CPLX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CPLX1
Entrez Gene ID	10815
Full Name	complexin 1
Synonyms	CPX-I,CPX1
General protein information	Preferred Names complexin 1 Names complexin-1 CPX I complexin I synaphin 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.3
Summary	Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008].
Disorder MIM:	605032

mRNA and Protein(s)

mRNA	Protein	Name
XM_011513391.1	XP_011511693.1	complexin-1 isoform X1
NM_006651.4	NP_006642.1	complexin-1
NM_006651.3	NP_006642.1	complexin-1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cplx1	NP_074055.1
	CPLX1	XP_001094482.1
Bos taurus (cattle)	CPLX1	NP_001071571.1
Mus musculus (house mouse)	Cplx1	NP_031782.3
Gallus gallus (chicken)	CPLX2	XP_424869.1
Xenopus tropicalis (tropical clawed frog)	cplx1	NP_001096263.1
Homo sapiens (human)	CPLX1	NP_006642.1
Canis lupus familiaris (dog)	CPLX1	XP_005618765.1
Danio rerio (zebrafish)	LOC563082	XP_005173398.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic association analysis of microRNA137 and its target complex 1 with schizophrenia in Han Chinese.
Lu W, Zhang Y, Fang X, Fan W, Tang W, Cai J, Song L, Zhang C
Scientific reports7(1)15084(2017 Nov)

Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID.
Redler S, Strom TM, Wieland T, Cremer K, Engels H, Distelmaier F, Schaper J, K?chler A, Lemke JR, Jeschke S, Schreyer N, Sticht H, Koch M, L?decke HJ, Wieczorek D
European journal of human genetics : EJHG25(7)889-893(2017 06)

Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.
Lahut S, Gispert S, ?m?r ?, Depboylu C, Seidel K, Dom?nguez-Bautista JA, Brehm N, Tireli H, Hackmann K, Pirkevi C, Leube B, Ries V, Reim K, Brose N, den Dunnen WF, Johnson M, Wolf Z, Schindewolf M, Schrempf W, Reetz K, Young P, Vadasz D, Frangakis AS, Schr?ck E, Steinmetz H, Jendrach M, R?b U, Ba?ak AN, Oertel W, Auburger G
Disease models & mechanisms10(5)619-631(2017 May)

Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.
Ramos-Miguel A, Sawada K, Jones AA, Thornton AE, Barr AM, Leurgans SE, Schneider JA, Bennett DA, Honer WG
Acta neuropathologica133(3)395-407(2017 Mar)

Carboxypeptidase X-1 (CPX-1) is a secreted collagen-binding glycoprotein.
Kim YH, O'Neill HM, Whitehead JP
Biochemical and biophysical research communications468(4)894-9(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Homozygous CPLX1 variants were identified in three patients with severe infantile myoclonic epilepsy and ID.
Title: Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID.

This study demonstrated that complexin-I influence cognitive function in early and late stages of Alzheimer's disease.
Title: Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.

Study showed for the first time that neuro-Behcet's disease and Behcet's disease patients are inclined to display the GG genotype of the CPLX1 rs936551 polymorphism and to exhibit increased CPLX1 expression levels
Title: Increased complexin-1 and decreased miR-185 expression levels in Beh?et's disease with and without neurological involvement.

Collectively these results demonstrate that CPX-1 is a secreted collagen-binding glycoprotein and provide a foundation for future studies investigating the function of CPX-1.
Title: Carboxypeptidase X-1 (CPX-1) is a secreted collagen-binding glycoprotein.

Studies indicate the role of the small regulatory factor complexin in Ca(2+)-dependent vesicle fusion and exocytosis.
Title: Complexins: small but capable.

The following CPLX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CPLX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17154	NM_006651.4 Latest version!	Homo sapiens complexin 1 (CPLX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu64401	XM_011513391.1 Latest version!	Homo sapiens complexin 1 (CPLX1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu17154	NM_006651.3	Homo sapiens complexin 1 (CPLX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CPLX1 ( NM_006651.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006642.1 Homo sapiens complexin 1 (CPLX1), mRNA.

Price & Availability↑

CloneID	OHu17154
Clone ID Related Accession (Same CDS sequence)	NM_006651.4 , NM_006651.3
Accession Version	NM_006651.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	complexin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC139887.3. On Nov 25, 2018 this sequence version replaced NM_006651.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002471.2, AB593095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267753, SAMN03267761 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304062.11/ ENSP00000305613.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGTTTG TGATGAAGCA GGCTCTAGGA GGGGCCACCA AGGACATGGG GAAGATGCTG 
GGGGGTGACG AGGAGAAGGA CCCAGACGCC GCCAAGAAGG AGGAGGAGCG GCAGGAGGCG 
CTGCGCCAGG CGGAGGAGGA GCGCAAGGCC AAGTACGCCA AGATGGAGGC GGAGCGCGAG 
GCCGTGCGCC AGGGCATCCG AGACAAGTAC GGCATCAAGA AGAAGGAGGA GCGCGAGGCC 
GAGGCCCAGG CCGCCATGGA GGCCAACTCC GAGGGGAGCT TGACGCGGCC CAAGAAGGCC 
ATCCCGCCGG GCTGCGGGGA CGAGGTGGAG GAGGAGGACG AGAGCATCCT GGACACCGTC 
ATCAAGTACC TGCCCGGGCC GCTGCAGGAC ATGCTCAAGA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006642.1
CDS	164..568
Translation	MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK

Target ORF information:

RefSeq Version	NM_006651.4
Organism	Homo sapiens(human)
Definition	Homo sapiens complexin 1 (CPLX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006651.4

ORF Insert Sequence:

ATGGAGTTTG TGATGAAGCA GGCTCTAGGA GGGGCCACCA AGGACATGGG GAAGATGCTG 
GGGGGTGACG AGGAGAAGGA CCCAGACGCC GCCAAGAAGG AGGAGGAGCG GCAGGAGGCG 
CTGCGCCAGG CGGAGGAGGA GCGCAAGGCC AAGTACGCCA AGATGGAGGC GGAGCGCGAG 
GCCGTGCGCC AGGGCATCCG AGACAAGTAC GGCATCAAGA AGAAGGAGGA GCGCGAGGCC 
GAGGCCCAGG CCGCCATGGA GGCCAACTCC GAGGGGAGCT TGACGCGGCC CAAGAAGGCC 
ATCCCGCCGG GCTGCGGGGA CGAGGTGGAG GAGGAGGACG AGAGCATCCT GGACACCGTC 
ATCAAGTACC TGCCCGGGCC GCTGCAGGAC ATGCTCAAGA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CPLX1 ( NM_006651.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006642.1 Homo sapiens complexin 1 (CPLX1), mRNA.

Price & Availability↑

CloneID	OHu17154
Clone ID Related Accession (Same CDS sequence)	NM_006651.4 , NM_006651.3
Accession Version	NM_006651.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	complexin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC002471.2. On Aug 29, 2003 this sequence version replaced NM_006651.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002471.2, AB593095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267753, SAMN03267761 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTTTG TGATGAAGCA GGCTCTAGGA GGGGCCACCA AGGACATGGG GAAGATGCTG 
GGGGGTGACG AGGAGAAGGA CCCAGACGCC GCCAAGAAGG AGGAGGAGCG GCAGGAGGCG 
CTGCGCCAGG CGGAGGAGGA GCGCAAGGCC AAGTACGCCA AGATGGAGGC GGAGCGCGAG 
GCCGTGCGCC AGGGCATCCG AGACAAGTAC GGCATCAAGA AGAAGGAGGA GCGCGAGGCC 
GAGGCCCAGG CCGCCATGGA GGCCAACTCC GAGGGGAGCT TGACGCGGCC CAAGAAGGCC 
ATCCCGCCGG GCTGCGGGGA CGAGGTGGAG GAGGAGGACG AGAGCATCCT GGACACCGTC 
ATCAAGTACC TGCCCGGGCC GCTGCAGGAC ATGCTCAAGA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006642.1
CDS	192..596
Translation	MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK

Target ORF information:

RefSeq Version	NM_006651.3
Organism	Homo sapiens(human)
Definition	Homo sapiens complexin 1 (CPLX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006651.3

ORF Insert Sequence:

ATGGAGTTTG TGATGAAGCA GGCTCTAGGA GGGGCCACCA AGGACATGGG GAAGATGCTG 
GGGGGTGACG AGGAGAAGGA CCCAGACGCC GCCAAGAAGG AGGAGGAGCG GCAGGAGGCG 
CTGCGCCAGG CGGAGGAGGA GCGCAAGGCC AAGTACGCCA AGATGGAGGC GGAGCGCGAG 
GCCGTGCGCC AGGGCATCCG AGACAAGTAC GGCATCAAGA AGAAGGAGGA GCGCGAGGCC 
GAGGCCCAGG CCGCCATGGA GGCCAACTCC GAGGGGAGCT TGACGCGGCC CAAGAAGGCC 
ATCCCGCCGG GCTGCGGGGA CGAGGTGGAG GAGGAGGACG AGAGCATCCT GGACACCGTC 
ATCAAGTACC TGCCCGGGCC GCTGCAGGAC ATGCTCAAGA AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CPLX1 ( XM_011513391.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511693.1 Homo sapiens complexin 1 (CPLX1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu64401
Clone ID Related Accession (Same CDS sequence)	XM_011513391.1
Accession Version	XM_011513391.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	complexin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGAAGA TGCTGGGGGG TGACGAGGAG AAGGACCCAG ACGCCGCCAA GAAGGAGGAG 
GAGCGGCAGG AGGCGCTGCG CCAGGCGGAG GAGGAGCGCA AGGCCAAGTA CGCCAAGATG 
GAGGCGGAGC GCGAGGCCGT GCGCCAGGGC ATCCGAGACA AGTACGGCAT CAAGAAGAAG 
GAGGAGCGCG AGGCCGAGGC CCAGGCCGCC ATGGAGGCCA ACTCCGAGGG GAGCTTGACG 
CGGCCCAAGA AGGCCATCCC GCCGGGCTGC GGGGACGAGG TGGAGGAGGA GGACGAGAGC 
ATCCTGGACA CCGTCATCAA GTACCTGCCC GGGCCGCTGC AGGACATGCT CAAGAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511693.1
CDS	168..527
Translation	MGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK

Target ORF information:

RefSeq Version	XM_011513391.1
Organism	Homo sapiens(human)
Definition	Homo sapiens complexin 1 (CPLX1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513391.1

ORF Insert Sequence:

ATGGGGAAGA TGCTGGGGGG TGACGAGGAG AAGGACCCAG ACGCCGCCAA GAAGGAGGAG 
GAGCGGCAGG AGGCGCTGCG CCAGGCGGAG GAGGAGCGCA AGGCCAAGTA CGCCAAGATG 
GAGGCGGAGC GCGAGGCCGT GCGCCAGGGC ATCCGAGACA AGTACGGCAT CAAGAAGAAG 
GAGGAGCGCG AGGCCGAGGC CCAGGCCGCC ATGGAGGCCA ACTCCGAGGG GAGCTTGACG 
CGGCCCAAGA AGGCCATCCC GCCGGGCTGC GGGGACGAGG TGGAGGAGGA GGACGAGAGC 
ATCCTGGACA CCGTCATCAA GTACCTGCCC GGGCCGCTGC AGGACATGCT CAAGAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic association analysis of microRNA137 and its target complex 1 with schizophrenia in Han Chinese.
Scientific reports7(1)15084(2017 Nov)
Lu W,Zhang Y,Fang X,Fan W,Tang W,Cai J,Song L,Zhang C

Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID.
European journal of human genetics : EJHG25(7)889-893(2017 06)
Redler S,Strom TM,Wieland T,Cremer K,Engels H,Distelmaier F,Schaper J,K?chler A,Lemke JR,Jeschke S,Schreyer N,Sticht H,Koch M,L?decke HJ,Wieczorek D

Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.
Disease models & mechanisms10(5)619-631(2017 May)
Lahut S,Gispert S,?m?r ?,Depboylu C,Seidel K,Dom?nguez-Bautista JA,Brehm N,Tireli H,Hackmann K,Pirkevi C,Leube B,Ries V,Reim K,Brose N,den Dunnen WF,Johnson M,Wolf Z,Schindewolf M,Schrempf W,Reetz K,Young P,Vadasz D,Frangakis AS,Schr?ck E,Steinmetz H,Jendrach M,R?b U,Ba?ak AN,Oertel W,Auburger G

Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.
Acta neuropathologica133(3)395-407(2017 Mar)
Ramos-Miguel A,Sawada K,Jones AA,Thornton AE,Barr AM,Leurgans SE,Schneider JA,Bennett DA,Honer WG

Carboxypeptidase X-1 (CPX-1) is a secreted collagen-binding glycoprotein.
Biochemical and biophysical research communications468(4)894-9(2015 Dec)
Kim YH,O'Neill HM,Whitehead JP

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CPLX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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