MRPS30 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPS30
Entrez Gene ID	10884
Full Name	mitochondrial ribosomal protein S30
Synonyms	MRP-S30,PAP,PDCD9,S30mt
General protein information	Preferred Names mitochondrial ribosomal protein S30 Names 39S ribosomal protein S30, mitochondrial 28S ribosomal protein S30, mitochondrial mitochondrial large ribosomal subunit protein mL65 mitochondrial large ribosomal subunit protein mS30 programmed cell death 9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p12
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008].
Disorder MIM:	611991

mRNA and Protein(s)

mRNA	Protein	Name
NM_016640.4	NP_057724.2	39S ribosomal protein S30, mitochondrial
NM_016640.3	NP_057724.2	39S ribosomal protein S30, mitochondrial

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Mrps30	NP_067531.1
Bos taurus (cattle)	MRPS30	NP_001073063.1
Danio rerio (zebrafish)	LOC100332353	XP_002667146.2
Pan troglodytes (chimpanzee)	MRPS30	XP_517775.2
	MRPS30	XP_001092818.1
Rattus norvegicus (Norway rat)	Mrps30	NP_001099882.1
Drosophila melanogaster (fruit fly)	mRpS30	NP_511167.1
Homo sapiens (human)	MRPS30	NP_057724.2
Canis lupus familiaris (dog)	MRPS30	XP_536480.3
Danio rerio (zebrafish)	mrps30	NP_001082840.1
Xenopus tropicalis (tropical clawed frog)	mrps30	NP_001017073.1
Gallus gallus (chicken)	MRPS30	NP_990270.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001134	XP_322027.4

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J, Canisus S, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Dennis J, Bolla MK, Wang Q, Dicks E, Milne RL, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Fletcher O, Johnson N, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Gu?nel P, Truong T, Bojesen SE, Flyger H, Benitez J, Gonz?lez-Neira A, Alonso MR, Pita G, Neuhausen SL, Anton-Culver H, Brenner H, Arndt V, Meindl A, Schmutzler RK, Brauch H, Hamann U, Tessier DC, Vincent D, Nevanlinna H, Khan S, Matsuo K, Ito H, D?rk T, Bogdanova NV, Lindblom A, Margolin S, Mannermaa A, Kosma VM, , Wu AH, Van Den Berg D, Lambrechts D, Floris G, Chang-Claude J, Rudolph A, Radice P, Barile M, Couch FJ, Hallberg E, Giles GG, Haiman CA, Le Marchand L, Goldberg MS, Teo SH, Yip CH, Borresen-Dale AL, , Zheng W, Cai Q, Winqvist R, Pylk?s K, Andrulis IL, Devilee P, Tollenaar RA, Garc?a-Closas M, Figueroa J, Hall P, Czene K, Brand JS, Darabi H, Eriksson M, Hooning MJ, Koppert LB, Li J, Shu XO, Zheng Y, Cox A, Cross SS, Shah M, Rhenius V, Choi JY, Kang D, Hartman M, Chia KS, Kabisch M, Torres D, Luccarini C, Conroy DM, Jakubowska A, Lubinski J, Sangrajrang S, Brennan P, Olswold C, Slager S, Shen CY, Hou MF, Swerdlow A, Schoemaker MJ, Simard J, Pharoah PD, Kristensen V, Chenevix-Trench G, Easton DF, Dunning AM, Edwards SL
American journal of human genetics99(4)903-911(2016 Oct)

The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.
Quigley DA, Fiorito E, Nord S, Van Loo P, Aln?s GG, Fleischer T, Tost J, Moen Vollan HK, Tramm T, Overgaard J, Bukholm IR, Hurtado A, Balmain A, B?rresen-Dale AL, Kristensen V
Molecular oncology8(2)273-84(2014 Mar)

Breast cancer association studies in a Han Chinese population using 10 European-ancestry-associated breast cancer susceptibility SNPs.
Guan YP, Yang XX, Yao GY, Qiu F, Chen J, Chen LJ, Ye CS, Li M
Asian Pacific journal of cancer prevention : APJCP15(1)85-91(2014)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30, two candidate genes for breast cancer pathogenesis
Title: Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.

The risk-associated allele of rs7716600 in the 5p12 ER-positive susceptibility locus was associated with elevated expression of the nearby gene MRPS30 and decreased MRPS30 promoter methylation exclusively in ER-positive tumors. eQTL and in vitro experiments suggest this allele affects MRPS30 expression in estrogen-responsive tumor cells after tumor initiation by a mechanism affecting chromatin availability.
Title: The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.

Among the 10 SNPs studied, rs10941679 in MRPS30 showed significant association with breast cancer risk when differences between the case and control groups in this Han Chinese population were compared.
Title: Breast cancer association studies in a Han Chinese population using 10 European-ancestry-associated breast cancer susceptibility SNPs.

Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPS30 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPS30 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17126	NM_016640.4 Latest version!	Homo sapiens mitochondrial ribosomal protein S30 (MRPS30), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu17126	NM_016640.3	Homo sapiens mitochondrial ribosomal protein S30 (MRPS30), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPS30 ( NM_016640.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057724.2 Homo sapiens mitochondrial ribosomal protein S30 (MRPS30), mRNA.

Price & Availability↑

CloneID	OHu17126
Clone ID Related Accession (Same CDS sequence)	NM_016640.4 , NM_016640.3
Accession Version	NM_016640.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	39S ribosomal protein S30, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF146192.2, BC007735.2 and BU676154.1. On Nov 23, 2018 this sequence version replaced NM_016640.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.145963.1, SRR1660803.3338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000507110.6/ ENSP00000424328.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGG CCAGGTGTTG GAGGCCTTTG CTACGCGGTC CGAGGCTTTC ATTGCACACC 
GCGGCTAATG CCGCCGCCAC GGCTACAGAA ACGACCTGCC AAGACGTCGC GGCGACCCCC 
GTCGCGCGGT ACCCGCCGAT TGTGGCCTCC ATGACAGCCG ACAGCAAAGC TGCACGGCTG 
CGGCGGATCG AGCGCTGGCA GGCGACGGTG CACGCTGCGG AGTCGGTAGA CGAGAAGCTG 
CGAATCCTCA CCAAGATGCA GTTTATGAAG TACATGGTTT ACCCGCAGAC CTTCGCGCTG 
AATGCCGACC GCTGGTACCA GTACTTCACC AAGACCGTGT TCCTGTCGGG TCTGCCGCCG 
CCCCCAGCGG AGCCCGAGCC CGAGCCCGAA CCCGAACCTG AACCTGCGCT GGACCTCGCG 
GCGCTGCGTG CGGTCGCCTG CGACTGCCTG CTGCAGGAGC ACTTCTACCT GCGGCGCAGG 
CGGCGCGTGC ACCGTTACGA GGAGAGCGAG GTCATATCTT TGCCCTTCCT GGATCAGCTG 
GTGTCAACCC TCGTGGGCCT CCTCAGCCCA CACAACCCGG CCCTGGCCGC TGCCGCCCTC 
GATTATAGAT GCCCAGTTCA TTTTTACTGG GTGCGTGGTG AAGAAATTAT TCCTCGTGGT 
CATCGAAGAG GTCGAATTGA TGACTTGCGA TACCAGATAG ATGATAAACC AAACAACCAG 
ATTCGAATAT CCAAGCAACT CGCAGAGTTT GTGCCATTGG ATTATTCTGT TCCTATAGAA 
ATCCCCACTA TAAAATGTAA ACCAGACAAA CTTCCATTAT TCAAACGGCA GTATGAAAAC 
CACATATTTG TTGGCTCAAA AACTGCAGAT CCTTGCTGTT ACGGTCACAC CCAGTTTCAT 
CTGTTACCTG ACAAATTAAG AAGGGAAAGG CTTTTGAGAC AAAACTGTGC TGATCAGATA 
GAAGTTGTTT TTAGAGCTAA TGCTATTGCA AGCCTTTTTG CTTGGACTGG AGCACAAGCT 
ATGTATCAAG GATTCTGGAG TGAAGCAGAT GTTACTCGAC CTTTTGTCTC CCAGGCTGTG 
ATCACAGATG GAAAATACTT TTCCTTTTTC TGCTACCAGC TAAATACTTT GGCACTGACT 
ACACAAGCTG ATCAAAATAA CCCTCGTAAA AATATATGTT GGGGTACACA AAGTAAGCCT 
CTTTATGAAA CAATTGAGGA TAATGATGTG AAAGGTTTTA ATGATGATGT TCTACTTCAG 
ATAGTTCACT TTCTACTGAA TAGACCAAAA GAAGAAAAAT CACAGCTGTT GGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057724.2
CDS	17..1336
Translation	MAAARCWRPLLRGPRLSLHTAANAAATATETTCQDVAATPVARYPPIVASMTADSKAARLRRIERWQATVHAAESVDEKLRILTKMQFMKYMVYPQTFALNADRWYQYFTKTVFLSGLPPPPAEPEPEPEPEPEPALDLAALRAVACDCLLQEHFYLRRRRRVHRYEESEVISLPFLDQLVSTLVGLLSPHNPALAAAALDYRCPVHFYWVRGEEIIPRGHRRGRIDDLRYQIDDKPNNQIRISKQLAEFVPLDYSVPIEIPTIKCKPDKLPLFKRQYENHIFVGSKTADPCCYGHTQFHLLPDKLRRERLLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQSKPLYETIEDNDVKGFNDDVLLQIVHFLLNRPKEEKSQLLEN

Target ORF information:

RefSeq Version	NM_016640.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S30 (MRPS30), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016640.4

ORF Insert Sequence:

ATGGCGGCGG CCAGGTGTTG GAGGCCTTTG CTACGCGGTC CGAGGCTTTC ATTGCACACC 
GCGGCTAATG CCGCCGCCAC GGCTACAGAA ACGACCTGCC AAGACGTCGC GGCGACCCCC 
GTCGCGCGGT ACCCGCCGAT TGTGGCCTCC ATGACAGCCG ACAGCAAAGC TGCACGGCTG 
CGGCGGATCG AGCGCTGGCA GGCGACGGTG CACGCTGCGG AGTCGGTAGA CGAGAAGCTG 
CGAATCCTCA CCAAGATGCA GTTTATGAAG TACATGGTTT ACCCGCAGAC CTTCGCGCTG 
AATGCCGACC GCTGGTACCA GTACTTCACC AAGACCGTGT TCCTGTCGGG TCTGCCGCCG 
CCCCCAGCGG AGCCCGAGCC CGAGCCCGAA CCCGAACCTG AACCTGCGCT GGACCTCGCG 
GCGCTGCGTG CGGTCGCCTG CGACTGCCTG CTGCAGGAGC ACTTCTACCT GCGGCGCAGG 
CGGCGCGTGC ACCGTTACGA GGAGAGCGAG GTCATATCTT TGCCCTTCCT GGATCAGCTG 
GTGTCAACCC TCGTGGGCCT CCTCAGCCCA CACAACCCGG CCCTGGCCGC TGCCGCCCTC 
GATTATAGAT GCCCAGTTCA TTTTTACTGG GTGCGTGGTG AAGAAATTAT TCCTCGTGGT 
CATCGAAGAG GTCGAATTGA TGACTTGCGA TACCAGATAG ATGATAAACC AAACAACCAG 
ATTCGAATAT CCAAGCAACT CGCAGAGTTT GTGCCATTGG ATTATTCTGT TCCTATAGAA 
ATCCCCACTA TAAAATGTAA ACCAGACAAA CTTCCATTAT TCAAACGGCA GTATGAAAAC 
CACATATTTG TTGGCTCAAA AACTGCAGAT CCTTGCTGTT ACGGTCACAC CCAGTTTCAT 
CTGTTACCTG ACAAATTAAG AAGGGAAAGG CTTTTGAGAC AAAACTGTGC TGATCAGATA 
GAAGTTGTTT TTAGAGCTAA TGCTATTGCA AGCCTTTTTG CTTGGACTGG AGCACAAGCT 
ATGTATCAAG GATTCTGGAG TGAAGCAGAT GTTACTCGAC CTTTTGTCTC CCAGGCTGTG 
ATCACAGATG GAAAATACTT TTCCTTTTTC TGCTACCAGC TAAATACTTT GGCACTGACT 
ACACAAGCTG ATCAAAATAA CCCTCGTAAA AATATATGTT GGGGTACACA AAGTAAGCCT 
CTTTATGAAA CAATTGAGGA TAATGATGTG AAAGGTTTTA ATGATGATGT TCTACTTCAG 
ATAGTTCACT TTCTACTGAA TAGACCAAAA GAAGAAAAAT CACAGCTGTT GGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS30 ( NM_016640.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057724.2 Homo sapiens mitochondrial ribosomal protein S30 (MRPS30), mRNA.

Price & Availability↑

CloneID	OHu17126
Clone ID Related Accession (Same CDS sequence)	NM_016640.4 , NM_016640.3
Accession Version	NM_016640.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	39S ribosomal protein S30, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF146192.2, BC007735.2 and BU676154.1. On Jan 29, 2005 this sequence version replaced NM_016640.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.447714.1, SRR1660803.3338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CCAGGTGTTG GAGGCCTTTG CTACGCGGTC CGAGGCTTTC ATTGCACACC 
GCGGCTAATG CCGCCGCCAC GGCTACAGAA ACGACCTGCC AAGACGTCGC GGCGACCCCC 
GTCGCGCGGT ACCCGCCGAT TGTGGCCTCC ATGACAGCCG ACAGCAAAGC TGCACGGCTG 
CGGCGGATCG AGCGCTGGCA GGCGACGGTG CACGCTGCGG AGTCGGTAGA CGAGAAGCTG 
CGAATCCTCA CCAAGATGCA GTTTATGAAG TACATGGTTT ACCCGCAGAC CTTCGCGCTG 
AATGCCGACC GCTGGTACCA GTACTTCACC AAGACCGTGT TCCTGTCGGG TCTGCCGCCG 
CCCCCAGCGG AGCCCGAGCC CGAGCCCGAA CCCGAACCTG AACCTGCGCT GGACCTCGCG 
GCGCTGCGTG CGGTCGCCTG CGACTGCCTG CTGCAGGAGC ACTTCTACCT GCGGCGCAGG 
CGGCGCGTGC ACCGTTACGA GGAGAGCGAG GTCATATCTT TGCCCTTCCT GGATCAGCTG 
GTGTCAACCC TCGTGGGCCT CCTCAGCCCA CACAACCCGG CCCTGGCCGC TGCCGCCCTC 
GATTATAGAT GCCCAGTTCA TTTTTACTGG GTGCGTGGTG AAGAAATTAT TCCTCGTGGT 
CATCGAAGAG GTCGAATTGA TGACTTGCGA TACCAGATAG ATGATAAACC AAACAACCAG 
ATTCGAATAT CCAAGCAACT CGCAGAGTTT GTGCCATTGG ATTATTCTGT TCCTATAGAA 
ATCCCCACTA TAAAATGTAA ACCAGACAAA CTTCCATTAT TCAAACGGCA GTATGAAAAC 
CACATATTTG TTGGCTCAAA AACTGCAGAT CCTTGCTGTT ACGGTCACAC CCAGTTTCAT 
CTGTTACCTG ACAAATTAAG AAGGGAAAGG CTTTTGAGAC AAAACTGTGC TGATCAGATA 
GAAGTTGTTT TTAGAGCTAA TGCTATTGCA AGCCTTTTTG CTTGGACTGG AGCACAAGCT 
ATGTATCAAG GATTCTGGAG TGAAGCAGAT GTTACTCGAC CTTTTGTCTC CCAGGCTGTG 
ATCACAGATG GAAAATACTT TTCCTTTTTC TGCTACCAGC TAAATACTTT GGCACTGACT 
ACACAAGCTG ATCAAAATAA CCCTCGTAAA AATATATGTT GGGGTACACA AAGTAAGCCT 
CTTTATGAAA CAATTGAGGA TAATGATGTG AAAGGTTTTA ATGATGATGT TCTACTTCAG 
ATAGTTCACT TTCTACTGAA TAGACCAAAA GAAGAAAAAT CACAGCTGTT GGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057724.2
CDS	39..1358
Translation	MAAARCWRPLLRGPRLSLHTAANAAATATETTCQDVAATPVARYPPIVASMTADSKAARLRRIERWQATVHAAESVDEKLRILTKMQFMKYMVYPQTFALNADRWYQYFTKTVFLSGLPPPPAEPEPEPEPEPEPALDLAALRAVACDCLLQEHFYLRRRRRVHRYEESEVISLPFLDQLVSTLVGLLSPHNPALAAAALDYRCPVHFYWVRGEEIIPRGHRRGRIDDLRYQIDDKPNNQIRISKQLAEFVPLDYSVPIEIPTIKCKPDKLPLFKRQYENHIFVGSKTADPCCYGHTQFHLLPDKLRRERLLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQSKPLYETIEDNDVKGFNDDVLLQIVHFLLNRPKEEKSQLLEN

Target ORF information:

RefSeq Version	NM_016640.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S30 (MRPS30), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016640.3

ORF Insert Sequence:

ATGGCGGCGG CCAGGTGTTG GAGGCCTTTG CTACGCGGTC CGAGGCTTTC ATTGCACACC 
GCGGCTAATG CCGCCGCCAC GGCTACAGAA ACGACCTGCC AAGACGTCGC GGCGACCCCC 
GTCGCGCGGT ACCCGCCGAT TGTGGCCTCC ATGACAGCCG ACAGCAAAGC TGCACGGCTG 
CGGCGGATCG AGCGCTGGCA GGCGACGGTG CACGCTGCGG AGTCGGTAGA CGAGAAGCTG 
CGAATCCTCA CCAAGATGCA GTTTATGAAG TACATGGTTT ACCCGCAGAC CTTCGCGCTG 
AATGCCGACC GCTGGTACCA GTACTTCACC AAGACCGTGT TCCTGTCGGG TCTGCCGCCG 
CCCCCAGCGG AGCCCGAGCC CGAGCCCGAA CCCGAACCTG AACCTGCGCT GGACCTCGCG 
GCGCTGCGTG CGGTCGCCTG CGACTGCCTG CTGCAGGAGC ACTTCTACCT GCGGCGCAGG 
CGGCGCGTGC ACCGTTACGA GGAGAGCGAG GTCATATCTT TGCCCTTCCT GGATCAGCTG 
GTGTCAACCC TCGTGGGCCT CCTCAGCCCA CACAACCCGG CCCTGGCCGC TGCCGCCCTC 
GATTATAGAT GCCCAGTTCA TTTTTACTGG GTGCGTGGTG AAGAAATTAT TCCTCGTGGT 
CATCGAAGAG GTCGAATTGA TGACTTGCGA TACCAGATAG ATGATAAACC AAACAACCAG 
ATTCGAATAT CCAAGCAACT CGCAGAGTTT GTGCCATTGG ATTATTCTGT TCCTATAGAA 
ATCCCCACTA TAAAATGTAA ACCAGACAAA CTTCCATTAT TCAAACGGCA GTATGAAAAC 
CACATATTTG TTGGCTCAAA AACTGCAGAT CCTTGCTGTT ACGGTCACAC CCAGTTTCAT 
CTGTTACCTG ACAAATTAAG AAGGGAAAGG CTTTTGAGAC AAAACTGTGC TGATCAGATA 
GAAGTTGTTT TTAGAGCTAA TGCTATTGCA AGCCTTTTTG CTTGGACTGG AGCACAAGCT 
ATGTATCAAG GATTCTGGAG TGAAGCAGAT GTTACTCGAC CTTTTGTCTC CCAGGCTGTG 
ATCACAGATG GAAAATACTT TTCCTTTTTC TGCTACCAGC TAAATACTTT GGCACTGACT 
ACACAAGCTG ATCAAAATAA CCCTCGTAAA AATATATGTT GGGGTACACA AAGTAAGCCT 
CTTTATGAAA CAATTGAGGA TAATGATGTG AAAGGTTTTA ATGATGATGT TCTACTTCAG 
ATAGTTCACT TTCTACTGAA TAGACCAAAA GAAGAAAAAT CACAGCTGTT GGAAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
American journal of human genetics99(4)903-911(2016 Oct)
Ghoussaini M,French JD,Michailidou K,Nord S,Beesley J,Canisus S,Hillman KM,Kaufmann S,Sivakumaran H,Moradi Marjaneh M,Lee JS,Dennis J,Bolla MK,Wang Q,Dicks E,Milne RL,Hopper JL,Southey MC,Schmidt MK,Broeks A,Muir K,Lophatananon A,Fasching PA,Beckmann MW,Fletcher O,Johnson N,Sawyer EJ,Tomlinson I,Burwinkel B,Marme F,Gu?nel P,Truong T,Bojesen SE,Flyger H,Benitez J,Gonz?lez-Neira A,Alonso MR,Pita G,Neuhausen SL,Anton-Culver H,Brenner H,Arndt V,Meindl A,Schmutzler RK,Brauch H,Hamann U,Tessier DC,Vincent D,Nevanlinna H,Khan S,Matsuo K,Ito H,D?rk T,Bogdanova NV,Lindblom A,Margolin S,Mannermaa A,Kosma VM,,Wu AH,Van Den Berg D,Lambrechts D,Floris G,Chang-Claude J,Rudolph A,Radice P,Barile M,Couch FJ,Hallberg E,Giles GG,Haiman CA,Le Marchand L,Goldberg MS,Teo SH,Yip CH,Borresen-Dale AL,,Zheng W,Cai Q,Winqvist R,Pylk?s K,Andrulis IL,Devilee P,Tollenaar RA,Garc?a-Closas M,Figueroa J,Hall P,Czene K,Brand JS,Darabi H,Eriksson M,Hooning MJ,Koppert LB,Li J,Shu XO,Zheng Y,Cox A,Cross SS,Shah M,Rhenius V,Choi JY,Kang D,Hartman M,Chia KS,Kabisch M,Torres D,Luccarini C,Conroy DM,Jakubowska A,Lubinski J,Sangrajrang S,Brennan P,Olswold C,Slager S,Shen CY,Hou MF,Swerdlow A,Schoemaker MJ,Simard J,Pharoah PD,Kristensen V,Chenevix-Trench G,Easton DF,Dunning AM,Edwards SL

The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.
Molecular oncology8(2)273-84(2014 Mar)
Quigley DA,Fiorito E,Nord S,Van Loo P,Aln?s GG,Fleischer T,Tost J,Moen Vollan HK,Tramm T,Overgaard J,Bukholm IR,Hurtado A,Balmain A,B?rresen-Dale AL,Kristensen V

Breast cancer association studies in a Han Chinese population using 10 European-ancestry-associated breast cancer susceptibility SNPs.
Asian Pacific journal of cancer prevention : APJCP15(1)85-91(2014)
Guan YP,Yang XX,Yao GY,Qiu F,Chen J,Chen LJ,Ye CS,Li M

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

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MRPS30 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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