CETN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CETN2
Entrez Gene ID	1069
Full Name	centrin 2
Synonyms	CALT,CEN2
General protein information	Preferred Names centrin 2 Names centrin-2 caltractin (20kD calcium-binding protein) centrin, EF-hand protein, 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008].
Disorder MIM:	300006

mRNA and Protein(s)

mRNA	Protein	Name
NM_004344.2	NP_004335.1	centrin-2
NM_004344.3	NP_004335.1	centrin-2
NM_004344.1	NP_004335.1	centrin-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CETN2	NP_004335.1
Bos taurus (cattle)	CETN2	NP_001033604.1
Rattus norvegicus (Norway rat)	Cetn2	XP_215222.5
Danio rerio (zebrafish)	LOC100006257	XP_001345066.1
Oryza sativa (rice)	Os07g0618800	NP_001060290.1
Pan troglodytes (chimpanzee)	CETN2	XP_001139392.3
Canis lupus familiaris (dog)	CETN2	XP_005642021.1
Gallus gallus (chicken)	CETN2	NP_001264569.1
	CETN2	XP_001082083.1
Xenopus tropicalis (tropical clawed frog)	cetn1	NP_001017149.1
Mus musculus (house mouse)	Cetn2	NP_062278.2
Drosophila melanogaster (fruit fly)	CG17493	NP_001036396.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009260	XP_320052.4
Arabidopsis thaliana (thale cress)	CEN2	NP_190605.1

Gene Ontology
Bibliography

Related articles in PubMed

Prp40 Homolog A Is a Novel Centrin Target.
D?az Casas A, Chazin WJ, Pastrana-R?os B
Biophysical journal112(12)2529-2539(2017 Jun)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
Gupta GD, Coyaud ?, Gon?alves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, Bashkurov M, Hasegan M, Knight JD, Lin ZY, Schueler M, Hildebrandt F, Moffat J, Gingras AC, Raught B, Pelletier L
Cell163(6)1484-99(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Multidisciplinary approach showed that HsPrp40Ap interacts with centrin in vitro, supporting a coupled functional role for these proteins in pre-mRNA splicing.
Title: Prp40 Homolog A Is a Novel Centrin Target.

Cetn3 inhibits Mps1 autophosphorylation at Thr-676, a known site of T-loop autoactivation, and interferes with Mps1-dependent phosphorylation of Cetn2. The cellular overexpression of Cetn3 attenuates the incorporation of Cetn2 into centrioles and centrosome reduplication, whereas depletion of Cetn3 generates extra centrioles.
Title: Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function.

Centrin2 regulates primary ciliogenesis through controlling CP110 levels.
Title: Centrin2 regulates CP110 removal in primary cilium formation.

co-depletion of centrin 2 and PCID2 leads to blocking rather than delaying nuclear protein export, indicating the dominance of the centrin 2 phenotype.
Title: Human TREX2 components PCID2 and centrin 2, but not ENY2, have distinct functions in protein export and co-localize to the centrosome.

Data indicate that overexpression of the centrin interactor POC5 leads to the assembly of linear, centrin-dependent structures.
Title: Calcium-binding capacity of centrin2 is required for linear POC5 assembly but not for nucleotide excision repair.

The following CETN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CETN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11608	NM_004344.3 Latest version!	Homo sapiens centrin 2 (CETN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11608	NM_004344.2	Homo sapiens centrin 2 (CETN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11608	NM_004344.1	Homo sapiens centrin 2 (CETN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CETN2 ( NM_004344.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004335.1 Homo sapiens centrin 2 (CETN2), mRNA.

Price & Availability↑

CloneID	OHu11608
Clone ID Related Accession (Same CDS sequence)	NM_004344.2 , NM_004344.3 , NM_004344.1
Accession Version	NM_004344.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-16
Organism	Homo sapiens(human)
Product	centrin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X72964.1 and U82671.5. On May 17, 2019 this sequence version replaced NM_004344.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.84239.1, X72964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCA ACTTTAAGAA GGCAAACATG GCATCAAGTT CTCAGCGAAA AAGAATGAGC 
CCTAAGCCTG AGCTTACTGA AGAGCAAAAG CAGGAGATCC GGGAAGCTTT TGATCTTTTC 
GATGCGGATG GAACTGGCAC CATAGATGTT AAAGAACTGA AGGTGGCAAT GAGGGCCCTG 
GGCTTTGAAC CCAAGAAAGA AGAAATTAAG AAAATGATAA GTGAAATTGA TAAGGAAGGG 
ACAGGAAAAA TGAACTTTGG TGACTTTTTA ACTGTGATGA CCCAGAAAAT GTCTGAGAAA 
GATACTAAAG AAGAAATCCT GAAAGCTTTC AAGCTCTTTG ATGATGATGA AACTGGGAAG 
ATTTCGTTCA AAAATCTGAA ACGCGTGGCC AAGGAGTTGG GTGAGAACCT GACTGATGAG 
GAGCTGCAGG AAATGATTGA TGAAGCTGAT CGAGATGGAG ATGGAGAGGT CAGTGAGCAA 
GAGTTCCTGC GCATCATGAA AAAGACCAGC CTCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004335.1
CDS	48..566
Translation	MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY

Target ORF information:

RefSeq Version	NM_004344.2
Organism	Homo sapiens(human)
Definition	Homo sapiens centrin 2 (CETN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004344.2

ORF Insert Sequence:

ATGGCCTCCA ACTTTAAGAA GGCAAACATG GCATCAAGTT CTCAGCGAAA AAGAATGAGC 
CCTAAGCCTG AGCTTACTGA AGAGCAAAAG CAGGAGATCC GGGAAGCTTT TGATCTTTTC 
GATGCGGATG GAACTGGCAC CATAGATGTT AAAGAACTGA AGGTGGCAAT GAGGGCCCTG 
GGCTTTGAAC CCAAGAAAGA AGAAATTAAG AAAATGATAA GTGAAATTGA TAAGGAAGGG 
ACAGGAAAAA TGAACTTTGG TGACTTTTTA ACTGTGATGA CCCAGAAAAT GTCTGAGAAA 
GATACTAAAG AAGAAATCCT GAAAGCTTTC AAGCTCTTTG ATGATGATGA AACTGGGAAG 
ATTTCGTTCA AAAATCTGAA ACGCGTGGCC AAGGAGTTGG GTGAGAACCT GACTGATGAG 
GAGCTGCAGG AAATGATTGA TGAAGCTGAT CGAGATGGAG ATGGAGAGGT CAGTGAGCAA 
GAGTTCCTGC GCATCATGAA AAAGACCAGC CTCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CETN2 ( NM_004344.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004335.1 Homo sapiens centrin 2 (CETN2), mRNA.

Price & Availability↑

CloneID	OHu11608
Clone ID Related Accession (Same CDS sequence)	NM_004344.2 , NM_004344.3 , NM_004344.1
Accession Version	NM_004344.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	centrin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X72964.1 and U82671.5. On Aug 31, 2019 this sequence version replaced NM_004344.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X72964.1, BC005334.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCA ACTTTAAGAA GGCAAACATG GCATCAAGTT CTCAGCGAAA AAGAATGAGC 
CCTAAGCCTG AGCTTACTGA AGAGCAAAAG CAGGAGATCC GGGAAGCTTT TGATCTTTTC 
GATGCGGATG GAACTGGCAC CATAGATGTT AAAGAACTGA AGGTGGCAAT GAGGGCCCTG 
GGCTTTGAAC CCAAGAAAGA AGAAATTAAG AAAATGATAA GTGAAATTGA TAAGGAAGGG 
ACAGGAAAAA TGAACTTTGG TGACTTTTTA ACTGTGATGA CCCAGAAAAT GTCTGAGAAA 
GATACTAAAG AAGAAATCCT GAAAGCTTTC AAGCTCTTTG ATGATGATGA AACTGGGAAG 
ATTTCGTTCA AAAATCTGAA ACGCGTGGCC AAGGAGTTGG GTGAGAACCT GACTGATGAG 
GAGCTGCAGG AAATGATTGA TGAAGCTGAT CGAGATGGAG ATGGAGAGGT CAGTGAGCAA 
GAGTTCCTGC GCATCATGAA AAAGACCAGC CTCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004335.1
CDS	48..566
Translation	MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY

Target ORF information:

RefSeq Version	NM_004344.3
Organism	Homo sapiens(human)
Definition	Homo sapiens centrin 2 (CETN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004344.3

ORF Insert Sequence:

ATGGCCTCCA ACTTTAAGAA GGCAAACATG GCATCAAGTT CTCAGCGAAA AAGAATGAGC 
CCTAAGCCTG AGCTTACTGA AGAGCAAAAG CAGGAGATCC GGGAAGCTTT TGATCTTTTC 
GATGCGGATG GAACTGGCAC CATAGATGTT AAAGAACTGA AGGTGGCAAT GAGGGCCCTG 
GGCTTTGAAC CCAAGAAAGA AGAAATTAAG AAAATGATAA GTGAAATTGA TAAGGAAGGG 
ACAGGAAAAA TGAACTTTGG TGACTTTTTA ACTGTGATGA CCCAGAAAAT GTCTGAGAAA 
GATACTAAAG AAGAAATCCT GAAAGCTTTC AAGCTCTTTG ATGATGATGA AACTGGGAAG 
ATTTCGTTCA AAAATCTGAA ACGCGTGGCC AAGGAGTTGG GTGAGAACCT GACTGATGAG 
GAGCTGCAGG AAATGATTGA TGAAGCTGAT CGAGATGGAG ATGGAGAGGT CAGTGAGCAA 
GAGTTCCTGC GCATCATGAA AAAGACCAGC CTCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CETN2 ( NM_004344.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_004335.1 Homo sapiens centrin 2 (CETN2), mRNA.

Price & Availability↑

CloneID	OHu11608
Clone ID Related Accession (Same CDS sequence)	NM_004344.2 , NM_004344.3 , NM_004344.1
Accession Version	NM_004344.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	centrin-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X72964.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X72964.1, SRR1163655.453002.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCA ACTTTAAGAA GGCAAACATG GCATCAAGTT CTCAGCGAAA AAGAATGAGC 
CCTAAGCCTG AGCTTACTGA AGAGCAAAAG CAGGAGATCC GGGAAGCTTT TGATCTTTTC 
GATGCGGATG GAACTGGCAC CATAGATGTT AAAGAACTGA AGGTGGCAAT GAGGGCCCTG 
GGCTTTGAAC CCAAGAAAGA AGAAATTAAG AAAATGATAA GTGAAATTGA TAAGGAAGGG 
ACAGGAAAAA TGAACTTTGG TGACTTTTTA ACTGTGATGA CCCAGAAAAT GTCTGAGAAA 
GATACTAAAG AAGAAATCCT GAAAGCTTTC AAGCTCTTTG ATGATGATGA AACTGGGAAG 
ATTTCGTTCA AAAATCTGAA ACGCGTGGCC AAGGAGTTGG GTGAGAACCT GACTGATGAG 
GAGCTGCAGG AAATGATTGA TGAAGCTGAT CGAGATGGAG ATGGAGAGGT CAGTGAGCAA 
GAGTTCCTGC GCATCATGAA AAAGACCAGC CTCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004335.1
CDS	48..566
Translation	MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY

Target ORF information:

RefSeq Version	NM_004344.1
Organism	Homo sapiens(human)
Definition	Homo sapiens centrin 2 (CETN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004344.1

ORF Insert Sequence:

ATGGCCTCCA ACTTTAAGAA GGCAAACATG GCATCAAGTT CTCAGCGAAA AAGAATGAGC 
CCTAAGCCTG AGCTTACTGA AGAGCAAAAG CAGGAGATCC GGGAAGCTTT TGATCTTTTC 
GATGCGGATG GAACTGGCAC CATAGATGTT AAAGAACTGA AGGTGGCAAT GAGGGCCCTG 
GGCTTTGAAC CCAAGAAAGA AGAAATTAAG AAAATGATAA GTGAAATTGA TAAGGAAGGG 
ACAGGAAAAA TGAACTTTGG TGACTTTTTA ACTGTGATGA CCCAGAAAAT GTCTGAGAAA 
GATACTAAAG AAGAAATCCT GAAAGCTTTC AAGCTCTTTG ATGATGATGA AACTGGGAAG 
ATTTCGTTCA AAAATCTGAA ACGCGTGGCC AAGGAGTTGG GTGAGAACCT GACTGATGAG 
GAGCTGCAGG AAATGATTGA TGAAGCTGAT CGAGATGGAG ATGGAGAGGT CAGTGAGCAA 
GAGTTCCTGC GCATCATGAA AAAGACCAGC CTCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prp40 Homolog A Is a Novel Centrin Target.
Biophysical journal112(12)2529-2539(2017 Jun)
D?az Casas A,Chazin WJ,Pastrana-R?os B

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
Cell163(6)1484-99(2015 Dec)
Gupta GD,Coyaud ?,Gon?alves J,Mojarad BA,Liu Y,Wu Q,Gheiratmand L,Comartin D,Tkach JM,Cheung SW,Bashkurov M,Hasegan M,Knight JD,Lin ZY,Schueler M,Hildebrandt F,Moffat J,Gingras AC,Raught B,Pelletier L

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CETN2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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