CCL27 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL27
Entrez Gene ID	10850
Full Name	C-C motif chemokine ligand 27
Synonyms	ALP,CTACK,CTAK,ESKINE,ILC,PESKY,SCYA27
General protein information	Preferred Names C-C motif chemokine ligand 27 Names C-C motif chemokine 27 CC chemokine ILC IL-11 R-alpha-locus chemokine IL-11 Ralpha-locus chemokine chemokine (C-C motif) ligand 27 cutaneous T-cell attracting chemokine skinkine small inducible cytokine subfamily A (Cys-Cys), member 27 small-inducible cytokine A27
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p13.3
Summary	This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].
Disorder MIM:	604833

mRNA and Protein(s)

mRNA	Protein	Name
NM_006664.3	NP_006655.1	C-C motif chemokine 27 precursor
NM_006664.4	NP_006655.1	C-C motif chemokine 27 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CCL27	XP_005210414.1
Mus musculus (house mouse)	Gm2506	NP_001186894.1
Mus musculus (house mouse)	Ccl27b	NP_001186888.1
Pan troglodytes (chimpanzee)	CCL27	XP_003951464.1
	CCL27	NP_001028048.1
Canis lupus familiaris (dog)	CCL27	NP_001003968.1
Mus musculus (house mouse)	LOC100861978	NP_001254633.1
Homo sapiens (human)	CCL27	NP_006655.1
Mus musculus (house mouse)	Gm13306	NP_001157518.1

Gene Ontology
Bibliography

Related articles in PubMed

Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigen-specific IgA seropositive population.
Mao MJ, Xue N, Wang XP, Chi PD, Liu YJ, Huang Q, Dai SQ, Liu WL
BMC cancer18(1)9(2018 01)

Oral keratinocytes synthesize CTACK: A new insight into the pathophysiology of the oral mucosa.
Marshall A, Celentano A, Cirillo N, McCullough M, Porter S
Experimental dermatology(2017 Nov)

Selective Expression of CCR10 and CXCR3 by Circulating Human Herpes Simplex Virus-Specific CD8 T Cells.
Hensel MT, Peng T, Cheng A, De Rosa SC, Wald A, Laing KJ, Jing L, Dong L, Magaret AS, Koelle DM
Journal of virology91(19)(2017 Oct)

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, D?ring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C
Science translational medicine9(384)(2017 Apr)

Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF-? and ROS.
Zhang Q, Zhu L, Wang G, Zhao Y, Xiong N, Bao H, Jin W
Journal of biochemical and molecular toxicology31(3)(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CCL27 drives baseline recruitment of Herpes simplex virus-specific CD8 T cells expressing CCR10, while interferon-responsive CXCR3 ligands recruit additional cells in response to virus-driven inflammation.
Title: Selective Expression of CCR10 and CXCR3 by Circulating Human Herpes Simplex Virus-Specific CD8 T Cells.

We therefore concluded that the cross talk between TNFa and ROS after keratinocytes was exposed to radiation, triggered CCL27 secretion for subsequent inflammation response.
Title: Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF-? and ROS.

Our study showed that a higher immunostaining of CCL27 in supratumoral epidermis is associated with longer progression-free interval and melanoma-specific survival.
Title: High CCL27 immunoreactivity in 'supratumoral' epidermis correlates with better prognosis in patients with cutaneous malignant melanoma.

NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management.
Title: NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management.

Our data supports previous reports showing IL-17 and -23 upregulation in association with Multiple sclerosis and potentially identify a previously unknown involvement for CCL27.
Title: CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis.

The following CCL27 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL27 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15742	NM_006664.4 Latest version!	Homo sapiens C-C motif chemokine ligand 27 (CCL27), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu15742	NM_006664.3	Homo sapiens C-C motif chemokine ligand 27 (CCL27), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL27 ( NM_006664.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006655.1 Homo sapiens C-C motif chemokine ligand 27 (CCL27), mRNA.

Price & Availability↑

CloneID	OHu15742
Clone ID Related Accession (Same CDS sequence)	NM_006664.3 , NM_006664.4
Accession Version	NM_006664.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-18
Organism	Homo sapiens(human)
Product	C-C motif chemokine 27 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB010445.1 and CA433929.1. On Sep 23, 2014 this sequence version replaced NM_006664.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB010445.1, AJ243542.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGGGC CCCCAACCTT CTGCAGCCTC CTGCTGCTGT CATTGCTCCT GAGCCCAGAC 
CCTACAGCAG CATTCCTACT GCCACCCAGC ACTGCCTGCT GTACTCAGCT CTACCGAAAG 
CCACTCTCAG ACAAGCTACT GAGGAAGGTC ATCCAGGTGG AACTGCAGGA GGCTGACGGG 
GACTGTCACC TCCAGGCTTT CGTGCTTCAC CTGGCTCAAC GCAGCATCTG CATCCACCCC 
CAGAACCCCA GCCTGTCACA GTGGTTTGAG CACCAAGAGA GAAAGCTCCA TGGGACTCTG 
CCCAAGCTGA ATTTTGGGAT GCTAAGGAAA ATGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006655.1
CDS	60..398
Translation	MKGPPTFCSLLLLSLLLSPDPTAAFLLPPSTACCTQLYRKPLSDKLLRKVIQVELQEADGDCHLQAFVLHLAQRSICIHPQNPSLSQWFEHQERKLHGTLPKLNFGMLRKMG

Target ORF information:

RefSeq Version	NM_006664.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 27 (CCL27), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006664.3

ORF Insert Sequence:

ATGAAGGGGC CCCCAACCTT CTGCAGCCTC CTGCTGCTGT CATTGCTCCT GAGCCCAGAC 
CCTACAGCAG CATTCCTACT GCCACCCAGC ACTGCCTGCT GTACTCAGCT CTACCGAAAG 
CCACTCTCAG ACAAGCTACT GAGGAAGGTC ATCCAGGTGG AACTGCAGGA GGCTGACGGG 
GACTGTCACC TCCAGGCTTT CGTGCTTCAC CTGGCTCAAC GCAGCATCTG CATCCACCCC 
CAGAACCCCA GCCTGTCACA GTGGTTTGAG CACCAAGAGA GAAAGCTCCA TGGGACTCTG 
CCCAAGCTGA ATTTTGGGAT GCTAAGGAAA ATGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCL27 ( NM_006664.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006655.1 Homo sapiens C-C motif chemokine ligand 27 (CCL27), mRNA.

Price & Availability↑

CloneID	OHu15742
Clone ID Related Accession (Same CDS sequence)	NM_006664.3 , NM_006664.4
Accession Version	NM_006664.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 339bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	C-C motif chemokine 27 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB010445.1 and CA433929.1. On May 17, 2019 this sequence version replaced NM_006664.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ243542.1, AB010445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259631.5/ ENSP00000259631.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGGGGC CCCCAACCTT CTGCAGCCTC CTGCTGCTGT CATTGCTCCT GAGCCCAGAC 
CCTACAGCAG CATTCCTACT GCCACCCAGC ACTGCCTGCT GTACTCAGCT CTACCGAAAG 
CCACTCTCAG ACAAGCTACT GAGGAAGGTC ATCCAGGTGG AACTGCAGGA GGCTGACGGG 
GACTGTCACC TCCAGGCTTT CGTGCTTCAC CTGGCTCAAC GCAGCATCTG CATCCACCCC 
CAGAACCCCA GCCTGTCACA GTGGTTTGAG CACCAAGAGA GAAAGCTCCA TGGGACTCTG 
CCCAAGCTGA ATTTTGGGAT GCTAAGGAAA ATGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006655.1
CDS	25..363
Translation	MKGPPTFCSLLLLSLLLSPDPTAAFLLPPSTACCTQLYRKPLSDKLLRKVIQVELQEADGDCHLQAFVLHLAQRSICIHPQNPSLSQWFEHQERKLHGTLPKLNFGMLRKMG

Target ORF information:

RefSeq Version	NM_006664.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 27 (CCL27), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006664.4

ORF Insert Sequence:

ATGAAGGGGC CCCCAACCTT CTGCAGCCTC CTGCTGCTGT CATTGCTCCT GAGCCCAGAC 
CCTACAGCAG CATTCCTACT GCCACCCAGC ACTGCCTGCT GTACTCAGCT CTACCGAAAG 
CCACTCTCAG ACAAGCTACT GAGGAAGGTC ATCCAGGTGG AACTGCAGGA GGCTGACGGG 
GACTGTCACC TCCAGGCTTT CGTGCTTCAC CTGGCTCAAC GCAGCATCTG CATCCACCCC 
CAGAACCCCA GCCTGTCACA GTGGTTTGAG CACCAAGAGA GAAAGCTCCA TGGGACTCTG 
CCCAAGCTGA ATTTTGGGAT GCTAAGGAAA ATGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigen-specific IgA seropositive population.
BMC cancer18(1)9(2018 01)
Mao MJ,Xue N,Wang XP,Chi PD,Liu YJ,Huang Q,Dai SQ,Liu WL

Oral keratinocytes synthesize CTACK: A new insight into the pathophysiology of the oral mucosa.
Experimental dermatology(2017 Nov)
Marshall A,Celentano A,Cirillo N,McCullough M,Porter S

Selective Expression of CCR10 and CXCR3 by Circulating Human Herpes Simplex Virus-Specific CD8 T Cells.
Journal of virology91(19)(2017 Oct)
Hensel MT,Peng T,Cheng A,De Rosa SC,Wald A,Laing KJ,Jing L,Dong L,Magaret AS,Koelle DM

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
Science translational medicine9(384)(2017 Apr)
von Hundelshausen P,Agten SM,Eckardt V,Blanchet X,Schmitt MM,Ippel H,Neideck C,Bidzhekov K,Leberzammer J,Wichapong K,Faussner A,Drechsler M,Grommes J,van Geffen JP,Li H,Ortega-Gomez A,Megens RT,Naumann R,Dijkgraaf I,Nicolaes GA,D?ring Y,Soehnlein O,Lutgens E,Heemskerk JW,Koenen RR,Mayo KH,Hackeng TM,Weber C

Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF-? and ROS.
Journal of biochemical and molecular toxicology31(3)(2017 Mar)
Zhang Q,Zhu L,Wang G,Zhao Y,Xiong N,Bao H,Jin W

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CCL27 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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