YME1L1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	YME1L1
Entrez Gene ID	10730
Full Name	YME1 like 1 ATPase
Synonyms	FTSH,MEG4,OPA11,PAMP,YME1L
General protein information	Preferred Names YME1 like 1 ATPase Names ATP-dependent zinc metalloprotease YME1L1 ATP-dependent metalloprotease FtsH1 homolog YME1-like protein 1 meg-4 presenilin-associated metalloprotease
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p12.1
Summary	The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Disorder MIM:	607472
Disorder Html:	?Optic atrophy 11, 617302 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_014263.3	NP_055078.1	ATP-dependent zinc metalloprotease YME1L1 isoform 3
NM_014263.4	NP_055078.1	ATP-dependent zinc metalloprotease YME1L1 isoform 3
NM_139312.3	NP_647473.1	ATP-dependent zinc metalloprotease YME1L1 isoform 1
XM_011519300.3	XP_011517602.1	ATP-dependent zinc metalloprotease YME1L1 isoform X1
NM_139312.2	NP_647473.1	ATP-dependent zinc metalloprotease YME1L1 isoform 1
NM_001253866.1	NP_001240795.1	ATP-dependent zinc metalloprotease YME1L1 isoform 4
XM_011519300.2	XP_011517602.1	ATP-dependent zinc metalloprotease YME1L1 isoform X1

Pathways from BioSystems

Homologies

	LOC714687	XP_002805640.1
Canis lupus familiaris (dog)	YME1L1	XP_535172.3
Rattus norvegicus (Norway rat)	Yme1l1	NP_446134.2
Homo sapiens (human)	YME1L1	NP_647473.1
Danio rerio (zebrafish)	yme1l1b	NP_001082983.1
Caenorhabditis elegans (roundworm)	ymel-1	NP_499298.2
Bos taurus (cattle)	YME1L1	NP_001095320.1
Rattus norvegicus (Norway rat)	LOC100910779	XP_003751780.1
Drosophila melanogaster (fruit fly)	CG3499	NP_001261142.1
Xenopus tropicalis (tropical clawed frog)	yme1l1	XP_002933186.2
Pan troglodytes (chimpanzee)	YME1L1	XP_507710.3
Mus musculus (house mouse)	Yme1l1	NP_038799.1
Gallus gallus (chicken)	YME1L1	NP_001026683.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009973	XP_319111.4

Gene Ontology
Bibliography

Related articles in PubMed

Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma.
Srinivasainagendra V, Sandel MW, Singh B, Sundaresan A, Mooga VP, Bajpai P, Tiwari HK, Singh KK
Genome medicine9(1)31(2017 03)

Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane.
Shi H, Rampello AJ, Glynn SE
Nature communications713301(2016 Oct)

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation.
Hartmann B, Wai T, Hu H, MacVicar T, Musante L, Fischer-Zirnsak B, Stenzel W, Gr?f R, van den Heuvel L, Ropers HH, Wienker TF, H?bner C, Langer T, Kaindl AM
eLife5(2016 08)

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.
Rainbolt TK, Lebeau J, Puchades C, Wiseman RL
Cell reports14(9)2041-2049(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

YME1L1 was identified as the first NUMT (nuclear mtDNA) suppressor gene in human and demonstrate that inactivation of YME1L1 induces migration of mtDNA to the nuclear genome.
Title: Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma.

These results identify mutations in YME1L1 as a cause of a mitochondriopathy with optic nerve atrophy highlighting the importance of YME1L1 for mitochondrial functionality in humans.
Title: Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation.

differential stress-induced degradation of YME1L and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults.
Title: Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.

YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.Loss of YME1L compromises the regulation of mitochondrial inner membrane proteostasis.
Title: YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.

Results reveal a crucial role for YME1L in the maintenance of mitochondrial inner-membrane proteostasis and in the proteolytic regulation of respiratory chain biogenesis.
Title: YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation.

The following YME1L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YME1L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11214	NM_014263.4 Latest version!	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu01580	NM_001253866.1 Latest version!	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu01739	NM_139312.3 Latest version!	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00
OHu64339	XM_011519300.3 Latest version!	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu11214	NM_014263.3	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu01739	NM_139312.2	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00
OHu64339	XM_011519300.2	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

YME1L1 ( NM_014263.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055078.1 Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu11214
Clone ID Related Accession (Same CDS sequence)	NM_014263.3 , NM_014263.4
Accession Version	NM_014263.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2151bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-01
Organism	Homo sapiens(human)
Product	ATP-dependent zinc metalloprotease YME1L1 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA395557.1, AJ132637.1, AL162272.10 and AI042625.1. On Dec 8, 2011 this sequence version replaced NM_014263.2. Transcript Variant: This variant (3) lacks an internal coding exon compared to transcript variant 1. However, it maintains the same reading frame, and encodes an isoform (3) that is missing a 57 aa segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.76442.1, SRR1660807.56801.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGCC TTCACTTAAC 
TTAAGGGACC TTGGATTATC TGAACTAAAA ATTGGACAGA TTGATCAGCT GGTAGAAAAT 
CTACTTCCTG GATTTTGTAA AGGCAAAAAC ATTTCTTCCC ATTGGCATAC ATCCCATGTC 
TCTGCACAAT CCTTCTTTGA AAATAAATAT GGTAACTTAG ATATATTTAG TACATTACGT 
TCCTCTTGCT TGTATCGACA TCATTCAAGA GCTCTTCAAA GCATTTGTTC AGATCTTCAG 
TACTGGCCAG TTTTCATACA GTCTCGGGGT TTTAAAACTT TGAAATCAAG GACACGACGT 
CTCCAGTCTA CCTCCGAGAG ATTAGCTGAA ACACAGAATA TAGCGCCATC ATTCGTGAAG 
GGGTTTCTTT TGCGGGACAG AGGATCAGAT GTTGAGAGTT TGGACAAACT CATGAAAACC 
AAAAATATAC CTGAAGCTCA CCAAGATGCA TTTAAAACTG GTTTTGCGGA AGGTTTTCTG 
AAAGCTCAAG CACTCACACA AAAAACCAAT GATTCCCTAA GGCGAACCCG TCTGATTCTC 
TTCGTTCTGC TGCTATTCGG CATTTATGGA CTTCTAAAAA ACCCATTTTT ATCTGTCCGC 
TTCCGGACAA CAACAGGGCT TGATTCTGCA GTAGATCCTG TCCAGATGAA AAATGTCACC 
TTTGAACATG TTAAAGGGGT GGAGGAAGCT AAACAAGAAT TACAGGAAGT TGTTGAATTC 
TTGAAAAATC CACAAAAATT TACTATTCTT GGAGGTAAAC TTCCAAAAGG AATTCTTTTA 
GTTGGACCCC CAGGGACTGG AAAGACACTT CTTGCCCGAG CTGTGGCGGG AGAAGCTGAT 
GTTCCTTTTT ATTATGCTTC TGGATCCGAA TTTGATGAGA TGTTTGTGGG TGTGGGAGCC 
AGCCGTATCA GAAATCTTTT TAGGGAAGCA AAGGCGAATG CTCCTTGTGT TATATTTATT 
GATGAATTAG ATTCTGTTGG TGGGAAGAGA ATTGAATCTC CAATGCATCC ATATTCAAGG 
CAGACCATAA ATCAACTTCT TGCTGAAATG GATGGTTTTA AACCCAATGA AGGAGTTATC 
ATAATAGGAG CCACAAACTT CCCAGAGGCA TTAGATAATG CCTTAATACG TCCTGGTCGT 
TTTGACATGC AAGTTACAGT TCCAAGGCCA GATGTAAAAG GTCGAACAGA AATTTTGAAA 
TGGTATCTCA ATAAAATAAA GTTTGATCAA TCCGTTGATC CAGAAATTAT AGCTCGAGGT 
ACTGTTGGCT TTTCCGGAGC AGAGTTGGAG AATCTTGTGA ACCAGGCTGC ATTAAAAGCA 
GCTGTTGATG GAAAAGAAAT GGTTACCATG AAGGAGCTGG AGTTTTCCAA AGACAAAATT 
CTAATGGGGC CTGAAAGAAG AAGTGTGGAA ATTGATAACA AAAACAAAAC CATCACAGCA 
TATCATGAAT CTGGTCATGC CATTATTGCA TATTACACAA AAGATGCAAT GCCTATCAAC 
AAAGCTACAA TCATGCCACG GGGGCCAACA CTTGGACATG TGTCCCTGTT ACCTGAGAAT 
GACAGATGGA ATGAAACTAG AGCCCAGCTG CTTGCACAAA TGGATGTTAG TATGGGAGGA 
AGAGTGGCAG AGGAGCTTAT ATTTGGAACC GACCATATTA CAACAGGTGC TTCCAGTGAT 
TTTGATAATG CCACTAAAAT AGCAAAGCGG ATGGTTACCA AATTTGGAAT GAGTGAAAAG 
CTTGGAGTTA TGACCTACAG TGATACAGGG AAACTAAGTC CAGAAACCCA ATCTGCCATC 
GAACAAGAAA TAAGAATCCT TCTAAGGGAC TCATATGAAC GAGCAAAACA TATCTTGAAA 
ACTCATGCAA AGGAGCATAA GAATCTCGCA GAAGCTTTAT TGACCTATGA GACTTTGGAT 
GCCAAAGAGA TTCAAATTGT TCTTGAGGGG AAAAAGTTGG AAGTGAGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055078.1
CDS	211..2361
Translation	MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSEPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

Target ORF information:

RefSeq Version	NM_014263.3
Organism	Homo sapiens(human)
Definition	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014263.3

ORF Insert Sequence:

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGCC TTCACTTAAC 
TTAAGGGACC TTGGATTATC TGAACTAAAA ATTGGACAGA TTGATCAGCT GGTAGAAAAT 
CTACTTCCTG GATTTTGTAA AGGCAAAAAC ATTTCTTCCC ATTGGCATAC ATCCCATGTC 
TCTGCACAAT CCTTCTTTGA AAATAAATAT GGTAACTTAG ATATATTTAG TACATTACGT 
TCCTCTTGCT TGTATCGACA TCATTCAAGA GCTCTTCAAA GCATTTGTTC AGATCTTCAG 
TACTGGCCAG TTTTCATACA GTCTCGGGGT TTTAAAACTT TGAAATCAAG GACACGACGT 
CTCCAGTCTA CCTCCGAGAG ATTAGCTGAA ACACAGAATA TAGCGCCATC ATTCGTGAAG 
GGGTTTCTTT TGCGGGACAG AGGATCAGAT GTTGAGAGTT TGGACAAACT CATGAAAACC 
AAAAATATAC CTGAAGCTCA CCAAGATGCA TTTAAAACTG GTTTTGCGGA AGGTTTTCTG 
AAAGCTCAAG CACTCACACA AAAAACCAAT GATTCCCTAA GGCGAACCCG TCTGATTCTC 
TTCGTTCTGC TGCTATTCGG CATTTATGGA CTTCTAAAAA ACCCATTTTT ATCTGTCCGC 
TTCCGGACAA CAACAGGGCT TGATTCTGCA GTAGATCCTG TCCAGATGAA AAATGTCACC 
TTTGAACATG TTAAAGGGGT GGAGGAAGCT AAACAAGAAT TACAGGAAGT TGTTGAATTC 
TTGAAAAATC CACAAAAATT TACTATTCTT GGAGGTAAAC TTCCAAAAGG AATTCTTTTA 
GTTGGACCCC CAGGGACTGG AAAGACACTT CTTGCCCGAG CTGTGGCGGG AGAAGCTGAT 
GTTCCTTTTT ATTATGCTTC TGGATCCGAA TTTGATGAGA TGTTTGTGGG TGTGGGAGCC 
AGCCGTATCA GAAATCTTTT TAGGGAAGCA AAGGCGAATG CTCCTTGTGT TATATTTATT 
GATGAATTAG ATTCTGTTGG TGGGAAGAGA ATTGAATCTC CAATGCATCC ATATTCAAGG 
CAGACCATAA ATCAACTTCT TGCTGAAATG GATGGTTTTA AACCCAATGA AGGAGTTATC 
ATAATAGGAG CCACAAACTT CCCAGAGGCA TTAGATAATG CCTTAATACG TCCTGGTCGT 
TTTGACATGC AAGTTACAGT TCCAAGGCCA GATGTAAAAG GTCGAACAGA AATTTTGAAA 
TGGTATCTCA ATAAAATAAA GTTTGATCAA TCCGTTGATC CAGAAATTAT AGCTCGAGGT 
ACTGTTGGCT TTTCCGGAGC AGAGTTGGAG AATCTTGTGA ACCAGGCTGC ATTAAAAGCA 
GCTGTTGATG GAAAAGAAAT GGTTACCATG AAGGAGCTGG AGTTTTCCAA AGACAAAATT 
CTAATGGGGC CTGAAAGAAG AAGTGTGGAA ATTGATAACA AAAACAAAAC CATCACAGCA 
TATCATGAAT CTGGTCATGC CATTATTGCA TATTACACAA AAGATGCAAT GCCTATCAAC 
AAAGCTACAA TCATGCCACG GGGGCCAACA CTTGGACATG TGTCCCTGTT ACCTGAGAAT 
GACAGATGGA ATGAAACTAG AGCCCAGCTG CTTGCACAAA TGGATGTTAG TATGGGAGGA 
AGAGTGGCAG AGGAGCTTAT ATTTGGAACC GACCATATTA CAACAGGTGC TTCCAGTGAT 
TTTGATAATG CCACTAAAAT AGCAAAGCGG ATGGTTACCA AATTTGGAAT GAGTGAAAAG 
CTTGGAGTTA TGACCTACAG TGATACAGGG AAACTAAGTC CAGAAACCCA ATCTGCCATC 
GAACAAGAAA TAAGAATCCT TCTAAGGGAC TCATATGAAC GAGCAAAACA TATCTTGAAA 
ACTCATGCAA AGGAGCATAA GAATCTCGCA GAAGCTTTAT TGACCTATGA GACTTTGGAT 
GCCAAAGAGA TTCAAATTGT TCTTGAGGGG AAAAAGTTGG AAGTGAGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YME1L1 ( NM_014263.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055078.1 Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu11214
Clone ID Related Accession (Same CDS sequence)	NM_014263.3 , NM_014263.4
Accession Version	NM_014263.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2151bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	ATP-dependent zinc metalloprotease YME1L1 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ132637.1, AL162272.10 and AI042625.1. On Jun 2, 2019 this sequence version replaced NM_014263.3. Transcript Variant: This variant (3) lacks an internal coding exon compared to transcript variant 1. However, it maintains the same reading frame, and encodes an isoform (3) that is missing a 57 aa segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.34727.1, SRR1803616.247379.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGCC TTCACTTAAC 
TTAAGGGACC TTGGATTATC TGAACTAAAA ATTGGACAGA TTGATCAGCT GGTAGAAAAT 
CTACTTCCTG GATTTTGTAA AGGCAAAAAC ATTTCTTCCC ATTGGCATAC ATCCCATGTC 
TCTGCACAAT CCTTCTTTGA AAATAAATAT GGTAACTTAG ATATATTTAG TACATTACGT 
TCCTCTTGCT TGTATCGACA TCATTCAAGA GCTCTTCAAA GCATTTGTTC AGATCTTCAG 
TACTGGCCAG TTTTCATACA GTCTCGGGGT TTTAAAACTT TGAAATCAAG GACACGACGT 
CTCCAGTCTA CCTCCGAGAG ATTAGCTGAA ACACAGAATA TAGCGCCATC ATTCGTGAAG 
GGGTTTCTTT TGCGGGACAG AGGATCAGAT GTTGAGAGTT TGGACAAACT CATGAAAACC 
AAAAATATAC CTGAAGCTCA CCAAGATGCA TTTAAAACTG GTTTTGCGGA AGGTTTTCTG 
AAAGCTCAAG CACTCACACA AAAAACCAAT GATTCCCTAA GGCGAACCCG TCTGATTCTC 
TTCGTTCTGC TGCTATTCGG CATTTATGGA CTTCTAAAAA ACCCATTTTT ATCTGTCCGC 
TTCCGGACAA CAACAGGGCT TGATTCTGCA GTAGATCCTG TCCAGATGAA AAATGTCACC 
TTTGAACATG TTAAAGGGGT GGAGGAAGCT AAACAAGAAT TACAGGAAGT TGTTGAATTC 
TTGAAAAATC CACAAAAATT TACTATTCTT GGAGGTAAAC TTCCAAAAGG AATTCTTTTA 
GTTGGACCCC CAGGGACTGG AAAGACACTT CTTGCCCGAG CTGTGGCGGG AGAAGCTGAT 
GTTCCTTTTT ATTATGCTTC TGGATCCGAA TTTGATGAGA TGTTTGTGGG TGTGGGAGCC 
AGCCGTATCA GAAATCTTTT TAGGGAAGCA AAGGCGAATG CTCCTTGTGT TATATTTATT 
GATGAATTAG ATTCTGTTGG TGGGAAGAGA ATTGAATCTC CAATGCATCC ATATTCAAGG 
CAGACCATAA ATCAACTTCT TGCTGAAATG GATGGTTTTA AACCCAATGA AGGAGTTATC 
ATAATAGGAG CCACAAACTT CCCAGAGGCA TTAGATAATG CCTTAATACG TCCTGGTCGT 
TTTGACATGC AAGTTACAGT TCCAAGGCCA GATGTAAAAG GTCGAACAGA AATTTTGAAA 
TGGTATCTCA ATAAAATAAA GTTTGATCAA TCCGTTGATC CAGAAATTAT AGCTCGAGGT 
ACTGTTGGCT TTTCCGGAGC AGAGTTGGAG AATCTTGTGA ACCAGGCTGC ATTAAAAGCA 
GCTGTTGATG GAAAAGAAAT GGTTACCATG AAGGAGCTGG AGTTTTCCAA AGACAAAATT 
CTAATGGGGC CTGAAAGAAG AAGTGTGGAA ATTGATAACA AAAACAAAAC CATCACAGCA 
TATCATGAAT CTGGTCATGC CATTATTGCA TATTACACAA AAGATGCAAT GCCTATCAAC 
AAAGCTACAA TCATGCCACG GGGGCCAACA CTTGGACATG TGTCCCTGTT ACCTGAGAAT 
GACAGATGGA ATGAAACTAG AGCCCAGCTG CTTGCACAAA TGGATGTTAG TATGGGAGGA 
AGAGTGGCAG AGGAGCTTAT ATTTGGAACC GACCATATTA CAACAGGTGC TTCCAGTGAT 
TTTGATAATG CCACTAAAAT AGCAAAGCGG ATGGTTACCA AATTTGGAAT GAGTGAAAAG 
CTTGGAGTTA TGACCTACAG TGATACAGGG AAACTAAGTC CAGAAACCCA ATCTGCCATC 
GAACAAGAAA TAAGAATCCT TCTAAGGGAC TCATATGAAC GAGCAAAACA TATCTTGAAA 
ACTCATGCAA AGGAGCATAA GAATCTCGCA GAAGCTTTAT TGACCTATGA GACTTTGGAT 
GCCAAAGAGA TTCAAATTGT TCTTGAGGGG AAAAAGTTGG AAGTGAGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055078.1
CDS	175..2325
Translation	MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSEPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

Target ORF information:

RefSeq Version	NM_014263.4
Organism	Homo sapiens(human)
Definition	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014263.4

ORF Insert Sequence:

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGCC TTCACTTAAC 
TTAAGGGACC TTGGATTATC TGAACTAAAA ATTGGACAGA TTGATCAGCT GGTAGAAAAT 
CTACTTCCTG GATTTTGTAA AGGCAAAAAC ATTTCTTCCC ATTGGCATAC ATCCCATGTC 
TCTGCACAAT CCTTCTTTGA AAATAAATAT GGTAACTTAG ATATATTTAG TACATTACGT 
TCCTCTTGCT TGTATCGACA TCATTCAAGA GCTCTTCAAA GCATTTGTTC AGATCTTCAG 
TACTGGCCAG TTTTCATACA GTCTCGGGGT TTTAAAACTT TGAAATCAAG GACACGACGT 
CTCCAGTCTA CCTCCGAGAG ATTAGCTGAA ACACAGAATA TAGCGCCATC ATTCGTGAAG 
GGGTTTCTTT TGCGGGACAG AGGATCAGAT GTTGAGAGTT TGGACAAACT CATGAAAACC 
AAAAATATAC CTGAAGCTCA CCAAGATGCA TTTAAAACTG GTTTTGCGGA AGGTTTTCTG 
AAAGCTCAAG CACTCACACA AAAAACCAAT GATTCCCTAA GGCGAACCCG TCTGATTCTC 
TTCGTTCTGC TGCTATTCGG CATTTATGGA CTTCTAAAAA ACCCATTTTT ATCTGTCCGC 
TTCCGGACAA CAACAGGGCT TGATTCTGCA GTAGATCCTG TCCAGATGAA AAATGTCACC 
TTTGAACATG TTAAAGGGGT GGAGGAAGCT AAACAAGAAT TACAGGAAGT TGTTGAATTC 
TTGAAAAATC CACAAAAATT TACTATTCTT GGAGGTAAAC TTCCAAAAGG AATTCTTTTA 
GTTGGACCCC CAGGGACTGG AAAGACACTT CTTGCCCGAG CTGTGGCGGG AGAAGCTGAT 
GTTCCTTTTT ATTATGCTTC TGGATCCGAA TTTGATGAGA TGTTTGTGGG TGTGGGAGCC 
AGCCGTATCA GAAATCTTTT TAGGGAAGCA AAGGCGAATG CTCCTTGTGT TATATTTATT 
GATGAATTAG ATTCTGTTGG TGGGAAGAGA ATTGAATCTC CAATGCATCC ATATTCAAGG 
CAGACCATAA ATCAACTTCT TGCTGAAATG GATGGTTTTA AACCCAATGA AGGAGTTATC 
ATAATAGGAG CCACAAACTT CCCAGAGGCA TTAGATAATG CCTTAATACG TCCTGGTCGT 
TTTGACATGC AAGTTACAGT TCCAAGGCCA GATGTAAAAG GTCGAACAGA AATTTTGAAA 
TGGTATCTCA ATAAAATAAA GTTTGATCAA TCCGTTGATC CAGAAATTAT AGCTCGAGGT 
ACTGTTGGCT TTTCCGGAGC AGAGTTGGAG AATCTTGTGA ACCAGGCTGC ATTAAAAGCA 
GCTGTTGATG GAAAAGAAAT GGTTACCATG AAGGAGCTGG AGTTTTCCAA AGACAAAATT 
CTAATGGGGC CTGAAAGAAG AAGTGTGGAA ATTGATAACA AAAACAAAAC CATCACAGCA 
TATCATGAAT CTGGTCATGC CATTATTGCA TATTACACAA AAGATGCAAT GCCTATCAAC 
AAAGCTACAA TCATGCCACG GGGGCCAACA CTTGGACATG TGTCCCTGTT ACCTGAGAAT 
GACAGATGGA ATGAAACTAG AGCCCAGCTG CTTGCACAAA TGGATGTTAG TATGGGAGGA 
AGAGTGGCAG AGGAGCTTAT ATTTGGAACC GACCATATTA CAACAGGTGC TTCCAGTGAT 
TTTGATAATG CCACTAAAAT AGCAAAGCGG ATGGTTACCA AATTTGGAAT GAGTGAAAAG 
CTTGGAGTTA TGACCTACAG TGATACAGGG AAACTAAGTC CAGAAACCCA ATCTGCCATC 
GAACAAGAAA TAAGAATCCT TCTAAGGGAC TCATATGAAC GAGCAAAACA TATCTTGAAA 
ACTCATGCAA AGGAGCATAA GAATCTCGCA GAAGCTTTAT TGACCTATGA GACTTTGGAT 
GCCAAAGAGA TTCAAATTGT TCTTGAGGGG AAAAAGTTGG AAGTGAGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YME1L1 ( NM_001253866.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001240795.1 Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 4, mRNA.

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CloneID	OHu01580
Clone ID Related Accession (Same CDS sequence)	NM_001253866.1
Accession Version	NM_001253866.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2052bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	ATP-dependent zinc metalloprotease YME1L1 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA395557.1, AK297973.1, AJ132637.1, AL162272.10 and AI042625.1. Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.250028.1, SRR1803614.195072.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGCC TTCACTTAAC 
TTAAGGGACC TTGGATTATC TGAACTAAAA ATTGGACAGA TTGATCAGCT GGTAGAAAAT 
CTACTTCCTG GATTTTGTAA AGGCAAAAAC ATTTCTTCCC ATTGGCATAC ATCCCATGTC 
TCTGCACAAT CCTTCTTTGA AAATAAATAT GTTTTCATAC AGTCTCGGGG TTTTAAAACT 
TTGAAATCAA GGACACGACG TCTCCAGTCT ACCTCCGAGA GATTAGCTGA AACACAGAAT 
ATAGCGCCAT CATTCGTGAA GGGGTTTCTT TTGCGGGACA GAGGATCAGA TGTTGAGAGT 
TTGGACAAAC TCATGAAAAC CAAAAATATA CCTGAAGCTC ACCAAGATGC ATTTAAAACT 
GGTTTTGCGG AAGGTTTTCT GAAAGCTCAA GCACTCACAC AAAAAACCAA TGATTCCCTA 
AGGCGAACCC GTCTGATTCT CTTCGTTCTG CTGCTATTCG GCATTTATGG ACTTCTAAAA 
AACCCATTTT TATCTGTCCG CTTCCGGACA ACAACAGGGC TTGATTCTGC AGTAGATCCT 
GTCCAGATGA AAAATGTCAC CTTTGAACAT GTTAAAGGGG TGGAGGAAGC TAAACAAGAA 
TTACAGGAAG TTGTTGAATT CTTGAAAAAT CCACAAAAAT TTACTATTCT TGGAGGTAAA 
CTTCCAAAAG GAATTCTTTT AGTTGGACCC CCAGGGACTG GAAAGACACT TCTTGCCCGA 
GCTGTGGCGG GAGAAGCTGA TGTTCCTTTT TATTATGCTT CTGGATCCGA ATTTGATGAG 
ATGTTTGTGG GTGTGGGAGC CAGCCGTATC AGAAATCTTT TTAGGGAAGC AAAGGCGAAT 
GCTCCTTGTG TTATATTTAT TGATGAATTA GATTCTGTTG GTGGGAAGAG AATTGAATCT 
CCAATGCATC CATATTCAAG GCAGACCATA AATCAACTTC TTGCTGAAAT GGATGGTTTT 
AAACCCAATG AAGGAGTTAT CATAATAGGA GCCACAAACT TCCCAGAGGC ATTAGATAAT 
GCCTTAATAC GTCCTGGTCG TTTTGACATG CAAGTTACAG TTCCAAGGCC AGATGTAAAA 
GGTCGAACAG AAATTTTGAA ATGGTATCTC AATAAAATAA AGTTTGATCA ATCCGTTGAT 
CCAGAAATTA TAGCTCGAGG TACTGTTGGC TTTTCCGGAG CAGAGTTGGA GAATCTTGTG 
AACCAGGCTG CATTAAAAGC AGCTGTTGAT GGAAAAGAAA TGGTTACCAT GAAGGAGCTG 
GAGTTTTCCA AAGACAAAAT TCTAATGGGG CCTGAAAGAA GAAGTGTGGA AATTGATAAC 
AAAAACAAAA CCATCACAGC ATATCATGAA TCTGGTCATG CCATTATTGC ATATTACACA 
AAAGATGCAA TGCCTATCAA CAAAGCTACA ATCATGCCAC GGGGGCCAAC ACTTGGACAT 
GTGTCCCTGT TACCTGAGAA TGACAGATGG AATGAAACTA GAGCCCAGCT GCTTGCACAA 
ATGGATGTTA GTATGGGAGG AAGAGTGGCA GAGGAGCTTA TATTTGGAAC CGACCATATT 
ACAACAGGTG CTTCCAGTGA TTTTGATAAT GCCACTAAAA TAGCAAAGCG GATGGTTACC 
AAATTTGGAA TGAGTGAAAA GCTTGGAGTT ATGACCTACA GTGATACAGG GAAACTAAGT 
CCAGAAACCC AATCTGCCAT CGAACAAGAA ATAAGAATCC TTCTAAGGGA CTCATATGAA 
CGAGCAAAAC ATATCTTGAA AACTCATGCA AAGGAGCATA AGAATCTCGC AGAAGCTTTA 
TTGACCTATG AGACTTTGGA TGCCAAAGAG ATTCAAATTG TTCTTGAGGG GAAAAAGTTG 
GAAGTGAGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001240795.1
CDS	211..2262
Translation	MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSEPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

Target ORF information:

RefSeq Version	NM_001253866.1
Organism	Homo sapiens(human)
Definition	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001253866.1

ORF Insert Sequence:

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGCC TTCACTTAAC 
TTAAGGGACC TTGGATTATC TGAACTAAAA ATTGGACAGA TTGATCAGCT GGTAGAAAAT 
CTACTTCCTG GATTTTGTAA AGGCAAAAAC ATTTCTTCCC ATTGGCATAC ATCCCATGTC 
TCTGCACAAT CCTTCTTTGA AAATAAATAT GTTTTCATAC AGTCTCGGGG TTTTAAAACT 
TTGAAATCAA GGACACGACG TCTCCAGTCT ACCTCCGAGA GATTAGCTGA AACACAGAAT 
ATAGCGCCAT CATTCGTGAA GGGGTTTCTT TTGCGGGACA GAGGATCAGA TGTTGAGAGT 
TTGGACAAAC TCATGAAAAC CAAAAATATA CCTGAAGCTC ACCAAGATGC ATTTAAAACT 
GGTTTTGCGG AAGGTTTTCT GAAAGCTCAA GCACTCACAC AAAAAACCAA TGATTCCCTA 
AGGCGAACCC GTCTGATTCT CTTCGTTCTG CTGCTATTCG GCATTTATGG ACTTCTAAAA 
AACCCATTTT TATCTGTCCG CTTCCGGACA ACAACAGGGC TTGATTCTGC AGTAGATCCT 
GTCCAGATGA AAAATGTCAC CTTTGAACAT GTTAAAGGGG TGGAGGAAGC TAAACAAGAA 
TTACAGGAAG TTGTTGAATT CTTGAAAAAT CCACAAAAAT TTACTATTCT TGGAGGTAAA 
CTTCCAAAAG GAATTCTTTT AGTTGGACCC CCAGGGACTG GAAAGACACT TCTTGCCCGA 
GCTGTGGCGG GAGAAGCTGA TGTTCCTTTT TATTATGCTT CTGGATCCGA ATTTGATGAG 
ATGTTTGTGG GTGTGGGAGC CAGCCGTATC AGAAATCTTT TTAGGGAAGC AAAGGCGAAT 
GCTCCTTGTG TTATATTTAT TGATGAATTA GATTCTGTTG GTGGGAAGAG AATTGAATCT 
CCAATGCATC CATATTCAAG GCAGACCATA AATCAACTTC TTGCTGAAAT GGATGGTTTT 
AAACCCAATG AAGGAGTTAT CATAATAGGA GCCACAAACT TCCCAGAGGC ATTAGATAAT 
GCCTTAATAC GTCCTGGTCG TTTTGACATG CAAGTTACAG TTCCAAGGCC AGATGTAAAA 
GGTCGAACAG AAATTTTGAA ATGGTATCTC AATAAAATAA AGTTTGATCA ATCCGTTGAT 
CCAGAAATTA TAGCTCGAGG TACTGTTGGC TTTTCCGGAG CAGAGTTGGA GAATCTTGTG 
AACCAGGCTG CATTAAAAGC AGCTGTTGAT GGAAAAGAAA TGGTTACCAT GAAGGAGCTG 
GAGTTTTCCA AAGACAAAAT TCTAATGGGG CCTGAAAGAA GAAGTGTGGA AATTGATAAC 
AAAAACAAAA CCATCACAGC ATATCATGAA TCTGGTCATG CCATTATTGC ATATTACACA 
AAAGATGCAA TGCCTATCAA CAAAGCTACA ATCATGCCAC GGGGGCCAAC ACTTGGACAT 
GTGTCCCTGT TACCTGAGAA TGACAGATGG AATGAAACTA GAGCCCAGCT GCTTGCACAA 
ATGGATGTTA GTATGGGAGG AAGAGTGGCA GAGGAGCTTA TATTTGGAAC CGACCATATT 
ACAACAGGTG CTTCCAGTGA TTTTGATAAT GCCACTAAAA TAGCAAAGCG GATGGTTACC 
AAATTTGGAA TGAGTGAAAA GCTTGGAGTT ATGACCTACA GTGATACAGG GAAACTAAGT 
CCAGAAACCC AATCTGCCAT CGAACAAGAA ATAAGAATCC TTCTAAGGGA CTCATATGAA 
CGAGCAAAAC ATATCTTGAA AACTCATGCA AAGGAGCATA AGAATCTCGC AGAAGCTTTA 
TTGACCTATG AGACTTTGGA TGCCAAAGAG ATTCAAATTG TTCTTGAGGG GAAAAAGTTG 
GAAGTGAGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YME1L1 ( NM_139312.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_647473.1 Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 1, mRNA.

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CloneID	OHu01739
Clone ID Related Accession (Same CDS sequence)	NM_139312.3 , NM_139312.2
Accession Version	NM_139312.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2322bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	ATP-dependent zinc metalloprotease YME1L1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA395557.1, DA489399.1, AJ132637.1, AL162272.10 and AI042625.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_139312.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.23794.1, SRR1660807.247585.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGTG TATGTTCAGT 
GACTTCCTGA CGAAGCTTAA CATTGTTTCA ATTGGCAAAG GAAAAATATT CGAAGGGTAC 
AGATCCATGT TCATGGAGCC AGCAAAAAGG ATGAAGAAGA GCTTGGACAC AACCGATAAC 
TGGCACATCC GTCCAGAACC CTTCTCCCTC TCAATCCCTC CTTCACTTAA CTTAAGGGAC 
CTTGGATTAT CTGAACTAAA AATTGGACAG ATTGATCAGC TGGTAGAAAA TCTACTTCCT 
GGATTTTGTA AAGGCAAAAA CATTTCTTCC CATTGGCATA CATCCCATGT CTCTGCACAA 
TCCTTCTTTG AAAATAAATA TGGTAACTTA GATATATTTA GTACATTACG TTCCTCTTGC 
TTGTATCGAC ATCATTCAAG AGCTCTTCAA AGCATTTGTT CAGATCTTCA GTACTGGCCA 
GTTTTCATAC AGTCTCGGGG TTTTAAAACT TTGAAATCAA GGACACGACG TCTCCAGTCT 
ACCTCCGAGA GATTAGCTGA AACACAGAAT ATAGCGCCAT CATTCGTGAA GGGGTTTCTT 
TTGCGGGACA GAGGATCAGA TGTTGAGAGT TTGGACAAAC TCATGAAAAC CAAAAATATA 
CCTGAAGCTC ACCAAGATGC ATTTAAAACT GGTTTTGCGG AAGGTTTTCT GAAAGCTCAA 
GCACTCACAC AAAAAACCAA TGATTCCCTA AGGCGAACCC GTCTGATTCT CTTCGTTCTG 
CTGCTATTCG GCATTTATGG ACTTCTAAAA AACCCATTTT TATCTGTCCG CTTCCGGACA 
ACAACAGGGC TTGATTCTGC AGTAGATCCT GTCCAGATGA AAAATGTCAC CTTTGAACAT 
GTTAAAGGGG TGGAGGAAGC TAAACAAGAA TTACAGGAAG TTGTTGAATT CTTGAAAAAT 
CCACAAAAAT TTACTATTCT TGGAGGTAAA CTTCCAAAAG GAATTCTTTT AGTTGGACCC 
CCAGGGACTG GAAAGACACT TCTTGCCCGA GCTGTGGCGG GAGAAGCTGA TGTTCCTTTT 
TATTATGCTT CTGGATCCGA ATTTGATGAG ATGTTTGTGG GTGTGGGAGC CAGCCGTATC 
AGAAATCTTT TTAGGGAAGC AAAGGCGAAT GCTCCTTGTG TTATATTTAT TGATGAATTA 
GATTCTGTTG GTGGGAAGAG AATTGAATCT CCAATGCATC CATATTCAAG GCAGACCATA 
AATCAACTTC TTGCTGAAAT GGATGGTTTT AAACCCAATG AAGGAGTTAT CATAATAGGA 
GCCACAAACT TCCCAGAGGC ATTAGATAAT GCCTTAATAC GTCCTGGTCG TTTTGACATG 
CAAGTTACAG TTCCAAGGCC AGATGTAAAA GGTCGAACAG AAATTTTGAA ATGGTATCTC 
AATAAAATAA AGTTTGATCA ATCCGTTGAT CCAGAAATTA TAGCTCGAGG TACTGTTGGC 
TTTTCCGGAG CAGAGTTGGA GAATCTTGTG AACCAGGCTG CATTAAAAGC AGCTGTTGAT 
GGAAAAGAAA TGGTTACCAT GAAGGAGCTG GAGTTTTCCA AAGACAAAAT TCTAATGGGG 
CCTGAAAGAA GAAGTGTGGA AATTGATAAC AAAAACAAAA CCATCACAGC ATATCATGAA 
TCTGGTCATG CCATTATTGC ATATTACACA AAAGATGCAA TGCCTATCAA CAAAGCTACA 
ATCATGCCAC GGGGGCCAAC ACTTGGACAT GTGTCCCTGT TACCTGAGAA TGACAGATGG 
AATGAAACTA GAGCCCAGCT GCTTGCACAA ATGGATGTTA GTATGGGAGG AAGAGTGGCA 
GAGGAGCTTA TATTTGGAAC CGACCATATT ACAACAGGTG CTTCCAGTGA TTTTGATAAT 
GCCACTAAAA TAGCAAAGCG GATGGTTACC AAATTTGGAA TGAGTGAAAA GCTTGGAGTT 
ATGACCTACA GTGATACAGG GAAACTAAGT CCAGAAACCC AATCTGCCAT CGAACAAGAA 
ATAAGAATCC TTCTAAGGGA CTCATATGAA CGAGCAAAAC ATATCTTGAA AACTCATGCA 
AAGGAGCATA AGAATCTCGC AGAAGCTTTA TTGACCTATG AGACTTTGGA TGCCAAAGAG 
ATTCAAATTG TTCTTGAGGG GAAAAAGTTG GAAGTGAGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647473.1
CDS	175..2496
Translation	MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

Target ORF information:

RefSeq Version	NM_139312.3
Organism	Homo sapiens(human)
Definition	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139312.3

ORF Insert Sequence:

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGTG TATGTTCAGT 
GACTTCCTGA CGAAGCTTAA CATTGTTTCA ATTGGCAAAG GAAAAATATT CGAAGGGTAC 
AGATCCATGT TCATGGAGCC AGCAAAAAGG ATGAAGAAGA GCTTGGACAC AACCGATAAC 
TGGCACATCC GTCCAGAACC CTTCTCCCTC TCAATCCCTC CTTCACTTAA CTTAAGGGAC 
CTTGGATTAT CTGAACTAAA AATTGGACAG ATTGATCAGC TGGTAGAAAA TCTACTTCCT 
GGATTTTGTA AAGGCAAAAA CATTTCTTCC CATTGGCATA CATCCCATGT CTCTGCACAA 
TCCTTCTTTG AAAATAAATA TGGTAACTTA GATATATTTA GTACATTACG TTCCTCTTGC 
TTGTATCGAC ATCATTCAAG AGCTCTTCAA AGCATTTGTT CAGATCTTCA GTACTGGCCA 
GTTTTCATAC AGTCTCGGGG TTTTAAAACT TTGAAATCAA GGACACGACG TCTCCAGTCT 
ACCTCCGAGA GATTAGCTGA AACACAGAAT ATAGCGCCAT CATTCGTGAA GGGGTTTCTT 
TTGCGGGACA GAGGATCAGA TGTTGAGAGT TTGGACAAAC TCATGAAAAC CAAAAATATA 
CCTGAAGCTC ACCAAGATGC ATTTAAAACT GGTTTTGCGG AAGGTTTTCT GAAAGCTCAA 
GCACTCACAC AAAAAACCAA TGATTCCCTA AGGCGAACCC GTCTGATTCT CTTCGTTCTG 
CTGCTATTCG GCATTTATGG ACTTCTAAAA AACCCATTTT TATCTGTCCG CTTCCGGACA 
ACAACAGGGC TTGATTCTGC AGTAGATCCT GTCCAGATGA AAAATGTCAC CTTTGAACAT 
GTTAAAGGGG TGGAGGAAGC TAAACAAGAA TTACAGGAAG TTGTTGAATT CTTGAAAAAT 
CCACAAAAAT TTACTATTCT TGGAGGTAAA CTTCCAAAAG GAATTCTTTT AGTTGGACCC 
CCAGGGACTG GAAAGACACT TCTTGCCCGA GCTGTGGCGG GAGAAGCTGA TGTTCCTTTT 
TATTATGCTT CTGGATCCGA ATTTGATGAG ATGTTTGTGG GTGTGGGAGC CAGCCGTATC 
AGAAATCTTT TTAGGGAAGC AAAGGCGAAT GCTCCTTGTG TTATATTTAT TGATGAATTA 
GATTCTGTTG GTGGGAAGAG AATTGAATCT CCAATGCATC CATATTCAAG GCAGACCATA 
AATCAACTTC TTGCTGAAAT GGATGGTTTT AAACCCAATG AAGGAGTTAT CATAATAGGA 
GCCACAAACT TCCCAGAGGC ATTAGATAAT GCCTTAATAC GTCCTGGTCG TTTTGACATG 
CAAGTTACAG TTCCAAGGCC AGATGTAAAA GGTCGAACAG AAATTTTGAA ATGGTATCTC 
AATAAAATAA AGTTTGATCA ATCCGTTGAT CCAGAAATTA TAGCTCGAGG TACTGTTGGC 
TTTTCCGGAG CAGAGTTGGA GAATCTTGTG AACCAGGCTG CATTAAAAGC AGCTGTTGAT 
GGAAAAGAAA TGGTTACCAT GAAGGAGCTG GAGTTTTCCA AAGACAAAAT TCTAATGGGG 
CCTGAAAGAA GAAGTGTGGA AATTGATAAC AAAAACAAAA CCATCACAGC ATATCATGAA 
TCTGGTCATG CCATTATTGC ATATTACACA AAAGATGCAA TGCCTATCAA CAAAGCTACA 
ATCATGCCAC GGGGGCCAAC ACTTGGACAT GTGTCCCTGT TACCTGAGAA TGACAGATGG 
AATGAAACTA GAGCCCAGCT GCTTGCACAA ATGGATGTTA GTATGGGAGG AAGAGTGGCA 
GAGGAGCTTA TATTTGGAAC CGACCATATT ACAACAGGTG CTTCCAGTGA TTTTGATAAT 
GCCACTAAAA TAGCAAAGCG GATGGTTACC AAATTTGGAA TGAGTGAAAA GCTTGGAGTT 
ATGACCTACA GTGATACAGG GAAACTAAGT CCAGAAACCC AATCTGCCAT CGAACAAGAA 
ATAAGAATCC TTCTAAGGGA CTCATATGAA CGAGCAAAAC ATATCTTGAA AACTCATGCA 
AAGGAGCATA AGAATCTCGC AGAAGCTTTA TTGACCTATG AGACTTTGGA TGCCAAAGAG 
ATTCAAATTG TTCTTGAGGG GAAAAAGTTG GAAGTGAGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YME1L1 ( NM_139312.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_647473.1 Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 1, mRNA.

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CloneID	OHu01739
Clone ID Related Accession (Same CDS sequence)	NM_139312.3 , NM_139312.2
Accession Version	NM_139312.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2322bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-01
Organism	Homo sapiens(human)
Product	ATP-dependent zinc metalloprotease YME1L1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA395557.1, DA489399.1, AJ132637.1, AL162272.10 and AI042625.1. This sequence is a reference standard in the RefSeqGene project. On Dec 8, 2011 this sequence version replaced NM_139312.1. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.247585.1, AF151782.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGTG TATGTTCAGT 
GACTTCCTGA CGAAGCTTAA CATTGTTTCA ATTGGCAAAG GAAAAATATT CGAAGGGTAC 
AGATCCATGT TCATGGAGCC AGCAAAAAGG ATGAAGAAGA GCTTGGACAC AACCGATAAC 
TGGCACATCC GTCCAGAACC CTTCTCCCTC TCAATCCCTC CTTCACTTAA CTTAAGGGAC 
CTTGGATTAT CTGAACTAAA AATTGGACAG ATTGATCAGC TGGTAGAAAA TCTACTTCCT 
GGATTTTGTA AAGGCAAAAA CATTTCTTCC CATTGGCATA CATCCCATGT CTCTGCACAA 
TCCTTCTTTG AAAATAAATA TGGTAACTTA GATATATTTA GTACATTACG TTCCTCTTGC 
TTGTATCGAC ATCATTCAAG AGCTCTTCAA AGCATTTGTT CAGATCTTCA GTACTGGCCA 
GTTTTCATAC AGTCTCGGGG TTTTAAAACT TTGAAATCAA GGACACGACG TCTCCAGTCT 
ACCTCCGAGA GATTAGCTGA AACACAGAAT ATAGCGCCAT CATTCGTGAA GGGGTTTCTT 
TTGCGGGACA GAGGATCAGA TGTTGAGAGT TTGGACAAAC TCATGAAAAC CAAAAATATA 
CCTGAAGCTC ACCAAGATGC ATTTAAAACT GGTTTTGCGG AAGGTTTTCT GAAAGCTCAA 
GCACTCACAC AAAAAACCAA TGATTCCCTA AGGCGAACCC GTCTGATTCT CTTCGTTCTG 
CTGCTATTCG GCATTTATGG ACTTCTAAAA AACCCATTTT TATCTGTCCG CTTCCGGACA 
ACAACAGGGC TTGATTCTGC AGTAGATCCT GTCCAGATGA AAAATGTCAC CTTTGAACAT 
GTTAAAGGGG TGGAGGAAGC TAAACAAGAA TTACAGGAAG TTGTTGAATT CTTGAAAAAT 
CCACAAAAAT TTACTATTCT TGGAGGTAAA CTTCCAAAAG GAATTCTTTT AGTTGGACCC 
CCAGGGACTG GAAAGACACT TCTTGCCCGA GCTGTGGCGG GAGAAGCTGA TGTTCCTTTT 
TATTATGCTT CTGGATCCGA ATTTGATGAG ATGTTTGTGG GTGTGGGAGC CAGCCGTATC 
AGAAATCTTT TTAGGGAAGC AAAGGCGAAT GCTCCTTGTG TTATATTTAT TGATGAATTA 
GATTCTGTTG GTGGGAAGAG AATTGAATCT CCAATGCATC CATATTCAAG GCAGACCATA 
AATCAACTTC TTGCTGAAAT GGATGGTTTT AAACCCAATG AAGGAGTTAT CATAATAGGA 
GCCACAAACT TCCCAGAGGC ATTAGATAAT GCCTTAATAC GTCCTGGTCG TTTTGACATG 
CAAGTTACAG TTCCAAGGCC AGATGTAAAA GGTCGAACAG AAATTTTGAA ATGGTATCTC 
AATAAAATAA AGTTTGATCA ATCCGTTGAT CCAGAAATTA TAGCTCGAGG TACTGTTGGC 
TTTTCCGGAG CAGAGTTGGA GAATCTTGTG AACCAGGCTG CATTAAAAGC AGCTGTTGAT 
GGAAAAGAAA TGGTTACCAT GAAGGAGCTG GAGTTTTCCA AAGACAAAAT TCTAATGGGG 
CCTGAAAGAA GAAGTGTGGA AATTGATAAC AAAAACAAAA CCATCACAGC ATATCATGAA 
TCTGGTCATG CCATTATTGC ATATTACACA AAAGATGCAA TGCCTATCAA CAAAGCTACA 
ATCATGCCAC GGGGGCCAAC ACTTGGACAT GTGTCCCTGT TACCTGAGAA TGACAGATGG 
AATGAAACTA GAGCCCAGCT GCTTGCACAA ATGGATGTTA GTATGGGAGG AAGAGTGGCA 
GAGGAGCTTA TATTTGGAAC CGACCATATT ACAACAGGTG CTTCCAGTGA TTTTGATAAT 
GCCACTAAAA TAGCAAAGCG GATGGTTACC AAATTTGGAA TGAGTGAAAA GCTTGGAGTT 
ATGACCTACA GTGATACAGG GAAACTAAGT CCAGAAACCC AATCTGCCAT CGAACAAGAA 
ATAAGAATCC TTCTAAGGGA CTCATATGAA CGAGCAAAAC ATATCTTGAA AACTCATGCA 
AAGGAGCATA AGAATCTCGC AGAAGCTTTA TTGACCTATG AGACTTTGGA TGCCAAAGAG 
ATTCAAATTG TTCTTGAGGG GAAAAAGTTG GAAGTGAGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647473.1
CDS	211..2532
Translation	MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

Target ORF information:

RefSeq Version	NM_139312.2
Organism	Homo sapiens(human)
Definition	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139312.2

ORF Insert Sequence:

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGTG TATGTTCAGT 
GACTTCCTGA CGAAGCTTAA CATTGTTTCA ATTGGCAAAG GAAAAATATT CGAAGGGTAC 
AGATCCATGT TCATGGAGCC AGCAAAAAGG ATGAAGAAGA GCTTGGACAC AACCGATAAC 
TGGCACATCC GTCCAGAACC CTTCTCCCTC TCAATCCCTC CTTCACTTAA CTTAAGGGAC 
CTTGGATTAT CTGAACTAAA AATTGGACAG ATTGATCAGC TGGTAGAAAA TCTACTTCCT 
GGATTTTGTA AAGGCAAAAA CATTTCTTCC CATTGGCATA CATCCCATGT CTCTGCACAA 
TCCTTCTTTG AAAATAAATA TGGTAACTTA GATATATTTA GTACATTACG TTCCTCTTGC 
TTGTATCGAC ATCATTCAAG AGCTCTTCAA AGCATTTGTT CAGATCTTCA GTACTGGCCA 
GTTTTCATAC AGTCTCGGGG TTTTAAAACT TTGAAATCAA GGACACGACG TCTCCAGTCT 
ACCTCCGAGA GATTAGCTGA AACACAGAAT ATAGCGCCAT CATTCGTGAA GGGGTTTCTT 
TTGCGGGACA GAGGATCAGA TGTTGAGAGT TTGGACAAAC TCATGAAAAC CAAAAATATA 
CCTGAAGCTC ACCAAGATGC ATTTAAAACT GGTTTTGCGG AAGGTTTTCT GAAAGCTCAA 
GCACTCACAC AAAAAACCAA TGATTCCCTA AGGCGAACCC GTCTGATTCT CTTCGTTCTG 
CTGCTATTCG GCATTTATGG ACTTCTAAAA AACCCATTTT TATCTGTCCG CTTCCGGACA 
ACAACAGGGC TTGATTCTGC AGTAGATCCT GTCCAGATGA AAAATGTCAC CTTTGAACAT 
GTTAAAGGGG TGGAGGAAGC TAAACAAGAA TTACAGGAAG TTGTTGAATT CTTGAAAAAT 
CCACAAAAAT TTACTATTCT TGGAGGTAAA CTTCCAAAAG GAATTCTTTT AGTTGGACCC 
CCAGGGACTG GAAAGACACT TCTTGCCCGA GCTGTGGCGG GAGAAGCTGA TGTTCCTTTT 
TATTATGCTT CTGGATCCGA ATTTGATGAG ATGTTTGTGG GTGTGGGAGC CAGCCGTATC 
AGAAATCTTT TTAGGGAAGC AAAGGCGAAT GCTCCTTGTG TTATATTTAT TGATGAATTA 
GATTCTGTTG GTGGGAAGAG AATTGAATCT CCAATGCATC CATATTCAAG GCAGACCATA 
AATCAACTTC TTGCTGAAAT GGATGGTTTT AAACCCAATG AAGGAGTTAT CATAATAGGA 
GCCACAAACT TCCCAGAGGC ATTAGATAAT GCCTTAATAC GTCCTGGTCG TTTTGACATG 
CAAGTTACAG TTCCAAGGCC AGATGTAAAA GGTCGAACAG AAATTTTGAA ATGGTATCTC 
AATAAAATAA AGTTTGATCA ATCCGTTGAT CCAGAAATTA TAGCTCGAGG TACTGTTGGC 
TTTTCCGGAG CAGAGTTGGA GAATCTTGTG AACCAGGCTG CATTAAAAGC AGCTGTTGAT 
GGAAAAGAAA TGGTTACCAT GAAGGAGCTG GAGTTTTCCA AAGACAAAAT TCTAATGGGG 
CCTGAAAGAA GAAGTGTGGA AATTGATAAC AAAAACAAAA CCATCACAGC ATATCATGAA 
TCTGGTCATG CCATTATTGC ATATTACACA AAAGATGCAA TGCCTATCAA CAAAGCTACA 
ATCATGCCAC GGGGGCCAAC ACTTGGACAT GTGTCCCTGT TACCTGAGAA TGACAGATGG 
AATGAAACTA GAGCCCAGCT GCTTGCACAA ATGGATGTTA GTATGGGAGG AAGAGTGGCA 
GAGGAGCTTA TATTTGGAAC CGACCATATT ACAACAGGTG CTTCCAGTGA TTTTGATAAT 
GCCACTAAAA TAGCAAAGCG GATGGTTACC AAATTTGGAA TGAGTGAAAA GCTTGGAGTT 
ATGACCTACA GTGATACAGG GAAACTAAGT CCAGAAACCC AATCTGCCAT CGAACAAGAA 
ATAAGAATCC TTCTAAGGGA CTCATATGAA CGAGCAAAAC ATATCTTGAA AACTCATGCA 
AAGGAGCATA AGAATCTCGC AGAAGCTTTA TTGACCTATG AGACTTTGGA TGCCAAAGAG 
ATTCAAATTG TTCTTGAGGG GAAAAAGTTG GAAGTGAGAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YME1L1 ( XM_011519300.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011517602.1 Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant X1, mRNA.

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CloneID	OHu64339
Clone ID Related Accession (Same CDS sequence)	XM_011519300.3 , XM_011519300.2
Accession Version	XM_011519300.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ATP-dependent zinc metalloprotease YME1L1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011519300.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGTG TATGTTCAGT 
GACTTCCTGA CGAAGCTTAA CATTGTTTCA ATTGGCAAAG GAAAAATATT CGAAGGGTAC 
AGATCCATGT TCATGGAGCC AGCAAAAAGG ATGAAGAAGA GCTTGGACAC AACCGATAAC 
TGGCACATCC GTCCAGAACC CTTCTCCCTC TCAATCCCTC CTTCACTTAA CTTAAGGGAC 
CTTGGATTAT CTGAACTAAA AATTGGACAG ATTGATCAGC TGGTAGAAAA TCTACTTCCT 
GGATTTTGTA AAGGCAAAAA CATTTCTTCC CATTGGCATA CATCCCATGT CTCTGCACAA 
TCCTTCTTTG AAAATAAATA TGTTTTCATA CAGTCTCGGG GTTTTAAAAC TTTGAAATCA 
AGGACACGAC GTCTCCAGTC TACCTCCGAG AGATTAGCTG AAACACAGAA TATAGCGCCA 
TCATTCGTGA AGGGGTTTCT TTTGCGGGAC AGAGGATCAG ATGTTGAGAG TTTGGACAAA 
CTCATGAAAA CCAAAAATAT ACCTGAAGCT CACCAAGATG CATTTAAAAC TGGTTTTGCG 
GAAGGTTTTC TGAAAGCTCA AGCACTCACA CAAAAAACCA ATGATTCCCT AAGGCGAACC 
CGTCTGATTC TCTTCGTTCT GCTGCTATTC GGCATTTATG GACTTCTAAA AAACCCATTT 
TTATCTGTCC GCTTCCGGAC AACAACAGGG CTTGATTCTG CAGTAGATCC TGTCCAGATG 
AAAAATGTCA CCTTTGAACA TGTTAAAGGG GTGGAGGAAG CTAAACAAGA ATTACAGGAA 
GTTGTTGAAT TCTTGAAAAA TCCACAAAAA TTTACTATTC TTGGAGGTAA ACTTCCAAAA 
GGAATTCTTT TAGTTGGACC CCCAGGGACT GGAAAGACAC TTCTTGCCCG AGCTGTGGCG 
GGAGAAGCTG ATGTTCCTTT TTATTATGCT TCTGGATCCG AATTTGATGA GATGTTTGTG 
GGTGTGGGAG CCAGCCGTAT CAGAAATCTT TTTAGGGAAG CAAAGGCGAA TGCTCCTTGT 
GTTATATTTA TTGATGAATT AGATTCTGTT GGTGGGAAGA GAATTGAATC TCCAATGCAT 
CCATATTCAA GGCAGACCAT AAATCAACTT CTTGCTGAAA TGGATGGTTT TAAACCCAAT 
GAAGGAGTTA TCATAATAGG AGCCACAAAC TTCCCAGAGG CATTAGATAA TGCCTTAATA 
CGTCCTGGTC GTTTTGACAT GCAAGTTACA GTTCCAAGGC CAGATGTAAA AGGTCGAACA 
GAAATTTTGA AATGGTATCT CAATAAAATA AAGTTTGATC AATCCGTTGA TCCAGAAATT 
ATAGCTCGAG GTACTGTTGG CTTTTCCGGA GCAGAGTTGG AGAATCTTGT GAACCAGGCT 
GCATTAAAAG CAGCTGTTGA TGGAAAAGAA ATGGTTACCA TGAAGGAGCT GGAGTTTTCC 
AAAGACAAAA TTCTAATGGG GCCTGAAAGA AGAAGTGTGG AAATTGATAA CAAAAACAAA 
ACCATCACAG CATATCATGA ATCTGGTCAT GCCATTATTG CATATTACAC AAAAGATGCA 
ATGCCTATCA ACAAAGCTAC AATCATGCCA CGGGGGCCAA CACTTGGACA TGTGTCCCTG 
TTACCTGAGA ATGACAGATG GAATGAAACT AGAGCCCAGC TGCTTGCACA AATGGATGTT 
AGTATGGGAG GAAGAGTGGC AGAGGAGCTT ATATTTGGAA CCGACCATAT TACAACAGGT 
GCTTCCAGTG ATTTTGATAA TGCCACTAAA ATAGCAAAGC GGATGGTTAC CAAATTTGGA 
ATGAGTGAAA AGCTTGGAGT TATGACCTAC AGTGATACAG GGAAACTAAG TCCAGAAACC 
CAATCTGCCA TCGAACAAGA AATAAGAATC CTTCTAAGGG ACTCATATGA ACGAGCAAAA 
CATATCTTGA AAACTCATGC AAAGGAGCAT AAGAATCTCG CAGAAGCTTT ATTGACCTAT 
GAGACTTTGG ATGCCAAAGA GATTCAAATT GTTCTTGAGG GGAAAAAGTT GGAAGTGAGA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011517602.1
CDS	842..3064
Translation	MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

Target ORF information:

RefSeq Version	XM_011519300.3
Organism	Homo sapiens(human)
Definition	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011519300.3

ORF Insert Sequence:

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGTG TATGTTCAGT 
GACTTCCTGA CGAAGCTTAA CATTGTTTCA ATTGGCAAAG GAAAAATATT CGAAGGGTAC 
AGATCCATGT TCATGGAGCC AGCAAAAAGG ATGAAGAAGA GCTTGGACAC AACCGATAAC 
TGGCACATCC GTCCAGAACC CTTCTCCCTC TCAATCCCTC CTTCACTTAA CTTAAGGGAC 
CTTGGATTAT CTGAACTAAA AATTGGACAG ATTGATCAGC TGGTAGAAAA TCTACTTCCT 
GGATTTTGTA AAGGCAAAAA CATTTCTTCC CATTGGCATA CATCCCATGT CTCTGCACAA 
TCCTTCTTTG AAAATAAATA TGTTTTCATA CAGTCTCGGG GTTTTAAAAC TTTGAAATCA 
AGGACACGAC GTCTCCAGTC TACCTCCGAG AGATTAGCTG AAACACAGAA TATAGCGCCA 
TCATTCGTGA AGGGGTTTCT TTTGCGGGAC AGAGGATCAG ATGTTGAGAG TTTGGACAAA 
CTCATGAAAA CCAAAAATAT ACCTGAAGCT CACCAAGATG CATTTAAAAC TGGTTTTGCG 
GAAGGTTTTC TGAAAGCTCA AGCACTCACA CAAAAAACCA ATGATTCCCT AAGGCGAACC 
CGTCTGATTC TCTTCGTTCT GCTGCTATTC GGCATTTATG GACTTCTAAA AAACCCATTT 
TTATCTGTCC GCTTCCGGAC AACAACAGGG CTTGATTCTG CAGTAGATCC TGTCCAGATG 
AAAAATGTCA CCTTTGAACA TGTTAAAGGG GTGGAGGAAG CTAAACAAGA ATTACAGGAA 
GTTGTTGAAT TCTTGAAAAA TCCACAAAAA TTTACTATTC TTGGAGGTAA ACTTCCAAAA 
GGAATTCTTT TAGTTGGACC CCCAGGGACT GGAAAGACAC TTCTTGCCCG AGCTGTGGCG 
GGAGAAGCTG ATGTTCCTTT TTATTATGCT TCTGGATCCG AATTTGATGA GATGTTTGTG 
GGTGTGGGAG CCAGCCGTAT CAGAAATCTT TTTAGGGAAG CAAAGGCGAA TGCTCCTTGT 
GTTATATTTA TTGATGAATT AGATTCTGTT GGTGGGAAGA GAATTGAATC TCCAATGCAT 
CCATATTCAA GGCAGACCAT AAATCAACTT CTTGCTGAAA TGGATGGTTT TAAACCCAAT 
GAAGGAGTTA TCATAATAGG AGCCACAAAC TTCCCAGAGG CATTAGATAA TGCCTTAATA 
CGTCCTGGTC GTTTTGACAT GCAAGTTACA GTTCCAAGGC CAGATGTAAA AGGTCGAACA 
GAAATTTTGA AATGGTATCT CAATAAAATA AAGTTTGATC AATCCGTTGA TCCAGAAATT 
ATAGCTCGAG GTACTGTTGG CTTTTCCGGA GCAGAGTTGG AGAATCTTGT GAACCAGGCT 
GCATTAAAAG CAGCTGTTGA TGGAAAAGAA ATGGTTACCA TGAAGGAGCT GGAGTTTTCC 
AAAGACAAAA TTCTAATGGG GCCTGAAAGA AGAAGTGTGG AAATTGATAA CAAAAACAAA 
ACCATCACAG CATATCATGA ATCTGGTCAT GCCATTATTG CATATTACAC AAAAGATGCA 
ATGCCTATCA ACAAAGCTAC AATCATGCCA CGGGGGCCAA CACTTGGACA TGTGTCCCTG 
TTACCTGAGA ATGACAGATG GAATGAAACT AGAGCCCAGC TGCTTGCACA AATGGATGTT 
AGTATGGGAG GAAGAGTGGC AGAGGAGCTT ATATTTGGAA CCGACCATAT TACAACAGGT 
GCTTCCAGTG ATTTTGATAA TGCCACTAAA ATAGCAAAGC GGATGGTTAC CAAATTTGGA 
ATGAGTGAAA AGCTTGGAGT TATGACCTAC AGTGATACAG GGAAACTAAG TCCAGAAACC 
CAATCTGCCA TCGAACAAGA AATAAGAATC CTTCTAAGGG ACTCATATGA ACGAGCAAAA 
CATATCTTGA AAACTCATGC AAAGGAGCAT AAGAATCTCG CAGAAGCTTT ATTGACCTAT 
GAGACTTTGG ATGCCAAAGA GATTCAAATT GTTCTTGAGG GGAAAAAGTT GGAAGTGAGA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

YME1L1 ( XM_011519300.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011517602.1 Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant X1, mRNA.

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CloneID	OHu64339
Clone ID Related Accession (Same CDS sequence)	XM_011519300.3 , XM_011519300.2
Accession Version	XM_011519300.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2223bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	ATP-dependent zinc metalloprotease YME1L1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011519300.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGTG TATGTTCAGT 
GACTTCCTGA CGAAGCTTAA CATTGTTTCA ATTGGCAAAG GAAAAATATT CGAAGGGTAC 
AGATCCATGT TCATGGAGCC AGCAAAAAGG ATGAAGAAGA GCTTGGACAC AACCGATAAC 
TGGCACATCC GTCCAGAACC CTTCTCCCTC TCAATCCCTC CTTCACTTAA CTTAAGGGAC 
CTTGGATTAT CTGAACTAAA AATTGGACAG ATTGATCAGC TGGTAGAAAA TCTACTTCCT 
GGATTTTGTA AAGGCAAAAA CATTTCTTCC CATTGGCATA CATCCCATGT CTCTGCACAA 
TCCTTCTTTG AAAATAAATA TGTTTTCATA CAGTCTCGGG GTTTTAAAAC TTTGAAATCA 
AGGACACGAC GTCTCCAGTC TACCTCCGAG AGATTAGCTG AAACACAGAA TATAGCGCCA 
TCATTCGTGA AGGGGTTTCT TTTGCGGGAC AGAGGATCAG ATGTTGAGAG TTTGGACAAA 
CTCATGAAAA CCAAAAATAT ACCTGAAGCT CACCAAGATG CATTTAAAAC TGGTTTTGCG 
GAAGGTTTTC TGAAAGCTCA AGCACTCACA CAAAAAACCA ATGATTCCCT AAGGCGAACC 
CGTCTGATTC TCTTCGTTCT GCTGCTATTC GGCATTTATG GACTTCTAAA AAACCCATTT 
TTATCTGTCC GCTTCCGGAC AACAACAGGG CTTGATTCTG CAGTAGATCC TGTCCAGATG 
AAAAATGTCA CCTTTGAACA TGTTAAAGGG GTGGAGGAAG CTAAACAAGA ATTACAGGAA 
GTTGTTGAAT TCTTGAAAAA TCCACAAAAA TTTACTATTC TTGGAGGTAA ACTTCCAAAA 
GGAATTCTTT TAGTTGGACC CCCAGGGACT GGAAAGACAC TTCTTGCCCG AGCTGTGGCG 
GGAGAAGCTG ATGTTCCTTT TTATTATGCT TCTGGATCCG AATTTGATGA GATGTTTGTG 
GGTGTGGGAG CCAGCCGTAT CAGAAATCTT TTTAGGGAAG CAAAGGCGAA TGCTCCTTGT 
GTTATATTTA TTGATGAATT AGATTCTGTT GGTGGGAAGA GAATTGAATC TCCAATGCAT 
CCATATTCAA GGCAGACCAT AAATCAACTT CTTGCTGAAA TGGATGGTTT TAAACCCAAT 
GAAGGAGTTA TCATAATAGG AGCCACAAAC TTCCCAGAGG CATTAGATAA TGCCTTAATA 
CGTCCTGGTC GTTTTGACAT GCAAGTTACA GTTCCAAGGC CAGATGTAAA AGGTCGAACA 
GAAATTTTGA AATGGTATCT CAATAAAATA AAGTTTGATC AATCCGTTGA TCCAGAAATT 
ATAGCTCGAG GTACTGTTGG CTTTTCCGGA GCAGAGTTGG AGAATCTTGT GAACCAGGCT 
GCATTAAAAG CAGCTGTTGA TGGAAAAGAA ATGGTTACCA TGAAGGAGCT GGAGTTTTCC 
AAAGACAAAA TTCTAATGGG GCCTGAAAGA AGAAGTGTGG AAATTGATAA CAAAAACAAA 
ACCATCACAG CATATCATGA ATCTGGTCAT GCCATTATTG CATATTACAC AAAAGATGCA 
ATGCCTATCA ACAAAGCTAC AATCATGCCA CGGGGGCCAA CACTTGGACA TGTGTCCCTG 
TTACCTGAGA ATGACAGATG GAATGAAACT AGAGCCCAGC TGCTTGCACA AATGGATGTT 
AGTATGGGAG GAAGAGTGGC AGAGGAGCTT ATATTTGGAA CCGACCATAT TACAACAGGT 
GCTTCCAGTG ATTTTGATAA TGCCACTAAA ATAGCAAAGC GGATGGTTAC CAAATTTGGA 
ATGAGTGAAA AGCTTGGAGT TATGACCTAC AGTGATACAG GGAAACTAAG TCCAGAAACC 
CAATCTGCCA TCGAACAAGA AATAAGAATC CTTCTAAGGG ACTCATATGA ACGAGCAAAA 
CATATCTTGA AAACTCATGC AAAGGAGCAT AAGAATCTCG CAGAAGCTTT ATTGACCTAT 
GAGACTTTGG ATGCCAAAGA GATTCAAATT GTTCTTGAGG GGAAAAAGTT GGAAGTGAGA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011517602.1
CDS	593..2815
Translation	MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

Target ORF information:

RefSeq Version	XM_011519300.2
Organism	Homo sapiens(human)
Definition	Homo sapiens YME1 like 1 ATPase (YME1L1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011519300.2

ORF Insert Sequence:

ATGTTTTCCT TGTCGAGCAC GGTGCAACCC CAGGTTACAG TTCCTCTGAG TCATCTCATC 
AATGCCTTCC ATACACCAAA AAACACTTCT GTTTCTCTCA GTGGAGTGTC AGTTTCTCAA 
AACCAGCATC GAGATGTAGT TCCTGAGCAT GAGGCTCCCA GCAGTGAGTG TATGTTCAGT 
GACTTCCTGA CGAAGCTTAA CATTGTTTCA ATTGGCAAAG GAAAAATATT CGAAGGGTAC 
AGATCCATGT TCATGGAGCC AGCAAAAAGG ATGAAGAAGA GCTTGGACAC AACCGATAAC 
TGGCACATCC GTCCAGAACC CTTCTCCCTC TCAATCCCTC CTTCACTTAA CTTAAGGGAC 
CTTGGATTAT CTGAACTAAA AATTGGACAG ATTGATCAGC TGGTAGAAAA TCTACTTCCT 
GGATTTTGTA AAGGCAAAAA CATTTCTTCC CATTGGCATA CATCCCATGT CTCTGCACAA 
TCCTTCTTTG AAAATAAATA TGTTTTCATA CAGTCTCGGG GTTTTAAAAC TTTGAAATCA 
AGGACACGAC GTCTCCAGTC TACCTCCGAG AGATTAGCTG AAACACAGAA TATAGCGCCA 
TCATTCGTGA AGGGGTTTCT TTTGCGGGAC AGAGGATCAG ATGTTGAGAG TTTGGACAAA 
CTCATGAAAA CCAAAAATAT ACCTGAAGCT CACCAAGATG CATTTAAAAC TGGTTTTGCG 
GAAGGTTTTC TGAAAGCTCA AGCACTCACA CAAAAAACCA ATGATTCCCT AAGGCGAACC 
CGTCTGATTC TCTTCGTTCT GCTGCTATTC GGCATTTATG GACTTCTAAA AAACCCATTT 
TTATCTGTCC GCTTCCGGAC AACAACAGGG CTTGATTCTG CAGTAGATCC TGTCCAGATG 
AAAAATGTCA CCTTTGAACA TGTTAAAGGG GTGGAGGAAG CTAAACAAGA ATTACAGGAA 
GTTGTTGAAT TCTTGAAAAA TCCACAAAAA TTTACTATTC TTGGAGGTAA ACTTCCAAAA 
GGAATTCTTT TAGTTGGACC CCCAGGGACT GGAAAGACAC TTCTTGCCCG AGCTGTGGCG 
GGAGAAGCTG ATGTTCCTTT TTATTATGCT TCTGGATCCG AATTTGATGA GATGTTTGTG 
GGTGTGGGAG CCAGCCGTAT CAGAAATCTT TTTAGGGAAG CAAAGGCGAA TGCTCCTTGT 
GTTATATTTA TTGATGAATT AGATTCTGTT GGTGGGAAGA GAATTGAATC TCCAATGCAT 
CCATATTCAA GGCAGACCAT AAATCAACTT CTTGCTGAAA TGGATGGTTT TAAACCCAAT 
GAAGGAGTTA TCATAATAGG AGCCACAAAC TTCCCAGAGG CATTAGATAA TGCCTTAATA 
CGTCCTGGTC GTTTTGACAT GCAAGTTACA GTTCCAAGGC CAGATGTAAA AGGTCGAACA 
GAAATTTTGA AATGGTATCT CAATAAAATA AAGTTTGATC AATCCGTTGA TCCAGAAATT 
ATAGCTCGAG GTACTGTTGG CTTTTCCGGA GCAGAGTTGG AGAATCTTGT GAACCAGGCT 
GCATTAAAAG CAGCTGTTGA TGGAAAAGAA ATGGTTACCA TGAAGGAGCT GGAGTTTTCC 
AAAGACAAAA TTCTAATGGG GCCTGAAAGA AGAAGTGTGG AAATTGATAA CAAAAACAAA 
ACCATCACAG CATATCATGA ATCTGGTCAT GCCATTATTG CATATTACAC AAAAGATGCA 
ATGCCTATCA ACAAAGCTAC AATCATGCCA CGGGGGCCAA CACTTGGACA TGTGTCCCTG 
TTACCTGAGA ATGACAGATG GAATGAAACT AGAGCCCAGC TGCTTGCACA AATGGATGTT 
AGTATGGGAG GAAGAGTGGC AGAGGAGCTT ATATTTGGAA CCGACCATAT TACAACAGGT 
GCTTCCAGTG ATTTTGATAA TGCCACTAAA ATAGCAAAGC GGATGGTTAC CAAATTTGGA 
ATGAGTGAAA AGCTTGGAGT TATGACCTAC AGTGATACAG GGAAACTAAG TCCAGAAACC 
CAATCTGCCA TCGAACAAGA AATAAGAATC CTTCTAAGGG ACTCATATGA ACGAGCAAAA 
CATATCTTGA AAACTCATGC AAAGGAGCAT AAGAATCTCG CAGAAGCTTT ATTGACCTAT 
GAGACTTTGG ATGCCAAAGA GATTCAAATT GTTCTTGAGG GGAAAAAGTT GGAAGTGAGA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma.
Genome medicine9(1)31(2017 03)
Srinivasainagendra V,Sandel MW,Singh B,Sundaresan A,Mooga VP,Bajpai P,Tiwari HK,Singh KK

Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane.
Nature communications713301(2016 Oct)
Shi H,Rampello AJ,Glynn SE

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation.
eLife5(2016 08)
Hartmann B,Wai T,Hu H,MacVicar T,Musante L,Fischer-Zirnsak B,Stenzel W,Gr?f R,van den Heuvel L,Ropers HH,Wienker TF,H?bner C,Langer T,Kaindl AM

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.
Cell reports14(9)2041-2049(2016 Mar)
Rainbolt TK,Lebeau J,Puchades C,Wiseman RL

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YME1L1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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