ADCY2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADCY2
Entrez Gene ID	108
Full Name	adenylate cyclase 2
Synonyms	AC2,HBAC2
General protein information	Preferred Names adenylate cyclase 2 Names adenylate cyclase type 2 3',5'-cyclic AMP synthetase ATP pyrophosphate-lyase 2 adenylate cyclase 2 (brain) adenylate cyclase II adenylate cyclase type II adenylyl cyclase 2 type II adenylate cyclase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p15.31
Summary	This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008].
Disorder MIM:	103071

mRNA and Protein(s)

mRNA	Protein	Name
NM_020546.3	NP_065433.2	adenylate cyclase type 2
XM_011513942.2	XP_011512244.1	adenylate cyclase type 2 isoform X1
NM_020546.2	NP_065433.2	adenylate cyclase type 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ADCY2	NP_065433.2
Canis lupus familiaris (dog)	ADCY2	XP_535798.3
Drosophila melanogaster (fruit fly)	Ac76E	NP_524173.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010436	XP_311511.4
Gallus gallus (chicken)	ADCY2	XP_419020.3
Danio rerio (zebrafish)	adcy2a	XP_692173.5
	ADCY2	XP_001083524.1
Bos taurus (cattle)	ADCY2	XP_002696478.1
Rattus norvegicus (Norway rat)	Adcy2	NP_112269.1
Danio rerio (zebrafish)	adcy2b	NP_001093457.1
Mus musculus (house mouse)	Adcy2	NP_705762.2

Gene Ontology
Bibliography

Related articles in PubMed

Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients.
van Huis-Tanja LH, Ewing E, van der Straaten RJ, Swen JJ, Baak-Pablo RF, Punt CJ, Gelderblom AJ, Guchelaar HJ
Pharmacogenetics and genomics25(6)279-88(2015 Jun)

Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms.
Bogard AS, Birg AV, Ostrom RS
Naunyn-Schmiedeberg's archives of pharmacology387(4)329-39(2014 Apr)

Genome-wide association study reveals two new risk loci for bipolar disorder.
M?hleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Forstner AJ, Schumacher J, Breuer R, Meier S, Herms S, Hoffmann P, Lacour A, Witt SH, Reif A, M?ller-Myhsok B, Lucae S, Maier W, Schwarz M, Vedder H, Kammerer-Ciernioch J, Pfennig A, Bauer M, Hautzinger M, Moebus S, Priebe L, Czerski PM, Hauser J, Lissowska J, Szeszenia-Dabrowska N, Brennan P, McKay JD, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Krasnow V, Chuchalin A, Babadjanova G, Pantelejeva G, Abramova LI, Tiganov AS, Polonikov A, Khusnutdinova E, Alda M, Grof P, Rouleau GA, Turecki G, Laprise C, Rivas F, Mayoral F, Kogevinas M, Grigoroiu-Serbanescu M, Propping P, Becker T, Rietschel M, N?then MM, Cichon S
Nature communications53339(2014 Mar)

AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex.
Shen JX, Cooper DM
The Biochemical journal455(1)47-56(2013 Oct)

Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
Simino J, Sung YJ, Kume R, Schwander K, Rao DC
Frontiers in genetics4277(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In patients receiving capecitabine monotherapy, rs4702484, located in ADCY2 and close to MTRR, was associated with slightly reduced PFS for homozygous wild-type patients (CC 6.2 vs. CT 8.0 months; P=0.018).
Title: Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients.

Our present study defines an AC2 cAMP signaling compartment that specifically regulates IL-6 expression in bronchial smooth muscle cells.
Title: Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms.

AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex.
Title: AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex.

AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2.
Title: Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling.

A replication of association between two SNPs previously associated with COPD (CHRNA3/5 and IREB2), as well as an association with COPD of one locus initially associated with lung function (ADCY2).
Title: CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.

The following ADCY2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADCY2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16286	NM_020546.3 Latest version!	Homo sapiens adenylate cyclase 2 (ADCY2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$554.50-$776.30 $1109.00
OHu56151	XM_011513942.2 Latest version!	Homo sapiens adenylate cyclase 2 (ADCY2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
View Old Accession Versions >>
OHu16286	NM_020546.2	Homo sapiens adenylate cyclase 2 (ADCY2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$554.50-$776.30 $1109.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADCY2 ( NM_020546.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065433.2 Homo sapiens adenylate cyclase 2 (ADCY2), mRNA.

Price & Availability↑

CloneID	OHu16286
Clone ID Related Accession (Same CDS sequence)	NM_020546.3 , NM_020546.2
Accession Version	NM_020546.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	adenylate cyclase type 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC024577.5, DB481853.2, BE677757.1, BC111743.1, DB029098.1, AF070583.1 and AC010346.6. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_020546.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.93886.1, SRR1660803.36055.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000338316.9/ ENSP00000342952.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGCAGG AGGCGATGCG GCGCCGCCGC TACCTGCGGG ACCGCTCCGA GGAGGCGGCG 
GGCGGCGGAG ACGGGCTGCC GCGGTCCCGG GACTGGCTCT ACGAGTCCTA CTACTGCATG 
AGCCAGCAGC ACCCGCTCAT CGTCTTCCTG CTGCTCATCG TCATGGGCTC CTGCCTCGCC 
CTGCTCGCCG TCTTCTTCGC GCTCGGGCTG GAAGTTGAAG ACCATGTGGC GTTTCTAATA 
ACAGTTCCAA CTGCCCTGGC GATTTTCTTT GCGATATTTA TCCTGGTCTG CATCGAGTCT 
GTGTTTAAGA AGCTGCTGCG CCTCTTCTCG TTGGTGATAT GGATATGCCT TGTTGCCATG 
GGATACCTGT TCATGTGTTT TGGAGGCACC GTCTCTCCCT GGGACCAGGT ATCGTTCTTC 
CTCTTCATCA TCTTCGTGGT GTACACCATG CTGCCCTTCA ACATGCGAGA CGCCATCATT 
GCCAGCGTCC TCACCTCCTC CTCCCACACC ATCGTGCTTA GCGTCTGCCT GTCTGCAACA 
CCGGGAGGCA AGGAGCACCT GGTCTGGCAG ATCCTGGCCA ATGTGATCAT TTTCATCTGT 
GGGAACCTGG CGGGAGCCTA CCATAAGCAC CTCATGGAAC TCGCTCTTCA GCAAACATAT 
CAGGACACCT GTAATTGCAT CAAGTCGCGG ATCAAGTTGG AATTTGAAAA ACGTCAACAG 
GAGCGGCTTC TGCTCTCCCT GCTGCCGGCC CACATCGCCA TGGAGATGAA AGCGGAGATC 
ATCCAGAGGC TGCAGGGCCC CAAGGCGGGC CAGATGGAGA ACACAAATAA CTTCCACAAC 
CTGTATGTGA AGCGGCATAC AAACGTGAGC ATCTTATACG CTGACATCGT TGGCTTTACC 
CGGCTGGCAA GTGACTGCTC CCCGGGAGAA CTAGTCCACA TGCTGAATGA GCTCTTTGGA 
AAGTTTGATC AAATTGCAAA GGAGAATGAA TGCATGAGAA TTAAAATTTT AGGAGACTGC 
TACTACTGTG TATCTGGACT CCCTATATCT CTCCCTAACC ATGCCAAGAA CTGTGTGAAA 
ATGGGGCTGG ACATGTGTGA AGCCATAAAG AAAGTGAGGG ATGCTACTGG AGTTGATATC 
AACATGCGCG TGGGCGTGCA TTCTGGGAAT GTCCTGTGTG GCGTGATTGG TCTGCAGAAG 
TGGCAATATG ATGTGTGGTC ACATGATGTG ACCTTGGCCA ACCACATGGA AGCTGGAGGG 
GTCCCTGGAC GTGTTCACAT TTCTTCTGTC ACCCTGGAGC ACTTGAATGG CGCTTATAAA 
GTGGAGGAGG GAGATGGTGA CATTAGGGAC CCATATTTAA AACAGCACCT GGTGAAAACC 
TACTTTGTGA TCAACCCCAA GGGAGAACGA CGGAGCCCCC AGCATCTCTT CAGACCTCGC 
CACACCCTTG ATGGAGCCAA AATGAGGGCC TCGGTCCGCA TGACCCGGTA CTTGGAGTCC 
TGGGGGGCAG CCAAGCCCTT TGCACACCTA CATCACAGGG ACAGCATGAC CACAGAGAAC 
GGCAAGATCA GCACCACGGA TGTACCCATG GGTCAGCATA ATTTTCAAAA TCGCACCTTA 
AGAACCAAGT CACAAAAGAA GAGATTTGAA GAAGAATTGA ATGAAAGGAT GATTCAAGCA 
ATTGATGGGA TTAATGCACA GAAGCAATGG CTCAAGTCTG AAGACATTCA GAGAATCTCA 
CTGCTTTTCT ATAACAAAGT ACTAGAAAAA GAGTACCGGG CCACGGCACT GCCAGCGTTC 
AAGTATTATG TGACTTGTGC CTGTCTCATA TTCTTCTGCA TCTTCATTGT GCAGATTCTC 
GTGCTGCCAA AAACGTCCGT CCTGGGCATC TCCTTTGGGG CTGCGTTTCT CTTGCTGGCC 
TTCATCCTCT TCGTCTGCTT TGCTGGACAG CTTCTGCAAT GCAGCAAAAA AGCCTCTCCC 
CTGCTCATGT GGCTTTTGAA GTCCTCGGGC ATCATTGCCA ACCGCCCCTG GCCACGGATC 
TCTCTCACGA TCATCACCAC AGCCATCATA TTAATGATGG CCGTGTTCAA CATGTTTTTC 
CTGAGTGACT CAGAGGAAAC AATCCCTCCA ACTGCCAACA CAACAAACAC AAGCTTTTCA 
GCCTCAAATA ATCAGGTGGC GATTCTGCGT GCGCAGAATT TATTTTTCCT CCCGTACTTT 
ATCTACAGCT GCATTCTGGG ACTGATATCC TGTTCCGTGT TCCTGCGGGT AAACTATGAG 
CTGAAGATGT TGATCATGAT GGTGGCCTTG GTGGGCTACA ACACCATCCT ACTCCACACC 
CACGCCCACG TCCTGGGCGA CTACAGCCAG GTCTTATTTG AGAGACCAGG CATTTGGAAA 
GACCTGAAGA CCATGGGCTC TGTGTCTCTC TCTATATTCT TCATCACACT GCTTGTTCTG 
GGTAGACAGA ATGAATATTA CTGTAGGTTA GACTTCTTAT GGAAGAACAA ATTCAAAAAA 
GAGCGGGAGG AGATAGAGAC CATGGAGAAC CTGAACCGCG TGCTGCTGGA GAACGTGCTT 
CCCGCGCACG TGGCTGAGCA CTTCCTGGCC AGGAGCCTGA AGAATGAGGA GCTATACCAC 
CAGTCCTATG ACTGCGTCTG CGTCATGTTT GCCTCCATTC CGGATTTCAA AGAATTTTAT 
ACAGAATCCG ACGTGAACAA GGAGGGCTTG GAATGCCTTC GGCTCCTGAA CGAGATCATC 
GCTGACTTTG ATGATCTTCT TTCCAAGCCA AAATTCAGTG GAGTTGAAAA GATTAAGACC 
ATTGGCAGCA CATACATGGC AGCAACAGGT CTGAGCGCTG TGCCCAGCCA GGAGCACTCC 
CAGGAGCCCG AGCGGCAGTA CATGCACATT GGCACCATGG TGGAGTTTGC TTTTGCCCTG 
GTAGGGAAGC TGGATGCCAT CAACAAGCAC TCCTTCAACG ACTTCAAATT GCGAGTGGGT 
ATTAACCATG GACCTGTGAT AGCTGGTGTG ATTGGAGCTC AGAAGCCACA ATATGATATC 
TGGGGCAACA CTGTCAATGT GGCCAGTAGG ATGGACAGCA CCGGAGTCCT GGACAAAATA 
CAGGTTACCG AGGAGACGAG CCTCGTCCTG CAGACCCTCG GATACACGTG CACCTGTCGA 
GGAATAATCA ACGTGAAAGG AAAGGGGGAC CTGAAGACGT ACTTTGTAAA CACAGAAATG 
TCAAGGTCCC TTTCCCAGAG CAACGTGGCA TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065433.2
CDS	160..3435
Translation	MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS

Target ORF information:

RefSeq Version	NM_020546.3
Organism	Homo sapiens(human)
Definition	Homo sapiens adenylate cyclase 2 (ADCY2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020546.3

ORF Insert Sequence:

ATGTGGCAGG AGGCGATGCG GCGCCGCCGC TACCTGCGGG ACCGCTCCGA GGAGGCGGCG 
GGCGGCGGAG ACGGGCTGCC GCGGTCCCGG GACTGGCTCT ACGAGTCCTA CTACTGCATG 
AGCCAGCAGC ACCCGCTCAT CGTCTTCCTG CTGCTCATCG TCATGGGCTC CTGCCTCGCC 
CTGCTCGCCG TCTTCTTCGC GCTCGGGCTG GAAGTTGAAG ACCATGTGGC GTTTCTAATA 
ACAGTTCCAA CTGCCCTGGC GATTTTCTTT GCGATATTTA TCCTGGTCTG CATCGAGTCT 
GTGTTTAAGA AGCTGCTGCG CCTCTTCTCG TTGGTGATAT GGATATGCCT TGTTGCCATG 
GGATACCTGT TCATGTGTTT TGGAGGCACC GTCTCTCCCT GGGACCAGGT ATCGTTCTTC 
CTCTTCATCA TCTTCGTGGT GTACACCATG CTGCCCTTCA ACATGCGAGA CGCCATCATT 
GCCAGCGTCC TCACCTCCTC CTCCCACACC ATCGTGCTTA GCGTCTGCCT GTCTGCAACA 
CCGGGAGGCA AGGAGCACCT GGTCTGGCAG ATCCTGGCCA ATGTGATCAT TTTCATCTGT 
GGGAACCTGG CGGGAGCCTA CCATAAGCAC CTCATGGAAC TCGCTCTTCA GCAAACATAT 
CAGGACACCT GTAATTGCAT CAAGTCGCGG ATCAAGTTGG AATTTGAAAA ACGTCAACAG 
GAGCGGCTTC TGCTCTCCCT GCTGCCGGCC CACATCGCCA TGGAGATGAA AGCGGAGATC 
ATCCAGAGGC TGCAGGGCCC CAAGGCGGGC CAGATGGAGA ACACAAATAA CTTCCACAAC 
CTGTATGTGA AGCGGCATAC AAACGTGAGC ATCTTATACG CTGACATCGT TGGCTTTACC 
CGGCTGGCAA GTGACTGCTC CCCGGGAGAA CTAGTCCACA TGCTGAATGA GCTCTTTGGA 
AAGTTTGATC AAATTGCAAA GGAGAATGAA TGCATGAGAA TTAAAATTTT AGGAGACTGC 
TACTACTGTG TATCTGGACT CCCTATATCT CTCCCTAACC ATGCCAAGAA CTGTGTGAAA 
ATGGGGCTGG ACATGTGTGA AGCCATAAAG AAAGTGAGGG ATGCTACTGG AGTTGATATC 
AACATGCGCG TGGGCGTGCA TTCTGGGAAT GTCCTGTGTG GCGTGATTGG TCTGCAGAAG 
TGGCAATATG ATGTGTGGTC ACATGATGTG ACCTTGGCCA ACCACATGGA AGCTGGAGGG 
GTCCCTGGAC GTGTTCACAT TTCTTCTGTC ACCCTGGAGC ACTTGAATGG CGCTTATAAA 
GTGGAGGAGG GAGATGGTGA CATTAGGGAC CCATATTTAA AACAGCACCT GGTGAAAACC 
TACTTTGTGA TCAACCCCAA GGGAGAACGA CGGAGCCCCC AGCATCTCTT CAGACCTCGC 
CACACCCTTG ATGGAGCCAA AATGAGGGCC TCGGTCCGCA TGACCCGGTA CTTGGAGTCC 
TGGGGGGCAG CCAAGCCCTT TGCACACCTA CATCACAGGG ACAGCATGAC CACAGAGAAC 
GGCAAGATCA GCACCACGGA TGTACCCATG GGTCAGCATA ATTTTCAAAA TCGCACCTTA 
AGAACCAAGT CACAAAAGAA GAGATTTGAA GAAGAATTGA ATGAAAGGAT GATTCAAGCA 
ATTGATGGGA TTAATGCACA GAAGCAATGG CTCAAGTCTG AAGACATTCA GAGAATCTCA 
CTGCTTTTCT ATAACAAAGT ACTAGAAAAA GAGTACCGGG CCACGGCACT GCCAGCGTTC 
AAGTATTATG TGACTTGTGC CTGTCTCATA TTCTTCTGCA TCTTCATTGT GCAGATTCTC 
GTGCTGCCAA AAACGTCCGT CCTGGGCATC TCCTTTGGGG CTGCGTTTCT CTTGCTGGCC 
TTCATCCTCT TCGTCTGCTT TGCTGGACAG CTTCTGCAAT GCAGCAAAAA AGCCTCTCCC 
CTGCTCATGT GGCTTTTGAA GTCCTCGGGC ATCATTGCCA ACCGCCCCTG GCCACGGATC 
TCTCTCACGA TCATCACCAC AGCCATCATA TTAATGATGG CCGTGTTCAA CATGTTTTTC 
CTGAGTGACT CAGAGGAAAC AATCCCTCCA ACTGCCAACA CAACAAACAC AAGCTTTTCA 
GCCTCAAATA ATCAGGTGGC GATTCTGCGT GCGCAGAATT TATTTTTCCT CCCGTACTTT 
ATCTACAGCT GCATTCTGGG ACTGATATCC TGTTCCGTGT TCCTGCGGGT AAACTATGAG 
CTGAAGATGT TGATCATGAT GGTGGCCTTG GTGGGCTACA ACACCATCCT ACTCCACACC 
CACGCCCACG TCCTGGGCGA CTACAGCCAG GTCTTATTTG AGAGACCAGG CATTTGGAAA 
GACCTGAAGA CCATGGGCTC TGTGTCTCTC TCTATATTCT TCATCACACT GCTTGTTCTG 
GGTAGACAGA ATGAATATTA CTGTAGGTTA GACTTCTTAT GGAAGAACAA ATTCAAAAAA 
GAGCGGGAGG AGATAGAGAC CATGGAGAAC CTGAACCGCG TGCTGCTGGA GAACGTGCTT 
CCCGCGCACG TGGCTGAGCA CTTCCTGGCC AGGAGCCTGA AGAATGAGGA GCTATACCAC 
CAGTCCTATG ACTGCGTCTG CGTCATGTTT GCCTCCATTC CGGATTTCAA AGAATTTTAT 
ACAGAATCCG ACGTGAACAA GGAGGGCTTG GAATGCCTTC GGCTCCTGAA CGAGATCATC 
GCTGACTTTG ATGATCTTCT TTCCAAGCCA AAATTCAGTG GAGTTGAAAA GATTAAGACC 
ATTGGCAGCA CATACATGGC AGCAACAGGT CTGAGCGCTG TGCCCAGCCA GGAGCACTCC 
CAGGAGCCCG AGCGGCAGTA CATGCACATT GGCACCATGG TGGAGTTTGC TTTTGCCCTG 
GTAGGGAAGC TGGATGCCAT CAACAAGCAC TCCTTCAACG ACTTCAAATT GCGAGTGGGT 
ATTAACCATG GACCTGTGAT AGCTGGTGTG ATTGGAGCTC AGAAGCCACA ATATGATATC 
TGGGGCAACA CTGTCAATGT GGCCAGTAGG ATGGACAGCA CCGGAGTCCT GGACAAAATA 
CAGGTTACCG AGGAGACGAG CCTCGTCCTG CAGACCCTCG GATACACGTG CACCTGTCGA 
GGAATAATCA ACGTGAAAGG AAAGGGGGAC CTGAAGACGT ACTTTGTAAA CACAGAAATG 
TCAAGGTCCC TTTCCCAGAG CAACGTGGCA TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADCY2 ( NM_020546.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065433.2 Homo sapiens adenylate cyclase 2 (ADCY2), mRNA.

Price & Availability↑

CloneID	OHu16286
Clone ID Related Accession (Same CDS sequence)	NM_020546.3 , NM_020546.2
Accession Version	NM_020546.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	adenylate cyclase type 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB481853.2, BE677757.1, BC111743.1, DB029098.1, AF070583.1 and AC010346.6. This sequence is a reference standard in the RefSeqGene project. On Sep 28, 2006 this sequence version replaced NM_020546.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.93886.1, SRR1660803.36055.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGCAGG AGGCGATGCG GCGCCGCCGC TACCTGCGGG ACCGCTCCGA GGAGGCGGCG 
GGCGGCGGAG ACGGGCTGCC GCGGTCCCGG GACTGGCTCT ACGAGTCCTA CTACTGCATG 
AGCCAGCAGC ACCCGCTCAT CGTCTTCCTG CTGCTCATCG TCATGGGCTC CTGCCTCGCC 
CTGCTCGCCG TCTTCTTCGC GCTCGGGCTG GAAGTTGAAG ACCATGTGGC GTTTCTAATA 
ACAGTTCCAA CTGCCCTGGC GATTTTCTTT GCGATATTTA TCCTGGTCTG CATCGAGTCT 
GTGTTTAAGA AGCTGCTGCG CCTCTTCTCG TTGGTGATAT GGATATGCCT TGTTGCCATG 
GGATACCTGT TCATGTGTTT TGGAGGCACC GTCTCTCCCT GGGACCAGGT ATCGTTCTTC 
CTCTTCATCA TCTTCGTGGT GTACACCATG CTGCCCTTCA ACATGCGAGA CGCCATCATT 
GCCAGCGTCC TCACCTCCTC CTCCCACACC ATCGTGCTTA GCGTCTGCCT GTCTGCAACA 
CCGGGAGGCA AGGAGCACCT GGTCTGGCAG ATCCTGGCCA ATGTGATCAT TTTCATCTGT 
GGGAACCTGG CGGGAGCCTA CCATAAGCAC CTCATGGAAC TCGCTCTTCA GCAAACATAT 
CAGGACACCT GTAATTGCAT CAAGTCGCGG ATCAAGTTGG AATTTGAAAA ACGTCAACAG 
GAGCGGCTTC TGCTCTCCCT GCTGCCGGCC CACATCGCCA TGGAGATGAA AGCGGAGATC 
ATCCAGAGGC TGCAGGGCCC CAAGGCGGGC CAGATGGAGA ACACAAATAA CTTCCACAAC 
CTGTATGTGA AGCGGCATAC AAACGTGAGC ATCTTATACG CTGACATCGT TGGCTTTACC 
CGGCTGGCAA GTGACTGCTC CCCGGGAGAA CTAGTCCACA TGCTGAATGA GCTCTTTGGA 
AAGTTTGATC AAATTGCAAA GGAGAATGAA TGCATGAGAA TTAAAATTTT AGGAGACTGC 
TACTACTGTG TATCTGGACT CCCTATATCT CTCCCTAACC ATGCCAAGAA CTGTGTGAAA 
ATGGGGCTGG ACATGTGTGA AGCCATAAAG AAAGTGAGGG ATGCTACTGG AGTTGATATC 
AACATGCGCG TGGGCGTGCA TTCTGGGAAT GTCCTGTGTG GCGTGATTGG TCTGCAGAAG 
TGGCAATATG ATGTGTGGTC ACATGATGTG ACCTTGGCCA ACCACATGGA AGCTGGAGGG 
GTCCCTGGAC GTGTTCACAT TTCTTCTGTC ACCCTGGAGC ACTTGAATGG CGCTTATAAA 
GTGGAGGAGG GAGATGGTGA CATTAGGGAC CCATATTTAA AACAGCACCT GGTGAAAACC 
TACTTTGTGA TCAACCCCAA GGGAGAACGA CGGAGCCCCC AGCATCTCTT CAGACCTCGC 
CACACCCTTG ATGGAGCCAA AATGAGGGCC TCGGTCCGCA TGACCCGGTA CTTGGAGTCC 
TGGGGGGCAG CCAAGCCCTT TGCACACCTA CATCACAGGG ACAGCATGAC CACAGAGAAC 
GGCAAGATCA GCACCACGGA TGTACCCATG GGTCAGCATA ATTTTCAAAA TCGCACCTTA 
AGAACCAAGT CACAAAAGAA GAGATTTGAA GAAGAATTGA ATGAAAGGAT GATTCAAGCA 
ATTGATGGGA TTAATGCACA GAAGCAATGG CTCAAGTCTG AAGACATTCA GAGAATCTCA 
CTGCTTTTCT ATAACAAAGT ACTAGAAAAA GAGTACCGGG CCACGGCACT GCCAGCGTTC 
AAGTATTATG TGACTTGTGC CTGTCTCATA TTCTTCTGCA TCTTCATTGT GCAGATTCTC 
GTGCTGCCAA AAACGTCCGT CCTGGGCATC TCCTTTGGGG CTGCGTTTCT CTTGCTGGCC 
TTCATCCTCT TCGTCTGCTT TGCTGGACAG CTTCTGCAAT GCAGCAAAAA AGCCTCTCCC 
CTGCTCATGT GGCTTTTGAA GTCCTCGGGC ATCATTGCCA ACCGCCCCTG GCCACGGATC 
TCTCTCACGA TCATCACCAC AGCCATCATA TTAATGATGG CCGTGTTCAA CATGTTTTTC 
CTGAGTGACT CAGAGGAAAC AATCCCTCCA ACTGCCAACA CAACAAACAC AAGCTTTTCA 
GCCTCAAATA ATCAGGTGGC GATTCTGCGT GCGCAGAATT TATTTTTCCT CCCGTACTTT 
ATCTACAGCT GCATTCTGGG ACTGATATCC TGTTCCGTGT TCCTGCGGGT AAACTATGAG 
CTGAAGATGT TGATCATGAT GGTGGCCTTG GTGGGCTACA ACACCATCCT ACTCCACACC 
CACGCCCACG TCCTGGGCGA CTACAGCCAG GTCTTATTTG AGAGACCAGG CATTTGGAAA 
GACCTGAAGA CCATGGGCTC TGTGTCTCTC TCTATATTCT TCATCACACT GCTTGTTCTG 
GGTAGACAGA ATGAATATTA CTGTAGGTTA GACTTCTTAT GGAAGAACAA ATTCAAAAAA 
GAGCGGGAGG AGATAGAGAC CATGGAGAAC CTGAACCGCG TGCTGCTGGA GAACGTGCTT 
CCCGCGCACG TGGCTGAGCA CTTCCTGGCC AGGAGCCTGA AGAATGAGGA GCTATACCAC 
CAGTCCTATG ACTGCGTCTG CGTCATGTTT GCCTCCATTC CGGATTTCAA AGAATTTTAT 
ACAGAATCCG ACGTGAACAA GGAGGGCTTG GAATGCCTTC GGCTCCTGAA CGAGATCATC 
GCTGACTTTG ATGATCTTCT TTCCAAGCCA AAATTCAGTG GAGTTGAAAA GATTAAGACC 
ATTGGCAGCA CATACATGGC AGCAACAGGT CTGAGCGCTG TGCCCAGCCA GGAGCACTCC 
CAGGAGCCCG AGCGGCAGTA CATGCACATT GGCACCATGG TGGAGTTTGC TTTTGCCCTG 
GTAGGGAAGC TGGATGCCAT CAACAAGCAC TCCTTCAACG ACTTCAAATT GCGAGTGGGT 
ATTAACCATG GACCTGTGAT AGCTGGTGTG ATTGGAGCTC AGAAGCCACA ATATGATATC 
TGGGGCAACA CTGTCAATGT GGCCAGTAGG ATGGACAGCA CCGGAGTCCT GGACAAAATA 
CAGGTTACCG AGGAGACGAG CCTCGTCCTG CAGACCCTCG GATACACGTG CACCTGTCGA 
GGAATAATCA ACGTGAAAGG AAAGGGGGAC CTGAAGACGT ACTTTGTAAA CACAGAAATG 
TCAAGGTCCC TTTCCCAGAG CAACGTGGCA TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065433.2
CDS	68..3343
Translation	MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS

Target ORF information:

RefSeq Version	NM_020546.2
Organism	Homo sapiens(human)
Definition	Homo sapiens adenylate cyclase 2 (ADCY2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020546.2

ORF Insert Sequence:

ATGTGGCAGG AGGCGATGCG GCGCCGCCGC TACCTGCGGG ACCGCTCCGA GGAGGCGGCG 
GGCGGCGGAG ACGGGCTGCC GCGGTCCCGG GACTGGCTCT ACGAGTCCTA CTACTGCATG 
AGCCAGCAGC ACCCGCTCAT CGTCTTCCTG CTGCTCATCG TCATGGGCTC CTGCCTCGCC 
CTGCTCGCCG TCTTCTTCGC GCTCGGGCTG GAAGTTGAAG ACCATGTGGC GTTTCTAATA 
ACAGTTCCAA CTGCCCTGGC GATTTTCTTT GCGATATTTA TCCTGGTCTG CATCGAGTCT 
GTGTTTAAGA AGCTGCTGCG CCTCTTCTCG TTGGTGATAT GGATATGCCT TGTTGCCATG 
GGATACCTGT TCATGTGTTT TGGAGGCACC GTCTCTCCCT GGGACCAGGT ATCGTTCTTC 
CTCTTCATCA TCTTCGTGGT GTACACCATG CTGCCCTTCA ACATGCGAGA CGCCATCATT 
GCCAGCGTCC TCACCTCCTC CTCCCACACC ATCGTGCTTA GCGTCTGCCT GTCTGCAACA 
CCGGGAGGCA AGGAGCACCT GGTCTGGCAG ATCCTGGCCA ATGTGATCAT TTTCATCTGT 
GGGAACCTGG CGGGAGCCTA CCATAAGCAC CTCATGGAAC TCGCTCTTCA GCAAACATAT 
CAGGACACCT GTAATTGCAT CAAGTCGCGG ATCAAGTTGG AATTTGAAAA ACGTCAACAG 
GAGCGGCTTC TGCTCTCCCT GCTGCCGGCC CACATCGCCA TGGAGATGAA AGCGGAGATC 
ATCCAGAGGC TGCAGGGCCC CAAGGCGGGC CAGATGGAGA ACACAAATAA CTTCCACAAC 
CTGTATGTGA AGCGGCATAC AAACGTGAGC ATCTTATACG CTGACATCGT TGGCTTTACC 
CGGCTGGCAA GTGACTGCTC CCCGGGAGAA CTAGTCCACA TGCTGAATGA GCTCTTTGGA 
AAGTTTGATC AAATTGCAAA GGAGAATGAA TGCATGAGAA TTAAAATTTT AGGAGACTGC 
TACTACTGTG TATCTGGACT CCCTATATCT CTCCCTAACC ATGCCAAGAA CTGTGTGAAA 
ATGGGGCTGG ACATGTGTGA AGCCATAAAG AAAGTGAGGG ATGCTACTGG AGTTGATATC 
AACATGCGCG TGGGCGTGCA TTCTGGGAAT GTCCTGTGTG GCGTGATTGG TCTGCAGAAG 
TGGCAATATG ATGTGTGGTC ACATGATGTG ACCTTGGCCA ACCACATGGA AGCTGGAGGG 
GTCCCTGGAC GTGTTCACAT TTCTTCTGTC ACCCTGGAGC ACTTGAATGG CGCTTATAAA 
GTGGAGGAGG GAGATGGTGA CATTAGGGAC CCATATTTAA AACAGCACCT GGTGAAAACC 
TACTTTGTGA TCAACCCCAA GGGAGAACGA CGGAGCCCCC AGCATCTCTT CAGACCTCGC 
CACACCCTTG ATGGAGCCAA AATGAGGGCC TCGGTCCGCA TGACCCGGTA CTTGGAGTCC 
TGGGGGGCAG CCAAGCCCTT TGCACACCTA CATCACAGGG ACAGCATGAC CACAGAGAAC 
GGCAAGATCA GCACCACGGA TGTACCCATG GGTCAGCATA ATTTTCAAAA TCGCACCTTA 
AGAACCAAGT CACAAAAGAA GAGATTTGAA GAAGAATTGA ATGAAAGGAT GATTCAAGCA 
ATTGATGGGA TTAATGCACA GAAGCAATGG CTCAAGTCTG AAGACATTCA GAGAATCTCA 
CTGCTTTTCT ATAACAAAGT ACTAGAAAAA GAGTACCGGG CCACGGCACT GCCAGCGTTC 
AAGTATTATG TGACTTGTGC CTGTCTCATA TTCTTCTGCA TCTTCATTGT GCAGATTCTC 
GTGCTGCCAA AAACGTCCGT CCTGGGCATC TCCTTTGGGG CTGCGTTTCT CTTGCTGGCC 
TTCATCCTCT TCGTCTGCTT TGCTGGACAG CTTCTGCAAT GCAGCAAAAA AGCCTCTCCC 
CTGCTCATGT GGCTTTTGAA GTCCTCGGGC ATCATTGCCA ACCGCCCCTG GCCACGGATC 
TCTCTCACGA TCATCACCAC AGCCATCATA TTAATGATGG CCGTGTTCAA CATGTTTTTC 
CTGAGTGACT CAGAGGAAAC AATCCCTCCA ACTGCCAACA CAACAAACAC AAGCTTTTCA 
GCCTCAAATA ATCAGGTGGC GATTCTGCGT GCGCAGAATT TATTTTTCCT CCCGTACTTT 
ATCTACAGCT GCATTCTGGG ACTGATATCC TGTTCCGTGT TCCTGCGGGT AAACTATGAG 
CTGAAGATGT TGATCATGAT GGTGGCCTTG GTGGGCTACA ACACCATCCT ACTCCACACC 
CACGCCCACG TCCTGGGCGA CTACAGCCAG GTCTTATTTG AGAGACCAGG CATTTGGAAA 
GACCTGAAGA CCATGGGCTC TGTGTCTCTC TCTATATTCT TCATCACACT GCTTGTTCTG 
GGTAGACAGA ATGAATATTA CTGTAGGTTA GACTTCTTAT GGAAGAACAA ATTCAAAAAA 
GAGCGGGAGG AGATAGAGAC CATGGAGAAC CTGAACCGCG TGCTGCTGGA GAACGTGCTT 
CCCGCGCACG TGGCTGAGCA CTTCCTGGCC AGGAGCCTGA AGAATGAGGA GCTATACCAC 
CAGTCCTATG ACTGCGTCTG CGTCATGTTT GCCTCCATTC CGGATTTCAA AGAATTTTAT 
ACAGAATCCG ACGTGAACAA GGAGGGCTTG GAATGCCTTC GGCTCCTGAA CGAGATCATC 
GCTGACTTTG ATGATCTTCT TTCCAAGCCA AAATTCAGTG GAGTTGAAAA GATTAAGACC 
ATTGGCAGCA CATACATGGC AGCAACAGGT CTGAGCGCTG TGCCCAGCCA GGAGCACTCC 
CAGGAGCCCG AGCGGCAGTA CATGCACATT GGCACCATGG TGGAGTTTGC TTTTGCCCTG 
GTAGGGAAGC TGGATGCCAT CAACAAGCAC TCCTTCAACG ACTTCAAATT GCGAGTGGGT 
ATTAACCATG GACCTGTGAT AGCTGGTGTG ATTGGAGCTC AGAAGCCACA ATATGATATC 
TGGGGCAACA CTGTCAATGT GGCCAGTAGG ATGGACAGCA CCGGAGTCCT GGACAAAATA 
CAGGTTACCG AGGAGACGAG CCTCGTCCTG CAGACCCTCG GATACACGTG CACCTGTCGA 
GGAATAATCA ACGTGAAAGG AAAGGGGGAC CTGAAGACGT ACTTTGTAAA CACAGAAATG 
TCAAGGTCCC TTTCCCAGAG CAACGTGGCA TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADCY2 ( XM_011513942.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011512244.1 Homo sapiens adenylate cyclase 2 (ADCY2), transcript variant X2, mRNA.

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CloneID	OHu56151
Clone ID Related Accession (Same CDS sequence)	XM_011513942.2
Accession Version	XM_011513942.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3138bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	adenylate cyclase type 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011513942.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCAGG AGGCGATGCG GCGCCGCCGC TACCTGCGGG ACCGCTCCGA GGAGGCGGCG 
GGCGGCGGAG ACGGGCTGCC GCGGTCCCGG GACTGGCTCT ACGAGTCCTA CTACTGCATG 
AGCCAGCAGC ACCCGCTCAT CGTCTTCCTG CTGCTCATCG TCATGGGCTC CTGCCTCGCC 
CTGCTCGCCG TCTTCTTCGC GCTCGGGCTG GAAGTTGAAG ACCATGTGGC GTTTCTAATA 
ACAGTTCCAA CTGCCCTGGC GATTTTCTTT GCGATATTTA TCCTGGTCTG CATCGAGTCT 
GTGTTTAAGA AGCTGCTGCG CCTCTTCTCG TTGGTGATAT GGATATGCCT TGTTGCCATG 
GGATACCTGT TCATGTGTTT TGGAGGCACC GTCTCTCCCT GGGACCAGGT ATCGTTCTTC 
CTCTTCATCA TCTTCGTGGT GTACACCATG CTGCCCTTCA ACATGCGAGA CGCCATCATT 
GCCAGCGTCC TCACCTCCTC CTCCCACACC ATCGTGCTTA GCGTCTGCCT GTCTGCAACA 
CCGGGAGGCA AGGAGCACCT GGTCTGGCAG ATCCTGGCCA ATGTGATCAT TTTCATCTGT 
GGGAACCTGG CGGGAGCCTA CCATAAGCAC CTCATGGAAC TCGCTCTTCA GCAAACATAT 
CAGGACACCT GTAATTGCAT CAAGTCGCGG ATCAAGTTGG AATTTGAAAA ACGTCAACAG 
GAGCGGCTTC TGCTCTCCCT GCTGCCGGCC CACATCGCCA TGGAGATGAA AGCGGAGATC 
ATCCAGAGGC TGCAGGGCCC CAAGGCGGGC CAGATGGAGA ACACAAATAA CTTCCACAAC 
CTGTATGTGA AGCGGCATAC AAACGTGAGC ATCTTATACG CTGACATCGT TGGCTTTACC 
CGGCTGGCAA GTGACTGCTC CCCGGGAGAA CTAGTCCACA TGCTGAATGA GCTCTTTGGA 
AAGTTTGATC AAATTGCAAA GGAGAATGAA TGCATGAGAA TTAAAATTTT AGGAGACTGC 
TACTACTGTG TATCTGGACT CCCTATATCT CTCCCTAACC ATGCCAAGAA CTGTGTGAAA 
ATGGGGCTGG ACATGTGTGA AGCCATAAAG AAAGTGAGGG ATGCTACTGG AGTTGATATC 
AACATGCGCG TGGGCGTGCA TTCTGGGAAT GTCCTGTGTG GCGTGATTGG TCTGCAGAAG 
TGGCAATATG ATGTGTGGTC ACATGATGTG ACCTTGGCCA ACCACATGGA AGCTGGAGGG 
GTCCCTGGAC GTGTTCACAT TTCTTCTGTC ACCCTGGAGC ACTTGAATGG CGCTTATAAA 
GTGGAGGAGG GAGATGGTGA CATTAGGGAC CCATATTTAA AACAGCACCT GGTGAAAACC 
TACTTTGTGA TCAACCCCAA GGGAGAACGA CGGAGCCCCC AGCATCTCTT CAGACCTCGC 
CACACCCTTG ATGGAGCCAA AATGAGGGCC TCGGTCCGCA TGACCCGGTA CTTGGAGTCC 
TGGGGGGCAG CCAAGCCCTT TGCACACCTA CATCACAGGG ACAGCATGAC CACAGAGAAC 
GGCAAGATCA GCACCACGGA TGTACCCATG GGTCAGCATA ATTTTCAAAA TCGCACCTTA 
AGAACCAAGT CACAAAAGAA GAGATTTGAA GAAGAATTGA ATGAAAGGAT GATTCAAGCA 
ATTGATGGGA TTAATGCACA GAAGCAATGG CTCAAGTCTG AAGACATTCA GAGAATCTCA 
CTGCTTTTCT ATAACAAAGT ACTAGAAAAA GAGTACCGGG CCACGGCACT GCCAGCGTTC 
AAGTATTATG TGACTTGTGC CTGTCTCATA TTCTTCTGCA TCTTCATTGT GCAGATTCTC 
GTGCTGCCAA AAACGTCCGT CCTGGGCATC TCCTTTGGGG CTGCGTTTCT CTTGCTGGCC 
TTCATCCTCT TCGTCTGCTT TGCTGGACAG CTTCTGTTTT TCCTGAGTGA CTCAGAGGAA 
ACAATCCCTC CAACTGCCAA CACAACAAAC ACAAGCTTTT CAGCCTCAAA TAATCAGGTG 
GCGATTCTGC GTGCGCAGAA TTTATTTTTC CTCCCGTACT TTATCTACAG CTGCATTCTG 
GGACTGATAT CCTGTTCCGT GTTCCTGCGG GTAAACTATG AGCTGAAGAT GTTGATCATG 
ATGGTGGCCT TGGTGGGCTA CAACACCATC CTACTCCACA CCCACGCCCA CGTCCTGGGC 
GACTACAGCC AGGTCTTATT TGAGAGACCA GGCATTTGGA AAGACCTGAA GACCATGGGC 
TCTGTGTCTC TCTCTATATT CTTCATCACA CTGCTTGTTC TGGGTAGACA GAATGAATAT 
TACTGTAGGT TAGACTTCTT ATGGAAGAAC AAATTCAAAA AAGAGCGGGA GGAGATAGAG 
ACCATGGAGA ACCTGAACCG CGTGCTGCTG GAGAACGTGC TTCCCGCGCA CGTGGCTGAG 
CACTTCCTGG CCAGGAGCCT GAAGAATGAG GAGCTATACC ACCAGTCCTA TGACTGCGTC 
TGCGTCATGT TTGCCTCCAT TCCGGATTTC AAAGAATTTT ATACAGAATC CGACGTGAAC 
AAGGAGGGCT TGGAATGCCT TCGGCTCCTG AACGAGATCA TCGCTGACTT TGATGATCTT 
CTTTCCAAGC CAAAATTCAG TGGAGTTGAA AAGATTAAGA CCATTGGCAG CACATACATG 
GCAGCAACAG GTCTGAGCGC TGTGCCCAGC CAGGAGCACT CCCAGGAGCC CGAGCGGCAG 
TACATGCACA TTGGCACCAT GGTGGAGTTT GCTTTTGCCC TGGTAGGGAA GCTGGATGCC 
ATCAACAAGC ACTCCTTCAA CGACTTCAAA TTGCGAGTGG GTATTAACCA TGGACCTGTG 
ATAGCTGGTG TGATTGGAGC TCAGAAGCCA CAATATGATA TCTGGGGCAA CACTGTCAAT 
GTGGCCAGTA GGATGGACAG CACCGGAGTC CTGGACAAAA TACAGGTTAC CGAGGAGACG 
AGCCTCGTCC TGCAGACCCT CGGATACACG TGCACCTGTC GAGGAATAAT CAACGTGAAA 
GGAAAGGGGG ACCTGAAGAC GTACTTTGTA AACACAGAAA TGTCAAGGTC CCTTTCCCAG 
AGCAACGTGG CATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011512244.1
CDS	15..3152
Translation	MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS

Target ORF information:

RefSeq Version	XM_011513942.2
Organism	Homo sapiens(human)
Definition	Homo sapiens adenylate cyclase 2 (ADCY2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513942.2

ORF Insert Sequence:

ATGTGGCAGG AGGCGATGCG GCGCCGCCGC TACCTGCGGG ACCGCTCCGA GGAGGCGGCG 
GGCGGCGGAG ACGGGCTGCC GCGGTCCCGG GACTGGCTCT ACGAGTCCTA CTACTGCATG 
AGCCAGCAGC ACCCGCTCAT CGTCTTCCTG CTGCTCATCG TCATGGGCTC CTGCCTCGCC 
CTGCTCGCCG TCTTCTTCGC GCTCGGGCTG GAAGTTGAAG ACCATGTGGC GTTTCTAATA 
ACAGTTCCAA CTGCCCTGGC GATTTTCTTT GCGATATTTA TCCTGGTCTG CATCGAGTCT 
GTGTTTAAGA AGCTGCTGCG CCTCTTCTCG TTGGTGATAT GGATATGCCT TGTTGCCATG 
GGATACCTGT TCATGTGTTT TGGAGGCACC GTCTCTCCCT GGGACCAGGT ATCGTTCTTC 
CTCTTCATCA TCTTCGTGGT GTACACCATG CTGCCCTTCA ACATGCGAGA CGCCATCATT 
GCCAGCGTCC TCACCTCCTC CTCCCACACC ATCGTGCTTA GCGTCTGCCT GTCTGCAACA 
CCGGGAGGCA AGGAGCACCT GGTCTGGCAG ATCCTGGCCA ATGTGATCAT TTTCATCTGT 
GGGAACCTGG CGGGAGCCTA CCATAAGCAC CTCATGGAAC TCGCTCTTCA GCAAACATAT 
CAGGACACCT GTAATTGCAT CAAGTCGCGG ATCAAGTTGG AATTTGAAAA ACGTCAACAG 
GAGCGGCTTC TGCTCTCCCT GCTGCCGGCC CACATCGCCA TGGAGATGAA AGCGGAGATC 
ATCCAGAGGC TGCAGGGCCC CAAGGCGGGC CAGATGGAGA ACACAAATAA CTTCCACAAC 
CTGTATGTGA AGCGGCATAC AAACGTGAGC ATCTTATACG CTGACATCGT TGGCTTTACC 
CGGCTGGCAA GTGACTGCTC CCCGGGAGAA CTAGTCCACA TGCTGAATGA GCTCTTTGGA 
AAGTTTGATC AAATTGCAAA GGAGAATGAA TGCATGAGAA TTAAAATTTT AGGAGACTGC 
TACTACTGTG TATCTGGACT CCCTATATCT CTCCCTAACC ATGCCAAGAA CTGTGTGAAA 
ATGGGGCTGG ACATGTGTGA AGCCATAAAG AAAGTGAGGG ATGCTACTGG AGTTGATATC 
AACATGCGCG TGGGCGTGCA TTCTGGGAAT GTCCTGTGTG GCGTGATTGG TCTGCAGAAG 
TGGCAATATG ATGTGTGGTC ACATGATGTG ACCTTGGCCA ACCACATGGA AGCTGGAGGG 
GTCCCTGGAC GTGTTCACAT TTCTTCTGTC ACCCTGGAGC ACTTGAATGG CGCTTATAAA 
GTGGAGGAGG GAGATGGTGA CATTAGGGAC CCATATTTAA AACAGCACCT GGTGAAAACC 
TACTTTGTGA TCAACCCCAA GGGAGAACGA CGGAGCCCCC AGCATCTCTT CAGACCTCGC 
CACACCCTTG ATGGAGCCAA AATGAGGGCC TCGGTCCGCA TGACCCGGTA CTTGGAGTCC 
TGGGGGGCAG CCAAGCCCTT TGCACACCTA CATCACAGGG ACAGCATGAC CACAGAGAAC 
GGCAAGATCA GCACCACGGA TGTACCCATG GGTCAGCATA ATTTTCAAAA TCGCACCTTA 
AGAACCAAGT CACAAAAGAA GAGATTTGAA GAAGAATTGA ATGAAAGGAT GATTCAAGCA 
ATTGATGGGA TTAATGCACA GAAGCAATGG CTCAAGTCTG AAGACATTCA GAGAATCTCA 
CTGCTTTTCT ATAACAAAGT ACTAGAAAAA GAGTACCGGG CCACGGCACT GCCAGCGTTC 
AAGTATTATG TGACTTGTGC CTGTCTCATA TTCTTCTGCA TCTTCATTGT GCAGATTCTC 
GTGCTGCCAA AAACGTCCGT CCTGGGCATC TCCTTTGGGG CTGCGTTTCT CTTGCTGGCC 
TTCATCCTCT TCGTCTGCTT TGCTGGACAG CTTCTGTTTT TCCTGAGTGA CTCAGAGGAA 
ACAATCCCTC CAACTGCCAA CACAACAAAC ACAAGCTTTT CAGCCTCAAA TAATCAGGTG 
GCGATTCTGC GTGCGCAGAA TTTATTTTTC CTCCCGTACT TTATCTACAG CTGCATTCTG 
GGACTGATAT CCTGTTCCGT GTTCCTGCGG GTAAACTATG AGCTGAAGAT GTTGATCATG 
ATGGTGGCCT TGGTGGGCTA CAACACCATC CTACTCCACA CCCACGCCCA CGTCCTGGGC 
GACTACAGCC AGGTCTTATT TGAGAGACCA GGCATTTGGA AAGACCTGAA GACCATGGGC 
TCTGTGTCTC TCTCTATATT CTTCATCACA CTGCTTGTTC TGGGTAGACA GAATGAATAT 
TACTGTAGGT TAGACTTCTT ATGGAAGAAC AAATTCAAAA AAGAGCGGGA GGAGATAGAG 
ACCATGGAGA ACCTGAACCG CGTGCTGCTG GAGAACGTGC TTCCCGCGCA CGTGGCTGAG 
CACTTCCTGG CCAGGAGCCT GAAGAATGAG GAGCTATACC ACCAGTCCTA TGACTGCGTC 
TGCGTCATGT TTGCCTCCAT TCCGGATTTC AAAGAATTTT ATACAGAATC CGACGTGAAC 
AAGGAGGGCT TGGAATGCCT TCGGCTCCTG AACGAGATCA TCGCTGACTT TGATGATCTT 
CTTTCCAAGC CAAAATTCAG TGGAGTTGAA AAGATTAAGA CCATTGGCAG CACATACATG 
GCAGCAACAG GTCTGAGCGC TGTGCCCAGC CAGGAGCACT CCCAGGAGCC CGAGCGGCAG 
TACATGCACA TTGGCACCAT GGTGGAGTTT GCTTTTGCCC TGGTAGGGAA GCTGGATGCC 
ATCAACAAGC ACTCCTTCAA CGACTTCAAA TTGCGAGTGG GTATTAACCA TGGACCTGTG 
ATAGCTGGTG TGATTGGAGC TCAGAAGCCA CAATATGATA TCTGGGGCAA CACTGTCAAT 
GTGGCCAGTA GGATGGACAG CACCGGAGTC CTGGACAAAA TACAGGTTAC CGAGGAGACG 
AGCCTCGTCC TGCAGACCCT CGGATACACG TGCACCTGTC GAGGAATAAT CAACGTGAAA 
GGAAAGGGGG ACCTGAAGAC GTACTTTGTA AACACAGAAA TGTCAAGGTC CCTTTCCCAG 
AGCAACGTGG CATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients.
Pharmacogenetics and genomics25(6)279-88(2015 Jun)
van Huis-Tanja LH,Ewing E,van der Straaten RJ,Swen JJ,Baak-Pablo RF,Punt CJ,Gelderblom AJ,Guchelaar HJ

Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms.
Naunyn-Schmiedeberg's archives of pharmacology387(4)329-39(2014 Apr)
Bogard AS,Birg AV,Ostrom RS

Genome-wide association study reveals two new risk loci for bipolar disorder.
Nature communications53339(2014 Mar)
M?hleisen TW,Leber M,Schulze TG,Strohmaier J,Degenhardt F,Treutlein J,Mattheisen M,Forstner AJ,Schumacher J,Breuer R,Meier S,Herms S,Hoffmann P,Lacour A,Witt SH,Reif A,M?ller-Myhsok B,Lucae S,Maier W,Schwarz M,Vedder H,Kammerer-Ciernioch J,Pfennig A,Bauer M,Hautzinger M,Moebus S,Priebe L,Czerski PM,Hauser J,Lissowska J,Szeszenia-Dabrowska N,Brennan P,McKay JD,Wright A,Mitchell PB,Fullerton JM,Schofield PR,Montgomery GW,Medland SE,Gordon SD,Martin NG,Krasnow V,Chuchalin A,Babadjanova G,Pantelejeva G,Abramova LI,Tiganov AS,Polonikov A,Khusnutdinova E,Alda M,Grof P,Rouleau GA,Turecki G,Laprise C,Rivas F,Mayoral F,Kogevinas M,Grigoroiu-Serbanescu M,Propping P,Becker T,Rietschel M,N?then MM,Cichon S

AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex.
The Biochemical journal455(1)47-56(2013 Oct)
Shen JX,Cooper DM

Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
Frontiers in genetics4277(2013)
Simino J,Sung YJ,Kume R,Schwander K,Rao DC

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ADCY2 cDNA ORF clone, Homo sapiens(human)

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