CFL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CFL1
Entrez Gene ID	1072
Full Name	cofilin 1
Synonyms	CFL,HEL-S-15,cofilin
General protein information	Preferred Names cofilin 1 Names cofilin-1 18 kDa phosphoprotein cofilin 1 (non-muscle) cofilin, non-muscle isoform epididymis secretory protein Li 15 p18
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.1
Summary	The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004].
Disorder MIM:	601442

mRNA and Protein(s)

mRNA	Protein	Name
NM_005507.3	NP_005498.1	cofilin-1
NM_005507.2	NP_005498.1	cofilin-1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CFL1	NP_001015655.1
Pan troglodytes (chimpanzee)	CFL1	XP_003313184.1
Canis lupus familiaris (dog)	CFL1	XP_533231.1
Rattus norvegicus (Norway rat)	Cfl1	NP_058843.1
Xenopus tropicalis (tropical clawed frog)	cfl1	NP_998878.1
	CFL1	XP_002799522.1
Homo sapiens (human)	CFL1	NP_005498.1
Mus musculus (house mouse)	Cfl1	NP_031713.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance.
Wang L, Xiong L, Wu Z, Miao X, Liu Z, Li D, Zou Q, Yang Z
World journal of surgical oncology16(1)11(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our study indicates that Cofilin 1 holds an important position in the development and progression of human bladder cancer
Title: Study on the significance of Cofilin 1 overexpression in human bladder cancer.

High cofilin expression is associated with adrenocortical tumor.
Title: Cofilin is a cAMP effector in mediating actin cytoskeleton reorganization and steroidogenesis in mouse and human adrenocortical tumor cells.

STMN1,COF1 and PAIRBP1 thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 and POSTN were connected to low grade tumors with better prognosis
Title: Targeted proteomics driven verification of biomarker candidates associated with breast cancer aggressiveness.

Results suggest that the immune-complex (IC) of cofilin-1 in sera is a potentially attractive serum biomarker for the prognosis of pancreatic ductal adenocarcinoma (PDAC).
Title: Immune-complex level of cofilin-1 in sera is associated with cancer progression and poor prognosis in pancreatic cancer.

Our results revealed that CKS1 is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.
Title: Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.

The following CFL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CFL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20311	NM_005507.3 Latest version!	Homo sapiens cofilin 1 (CFL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu20311	NM_005507.2	Homo sapiens cofilin 1 (CFL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CFL1 ( NM_005507.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005498.1 Homo sapiens cofilin 1 (CFL1), mRNA.

Price & Availability↑

CloneID	OHu20311
Clone ID Related Accession (Same CDS sequence)	NM_005507.3 , NM_005507.2
Accession Version	NM_005507.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	cofilin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK097690.1, BC018256.2, CB850882.1 and AP001266.4. On Nov 23, 2018 this sequence version replaced NM_005507.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.75700.1, SRR1163657.204330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000308162.10/ ENSP00000309629.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTCCG GTGTGGCTGT CTCTGATGGT GTCATCAAGG TGTTCAACGA CATGAAGGTG 
CGTAAGTCTT CAACGCCAGA GGAGGTGAAG AAGCGCAAGA AGGCGGTGCT CTTCTGCCTG 
AGTGAGGACA AGAAGAACAT CATCCTGGAG GAGGGCAAGG AGATCCTGGT GGGCGATGTG 
GGCCAGACTG TCGACGACCC CTACGCCACC TTTGTCAAGA TGCTGCCAGA TAAGGACTGC 
CGCTATGCCC TCTATGATGC AACCTATGAG ACCAAGGAGA GCAAGAAGGA GGATCTGGTG 
TTTATCTTCT GGGCCCCCGA GTCTGCGCCC CTTAAGAGCA AAATGATTTA TGCCAGCTCC 
AAGGACGCCA TCAAGAAGAA GCTGACAGGG ATCAAGCATG AATTGCAAGC AAACTGCTAC 
GAGGAGGTCA AGGACCGCTG CACCCTGGCA GAGAAGCTGG GGGGCAGTGC CGTCATCTCC 
CTGGAGGGCA AGCCTTTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005498.1
CDS	82..582
Translation	MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL

Target ORF information:

RefSeq Version	NM_005507.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cofilin 1 (CFL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005507.3

ORF Insert Sequence:

ATGGCCTCCG GTGTGGCTGT CTCTGATGGT GTCATCAAGG TGTTCAACGA CATGAAGGTG 
CGTAAGTCTT CAACGCCAGA GGAGGTGAAG AAGCGCAAGA AGGCGGTGCT CTTCTGCCTG 
AGTGAGGACA AGAAGAACAT CATCCTGGAG GAGGGCAAGG AGATCCTGGT GGGCGATGTG 
GGCCAGACTG TCGACGACCC CTACGCCACC TTTGTCAAGA TGCTGCCAGA TAAGGACTGC 
CGCTATGCCC TCTATGATGC AACCTATGAG ACCAAGGAGA GCAAGAAGGA GGATCTGGTG 
TTTATCTTCT GGGCCCCCGA GTCTGCGCCC CTTAAGAGCA AAATGATTTA TGCCAGCTCC 
AAGGACGCCA TCAAGAAGAA GCTGACAGGG ATCAAGCATG AATTGCAAGC AAACTGCTAC 
GAGGAGGTCA AGGACCGCTG CACCCTGGCA GAGAAGCTGG GGGGCAGTGC CGTCATCTCC 
CTGGAGGGCA AGCCTTTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFL1 ( NM_005507.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005498.1 Homo sapiens cofilin 1 (CFL1), mRNA.

Price & Availability↑

CloneID	OHu20311
Clone ID Related Accession (Same CDS sequence)	NM_005507.3 , NM_005507.2
Accession Version	NM_005507.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	cofilin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK097690.1, BC018256.2 and CB850882.1. On Jun 30, 2004 this sequence version replaced NM_005507.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.244303.1, ERR279834.4639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCG GTGTGGCTGT CTCTGATGGT GTCATCAAGG TGTTCAACGA CATGAAGGTG 
CGTAAGTCTT CAACGCCAGA GGAGGTGAAG AAGCGCAAGA AGGCGGTGCT CTTCTGCCTG 
AGTGAGGACA AGAAGAACAT CATCCTGGAG GAGGGCAAGG AGATCCTGGT GGGCGATGTG 
GGCCAGACTG TCGACGACCC CTACGCCACC TTTGTCAAGA TGCTGCCAGA TAAGGACTGC 
CGCTATGCCC TCTATGATGC AACCTATGAG ACCAAGGAGA GCAAGAAGGA GGATCTGGTG 
TTTATCTTCT GGGCCCCCGA GTCTGCGCCC CTTAAGAGCA AAATGATTTA TGCCAGCTCC 
AAGGACGCCA TCAAGAAGAA GCTGACAGGG ATCAAGCATG AATTGCAAGC AAACTGCTAC 
GAGGAGGTCA AGGACCGCTG CACCCTGGCA GAGAAGCTGG GGGGCAGTGC CGTCATCTCC 
CTGGAGGGCA AGCCTTTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005498.1
CDS	235..735
Translation	MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL

Target ORF information:

RefSeq Version	NM_005507.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cofilin 1 (CFL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005507.2

ORF Insert Sequence:

ATGGCCTCCG GTGTGGCTGT CTCTGATGGT GTCATCAAGG TGTTCAACGA CATGAAGGTG 
CGTAAGTCTT CAACGCCAGA GGAGGTGAAG AAGCGCAAGA AGGCGGTGCT CTTCTGCCTG 
AGTGAGGACA AGAAGAACAT CATCCTGGAG GAGGGCAAGG AGATCCTGGT GGGCGATGTG 
GGCCAGACTG TCGACGACCC CTACGCCACC TTTGTCAAGA TGCTGCCAGA TAAGGACTGC 
CGCTATGCCC TCTATGATGC AACCTATGAG ACCAAGGAGA GCAAGAAGGA GGATCTGGTG 
TTTATCTTCT GGGCCCCCGA GTCTGCGCCC CTTAAGAGCA AAATGATTTA TGCCAGCTCC 
AAGGACGCCA TCAAGAAGAA GCTGACAGGG ATCAAGCATG AATTGCAAGC AAACTGCTAC 
GAGGAGGTCA AGGACCGCTG CACCCTGGCA GAGAAGCTGG GGGGCAGTGC CGTCATCTCC 
CTGGAGGGCA AGCCTTTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance.
World journal of surgical oncology16(1)11(2018 Jan)
Wang L,Xiong L,Wu Z,Miao X,Liu Z,Li D,Zou Q,Yang Z

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CFL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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