ATP5MG cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP5MG
Entrez Gene ID	10632
Full Name	ATP synthase membrane subunit g
Synonyms	ATP5JG,ATP5L
General protein information	Preferred Names ATP synthase membrane subunit g Names ATP synthase subunit g, mitochondrial ATP synthase g chain, mitochondrial ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G ATP synthase, H+ transporting, mitochondrial F1F0, subunit g ATP synthase, H+ transporting, mitochondrial Fo complex subunit G ATPase subunit G F1F0-type ATP synthase subunit g F1Fo-ATP synthase complex Fo membrane domain g subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010].
Disorder MIM:	617473

mRNA and Protein(s)

mRNA	Protein	Name
NM_006476.5	NP_006467.4	ATP synthase subunit g, mitochondrial
NM_006476.4	NP_006467.4	ATP synthase subunit g, mitochondrial

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ATP5L	XP_001161526.1
	ATP5L	XP_001098196.1
Mus musculus (house mouse)	Atp5l	NP_038823.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009491	XP_310207.3
Homo sapiens (human)	ATP5L	NP_006467.4
Rattus norvegicus (Norway rat)	Atp5l	NP_997681.1
Danio rerio (zebrafish)	atp5l	NP_956051.1
Xenopus tropicalis (tropical clawed frog)	atp5l	NP_001163975.1
Canis lupus familiaris (dog)	LOC102154486	XP_005627147.1
Gallus gallus (chicken)	ATP5L	XP_004948139.1
Canis lupus familiaris (dog)	ATP5L	XP_003434622.1
Bos taurus (cattle)	ATP5L	NP_001019721.4
Drosophila melanogaster (fruit fly)	l(2)06225	NP_001036353.1

Gene Ontology
Bibliography

Related articles in PubMed

Low energy costs of F1Fo ATP synthase reversal in colon carcinoma cells deficient in mitochondrial complex IV.
Zhdanov AV, Andreev DE, Baranov PV, Papkovsky DB
Free radical biology & medicine106184-195(2017 May)

miR-570 interacts with mitochondrial ATPase subunit g (ATP5L) encoding mRNA in stored platelets.
Dahiya N, Sarachana T, Kulkarni S, Wood WH III, Zhang Y, Becker KG, Wang BD, Atreya CD
Platelets28(1)74-81(2017 01)

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ
Molecular cell63(4)621-632(2016 Aug)

MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X
Carcinogenesis31(12)2118-23(2010 Dec)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study demonstrates that F1Fo ATP synthase can support general mitochondrial and cellular functions, working in extremely efficient 'energy saving' reverse mode and flexibly recruiting free radical detoxication and ATP producing / transporting pathways.
Title: Low energy costs of F1Fo ATP synthase reversal in colon carcinoma cells deficient in mitochondrial complex IV.

Overexpression of miR-570-3p in platelets resulted in reduced levels of ATP5L mRNA and concomitant ATP loss.
Title: miR-570 interacts with mitochondrial ATPase subunit g (ATP5L) encoding mRNA in stored platelets.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following ATP5MG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP5MG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29716	NM_006476.5 Latest version!	Homo sapiens ATP synthase membrane subunit g (ATP5MG), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29716	NM_006476.4	Homo sapiens ATP synthase membrane subunit g (ATP5MG), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP5MG ( NM_006476.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006467.4 Homo sapiens ATP synthase membrane subunit g (ATP5MG), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29716
Clone ID Related Accession (Same CDS sequence)	NM_006476.5 , NM_006476.4
Accession Version	NM_006476.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	ATP synthase subunit g, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA258888.1, BC070165.1 and AI337729.1. On Nov 23, 2018 this sequence version replaced NM_006476.4. Transcript Variant: This variant (1) represents the shorter transcript and is protein coding. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.136332.1, SRR5189655.120912.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000300688.8/ ENSP00000300688.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCAAT TTGTCCGTAA CCTTGTGGAG AAGACCCCGG CGCTGGTGAA CGCTGCTGTG 
ACTTACTCGA AGCCTCGATT GGCCACATTT TGGTACTACG CCAAGGTTGA GCTGGTTCCT 
CCCACCCCTG CTGAGATCCC TAGAGCTATT CAGAGCCTGA AAAAAATAGT CAATAGTGCT 
CAGACTGGTA GCTTCAAACA GCTCACAGTT AAGGAAGCTG TGCTGAATGG TTTGGTGGCC 
ACTGAGGTGT TGATGTGGTT TTATGTCGGA GAGATTATAG GCAAGCGGGG CATCATTGGC 
TATGATGTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006467.4
CDS	61..372
Translation	MAQFVRNLVEKTPALVNAAVTYSKPRLATFWYYAKVELVPPTPAEIPRAIQSLKKIVNSAQTGSFKQLTVKEAVLNGLVATEVLMWFYVGEIIGKRGIIGYDV

Target ORF information:

RefSeq Version	NM_006476.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit g (ATP5MG), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006476.5

ORF Insert Sequence:

ATGGCCCAAT TTGTCCGTAA CCTTGTGGAG AAGACCCCGG CGCTGGTGAA CGCTGCTGTG 
ACTTACTCGA AGCCTCGATT GGCCACATTT TGGTACTACG CCAAGGTTGA GCTGGTTCCT 
CCCACCCCTG CTGAGATCCC TAGAGCTATT CAGAGCCTGA AAAAAATAGT CAATAGTGCT 
CAGACTGGTA GCTTCAAACA GCTCACAGTT AAGGAAGCTG TGCTGAATGG TTTGGTGGCC 
ACTGAGGTGT TGATGTGGTT TTATGTCGGA GAGATTATAG GCAAGCGGGG CATCATTGGC 
TATGATGTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5MG ( NM_006476.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006467.4 Homo sapiens ATP synthase membrane subunit g (ATP5MG), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29716
Clone ID Related Accession (Same CDS sequence)	NM_006476.5 , NM_006476.4
Accession Version	NM_006476.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	ATP synthase subunit g, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA258888.1, BC070165.1 and AI337729.1. On Aug 20, 2004 this sequence version replaced NM_006476.3. Transcript Variant: This variant (1) represents the shorter transcript and is protein coding. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.171767.1, SRR1660809.8470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAAT TTGTCCGTAA CCTTGTGGAG AAGACCCCGG CGCTGGTGAA CGCTGCTGTG 
ACTTACTCGA AGCCTCGATT GGCCACATTT TGGTACTACG CCAAGGTTGA GCTGGTTCCT 
CCCACCCCTG CTGAGATCCC TAGAGCTATT CAGAGCCTGA AAAAAATAGT CAATAGTGCT 
CAGACTGGTA GCTTCAAACA GCTCACAGTT AAGGAAGCTG TGCTGAATGG TTTGGTGGCC 
ACTGAGGTGT TGATGTGGTT TTATGTCGGA GAGATTATAG GCAAGCGGGG CATCATTGGC 
TATGATGTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006467.4
CDS	278..589
Translation	MAQFVRNLVEKTPALVNAAVTYSKPRLATFWYYAKVELVPPTPAEIPRAIQSLKKIVNSAQTGSFKQLTVKEAVLNGLVATEVLMWFYVGEIIGKRGIIGYDV

Target ORF information:

RefSeq Version	NM_006476.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit g (ATP5MG), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006476.4

ORF Insert Sequence:

ATGGCCCAAT TTGTCCGTAA CCTTGTGGAG AAGACCCCGG CGCTGGTGAA CGCTGCTGTG 
ACTTACTCGA AGCCTCGATT GGCCACATTT TGGTACTACG CCAAGGTTGA GCTGGTTCCT 
CCCACCCCTG CTGAGATCCC TAGAGCTATT CAGAGCCTGA AAAAAATAGT CAATAGTGCT 
CAGACTGGTA GCTTCAAACA GCTCACAGTT AAGGAAGCTG TGCTGAATGG TTTGGTGGCC 
ACTGAGGTGT TGATGTGGTT TTATGTCGGA GAGATTATAG GCAAGCGGGG CATCATTGGC 
TATGATGTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Low energy costs of F1Fo ATP synthase reversal in colon carcinoma cells deficient in mitochondrial complex IV.
Free radical biology & medicine106184-195(2017 May)
Zhdanov AV,Andreev DE,Baranov PV,Papkovsky DB

miR-570 interacts with mitochondrial ATPase subunit g (ATP5L) encoding mRNA in stored platelets.
Platelets28(1)74-81(2017 01)
Dahiya N,Sarachana T,Kulkarni S,Wood WH III,Zhang Y,Becker KG,Wang BD,Atreya CD

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Molecular cell63(4)621-632(2016 Aug)
Floyd BJ,Wilkerson EM,Veling MT,Minogue CE,Xia C,Beebe ET,Wrobel RL,Cho H,Kremer LS,Alston CL,Gromek KA,Dolan BK,Ulbrich A,Stefely JA,Bohl SL,Werner KM,Jochem A,Westphall MS,Rensvold JW,Taylor RW,Prokisch H,Kim JP,Coon JJ,Pagliarini DJ

MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Carcinogenesis31(12)2118-23(2010 Dec)
Zhang X,Yang H,Lee JJ,Kim E,Lippman SM,Khuri FR,Spitz MR,Lotan R,Hong WK,Wu X

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

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ATP5MG cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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