SCGB1D2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCGB1D2
Entrez Gene ID	10647
Full Name	secretoglobin family 1D member 2
Synonyms	LIPB,LPHB,LPNB
General protein information	Preferred Names secretoglobin family 1D member 2 Names secretoglobin family 1D member 2 lipophilin-B prostatein-like lipophilin B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.3
Summary	The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008].
Disorder MIM:	615061

mRNA and Protein(s)

mRNA	Protein	Name
XM_006718422.2	XP_006718485.1	secretoglobin family 1D member 2 isoform X1
NM_006551.4	NP_006542.1	secretoglobin family 1D member 2 precursor
NM_006551.3	NP_006542.1	secretoglobin family 1D member 2 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SCGB1D	NP_001071275.1
Pan troglodytes (chimpanzee)	SCGB1D2	XP_001140718.2
	LOC722312	XP_001118473.1
Homo sapiens (human)	SCGB1D2	NP_006542.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential expression of secretoglobins in normal ovary and in ovarian carcinoma--overexpression of mammaglobin-1 is linked to tumor progression.
Fischer K, von Br?nneck AC, Hornung D, Denkert C, Ufer C, Schiebel H, Kuhn H, Borchert A
Archives of biochemistry and biophysics54727-36(2014 Apr)

Secretoglobin expression in ovarian carcinoma: lipophilin B gene upregulation as an independent marker of better prognosis.
Bignotti E, Tassi RA, Calza S, Ravaggi A, Rossi E, Donzelli C, Todeschini P, Romani C, Bandiera E, Zanotti L, Carnazza M, Quadraro F, Tognon G, Sartori E, Pecorelli S, Roque DM, Santin AD
Journal of translational medicine11162(2013 Jul)

Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily.
Jackson BC, Thompson DC, Wright MW, McAndrews M, Bernard A, Nebert DW, Vasiliou V
Human genomics5(6)691-702(2011 Oct)

Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation.
Sj?din A, Ljuslinder I, Henriksson R, Hedman H
Anticancer research28(3A)1493-8(2008 May-Jun)

Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer.
Culleton J, O'Brien N, Ryan BM, Hill AD, McDermott E, O'Higgins N, Duffy MJ
International journal of cancer120(5)1087-92(2007 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data indicate that MGB1, MGB2 and LIPB mRNAs are expressed at low levels in human tissues but basal expression is upregulated in ovarian cancer.
Title: Differential expression of secretoglobins in normal ovary and in ovarian carcinoma--overexpression of mammaglobin-1 is linked to tumor progression.

lipophilin B gene overexpression correlates with a less aggressive tumor phenotype and represents a novel ovarian carcinoma prognostic factor
Title: Secretoglobin expression in ovarian carcinoma: lipophilin B gene upregulation as an independent marker of better prognosis.

Ectopic overexpression of mammaglobin and lipophilin B did not affect the cell proliferation rate of Hs578T breast carcinoma cells in vitro.
Title: Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation.

We conclude that expression of LPB is preferentially but not exclusively restricted to breast tissue.
Title: Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer.

The present report demonstrates, for the first time, lipophilin B expression in the pituitary and its apparent down-regulation in pituitary adenomas.
Title: Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas.

The following SCGB1D2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCGB1D2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05603	NM_006551.4 Latest version!	Homo sapiens secretoglobin family 1D member 2 (SCGB1D2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu05603	XM_006718422.2 Latest version!	Homo sapiens secretoglobin, family 1D, member 2 (SCGB1D2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu05603	NM_006551.3	Homo sapiens secretoglobin family 1D member 2 (SCGB1D2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCGB1D2 ( NM_006551.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006542.1 Homo sapiens secretoglobin family 1D member 2 (SCGB1D2), mRNA.

Price & Availability↑

CloneID	OHu05603
Clone ID Related Accession (Same CDS sequence)	XM_006718422.2 , NM_006551.4 , NM_006551.3
Accession Version	NM_006551.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	secretoglobin family 1D member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP003306.2, AL708956.1 and AJ224172.1. On Nov 22, 2018 this sequence version replaced NM_006551.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL708956.1, BP314377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244926.4/ ENSP00000244926.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCTGT CGGTGTGTCT CCTGCTGGTC ACGCTGGCCC TCTGCTGCTA CCAGGCCAAT 
GCCGAGTTCT GCCCAGCTCT TGTTTCTGAG CTGTTAGACT TCTTCTTCAT TAGTGAACCT 
CTGTTCAAGT TAAGTCTTGC CAAATTTGAT GCCCCTCCGG AAGCTGTTGC AGCCAAGTTA 
GGAGTGAAGA GATGCACGGA TCAGATGTCC CTTCAGAAAC GAAGCCTCAT TGCGGAAGTC 
CTGGTGAAAA TATTGAAGAA ATGTAGTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006542.1
CDS	70..342
Translation	MKLSVCLLLVTLALCCYQANAEFCPALVSELLDFFFISEPLFKLSLAKFDAPPEAVAAKLGVKRCTDQMSLQKRSLIAEVLVKILKKCSV

Target ORF information:

RefSeq Version	NM_006551.4
Organism	Homo sapiens(human)
Definition	Homo sapiens secretoglobin family 1D member 2 (SCGB1D2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006551.4

ORF Insert Sequence:

ATGAAGCTGT CGGTGTGTCT CCTGCTGGTC ACGCTGGCCC TCTGCTGCTA CCAGGCCAAT 
GCCGAGTTCT GCCCAGCTCT TGTTTCTGAG CTGTTAGACT TCTTCTTCAT TAGTGAACCT 
CTGTTCAAGT TAAGTCTTGC CAAATTTGAT GCCCCTCCGG AAGCTGTTGC AGCCAAGTTA 
GGAGTGAAGA GATGCACGGA TCAGATGTCC CTTCAGAAAC GAAGCCTCAT TGCGGAAGTC 
CTGGTGAAAA TATTGAAGAA ATGTAGTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCGB1D2 ( NM_006551.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006542.1 Homo sapiens secretoglobin family 1D member 2 (SCGB1D2), mRNA.

Price & Availability↑

CloneID	OHu05603
Clone ID Related Accession (Same CDS sequence)	XM_006718422.2 , NM_006551.4 , NM_006551.3
Accession Version	NM_006551.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	secretoglobin family 1D member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL708956.1 and AJ224172.1. On Aug 19, 2005 this sequence version replaced NM_006551.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL708956.1, AW015055.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGT CGGTGTGTCT CCTGCTGGTC ACGCTGGCCC TCTGCTGCTA CCAGGCCAAT 
GCCGAGTTCT GCCCAGCTCT TGTTTCTGAG CTGTTAGACT TCTTCTTCAT TAGTGAACCT 
CTGTTCAAGT TAAGTCTTGC CAAATTTGAT GCCCCTCCGG AAGCTGTTGC AGCCAAGTTA 
GGAGTGAAGA GATGCACGGA TCAGATGTCC CTTCAGAAAC GAAGCCTCAT TGCGGAAGTC 
CTGGTGAAAA TATTGAAGAA ATGTAGTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006542.1
CDS	57..329
Translation	MKLSVCLLLVTLALCCYQANAEFCPALVSELLDFFFISEPLFKLSLAKFDAPPEAVAAKLGVKRCTDQMSLQKRSLIAEVLVKILKKCSV

Target ORF information:

RefSeq Version	NM_006551.3
Organism	Homo sapiens(human)
Definition	Homo sapiens secretoglobin family 1D member 2 (SCGB1D2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006551.3

ORF Insert Sequence:

ATGAAGCTGT CGGTGTGTCT CCTGCTGGTC ACGCTGGCCC TCTGCTGCTA CCAGGCCAAT 
GCCGAGTTCT GCCCAGCTCT TGTTTCTGAG CTGTTAGACT TCTTCTTCAT TAGTGAACCT 
CTGTTCAAGT TAAGTCTTGC CAAATTTGAT GCCCCTCCGG AAGCTGTTGC AGCCAAGTTA 
GGAGTGAAGA GATGCACGGA TCAGATGTCC CTTCAGAAAC GAAGCCTCAT TGCGGAAGTC 
CTGGTGAAAA TATTGAAGAA ATGTAGTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCGB1D2 ( XM_006718422.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006718485.1 Homo sapiens secretoglobin, family 1D, member 2 (SCGB1D2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu05603
Clone ID Related Accession (Same CDS sequence)	XM_006718422.2 , NM_006551.4 , NM_006551.3
Accession Version	XM_006718422.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	secretoglobin family 1D member 2 isoform X1
Comment

ATGAAGCTGT CGGTGTGTCT CCTGCTGGTC ACGCTGGCCC TCTGCTGCTA CCAGGCCAAT 
GCCGAGTTCT GCCCAGCTCT TGTTTCTGAG CTGTTAGACT TCTTCTTCAT TAGTGAACCT 
CTGTTCAAGT TAAGTCTTGC CAAATTTGAT GCCCCTCCGG AAGCTGTTGC AGCCAAGTTA 
GGAGTGAAGA GATGCACGGA TCAGATGTCC CTTCAGAAAC GAAGCCTCAT TGCGGAAGTC 
CTGGTGAAAA TATTGAAGAA ATGTAGTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006718485.1
Translation	MKLSVCLLLVTLALCCYQANAEFCPALVSELLDFFFISEPLFKLSLAKFDAPPEAVAAKLGVKRCTDQMSLQKRSLIAEVLVKILKKCSV

Target ORF information:

RefSeq Version	XM_006718422.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens secretoglobin, family 1D, member 2 (SCGB1D2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006718422.2

ORF Insert Sequence:

ATGAAGCTGT CGGTGTGTCT CCTGCTGGTC ACGCTGGCCC TCTGCTGCTA CCAGGCCAAT 
GCCGAGTTCT GCCCAGCTCT TGTTTCTGAG CTGTTAGACT TCTTCTTCAT TAGTGAACCT 
CTGTTCAAGT TAAGTCTTGC CAAATTTGAT GCCCCTCCGG AAGCTGTTGC AGCCAAGTTA 
GGAGTGAAGA GATGCACGGA TCAGATGTCC CTTCAGAAAC GAAGCCTCAT TGCGGAAGTC 
CTGGTGAAAA TATTGAAGAA ATGTAGTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential expression of secretoglobins in normal ovary and in ovarian carcinoma--overexpression of mammaglobin-1 is linked to tumor progression.
Archives of biochemistry and biophysics54727-36(2014 Apr)
Fischer K,von Br?nneck AC,Hornung D,Denkert C,Ufer C,Schiebel H,Kuhn H,Borchert A

Secretoglobin expression in ovarian carcinoma: lipophilin B gene upregulation as an independent marker of better prognosis.
Journal of translational medicine11162(2013 Jul)
Bignotti E,Tassi RA,Calza S,Ravaggi A,Rossi E,Donzelli C,Todeschini P,Romani C,Bandiera E,Zanotti L,Carnazza M,Quadraro F,Tognon G,Sartori E,Pecorelli S,Roque DM,Santin AD

Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily.
Human genomics5(6)691-702(2011 Oct)
Jackson BC,Thompson DC,Wright MW,McAndrews M,Bernard A,Nebert DW,Vasiliou V

Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation.
Anticancer research28(3A)1493-8(2008 May-Jun)
Sj?din A,Ljuslinder I,Henriksson R,Hedman H

Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer.
International journal of cancer120(5)1087-92(2007 Mar)
Culleton J,O'Brien N,Ryan BM,Hill AD,McDermott E,O'Higgins N,Duffy MJ

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SCGB1D2 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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