MAP3K2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAP3K2
Entrez Gene ID	10746
Full Name	mitogen-activated protein kinase kinase kinase 2
Synonyms	MEKK2,MEKK2B
General protein information	Preferred Names mitogen-activated protein kinase kinase kinase 2 Names mitogen-activated protein kinase kinase kinase 2 MAP/ERK kinase kinase 2 MAPK/ERK kinase kinase 2 MEK kinase 2 MEKK 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q14.3
Summary	The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008].
Disorder MIM:	609487

mRNA and Protein(s)

mRNA	Protein	Name
NM_006609.5	NP_006600.3	mitogen-activated protein kinase kinase kinase 2
XM_024452552.1	XP_024308320.1	mitogen-activated protein kinase kinase kinase 2 isoform X1
NM_001371911.1	NP_001358840.1	mitogen-activated protein kinase kinase kinase 2
NM_001371910.2	NP_001358839.1	mitogen-activated protein kinase kinase kinase 2
NM_006609.4	NP_006600.3	mitogen-activated protein kinase kinase kinase 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAP3K2	XP_001137344.1
Rattus norvegicus (Norway rat)	Map3k2	NP_612512.1
Gallus gallus (chicken)	MAP3K2	XP_004942945.1
Canis lupus familiaris (dog)	MAP3K2	XP_005631936.1
Mus musculus (house mouse)	Map3k2	NP_036076.2
Homo sapiens (human)	MAP3K2	NP_006600.3
Xenopus tropicalis (tropical clawed frog)	map3k2	XP_002942055.2
	MAP3K2	XP_002799467.1
Bos taurus (cattle)	MAP3K2	XP_002685278.2
Danio rerio (zebrafish)	map3k2	XP_686613.2

Gene Ontology
Bibliography

Related articles in PubMed

Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2).
Ahmad S, St Hilaire VR, Dandepally SR, Johnson GL, Williams AL, Scott JE
Biochemical and biophysical research communications496(1)205-211(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-34c-3p may regulate triple-negative breast cancer progression by directly targeting the 3'-untranslated region of mitogen-activated protein kinase kinase kinase 2 (MAP3K2).
Title: Regulation of cancerous progression and epithelial-mesenchymal transition by miR-34c-3p via modulation of MAP3K2 signaling in triple-negative breast cancer cells.

Study found miR-186 expression significantly decreased in lung cancer tissues and cells and MAP3K2 expression increased in the same cancer tissues. Also, results confirmed that MAP3K2 is a target gene of miR-186 and both expression correlated with prognosis.
Title: MicroRNA-186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non-small cell lung cancer.

HBXIP activated ERK1/2 through up-regulating MEKK2.
Title: The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling.

SMYD3-mediated methylation of MAP3K2 increases mutant K-Ras-induced activation of ERK1/2. (Review)
Title: Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.

MEKK2 has a novel function as a regulator of ubiquitylation-dependent paxillin redistribution in breast tumour cells.
Title: MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells.

The following MAP3K2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAP3K2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23944	NM_001371911.1 Latest version!	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu23944	NM_001371910.2 Latest version!	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu23944	NM_006609.5 Latest version!	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu23944	XM_024452552.1 Latest version!	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu23944	NM_006609.4	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAP3K2 ( NM_006609.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006600.3 Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23944
Clone ID Related Accession (Same CDS sequence)	NM_006609.5 , XM_024452552.1 , NM_001371911.1 , NM_001371910.2 , NM_006609.4
Accession Version	NM_006609.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068282.8 and AC110926.5. On Jul 26, 2019 this sequence version replaced NM_006609.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF111105.1, BC136293.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006600.3
CDS	101..1960
Translation	MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH

Target ORF information:

RefSeq Version	NM_006609.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006609.5

ORF Insert Sequence:

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K2 ( NM_001371911.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001358840.1 Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu23944
Clone ID Related Accession (Same CDS sequence)	NM_006609.5 , XM_024452552.1 , NM_001371911.1 , NM_001371910.2 , NM_006609.4
Accession Version	NM_001371911.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068282.8 and AC110926.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK315007.1 [ECO:0000332] ##Evidence-Data-END##

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001358840.1
CDS	284..2143
Translation	MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH

Target ORF information:

RefSeq Version	NM_001371911.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001371911.1

ORF Insert Sequence:

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K2 ( NM_001371910.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001358839.1 Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23944
Clone ID Related Accession (Same CDS sequence)	NM_006609.5 , XM_024452552.1 , NM_001371911.1 , NM_001371910.2 , NM_006609.4
Accession Version	NM_001371910.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068282.8 and AC110926.5. On Aug 28, 2019 this sequence version replaced NM_001371910.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1945160.1, SRR1163657.584836.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001358839.1
CDS	590..2449
Translation	MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH

Target ORF information:

RefSeq Version	NM_001371910.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001371910.2

ORF Insert Sequence:

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K2 ( NM_006609.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006600.3 Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), mRNA.

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CloneID	OHu23944
Clone ID Related Accession (Same CDS sequence)	NM_006609.5 , XM_024452552.1 , NM_001371911.1 , NM_001371910.2 , NM_006609.4
Accession Version	NM_006609.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-17
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068282.8, BC136293.1 and AC110926.5. On Jun 30, 2011 this sequence version replaced NM_006609.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF111105.1, BC136293.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006600.3
CDS	101..1960
Translation	MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH

Target ORF information:

RefSeq Version	NM_006609.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006609.4

ORF Insert Sequence:

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAP3K2 ( XM_024452552.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024308320.1 Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant X1, mRNA.

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CloneID	OHu23944
Clone ID Related Accession (Same CDS sequence)	NM_006609.5 , XM_024452552.1 , NM_001371911.1 , NM_001371910.2 , NM_006609.4
Accession Version	XM_024452552.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1860bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	mitogen-activated protein kinase kinase kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024308320.1
CDS	148..2007
Translation	MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH

Target ORF information:

RefSeq Version	XM_024452552.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mitogen-activated protein kinase kinase kinase 2 (MAP3K2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024452552.1

ORF Insert Sequence:

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 
AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 
CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 
AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 
GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 
AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 
ATAAATGGAA GTACACAGGC TACTAATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 
AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 
GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 
GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 
CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 
GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 
CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 
GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 
CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACCA GCTTACGGTC TCCTGTGAGT 
TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 
TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 
ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 
CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 
GAATTGGCTG TTAAGCAAGT TCAATTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 
AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 
TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 
CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 
AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 
CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 
GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 
GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTCATCA GTGGAGAAGG CTATGGAAGA 
AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 
AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 
GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2).
Biochemical and biophysical research communications496(1)205-211(2018 Jan)
Ahmad S,St Hilaire VR,Dandepally SR,Johnson GL,Williams AL,Scott JE

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MAP3K2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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