CYSLTR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYSLTR1
Entrez Gene ID	10800
Full Name	cysteinyl leukotriene receptor 1
Synonyms	CYSLT1,CYSLT1R,CYSLTR,HMTMF81
General protein information	Preferred Names cysteinyl leukotriene receptor 1 Names cysteinyl leukotriene receptor 1 G-protein coupled receptor HG55 LTD4 receptor cysteinyl leukotriene D4 receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq21.1
Summary	This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Disorder MIM:	300201

mRNA and Protein(s)

mRNA	Protein	Name
NM_001282187.1	NP_001269116.1	cysteinyl leukotriene receptor 1
NM_006639.4	NP_006630.1	cysteinyl leukotriene receptor 1
NM_006639.3	NP_006630.1	cysteinyl leukotriene receptor 1
NM_001282187.2	NP_001269116.1	cysteinyl leukotriene receptor 1
NM_001282188.1	NP_001269117.1	cysteinyl leukotriene receptor 1
NM_001282188.2	NP_001269117.1	cysteinyl leukotriene receptor 1
NM_001282186.1	NP_001269115.1	cysteinyl leukotriene receptor 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CYSLTR1	XP_003435638.1
Danio rerio (zebrafish)	cysltr1	NP_001018484.1
	CYSLTR1	XP_001100982.1
Rattus norvegicus (Norway rat)	Cysltr1	NP_446093.1
Gallus gallus (chicken)	CYSLTR1	XP_426249.3
Pan troglodytes (chimpanzee)	CYSLTR1	XP_003317577.1
Bos taurus (cattle)	CYSLTR1	NP_001093196.1
Mus musculus (house mouse)	Cysltr1	NP_001268788.1
Homo sapiens (human)	CYSLTR1	NP_001269115.1
Xenopus tropicalis (tropical clawed frog)	cysltr1	XP_004916956.1

Gene Ontology
Bibliography

Related articles in PubMed

Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes.
Song W, Zhang Y, Wang J, Ma T, Hao L, Wang K
Cytokine10383-89(2018 Jan)

The selective cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast regulates extracellular matrix remodeling.
Peng J, Zhou H, Kuang G, Xie L, Tian T, Liu R
Biochemical and biophysical research communications484(3)474-479(2017 03)

Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes.
Matsumoto H, Kanemitsu Y, Nagasaki T, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Izuhara Y, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Hirota T, Kawaguchi T, Tamari M, Yokoyama T, Tabara Y, Matsuda F, Izuhara K, Niimi A, Mishima M
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology118(2)197-203(2017 Feb)

Expression of cysteinyl leukotriene receptor 1 and 2 (CysLTR1 and CysLTR2) in the lymphocytes of hyperplastic tonsils: comparison between allergic and nonallergic snoring children.
Paulucci BP, Pereira J, Picciarelli P, Levy D, Di Francesco RC
International forum of allergy & rhinology6(11)1151-1158(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In addition, TGF-beta1-induced expression of MMP-1 and MMP-3, generation of fibronectin and type I collagen production, focal adhesion kinase (FAK) and paxillin phosphorylation in HTFs were also ameliorated by montelukast in a dose dependent manner. These results suggested that montelukast might provide therapeutic possibilities for inhibition of scar formation after such surgery.
Title: The selective cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast regulates extracellular matrix remodeling.

SE sensitization may be a risk factor for TH2 inflammation in nonatopic asthma and late-onset asthma and for pulmonary function decline in nonatopic asthma. In women with asthma, a CysLTR1 promoter polymorphism may be associated with SEB sensitization.
Title: Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes.

The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children
Title: Expression of cysteinyl leukotriene receptor 1 and 2 (CysLTR1 and CysLTR2) in the lymphocytes of hyperplastic tonsils: comparison between allergic and nonallergic snoring children.

CysLTRs -1 and -2 seem to be involved in lymphocyte maturation that occurs in tonsils, without influence of allergies.
Title: Expression of CysLTR1 and 2 in Maturating Lymphocytes of Hyperplasic Tonsils Compared to Peripheral Cells in Children.

Data show that cysteinyl leukotriene receptor antagonists (LTRAs) users had a significantly lower cancer incidence rate than LTRA non-users did.
Title: Cysteinyl Leukotriene Receptor Antagonists Decrease Cancer Risk in Asthma Patients.

The following CYSLTR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYSLTR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23290	NM_006639.4 Latest version!	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu23290	NM_001282186.1 Latest version!	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu23290	NM_001282187.2 Latest version!	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu23290	NM_001282188.2 Latest version!	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu23290	NM_006639.3	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu23290	NM_001282187.1	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu23290	NM_001282188.1	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYSLTR1 ( NM_001282187.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269116.1 Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23290
Clone ID Related Accession (Same CDS sequence)	NM_001282187.1 , NM_006639.4 , NM_006639.3 , NM_001282187.2 , NM_001282188.1 , NM_001282188.2 , NM_001282186.1
Accession Version	NM_001282187.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	cysteinyl leukotriene receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ131799.1, DQ131801.1, AF133266.1 and DQ131803.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ131801.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2152719, SAMEA2156670 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269116.1
CDS	585..1598
Translation	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

Target ORF information:

RefSeq Version	NM_001282187.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282187.1

ORF Insert Sequence:

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYSLTR1 ( NM_006639.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006630.1 Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu23290
Clone ID Related Accession (Same CDS sequence)	NM_001282187.1 , NM_006639.4 , NM_006639.3 , NM_001282187.2 , NM_001282188.1 , NM_001282188.2 , NM_001282186.1
Accession Version	NM_006639.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	cysteinyl leukotriene receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ131799.1, AF133266.1 and DQ131803.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_006639.3. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.398155.1, SRR1803615.240729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373304.4/ ENSP00000362401.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006630.1
CDS	422..1435
Translation	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

Target ORF information:

RefSeq Version	NM_006639.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006639.4

ORF Insert Sequence:

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYSLTR1 ( NM_006639.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006630.1 Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu23290
Clone ID Related Accession (Same CDS sequence)	NM_001282187.1 , NM_006639.4 , NM_006639.3 , NM_001282187.2 , NM_001282188.1 , NM_001282188.2 , NM_001282186.1
Accession Version	NM_006639.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	cysteinyl leukotriene receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ131799.1, AF133266.1 and DQ131803.1. This sequence is a reference standard in the RefSeqGene project. On Aug 22, 2013 this sequence version replaced NM_006639.2. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ131799.1, SRR1803615.240729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006630.1
CDS	502..1515
Translation	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

Target ORF information:

RefSeq Version	NM_006639.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006639.3

ORF Insert Sequence:

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYSLTR1 ( NM_001282187.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269116.1 Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23290
Clone ID Related Accession (Same CDS sequence)	NM_001282187.1 , NM_006639.4 , NM_006639.3 , NM_001282187.2 , NM_001282188.1 , NM_001282188.2 , NM_001282186.1
Accession Version	NM_001282187.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Homo sapiens(human)
Product	cysteinyl leukotriene receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ131799.1, DQ131801.1, AF133266.1 and DQ131803.1. On May 31, 2019 this sequence version replaced NM_001282187.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ131801.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2152719, SAMEA2156670 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269116.1
CDS	505..1518
Translation	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

Target ORF information:

RefSeq Version	NM_001282187.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282187.2

ORF Insert Sequence:

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYSLTR1 ( NM_001282188.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269117.1 Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu23290
Clone ID Related Accession (Same CDS sequence)	NM_001282187.1 , NM_006639.4 , NM_006639.3 , NM_001282187.2 , NM_001282188.1 , NM_001282188.2 , NM_001282186.1
Accession Version	NM_001282188.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	cysteinyl leukotriene receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ131799.1, DQ131802.1, AF133266.1 and DQ131803.1. Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ131802.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269117.1
CDS	562..1575
Translation	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

Target ORF information:

RefSeq Version	NM_001282188.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282188.1

ORF Insert Sequence:

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYSLTR1 ( NM_001282188.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269117.1 Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu23290
Clone ID Related Accession (Same CDS sequence)	NM_001282187.1 , NM_006639.4 , NM_006639.3 , NM_001282187.2 , NM_001282188.1 , NM_001282188.2 , NM_001282186.1
Accession Version	NM_001282188.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-06
Organism	Homo sapiens(human)
Product	cysteinyl leukotriene receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ131799.1, DQ131802.1, AF133266.1 and DQ131803.1. On May 31, 2019 this sequence version replaced NM_001282188.1. Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ131802.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269117.1
CDS	482..1495
Translation	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

Target ORF information:

RefSeq Version	NM_001282188.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282188.2

ORF Insert Sequence:

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYSLTR1 ( NM_001282186.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001269115.1 Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23290
Clone ID Related Accession (Same CDS sequence)	NM_001282187.1 , NM_006639.4 , NM_006639.3 , NM_001282187.2 , NM_001282188.1 , NM_001282188.2 , NM_001282186.1
Accession Version	NM_001282186.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	cysteinyl leukotriene receptor 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ131799.1, DQ131800.1, AF133266.1 and DQ131803.1. On Aug 22, 2013 this sequence version replaced XM_005262061.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.564770.1, SRR1163655.277816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269115.1
CDS	415..1428
Translation	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

Target ORF information:

RefSeq Version	NM_001282186.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282186.1

ORF Insert Sequence:

ATGGATGAAA CAGGAAATCT GACAGTATCT TCTGCCACAT GCCATGACAC TATTGATGAC 
TTCCGCAATC AAGTGTATTC CACCTTGTAC TCTATGATCT CTGTTGTAGG CTTCTTTGGC 
AATGGCTTTG TGCTCTATGT CCTCATAAAA ACCTATCACA AGAAGTCAGC CTTCCAAGTA 
TACATGATTA ATTTAGCAGT AGCAGATCTA CTTTGTGTGT GCACACTGCC TCTCCGTGTG 
GTCTATTATG TTCACAAAGG CATTTGGCTC TTTGGTGACT TCTTGTGCCG CCTCAGCACC 
TATGCTTTGT ATGTCAACCT CTATTGTAGC ATCTTCTTTA TGACAGCCAT GAGCTTTTTC 
CGGTGCATTG CAATTGTTTT TCCAGTCCAG AACATTAATT TGGTTACACA GAAAAAAGCC 
AGGTTTGTGT GTGTAGGTAT TTGGATTTTT GTGATTTTGA CCAGTTCTCC ATTTCTAATG 
GCCAAACCAC AAAAAGATGA GAAAAATAAT ACCAAGTGCT TTGAGCCCCC ACAAGACAAT 
CAAACTAAAA ATCATGTTTT GGTCTTGCAT TATGTGTCAT TGTTTGTTGG CTTTATCATC 
CCTTTTGTTA TTATAATTGT CTGTTACACA ATGATCATTT TGACCTTACT AAAAAAATCA 
ATGAAAAAAA ATCTGTCAAG TCATAAAAAG GCTATAGGAA TGATCATGGT CGTGACCGCT 
GCCTTTTTAG TCAGTTTCAT GCCATATCAT ATTCAACGTA CCATTCACCT TCATTTTTTA 
CACAATGAAA CTAAACCCTG TGATTCTGTC CTTAGAATGC AGAAGTCCGT GGTCATAACC 
TTGTCTCTGG CTGCATCCAA TTGTTGCTTT GACCCTCTCC TATATTTCTT TTCTGGGGGT 
AACTTTAGGA AAAGGCTGTC TACATTCAGA AAGCATTCTT TGTCCAGCGT GACTTATGTA 
CCCAGAAAGA AGGCCTCTTT GCCAGAAAAA GGAGAAGAAA TATGTAAAGT ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes.
Cytokine10383-89(2018 Jan)
Song W,Zhang Y,Wang J,Ma T,Hao L,Wang K

The selective cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast regulates extracellular matrix remodeling.
Biochemical and biophysical research communications484(3)474-479(2017 03)
Peng J,Zhou H,Kuang G,Xie L,Tian T,Liu R

Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology118(2)197-203(2017 Feb)
Matsumoto H,Kanemitsu Y,Nagasaki T,Tohda Y,Horiguchi T,Kita H,Kuwabara K,Tomii K,Otsuka K,Fujimura M,Ohkura N,Tomita K,Yokoyama A,Ohnishi H,Nakano Y,Oguma T,Hozawa S,Izuhara Y,Ito I,Oguma T,Inoue H,Tajiri T,Iwata T,Ono J,Ohta S,Hirota T,Kawaguchi T,Tamari M,Yokoyama T,Tabara Y,Matsuda F,Izuhara K,Niimi A,Mishima M

Expression of cysteinyl leukotriene receptor 1 and 2 (CysLTR1 and CysLTR2) in the lymphocytes of hyperplastic tonsils: comparison between allergic and nonallergic snoring children.
International forum of allergy & rhinology6(11)1151-1158(2016 11)
Paulucci BP,Pereira J,Picciarelli P,Levy D,Di Francesco RC

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CYSLTR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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