PPP1R17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPP1R17
Entrez Gene ID	10842
Full Name	protein phosphatase 1 regulatory subunit 17
Synonyms	C7orf16,GSBS
General protein information	Preferred Names protein phosphatase 1 regulatory subunit 17 Names protein phosphatase 1 regulatory subunit 17 G-substrate
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.3
Summary	The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Disorder MIM:	604088
Disorder Html:	{Hypercholesterolemia, susceptibility to}, 143890 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006658.4	NP_006649.2	protein phosphatase 1 regulatory subunit 17 isoform 1
NM_001145123.2	NP_001138595.1	protein phosphatase 1 regulatory subunit 17 isoform 2
XM_011515094.2	XP_011513396.1	protein phosphatase 1 regulatory subunit 17 isoform X1
NM_006658.5	NP_006649.2	protein phosphatase 1 regulatory subunit 17 isoform 1
XM_011515094.1	XP_011513396.1	protein phosphatase 1 regulatory subunit 17 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PPP1R17	XP_003431978.2
Mus musculus (house mouse)	Ppp1r17	NP_035283.1
Gallus gallus (chicken)	PPP1R17	XP_004939604.1
Pan troglodytes (chimpanzee)	PPP1R17	XP_001166815.1
Rattus norvegicus (Norway rat)	Ppp1r17	NP_703197.1
Homo sapiens (human)	PPP1R17	NP_006649.2
Bos taurus (cattle)	PPP1R17	XP_002686874.1
	C7orf16	XP_001083835.1
Xenopus tropicalis (tropical clawed frog)	ppp1r17	XP_002940295.1

Gene Ontology
Bibliography

Related articles in PubMed

G-substrate: the cerebellum and beyond.
Endo S
Progress in molecular biology and translational science106381-416(2012)

A promoter SNP (-1323T>C) in G-substrate gene (GSBS) correlates with hypercholesterolemia.
Ono S, Ezura Y, Emi M, Fujita Y, Takada D, Sato K, Ishigami T, Umemura S, Takahashi K, Kamimura K, Bujo H, Saito Y
Journal of human genetics48(9)447-50(2003)

Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells.
Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M
Proceedings of the National Academy of Sciences of the United States of America96(5)2467-72(1999 Mar)

Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent protein kinase.
Hall KU, Collins SP, Gamm DM, Massa E, DePaoli-Roach AA, Uhler MD
The Journal of biological chemistry274(6)3485-95(1999 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

G-substrate plays a role in the NO-sGC-cGMP-PKG pathway, cerebellum-dependent long-term memory, & neuroprotection of the ventral tegmentum and retina. Review.
Title: G-substrate: the cerebellum and beyond.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: A promoter SNP (-1323T>C) in G-substrate gene (GSBS) correlates with hypercholesterolemia.

The following PPP1R17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPP1R17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22989	NM_006658.5 Latest version!	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22989	XM_011515094.2 Latest version!	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu08376	NM_001145123.2 Latest version!	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu22989	NM_006658.4	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22989	XM_011515094.1	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPP1R17 ( NM_006658.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006649.2 Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22989
Clone ID Related Accession (Same CDS sequence)	NM_006658.4 , XM_011515094.2 , NM_006658.5 , XM_011515094.1
Accession Version	NM_006658.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 17 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA061079.1, DB039499.1 and AC006325.3. This sequence is a reference standard in the RefSeqGene project. On Jul 20, 2010 this sequence version replaced NM_006658.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC028094.1, SRR1660803.147751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGATGATCTT TCAGACCAGT TCATTAAGGA CTGTGATCTC 
AAAAAGAAGC CTAGAAAGGG AAAAAATGTA CAGGCCACCC TGAATGTTGA GTCAGACCAA 
AAAAAACCAA GGAGGAAAGA TACACCGGCG CTGCACATCC CACCTTTCAT ACCAGGTGTG 
TTTTCAGAAC ATTTAATTAA AAGATACGAT GTTCAAGAGA GACATCCAAA GGGCAAAATG 
ATCCCTGTTC TTCATAACAC TGACCTGGAA CAGAAAAAGC CAAGGAGAAA AGACACACCT 
GCCCTGCACA TGTCCCCCTT TGCAGCAGGT GTGACATTGC TCAGGGACGA GAGACCCAAA 
GCAATCGTGG AAGATGACGA AAAGGATGGT GACAAGATAG CTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006649.2
CDS	327..794
Translation	MMSTEQMQPLELSEDRLDKLDPRCSHLDDLSDQFIKDCDLKKKPRKGKNVQATLNVESDQKKPRRKDTPALHIPPFIPGVFSEHLIKRYDVQERHPKGKMIPVLHNTDLEQKKPRRKDTPALHMSPFAAGVTLLRDERPKAIVEDDEKDGDKIAI

Target ORF information:

RefSeq Version	NM_006658.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006658.4

ORF Insert Sequence:

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGATGATCTT TCAGACCAGT TCATTAAGGA CTGTGATCTC 
AAAAAGAAGC CTAGAAAGGG AAAAAATGTA CAGGCCACCC TGAATGTTGA GTCAGACCAA 
AAAAAACCAA GGAGGAAAGA TACACCGGCG CTGCACATCC CACCTTTCAT ACCAGGTGTG 
TTTTCAGAAC ATTTAATTAA AAGATACGAT GTTCAAGAGA GACATCCAAA GGGCAAAATG 
ATCCCTGTTC TTCATAACAC TGACCTGGAA CAGAAAAAGC CAAGGAGAAA AGACACACCT 
GCCCTGCACA TGTCCCCCTT TGCAGCAGGT GTGACATTGC TCAGGGACGA GAGACCCAAA 
GCAATCGTGG AAGATGACGA AAAGGATGGT GACAAGATAG CTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R17 ( NM_006658.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006649.2 Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22989
Clone ID Related Accession (Same CDS sequence)	NM_006658.4 , XM_011515094.2 , NM_006658.5 , XM_011515094.1
Accession Version	NM_006658.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 17 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB039499.1 and AC006325.3. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006658.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1170737.1, SRR3476690.762842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000342032.8/ ENSP00000340125.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGATGATCTT TCAGACCAGT TCATTAAGGA CTGTGATCTC 
AAAAAGAAGC CTAGAAAGGG AAAAAATGTA CAGGCCACCC TGAATGTTGA GTCAGACCAA 
AAAAAACCAA GGAGGAAAGA TACACCGGCG CTGCACATCC CACCTTTCAT ACCAGGTGTG 
TTTTCAGAAC ATTTAATTAA AAGATACGAT GTTCAAGAGA GACATCCAAA GGGCAAAATG 
ATCCCTGTTC TTCATAACAC TGACCTGGAA CAGAAAAAGC CAAGGAGAAA AGACACACCT 
GCCCTGCACA TGTCCCCCTT TGCAGCAGGT GTGACATTGC TCAGGGACGA GAGACCCAAA 
GCAATCGTGG AAGATGACGA AAAGGATGGT GACAAGATAG CTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006649.2
CDS	129..596
Translation	MMSTEQMQPLELSEDRLDKLDPRCSHLDDLSDQFIKDCDLKKKPRKGKNVQATLNVESDQKKPRRKDTPALHIPPFIPGVFSEHLIKRYDVQERHPKGKMIPVLHNTDLEQKKPRRKDTPALHMSPFAAGVTLLRDERPKAIVEDDEKDGDKIAI

Target ORF information:

RefSeq Version	NM_006658.5
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006658.5

ORF Insert Sequence:

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGATGATCTT TCAGACCAGT TCATTAAGGA CTGTGATCTC 
AAAAAGAAGC CTAGAAAGGG AAAAAATGTA CAGGCCACCC TGAATGTTGA GTCAGACCAA 
AAAAAACCAA GGAGGAAAGA TACACCGGCG CTGCACATCC CACCTTTCAT ACCAGGTGTG 
TTTTCAGAAC ATTTAATTAA AAGATACGAT GTTCAAGAGA GACATCCAAA GGGCAAAATG 
ATCCCTGTTC TTCATAACAC TGACCTGGAA CAGAAAAAGC CAAGGAGAAA AGACACACCT 
GCCCTGCACA TGTCCCCCTT TGCAGCAGGT GTGACATTGC TCAGGGACGA GAGACCCAAA 
GCAATCGTGG AAGATGACGA AAAGGATGGT GACAAGATAG CTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R17 ( XM_011515094.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011513396.1 Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu22989
Clone ID Related Accession (Same CDS sequence)	NM_006658.4 , XM_011515094.2 , NM_006658.5 , XM_011515094.1
Accession Version	XM_011515094.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 17 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011515094.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGATGATCTT TCAGACCAGT TCATTAAGGA CTGTGATCTC 
AAAAAGAAGC CTAGAAAGGG AAAAAATGTA CAGGCCACCC TGAATGTTGA GTCAGACCAA 
AAAAAACCAA GGAGGAAAGA TACACCGGCG CTGCACATCC CACCTTTCAT ACCAGGTGTG 
TTTTCAGAAC ATTTAATTAA AAGATACGAT GTTCAAGAGA GACATCCAAA GGGCAAAATG 
ATCCCTGTTC TTCATAACAC TGACCTGGAA CAGAAAAAGC CAAGGAGAAA AGACACACCT 
GCCCTGCACA TGTCCCCCTT TGCAGCAGGT GTGACATTGC TCAGGGACGA GAGACCCAAA 
GCAATCGTGG AAGATGACGA AAAGGATGGT GACAAGATAG CTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011513396.1
CDS	129..596
Translation	MMSTEQMQPLELSEDRLDKLDPRCSHLDDLSDQFIKDCDLKKKPRKGKNVQATLNVESDQKKPRRKDTPALHIPPFIPGVFSEHLIKRYDVQERHPKGKMIPVLHNTDLEQKKPRRKDTPALHMSPFAAGVTLLRDERPKAIVEDDEKDGDKIAI

Target ORF information:

RefSeq Version	XM_011515094.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011515094.2

ORF Insert Sequence:

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGATGATCTT TCAGACCAGT TCATTAAGGA CTGTGATCTC 
AAAAAGAAGC CTAGAAAGGG AAAAAATGTA CAGGCCACCC TGAATGTTGA GTCAGACCAA 
AAAAAACCAA GGAGGAAAGA TACACCGGCG CTGCACATCC CACCTTTCAT ACCAGGTGTG 
TTTTCAGAAC ATTTAATTAA AAGATACGAT GTTCAAGAGA GACATCCAAA GGGCAAAATG 
ATCCCTGTTC TTCATAACAC TGACCTGGAA CAGAAAAAGC CAAGGAGAAA AGACACACCT 
GCCCTGCACA TGTCCCCCTT TGCAGCAGGT GTGACATTGC TCAGGGACGA GAGACCCAAA 
GCAATCGTGG AAGATGACGA AAAGGATGGT GACAAGATAG CTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R17 ( XM_011515094.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011513396.1 Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu22989
Clone ID Related Accession (Same CDS sequence)	NM_006658.4 , XM_011515094.2 , NM_006658.5 , XM_011515094.1
Accession Version	XM_011515094.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 17 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGATGATCTT TCAGACCAGT TCATTAAGGA CTGTGATCTC 
AAAAAGAAGC CTAGAAAGGG AAAAAATGTA CAGGCCACCC TGAATGTTGA GTCAGACCAA 
AAAAAACCAA GGAGGAAAGA TACACCGGCG CTGCACATCC CACCTTTCAT ACCAGGTGTG 
TTTTCAGAAC ATTTAATTAA AAGATACGAT GTTCAAGAGA GACATCCAAA GGGCAAAATG 
ATCCCTGTTC TTCATAACAC TGACCTGGAA CAGAAAAAGC CAAGGAGAAA AGACACACCT 
GCCCTGCACA TGTCCCCCTT TGCAGCAGGT GTGACATTGC TCAGGGACGA GAGACCCAAA 
GCAATCGTGG AAGATGACGA AAAGGATGGT GACAAGATAG CTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011513396.1
CDS	159..626
Translation	MMSTEQMQPLELSEDRLDKLDPRCSHLDDLSDQFIKDCDLKKKPRKGKNVQATLNVESDQKKPRRKDTPALHIPPFIPGVFSEHLIKRYDVQERHPKGKMIPVLHNTDLEQKKPRRKDTPALHMSPFAAGVTLLRDERPKAIVEDDEKDGDKIAI

Target ORF information:

RefSeq Version	XM_011515094.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011515094.1

ORF Insert Sequence:

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGATGATCTT TCAGACCAGT TCATTAAGGA CTGTGATCTC 
AAAAAGAAGC CTAGAAAGGG AAAAAATGTA CAGGCCACCC TGAATGTTGA GTCAGACCAA 
AAAAAACCAA GGAGGAAAGA TACACCGGCG CTGCACATCC CACCTTTCAT ACCAGGTGTG 
TTTTCAGAAC ATTTAATTAA AAGATACGAT GTTCAAGAGA GACATCCAAA GGGCAAAATG 
ATCCCTGTTC TTCATAACAC TGACCTGGAA CAGAAAAAGC CAAGGAGAAA AGACACACCT 
GCCCTGCACA TGTCCCCCTT TGCAGCAGGT GTGACATTGC TCAGGGACGA GAGACCCAAA 
GCAATCGTGG AAGATGACGA AAAGGATGGT GACAAGATAG CTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R17 ( NM_001145123.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138595.1 Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08376
Clone ID Related Accession (Same CDS sequence)	NM_001145123.2
Accession Version	NM_001145123.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 17 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA061079.1, AK293478.1, DB039499.1 and AC006325.3. On Jul 20, 2010 this sequence version replaced NM_001145123.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) is shorter but has the identical N- and C-termini compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.257695.1, SRR1660803.175684.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820691, SAMN01820697 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGGTGTGTTT TCAGAACATT TAATTAAAAG ATACGATGTT 
CAAGAGAGAC ATCCAAAGGG CAAAATGATC CCTGTTCTTC ATAACACTGA CCTGGAACAG 
AAAAAGCCAA GGAGAAAAGA CACACCTGCC CTGCACATGT CCCCCTTTGC AGCAGGTGTG 
ACATTGCTCA GGGACGAGAG ACCCAAAGCA ATCGTGGAAG ATGACGAAAA GGATGGTGAC 
AAGATAGCTA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138595.1
CDS	327..641
Translation	MMSTEQMQPLELSEDRLDKLDPRCSHLGVFSEHLIKRYDVQERHPKGKMIPVLHNTDLEQKKPRRKDTPALHMSPFAAGVTLLRDERPKAIVEDDEKDGDKIAI

Target ORF information:

RefSeq Version	NM_001145123.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory subunit 17 (PPP1R17), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145123.2

ORF Insert Sequence:

ATGATGTCCA CTGAGCAAAT GCAGCCACTG GAACTCTCAG AAGACAGACT GGACAAGCTA 
GACCCTCGTT GCAGCCACTT AGGTGTGTTT TCAGAACATT TAATTAAAAG ATACGATGTT 
CAAGAGAGAC ATCCAAAGGG CAAAATGATC CCTGTTCTTC ATAACACTGA CCTGGAACAG 
AAAAAGCCAA GGAGAAAAGA CACACCTGCC CTGCACATGT CCCCCTTTGC AGCAGGTGTG 
ACATTGCTCA GGGACGAGAG ACCCAAAGCA ATCGTGGAAG ATGACGAAAA GGATGGTGAC 
AAGATAGCTA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

G-substrate: the cerebellum and beyond.
Progress in molecular biology and translational science106381-416(2012)
Endo S

A promoter SNP (-1323T>C) in G-substrate gene (GSBS) correlates with hypercholesterolemia.
Journal of human genetics48(9)447-50(2003)
Ono S,Ezura Y,Emi M,Fujita Y,Takada D,Sato K,Ishigami T,Umemura S,Takahashi K,Kamimura K,Bujo H,Saito Y

Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells.
Proceedings of the National Academy of Sciences of the United States of America96(5)2467-72(1999 Mar)
Endo S,Suzuki M,Sumi M,Nairn AC,Morita R,Yamakawa K,Greengard P,Ito M

Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent protein kinase.
The Journal of biological chemistry274(6)3485-95(1999 Feb)
Hall KU,Collins SP,Gamm DM,Massa E,DePaoli-Roach AA,Uhler MD

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PPP1R17 cDNA ORF clone, Homo sapiens(human)

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