RRAGA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RRAGA
Entrez Gene ID	10670
Full Name	Ras related GTP binding A
Synonyms	FIP-1,FIP1,RAGA
General protein information	Preferred Names Ras related GTP binding A Names ras-related GTP-binding protein A adenovirus E3 14.7 kDa-interacting protein 1 adenovirus E3-14.7K interacting protein 1 rag A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p22.1
Disorder MIM:	612194

mRNA and Protein(s)

mRNA	Protein	Name
NM_006570.5	NP_006561.1	ras-related GTP-binding protein A
NM_006570.4	NP_006561.1	ras-related GTP-binding protein A

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	gtr1	NP_595414.1
Bos taurus (cattle)	RRAGA	NP_001030576.1
Mus musculus (house mouse)	Rraga	NP_848463.1
Rattus norvegicus (Norway rat)	Rraga	NP_446425.1
Xenopus tropicalis (tropical clawed frog)	rraga	NP_001006897.1
Canis lupus familiaris (dog)	RRAGA	XP_003639405.2
Gallus gallus (chicken)	RRAGB	XP_420287.2
Danio rerio (zebrafish)	rraga	NP_956008.1
Homo sapiens (human)	RRAGA	NP_006561.1
Pan troglodytes (chimpanzee)	RRAGA	XP_528488.3
	RRAGA	XP_002800157.1

Gene Ontology
Bibliography

Related articles in PubMed

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH
Molecular cell68(5)835-846.e3(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Full-length RagA(GTP):RagC(GDP) dimer binds to regulator to activate mTORC1.
Title: Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

The dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing a rationale for why they exist as a dimer and revealing a distinct mode of control for a GTP-binding protein.
Title: Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

NUDT2 is a novel complex formation enhancing factor regulating mTORC1-Rag GTPase signaling that is crucial for cell growth control.
Title: Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization.

The data indicate that the RRAGA mutations, associated with autosomal dominant cataracts, play a role in the disease by acting through disruption of mTORC1 signaling.
Title: Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts.

Data suggest that both microtubule-associated DYNLT (dynein light chain Tctex-type 1) and cytoplasmic DYNLT (dynein 1 intermediate chain 2 DYNC1LI2) are equally able to bind to small GTPases Rab3D (Rab3d GTPase) and RagA (Ras-related GTP binding A).
Title: DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor.

The following RRAGA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RRAGA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30504	NM_006570.5 Latest version!	Homo sapiens Ras related GTP binding A (RRAGA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu30504	NM_006570.4	Homo sapiens Ras related GTP binding A (RRAGA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RRAGA ( NM_006570.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006561.1 Homo sapiens Ras related GTP binding A (RRAGA), mRNA.

Price & Availability↑

CloneID	OHu30504
Clone ID Related Accession (Same CDS sequence)	NM_006570.5 , NM_006570.4
Accession Version	NM_006570.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	ras-related GTP-binding protein A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC009990.2 and BX346838.2. On May 17, 2019 this sequence version replaced NM_006570.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR3476690.413698.1, SRR1660803.162941.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380527.3/ ENSP00000369899.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCAAATA CAGCCATGAA GAAAAAGGTG CTGCTGATGG GGAAGAGCGG GTCGGGGAAG 
ACCAGCATGA GGTCGATAAT CTTCGCCAAT TACATTGCTC GCGACACCCG GCGCCTGGGG 
GCCACCATTG ACGTGGAACA CTCCCACGTC CGATTCCTAG GGAACCTGGT GCTGAACCTG 
TGGGACTGTG GCGGTCAGGA CACCTTCATG GAAAATTACT TCACCAGCCA GCGAGACAAT 
ATCTTCCGTA ACGTGGAAGT TTTGATTTAC GTGTTTGACG TGGAGAGCCG CGAACTGGAA 
AAGGACATGC ATTATTACCA GTCGTGTCTG GAGGCCATCC TCCAGAACTC TCCTGACGCC 
AAAATCTTCT GCCTGGTGCA CAAAATGGAT CTGGTTCAGG AGGATCAGCG TGACCTGATT 
TTTAAAGAGC GAGAGGAAGA CCTGAGGCGT CTGTCTCGCC CGCTGGAGTG TGCTTGTTTT 
CGAACGTCCA TCTGGGATGA GACGCTCTAC AAAGCCTGGT CCAGCATCGT CTACCAGCTG 
ATTCCCAACG TTCAGCAGCT GGAGATGAAC CTCAGGAATT TTGCCCAAAT CATTGAGGCC 
GATGAAGTTC TGCTGTTCGA AAGAGCTACA TTCTTGGTTA TTTCCCACTA CCAGTGCAAA 
GAGCAGCGCG ACGTCCACCG GTTTGAGAAG ATCAGCAACA TCATCAAACA GTTCAAGCTG 
AGCTGCAGTA AATTGGCCGC TTCCTTCCAG AGCATGGAAG TTAGGAATTC CAACTTCGCT 
GCTTTCATCG ACATCTTCAC CTCAAATACG TACGTGATGG TGGTCATGTC AGATCCGTCG 
ATCCCTTCTG CGGCCACTCT GATCAACATT CGCAATGCCC GGAAACACTT TGAGAAGCTG 
GAGAGAGTGG ATGGCCCCAA GCACAGTCTC CTTATGCGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006561.1
CDS	234..1175
Translation	MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR

Target ORF information:

RefSeq Version	NM_006570.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Ras related GTP binding A (RRAGA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006570.5

ORF Insert Sequence:

ATGCCAAATA CAGCCATGAA GAAAAAGGTG CTGCTGATGG GGAAGAGCGG GTCGGGGAAG 
ACCAGCATGA GGTCGATAAT CTTCGCCAAT TACATTGCTC GCGACACCCG GCGCCTGGGG 
GCCACCATTG ACGTGGAACA CTCCCACGTC CGATTCCTAG GGAACCTGGT GCTGAACCTG 
TGGGACTGTG GCGGTCAGGA CACCTTCATG GAAAATTACT TCACCAGCCA GCGAGACAAT 
ATCTTCCGTA ACGTGGAAGT TTTGATTTAC GTGTTTGACG TGGAGAGCCG CGAACTGGAA 
AAGGACATGC ATTATTACCA GTCGTGTCTG GAGGCCATCC TCCAGAACTC TCCTGACGCC 
AAAATCTTCT GCCTGGTGCA CAAAATGGAT CTGGTTCAGG AGGATCAGCG TGACCTGATT 
TTTAAAGAGC GAGAGGAAGA CCTGAGGCGT CTGTCTCGCC CGCTGGAGTG TGCTTGTTTT 
CGAACGTCCA TCTGGGATGA GACGCTCTAC AAAGCCTGGT CCAGCATCGT CTACCAGCTG 
ATTCCCAACG TTCAGCAGCT GGAGATGAAC CTCAGGAATT TTGCCCAAAT CATTGAGGCC 
GATGAAGTTC TGCTGTTCGA AAGAGCTACA TTCTTGGTTA TTTCCCACTA CCAGTGCAAA 
GAGCAGCGCG ACGTCCACCG GTTTGAGAAG ATCAGCAACA TCATCAAACA GTTCAAGCTG 
AGCTGCAGTA AATTGGCCGC TTCCTTCCAG AGCATGGAAG TTAGGAATTC CAACTTCGCT 
GCTTTCATCG ACATCTTCAC CTCAAATACG TACGTGATGG TGGTCATGTC AGATCCGTCG 
ATCCCTTCTG CGGCCACTCT GATCAACATT CGCAATGCCC GGAAACACTT TGAGAAGCTG 
GAGAGAGTGG ATGGCCCCAA GCACAGTCTC CTTATGCGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRAGA ( NM_006570.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006561.1 Homo sapiens Ras related GTP binding A (RRAGA), mRNA.

Price & Availability↑

CloneID	OHu30504
Clone ID Related Accession (Same CDS sequence)	NM_006570.5 , NM_006570.4
Accession Version	NM_006570.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	ras-related GTP-binding protein A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX442654.2, BC009990.2 and BX346838.2. On Jan 15, 2005 this sequence version replaced NM_006570.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGCCAAATA CAGCCATGAA GAAAAAGGTG CTGCTGATGG GGAAGAGCGG GTCGGGGAAG 
ACCAGCATGA GGTCGATAAT CTTCGCCAAT TACATTGCTC GCGACACCCG GCGCCTGGGG 
GCCACCATTG ACGTGGAACA CTCCCACGTC CGATTCCTAG GGAACCTGGT GCTGAACCTG 
TGGGACTGTG GCGGTCAGGA CACCTTCATG GAAAATTACT TCACCAGCCA GCGAGACAAT 
ATCTTCCGTA ACGTGGAAGT TTTGATTTAC GTGTTTGACG TGGAGAGCCG CGAACTGGAA 
AAGGACATGC ATTATTACCA GTCGTGTCTG GAGGCCATCC TCCAGAACTC TCCTGACGCC 
AAAATCTTCT GCCTGGTGCA CAAAATGGAT CTGGTTCAGG AGGATCAGCG TGACCTGATT 
TTTAAAGAGC GAGAGGAAGA CCTGAGGCGT CTGTCTCGCC CGCTGGAGTG TGCTTGTTTT 
CGAACGTCCA TCTGGGATGA GACGCTCTAC AAAGCCTGGT CCAGCATCGT CTACCAGCTG 
ATTCCCAACG TTCAGCAGCT GGAGATGAAC CTCAGGAATT TTGCCCAAAT CATTGAGGCC 
GATGAAGTTC TGCTGTTCGA AAGAGCTACA TTCTTGGTTA TTTCCCACTA CCAGTGCAAA 
GAGCAGCGCG ACGTCCACCG GTTTGAGAAG ATCAGCAACA TCATCAAACA GTTCAAGCTG 
AGCTGCAGTA AATTGGCCGC TTCCTTCCAG AGCATGGAAG TTAGGAATTC CAACTTCGCT 
GCTTTCATCG ACATCTTCAC CTCAAATACG TACGTGATGG TGGTCATGTC AGATCCGTCG 
ATCCCTTCTG CGGCCACTCT GATCAACATT CGCAATGCCC GGAAACACTT TGAGAAGCTG 
GAGAGAGTGG ATGGCCCCAA GCACAGTCTC CTTATGCGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006561.1
CDS	287..1228
Translation	MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR

Target ORF information:

RefSeq Version	NM_006570.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Ras related GTP binding A (RRAGA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006570.4

ORF Insert Sequence:

ATGCCAAATA CAGCCATGAA GAAAAAGGTG CTGCTGATGG GGAAGAGCGG GTCGGGGAAG 
ACCAGCATGA GGTCGATAAT CTTCGCCAAT TACATTGCTC GCGACACCCG GCGCCTGGGG 
GCCACCATTG ACGTGGAACA CTCCCACGTC CGATTCCTAG GGAACCTGGT GCTGAACCTG 
TGGGACTGTG GCGGTCAGGA CACCTTCATG GAAAATTACT TCACCAGCCA GCGAGACAAT 
ATCTTCCGTA ACGTGGAAGT TTTGATTTAC GTGTTTGACG TGGAGAGCCG CGAACTGGAA 
AAGGACATGC ATTATTACCA GTCGTGTCTG GAGGCCATCC TCCAGAACTC TCCTGACGCC 
AAAATCTTCT GCCTGGTGCA CAAAATGGAT CTGGTTCAGG AGGATCAGCG TGACCTGATT 
TTTAAAGAGC GAGAGGAAGA CCTGAGGCGT CTGTCTCGCC CGCTGGAGTG TGCTTGTTTT 
CGAACGTCCA TCTGGGATGA GACGCTCTAC AAAGCCTGGT CCAGCATCGT CTACCAGCTG 
ATTCCCAACG TTCAGCAGCT GGAGATGAAC CTCAGGAATT TTGCCCAAAT CATTGAGGCC 
GATGAAGTTC TGCTGTTCGA AAGAGCTACA TTCTTGGTTA TTTCCCACTA CCAGTGCAAA 
GAGCAGCGCG ACGTCCACCG GTTTGAGAAG ATCAGCAACA TCATCAAACA GTTCAAGCTG 
AGCTGCAGTA AATTGGCCGC TTCCTTCCAG AGCATGGAAG TTAGGAATTC CAACTTCGCT 
GCTTTCATCG ACATCTTCAC CTCAAATACG TACGTGATGG TGGTCATGTC AGATCCGTCG 
ATCCCTTCTG CGGCCACTCT GATCAACATT CGCAATGCCC GGAAACACTT TGAGAAGCTG 
GAGAGAGTGG ATGGCCCCAA GCACAGTCTC CTTATGCGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Molecular cell68(5)835-846.e3(2017 Dec)
Su MY,Morris KL,Kim DJ,Fu Y,Lawrence R,Stjepanovic G,Zoncu R,Hurley JH

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RRAGA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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