCAACC CCATCCTAAT GGCTTATGGC 
AGTATCTCAC CTTCAGCTTA TGTATTAGAG ATTTTTAAAG GGATCAAGTC GAGTGAGCTG 
GAAGAATCTC TACTTGTGCT GCCTTTCTCT TATGTCCCAG ACATTCTTAA ACTCTTTAAC 
GAATTCATTC AGCTGGGCTC TGATGTTGAA CTTATATGCC GGTGCCTCTT CTTCCTCCTT 
AGGATTCACT TTGGACAGAT CACTAGCAAT CAAATGCTTG TGCCAGTGAT AGAAAAATTA 
AGGGAAACAA CTATTTCAAA AGTCAGCCAA GTCCGGGATG TTATCGGCTT CAATATGGCT 
GGTCTTGATT ATCTCAAGAG GGAATGCGAG GCAAAAAGTG AAGTTATGTT TTTTGCTGAT 
GCTACTAGCC ACTTGGAAGA GAAGAAGAGG AAGAGGAAAA AGAGGGAGAA GTTGATTCTA 
ACGTTGACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006775.1
CDS	67..2898
Translation	MGLTKQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMEREAEYEESVAKEDQPAVPGETQGDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT

Target ORF information:

RefSeq Version	NM_006784.2
Organism	Homo sapiens(human)
Definition	Homo sapiens WD repeat domain 3 (WDR3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006784.2

ORF Insert Sequence:

ATGGGGCTCA CCAAGCAGTA CCTACGCTAT GTTGCTAGTG CGGTCTTTGG CGTTATCGGC 
AGCCAAAAAG GTAATATTGT CTTTGTGACA CTTCGTGGTG AGAAAGGACG TTATGTGGCA 
GTACCAGCTT GTGAACACGT TTTCATCTGG GACTTAAGGA AAGGAGAGAA GATTCTTATC 
CTTCAGGGGC TTAAACAAGA AGTTACTTGC TTATGCCCCT CCCCAGATGG GCTACACTTA 
GCTGTTGGGT ATGAGGATGG GTCGATCCGA ATCTTCAGTC TCCTGAGTGG GGAAGGAAAT 
GTGACCTTCA ATGGTCACAA AGCAGCTATC ACTACCTTGA AGTATGATCA GCTAGGAGGC 
AGACTGGCAT CTGGGTCCAA GGACACAGAT ATTATTGTAT GGGATGTGAT CAATGAAAGT 
GGTCTGTACC GTCTAAAGGG GCACAAGGAT GCCATCACAC AAGCATTGTT TCTACGAGAA 
AAGAACCTGC TAGTTACTAG TGGGAAAGAT ACCATGGTGA AATGGTGGGA CCTTGATACT 
CAGCACTGCT TTAAAACAAT GGTTGGCCAC CGGACTGAGG TATGGGGGTT GGTTCTGTTG 
TCAGAAGAAA AGCGACTCAT CACTGGGGCC TCAGACAGTG AACTGAGGGT ATGGGACATA 
GCTTATCTGC AAGAGATTGA AGACCCGGAA GAACCAGACC CCAAGAAAAT CAAAGGATCT 
TCTCCTGGAA TACAAGATAC TCTTGAGGCA GAGGATGGTG CCTTTGAGAC GGATGAAGCC 
CCTGAGGATC GAATCCTTTC ATGCAGAAAA GCTGGTTCCA TAATGCGGGA AGGAAGAGAC 
AGAGTTGTAA ACCTTGCAGT CGACAAGACA GGCAGGATTC TTGCTTGCCA TGGAACTGAC 
TCTGTGCTAG AATTGTTTTG TATCCTTTCC AAAAAGGAAA TTCAGAAGAA AATGGATAAG 
AAGATGAAGA AAGCTAGAAA GAAAGCAAAA TTACATTCTA GCAAAGGAGA GGAGGAAGAT 
CCTGAGGTTA ATGTTGAAAT GAGTCTGCAA GATGAAATCC AGCGGGTGAC TAATATAAAA 
ACTTCTGCCA AAATCAAGTC CTTTGACTTG ATTCATTCAC CTCACGGAGA GTTAAAGGCT 
GTCTTCCTGC TGCAGAACAA CCTGGTGGAA TTGTATTCAC TGAATCCATC CTTGCCTACT 
CCTCAGCCTG TCAGGACAAG CAGAATCACT ATTGGGGGTC ATCGCAGTGA TGTGCGGACT 
TTGTCATTCA GCTCAGACAA TATTGCTGTT CTTTCAGCTG CAGCTGATTC CATTAAAATA 
TGGAACAGGT CTACACTGCA GTGTATTCGC ACAATGACCT GTGAATATGC ACTTTGCTCA 
TTCTTTGTAC CTGGTGATAG ACAGGTAGTC ATAGGAACAA AGACAGGGAA GCTGCAGCTT 
TATGACTTGG CTTCAGGGAA TCTGCTGGAG ACAATAGATG CACATGATGG AGCTTTGTGG 
TCCATGTCCC TCTCTCCAGA TCAGCGTGGC TTTGTGACAG GTGGTGCAGA TAAATCTGTC 
AAATTCTGGG ATTTTGAGTT AGTGAAAGAT GAAAATAGTA CCCAAAAGAG ACTTTCTGTG 
AAGCAAACCC GAACTTTGCA ACTAGATGAA GATGTTCTGT GTGTCAGTTA CTCTCCCAAT 
CAAAAGCTAT TGGCTGTGTC TTTGCTGGAC TGTACTGTGA AAATTTTCTA CGTTGATACT 
TTAAAGTTTT TTCTGTCACT GTATGGACAC AAACTGCCTG TTATATGCAT GGACATCTCT 
CATGATGGAG CACTCATAGC AACTGGCTCC GCTGATAGGA ATGTGAAAAT CTGGGGTTTG 
GACTTTGGGG ACTGCCACAA GTCTCTCTTT GCACATGATG ACAGTGTGAT GTACCTACAG 
TTTGTACCCA AGTCTCACCT CTTCTTCACT GCCGGAAAAG ATCATAAGAT TAAACAGTGG 
GATGCAGACA AATTTGAACA CATACAGACT CTGGAGGGTC ATCACCAGGA AATATGGTGT 
TTGGCTGTAA GCCCCAGTGG AGACTATGTT GTATCATCGT CCCATGACAA ATCTCTGAGA 
CTTTGGGAGA GAACAAGGGA GCCTCTTATT CTTGAGGAAG AAAGGGAGAT GGAAAGAGAA 
GCAGAATATG AGGAGAGTGT GGCCAAAGAA GACCAACCAG CAGTTCCAGG AGAGACTCAA 
GGTGACAGTT ACTTTACTGG AAAGAAAACT ATTGAAACAG TGAAAGCAGC TGAGAGGATT 
ATGGAGGCTA TTGAGTTGTA CCGAGAAGAA ACTGCAAAAA TGAAGGAACA CAAAGCCATT 
TGTAAAGCTG CAGGGAAAGA GGTTCCACTT CCCAGCAACC CCATCCTAAT GGCTTATGGC 
AGTATCTCAC CTTCAGCTTA TGTATTAGAG ATTTTTAAAG GGATCAAGTC GAGTGAGCTG 
GAAGAATCTC TACTTGTGCT GCCTTTCTCT TATGTCCCAG ACATTCTTAA ACTCTTTAAC 
GAATTCATTC AGCTGGGCTC TGATGTTGAA CTTATATGCC GGTGCCTCTT CTTCCTCCTT 
AGGATTCACT TTGGACAGAT CACTAGCAAT CAAATGCTTG TGCCAGTGAT AGAAAAATTA 
AGGGAAACAA CTATTTCAAA AGTCAGCCAA GTCCGGGATG TTATCGGCTT CAATATGGCT 
GGTCTTGATT ATCTCAAGAG GGAATGCGAG GCAAAAAGTG AAGTTATGTT TTTTGCTGAT 
GCTACTAGCC ACTTGGAAGA GAAGAAGAGG AAGAGGAAAA AGAGGGAGAA GTTGATTCTA 
ACGTTGACTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association studies of WD repeat domain 3 and chitobiosyldiphosphodolichol beta-mannosyltransferase genes with schizophrenia in a Japanese population.
PloS one13(1)e0190991(2018)
Kobayashi M,Jitoku D,Iwayama Y,Yamamoto N,Toyota T,Suzuki K,Kikuchi M,Hashimoto T,Kanahara N,Kurumaji A,Yoshikawa T,Nishikawa T

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

Possible role of the WDR3 gene on genome stability in thyroid cancer patients.
PloS one7(9)e44288(2012)
Garc?a-Quispes WA,Pastor S,Galofr? P,Biarn?s J,Castell J,Vel?zquez A,Marcos R

WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population.
Thyroid : official journal of the American Thyroid Association20(7)803-9(2010 Jul)
Akdi A,Gim?nez EM,Garc?a-Quispes W,Pastor S,Castell J,Biarn?s J,Marcos R,Vel?zquez A

Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.
The Journal of biological chemistry285(24)18309-18(2010 Jun)
McMahon M,Ayll?n V,Panov KI,O'Connor R

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WDR3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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