POP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	POP4
Entrez Gene ID	10775
Full Name	POP4 homolog, ribonuclease P/MRP subunit
Synonyms	RPP29
General protein information	Preferred Names POP4 homolog, ribonuclease P/MRP subunit Names ribonuclease P protein subunit p29 hPOP4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q12
Summary	This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].
Disorder MIM:	606114

mRNA and Protein(s)

mRNA	Protein	Name
NM_006627.3	NP_006618.1	ribonuclease P protein subunit p29
NM_006627.2	NP_006618.1	ribonuclease P protein subunit p29

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pop4	NP_079666.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011713	XP_320799.3
Homo sapiens (human)	POP4	NP_006618.1
Pan troglodytes (chimpanzee)	POP4	XP_003953484.1
Rattus norvegicus (Norway rat)	Pop4	NP_001009642.1
Drosophila melanogaster (fruit fly)	CG8038	NP_648168.1
	POP4	XP_001084400.1
Canis lupus familiaris (dog)	POP4	XP_005616960.1
Bos taurus (cattle)	POP4	NP_001106753.1
Gallus gallus (chicken)	POP4	NP_001139386.1
Danio rerio (zebrafish)	pop4	NP_001018585.1
Xenopus tropicalis (tropical clawed frog)	pop4	NP_001017252.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks.
Abu-Zhayia ER, Khoury-Haddad H, Guttmann-Raviv N, Serruya R, Jarrous N, Ayoub N
Scientific reports7(1)1002(2017 Apr)

Functional characterization of archaeal homologs of human nuclear RNase P proteins Rpp21 and Rpp29 provides insights into the molecular basis of their cooperativity in catalysis.
Jiang D, Izumi K, Ueda T, Oshima K, Nakashima T, Kimura M
Biochemical and biophysical research communications482(1)68-74(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Collectively, the present results suggest that PhoRpp21 binds the loop between P11 and P12 helices through overall positively charged clusters on the surface of the complex and serves as a scaffold for PhoRpp29 to optimize structural conformation of its N-terminal helix (alpha2) in PhoRpp21, as well as C-terminal residues in PhoRpp29, for RNase P activity.
Title: Functional characterization of archaeal homologs of human nuclear RNase P proteins Rpp21 and Rpp29 provides insights into the molecular basis of their cooperativity in catalysis.

Rpp29 represses H3.3 nucleosome deposition, a finding with implications for epigenetic regulation.
Title: RNase P protein subunit Rpp29 represses histone H3.3 nucleosome deposition.

The following POP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31554	NM_006627.3 Latest version!	Homo sapiens POP4 homolog, ribonuclease P/MRP subunit (POP4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31554	NM_006627.2	Homo sapiens POP4 homolog, ribonuclease P/MRP subunit (POP4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

POP4 ( NM_006627.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006618.1 Homo sapiens POP4 homolog, ribonuclease P/MRP subunit (POP4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31554
Clone ID Related Accession (Same CDS sequence)	NM_006627.3 , NM_006627.2
Accession Version	NM_006627.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	ribonuclease P protein subunit p29
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010505.6, Y18863.1 and BU727144.1. On Nov 22, 2018 this sequence version replaced NM_006627.2. Transcript Variant: This variant (1) represents the longer transcript and encodes processing of precursor 4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.220549.1, SRR1803617.25698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000585603.6/ ENSP00000465213.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGAGTG TGATCTACCA TGCATTGTCT CAGAAAGAGG CGAATGACTC CGATGTCCAG 
CCTTCAGGAG CACAGCGGGC CGAGGCCTTC GTGAGGGCCT TCCTGAAGCG CAGCACGCCC 
CGCATGAGCC CGCAGGCCCG CGAGGACCAG CTGCAGCGCA AGGCGGTGGT CCTGGAGTAC 
TTCACCCGCC ACAAGCGCAA GGAGAAGAAG AAGAAAGCCA AAGGCCTCTC TGCCAGGCAA 
AGGAGGGAGC TGCGGCTCTT TGACATTAAA CCAGAGCAGC AGAGATACAG CCTTTTCCTC 
CCTCTCCATG AACTCTGGAA ACAGTACATC AGGGACCTGT GCAGTGGGCT CAAGCCAGAC 
ACGCAGCCAC AGATGATTCA GGCCAAGCTC TTAAAGGCAG ATCTTCACGG GGCTATTATT 
TCAGTGACAA AATCCAAATG CCCCTCTTAT GTGGGTATTA CAGGAATCCT TCTACAGGAA 
ACAAAGCACA TTTTCAAAAT TATCACCAAA GAAGACCGCC TGAAAGTTAT CCCCAAGCTA 
AACTGCGTGT TCACTGTGGA AACCGATGGC TTTATTTCCT ACATTTACGG GAGCAAATTC 
CAGCTTCGGT CAAGTGAACG GTCTGCGAAG AAGTTCAAAG CGAAGGGAAC GATTGACCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006618.1
CDS	37..699
Translation	MKSVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSPQAREDQLQRKAVVLEYFTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCSGLKPDTQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITGILLQETKHIFKIITKEDRLKVIPKLNCVFTVETDGFISYIYGSKFQLRSSERSAKKFKAKGTIDL

Target ORF information:

RefSeq Version	NM_006627.3
Organism	Homo sapiens(human)
Definition	Homo sapiens POP4 homolog, ribonuclease P/MRP subunit (POP4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006627.3

ORF Insert Sequence:

ATGAAGAGTG TGATCTACCA TGCATTGTCT CAGAAAGAGG CGAATGACTC CGATGTCCAG 
CCTTCAGGAG CACAGCGGGC CGAGGCCTTC GTGAGGGCCT TCCTGAAGCG CAGCACGCCC 
CGCATGAGCC CGCAGGCCCG CGAGGACCAG CTGCAGCGCA AGGCGGTGGT CCTGGAGTAC 
TTCACCCGCC ACAAGCGCAA GGAGAAGAAG AAGAAAGCCA AAGGCCTCTC TGCCAGGCAA 
AGGAGGGAGC TGCGGCTCTT TGACATTAAA CCAGAGCAGC AGAGATACAG CCTTTTCCTC 
CCTCTCCATG AACTCTGGAA ACAGTACATC AGGGACCTGT GCAGTGGGCT CAAGCCAGAC 
ACGCAGCCAC AGATGATTCA GGCCAAGCTC TTAAAGGCAG ATCTTCACGG GGCTATTATT 
TCAGTGACAA AATCCAAATG CCCCTCTTAT GTGGGTATTA CAGGAATCCT TCTACAGGAA 
ACAAAGCACA TTTTCAAAAT TATCACCAAA GAAGACCGCC TGAAAGTTAT CCCCAAGCTA 
AACTGCGTGT TCACTGTGGA AACCGATGGC TTTATTTCCT ACATTTACGG GAGCAAATTC 
CAGCTTCGGT CAAGTGAACG GTCTGCGAAG AAGTTCAAAG CGAAGGGAAC GATTGACCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

POP4 ( NM_006627.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006618.1 Homo sapiens POP4 homolog, ribonuclease P/MRP subunit (POP4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31554
Clone ID Related Accession (Same CDS sequence)	NM_006627.3 , NM_006627.2
Accession Version	NM_006627.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ribonuclease P protein subunit p29
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010505.6, Y18863.1 and BU727144.1. On Mar 21, 2009 this sequence version replaced NM_006627.1. Transcript Variant: This variant (1) represents the longer transcript and encodes processing of precursor 4. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.25698.1, SRR1803614.144460.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGTG TGATCTACCA TGCATTGTCT CAGAAAGAGG CGAATGACTC CGATGTCCAG 
CCTTCAGGAG CACAGCGGGC CGAGGCCTTC GTGAGGGCCT TCCTGAAGCG CAGCACGCCC 
CGCATGAGCC CGCAGGCCCG CGAGGACCAG CTGCAGCGCA AGGCGGTGGT CCTGGAGTAC 
TTCACCCGCC ACAAGCGCAA GGAGAAGAAG AAGAAAGCCA AAGGCCTCTC TGCCAGGCAA 
AGGAGGGAGC TGCGGCTCTT TGACATTAAA CCAGAGCAGC AGAGATACAG CCTTTTCCTC 
CCTCTCCATG AACTCTGGAA ACAGTACATC AGGGACCTGT GCAGTGGGCT CAAGCCAGAC 
ACGCAGCCAC AGATGATTCA GGCCAAGCTC TTAAAGGCAG ATCTTCACGG GGCTATTATT 
TCAGTGACAA AATCCAAATG CCCCTCTTAT GTGGGTATTA CAGGAATCCT TCTACAGGAA 
ACAAAGCACA TTTTCAAAAT TATCACCAAA GAAGACCGCC TGAAAGTTAT CCCCAAGCTA 
AACTGCGTGT TCACTGTGGA AACCGATGGC TTTATTTCCT ACATTTACGG GAGCAAATTC 
CAGCTTCGGT CAAGTGAACG GTCTGCGAAG AAGTTCAAAG CGAAGGGAAC GATTGACCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006618.1
CDS	57..719
Translation	MKSVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSPQAREDQLQRKAVVLEYFTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCSGLKPDTQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITGILLQETKHIFKIITKEDRLKVIPKLNCVFTVETDGFISYIYGSKFQLRSSERSAKKFKAKGTIDL

Target ORF information:

RefSeq Version	NM_006627.2
Organism	Homo sapiens(human)
Definition	Homo sapiens POP4 homolog, ribonuclease P/MRP subunit (POP4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006627.2

ORF Insert Sequence:

ATGAAGAGTG TGATCTACCA TGCATTGTCT CAGAAAGAGG CGAATGACTC CGATGTCCAG 
CCTTCAGGAG CACAGCGGGC CGAGGCCTTC GTGAGGGCCT TCCTGAAGCG CAGCACGCCC 
CGCATGAGCC CGCAGGCCCG CGAGGACCAG CTGCAGCGCA AGGCGGTGGT CCTGGAGTAC 
TTCACCCGCC ACAAGCGCAA GGAGAAGAAG AAGAAAGCCA AAGGCCTCTC TGCCAGGCAA 
AGGAGGGAGC TGCGGCTCTT TGACATTAAA CCAGAGCAGC AGAGATACAG CCTTTTCCTC 
CCTCTCCATG AACTCTGGAA ACAGTACATC AGGGACCTGT GCAGTGGGCT CAAGCCAGAC 
ACGCAGCCAC AGATGATTCA GGCCAAGCTC TTAAAGGCAG ATCTTCACGG GGCTATTATT 
TCAGTGACAA AATCCAAATG CCCCTCTTAT GTGGGTATTA CAGGAATCCT TCTACAGGAA 
ACAAAGCACA TTTTCAAAAT TATCACCAAA GAAGACCGCC TGAAAGTTAT CCCCAAGCTA 
AACTGCGTGT TCACTGTGGA AACCGATGGC TTTATTTCCT ACATTTACGG GAGCAAATTC 
CAGCTTCGGT CAAGTGAACG GTCTGCGAAG AAGTTCAAAG CGAAGGGAAC GATTGACCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks.
Scientific reports7(1)1002(2017 Apr)
Abu-Zhayia ER,Khoury-Haddad H,Guttmann-Raviv N,Serruya R,Jarrous N,Ayoub N

Functional characterization of archaeal homologs of human nuclear RNase P proteins Rpp21 and Rpp29 provides insights into the molecular basis of their cooperativity in catalysis.
Biochemical and biophysical research communications482(1)68-74(2017 Jan)
Jiang D,Izumi K,Ueda T,Oshima K,Nakashima T,Kimura M

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POP4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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