PAICS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PAICS
Entrez Gene ID	10606
Full Name	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Synonyms	ADE2,ADE2H1,AIRC,PAIS
General protein information	Preferred Names phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Names multifunctional protein ADE2 AIR carboxylase SAICAR synthetase multifunctional protein ADE2H1 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q12
Summary	This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	172439

mRNA and Protein(s)

mRNA	Protein	Name
NM_001079524.1	NP_001072992.1	multifunctional protein ADE2 isoform 2
NM_001079525.2	NP_001072993.1	multifunctional protein ADE2 isoform 1
NM_001079524.2	NP_001072992.1	multifunctional protein ADE2 isoform 2
NM_001079525.1	NP_001072993.1	multifunctional protein ADE2 isoform 1
NM_006452.3	NP_006443.1	multifunctional protein ADE2 isoform 2
XM_011534366.1	XP_011532668.1	multifunctional protein ADE2 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Paics	NP_080215.1
Drosophila melanogaster (fruit fly)	ade5	NP_572826.1
Pan troglodytes (chimpanzee)	PAICS	XP_526618.2
Gallus gallus (chicken)	PAICS	NP_990855.1
Homo sapiens (human)	PAICS	NP_001072993.1
Danio rerio (zebrafish)	paics	NP_955831.1
Xenopus tropicalis (tropical clawed frog)	LOC100488155	XP_004911255.1
Bos taurus (cattle)	PAICS	NP_991382.2
Canis lupus familiaris (dog)	PAICS	XP_005628281.1
Rattus norvegicus (Norway rat)	Paics	NP_543186.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000180	XP_310955.4
Caenorhabditis elegans (roundworm)	B0286.3	NP_494771.1

Gene Ontology
Bibliography

Related articles in PubMed

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.
Goswami MT, Chen G, Chakravarthi BV, Pathi SS, Anand SK, Carskadon SL, Giordano TJ, Chinnaiyan AM, Thomas DG, Palanisamy N, Beer DG, Varambally S
Oncotarget6(27)23445-61(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

purine biosynthetic pathway enzymes PPAT and PAICS, as well as pyruvate kinase activity are increased in lung cancer
Title: Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Human variation in alcohol response is influenced by variation in neuronal signaling genes.

Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.

The following PAICS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAICS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05356	NM_001079525.2 Latest version!	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu30205	NM_006452.3 Latest version!	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu30205	NM_001079524.2 Latest version!	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu64181	XM_011534366.1 Latest version!	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu30205	NM_001079524.1	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu05356	NM_001079525.1	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$251.30 $359.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PAICS ( NM_001079525.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001072993.1 Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu05356
Clone ID Related Accession (Same CDS sequence)	NM_001079525.2 , NM_001079525.1
Accession Version	NM_001079525.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	multifunctional protein ADE2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CR749824.1, AC068620.5, BM807012.1, AC114766.5 and AA669362.1. On Jun 2, 2019 this sequence version replaced NM_001079525.1. Transcript Variant: This variant (1) represents one of the longest transcripts and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR749824.1, SRR1660807.41769.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGTTACCT CATATAAGTC AAATCGTATT 
AAAACTGCCT TCACCAGAAA ATGTGGGGAG ACAGCTTTCA TTGCACCGCA GTGTGAAATG 
ATTCCAATTG AATGGGTTTG CAGAAGAATA GCAACTGGTT CTTTTCTCAA AAGAAATCCT 
GGTGTCAAGG AAGGATATAA GTTTTACCCA CCTAAAGTGG AGTTGTTTTT CAAGGATGAT 
GCCAATAATG ACCCACAGTG GTCTGAGGAA CAGCTGATTG CTGCAAAATT TTGCTTTGCT 
GGACTTCTTA TAGGCCAGAC TGAAGTGGAT ATCATGAGTC ATGCTACACA GGCTATATTT 
GAAATACTGG AGAAATCCTG GTTGCCCCAG AATTGTACAC TGGTTGATAT GAAGATTGAA 
TTTGGTGTTG ATGTAACCAC CAAAGAAATT GTTCTTGCTG ATGTTATTGA CAATGATTCC 
TGGAGACTCT GGCCATCAGG AGATCGAAGC CAACAGAAAG ACAAACAGTC TTATCGGGAC 
CTCAAAGAAG TAACTCCTGA AGGGCTCCAA ATGGTAAAGA AAAACTTTGA GTGGGTTGCA 
GAGAGAGTAG AGTTGCTTTT GAAATCAGAA AGTCAGTGCA GGGTTGTAGT GTTGATGGGC 
TCTACTTCTG ATCTTGGTCA CTGTGAAAAA ATCAAGAAGG CCTGTGGAAA TTTTGGCATT 
CCATGTGAAC TTCGAGTAAC ATCTGCGCAT AAAGGACCAG ATGAAACTCT GAGGATTAAA 
GCTGAGTATG AAGGGGATGG CATTCCTACT GTATTTGTGG CAGTGGCAGG CAGAAGTAAT 
GGTTTGGGAC CAGTGATGTC TGGGAACACT GCATATCCAG TTATCAGCTG TCCTCCCCTC 
ACACCAGACT GGGGAGTTCA GGATGTGTGG TCTTCTCTTC GACTACCCAG TGGTCTTGGC 
TGTTCAACCG TACTTTCTCC AGAAGGATCA GCTCAATTTG CTGCTCAGAT ATTTGGGTTA 
AGCAACCATT TGGTATGGAG CAAACTGCGA GCAAGCATTT TGAACACATG GATTTCCTTG 
AAGCAGGCTG ACAAGAAAAT CAGAGAATGT AATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001072993.1
CDS	54..1352
Translation	MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAVTSYKSNRIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL

Target ORF information:

RefSeq Version	NM_001079525.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079525.2

ORF Insert Sequence:

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGTTACCT CATATAAGTC AAATCGTATT 
AAAACTGCCT TCACCAGAAA ATGTGGGGAG ACAGCTTTCA TTGCACCGCA GTGTGAAATG 
ATTCCAATTG AATGGGTTTG CAGAAGAATA GCAACTGGTT CTTTTCTCAA AAGAAATCCT 
GGTGTCAAGG AAGGATATAA GTTTTACCCA CCTAAAGTGG AGTTGTTTTT CAAGGATGAT 
GCCAATAATG ACCCACAGTG GTCTGAGGAA CAGCTGATTG CTGCAAAATT TTGCTTTGCT 
GGACTTCTTA TAGGCCAGAC TGAAGTGGAT ATCATGAGTC ATGCTACACA GGCTATATTT 
GAAATACTGG AGAAATCCTG GTTGCCCCAG AATTGTACAC TGGTTGATAT GAAGATTGAA 
TTTGGTGTTG ATGTAACCAC CAAAGAAATT GTTCTTGCTG ATGTTATTGA CAATGATTCC 
TGGAGACTCT GGCCATCAGG AGATCGAAGC CAACAGAAAG ACAAACAGTC TTATCGGGAC 
CTCAAAGAAG TAACTCCTGA AGGGCTCCAA ATGGTAAAGA AAAACTTTGA GTGGGTTGCA 
GAGAGAGTAG AGTTGCTTTT GAAATCAGAA AGTCAGTGCA GGGTTGTAGT GTTGATGGGC 
TCTACTTCTG ATCTTGGTCA CTGTGAAAAA ATCAAGAAGG CCTGTGGAAA TTTTGGCATT 
CCATGTGAAC TTCGAGTAAC ATCTGCGCAT AAAGGACCAG ATGAAACTCT GAGGATTAAA 
GCTGAGTATG AAGGGGATGG CATTCCTACT GTATTTGTGG CAGTGGCAGG CAGAAGTAAT 
GGTTTGGGAC CAGTGATGTC TGGGAACACT GCATATCCAG TTATCAGCTG TCCTCCCCTC 
ACACCAGACT GGGGAGTTCA GGATGTGTGG TCTTCTCTTC GACTACCCAG TGGTCTTGGC 
TGTTCAACCG TACTTTCTCC AGAAGGATCA GCTCAATTTG CTGCTCAGAT ATTTGGGTTA 
AGCAACCATT TGGTATGGAG CAAACTGCGA GCAAGCATTT TGAACACATG GATTTCCTTG 
AAGCAGGCTG ACAAGAAAAT CAGAGAATGT AATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAICS ( NM_001079524.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001072992.1 Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu30205
Clone ID Related Accession (Same CDS sequence)	NM_001079524.1 , NM_001079524.2 , NM_006452.3
Accession Version	NM_001079524.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	multifunctional protein ADE2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB503040.1, CF994644.1, BC019255.1, AC114766.5 and AA669362.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon in the CDS, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.212123.1, SRR1803617.187982.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGGTATTA AAACTGCCTT CACCAGAAAA 
TGTGGGGAGA CAGCTTTCAT TGCACCGCAG TGTGAAATGA TTCCAATTGA ATGGGTTTGC 
AGAAGAATAG CAACTGGTTC TTTTCTCAAA AGAAATCCTG GTGTCAAGGA AGGATATAAG 
TTTTACCCAC CTAAAGTGGA GTTGTTTTTC AAGGATGATG CCAATAATGA CCCACAGTGG 
TCTGAGGAAC AGCTGATTGC TGCAAAATTT TGCTTTGCTG GACTTCTTAT AGGCCAGACT 
GAAGTGGATA TCATGAGTCA TGCTACACAG GCTATATTTG AAATACTGGA GAAATCCTGG 
TTGCCCCAGA ATTGTACACT GGTTGATATG AAGATTGAAT TTGGTGTTGA TGTAACCACC 
AAAGAAATTG TTCTTGCTGA TGTTATTGAC AATGATTCCT GGAGACTCTG GCCATCAGGA 
GATCGAAGCC AACAGAAAGA CAAACAGTCT TATCGGGACC TCAAAGAAGT AACTCCTGAA 
GGGCTCCAAA TGGTAAAGAA AAACTTTGAG TGGGTTGCAG AGAGAGTAGA GTTGCTTTTG 
AAATCAGAAA GTCAGTGCAG GGTTGTAGTG TTGATGGGCT CTACTTCTGA TCTTGGTCAC 
TGTGAAAAAA TCAAGAAGGC CTGTGGAAAT TTTGGCATTC CATGTGAACT TCGAGTAACA 
TCTGCGCATA AAGGACCAGA TGAAACTCTG AGGATTAAAG CTGAGTATGA AGGGGATGGC 
ATTCCTACTG TATTTGTGGC AGTGGCAGGC AGAAGTAATG GTTTGGGACC AGTGATGTCT 
GGGAACACTG CATATCCAGT TATCAGCTGT CCTCCCCTCA CACCAGACTG GGGAGTTCAG 
GATGTGTGGT CTTCTCTTCG ACTACCCAGT GGTCTTGGCT GTTCAACCGT ACTTTCTCCA 
GAAGGATCAG CTCAATTTGC TGCTCAGATA TTTGGGTTAA GCAACCATTT GGTATGGAGC 
AAACTGCGAG CAAGCATTTT GAACACATGG ATTTCCTTGA AGCAGGCTGA CAAGAAAATC 
AGAGAATGTA ATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001072992.1
CDS	211..1488
Translation	MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL

Target ORF information:

RefSeq Version	NM_001079524.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079524.1

ORF Insert Sequence:

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGGTATTA AAACTGCCTT CACCAGAAAA 
TGTGGGGAGA CAGCTTTCAT TGCACCGCAG TGTGAAATGA TTCCAATTGA ATGGGTTTGC 
AGAAGAATAG CAACTGGTTC TTTTCTCAAA AGAAATCCTG GTGTCAAGGA AGGATATAAG 
TTTTACCCAC CTAAAGTGGA GTTGTTTTTC AAGGATGATG CCAATAATGA CCCACAGTGG 
TCTGAGGAAC AGCTGATTGC TGCAAAATTT TGCTTTGCTG GACTTCTTAT AGGCCAGACT 
GAAGTGGATA TCATGAGTCA TGCTACACAG GCTATATTTG AAATACTGGA GAAATCCTGG 
TTGCCCCAGA ATTGTACACT GGTTGATATG AAGATTGAAT TTGGTGTTGA TGTAACCACC 
AAAGAAATTG TTCTTGCTGA TGTTATTGAC AATGATTCCT GGAGACTCTG GCCATCAGGA 
GATCGAAGCC AACAGAAAGA CAAACAGTCT TATCGGGACC TCAAAGAAGT AACTCCTGAA 
GGGCTCCAAA TGGTAAAGAA AAACTTTGAG TGGGTTGCAG AGAGAGTAGA GTTGCTTTTG 
AAATCAGAAA GTCAGTGCAG GGTTGTAGTG TTGATGGGCT CTACTTCTGA TCTTGGTCAC 
TGTGAAAAAA TCAAGAAGGC CTGTGGAAAT TTTGGCATTC CATGTGAACT TCGAGTAACA 
TCTGCGCATA AAGGACCAGA TGAAACTCTG AGGATTAAAG CTGAGTATGA AGGGGATGGC 
ATTCCTACTG TATTTGTGGC AGTGGCAGGC AGAAGTAATG GTTTGGGACC AGTGATGTCT 
GGGAACACTG CATATCCAGT TATCAGCTGT CCTCCCCTCA CACCAGACTG GGGAGTTCAG 
GATGTGTGGT CTTCTCTTCG ACTACCCAGT GGTCTTGGCT GTTCAACCGT ACTTTCTCCA 
GAAGGATCAG CTCAATTTGC TGCTCAGATA TTTGGGTTAA GCAACCATTT GGTATGGAGC 
AAACTGCGAG CAAGCATTTT GAACACATGG ATTTCCTTGA AGCAGGCTGA CAAGAAAATC 
AGAGAATGTA ATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAICS ( NM_001079524.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001072992.1 Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu30205
Clone ID Related Accession (Same CDS sequence)	NM_001079524.1 , NM_001079524.2 , NM_006452.3
Accession Version	NM_001079524.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	multifunctional protein ADE2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC019255.1, AC114766.5 and AA669362.1. On Jun 2, 2019 this sequence version replaced NM_001079524.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon in the CDS, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.208291.1, SRR1803617.206701.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGGTATTA AAACTGCCTT CACCAGAAAA 
TGTGGGGAGA CAGCTTTCAT TGCACCGCAG TGTGAAATGA TTCCAATTGA ATGGGTTTGC 
AGAAGAATAG CAACTGGTTC TTTTCTCAAA AGAAATCCTG GTGTCAAGGA AGGATATAAG 
TTTTACCCAC CTAAAGTGGA GTTGTTTTTC AAGGATGATG CCAATAATGA CCCACAGTGG 
TCTGAGGAAC AGCTGATTGC TGCAAAATTT TGCTTTGCTG GACTTCTTAT AGGCCAGACT 
GAAGTGGATA TCATGAGTCA TGCTACACAG GCTATATTTG AAATACTGGA GAAATCCTGG 
TTGCCCCAGA ATTGTACACT GGTTGATATG AAGATTGAAT TTGGTGTTGA TGTAACCACC 
AAAGAAATTG TTCTTGCTGA TGTTATTGAC AATGATTCCT GGAGACTCTG GCCATCAGGA 
GATCGAAGCC AACAGAAAGA CAAACAGTCT TATCGGGACC TCAAAGAAGT AACTCCTGAA 
GGGCTCCAAA TGGTAAAGAA AAACTTTGAG TGGGTTGCAG AGAGAGTAGA GTTGCTTTTG 
AAATCAGAAA GTCAGTGCAG GGTTGTAGTG TTGATGGGCT CTACTTCTGA TCTTGGTCAC 
TGTGAAAAAA TCAAGAAGGC CTGTGGAAAT TTTGGCATTC CATGTGAACT TCGAGTAACA 
TCTGCGCATA AAGGACCAGA TGAAACTCTG AGGATTAAAG CTGAGTATGA AGGGGATGGC 
ATTCCTACTG TATTTGTGGC AGTGGCAGGC AGAAGTAATG GTTTGGGACC AGTGATGTCT 
GGGAACACTG CATATCCAGT TATCAGCTGT CCTCCCCTCA CACCAGACTG GGGAGTTCAG 
GATGTGTGGT CTTCTCTTCG ACTACCCAGT GGTCTTGGCT GTTCAACCGT ACTTTCTCCA 
GAAGGATCAG CTCAATTTGC TGCTCAGATA TTTGGGTTAA GCAACCATTT GGTATGGAGC 
AAACTGCGAG CAAGCATTTT GAACACATGG ATTTCCTTGA AGCAGGCTGA CAAGAAAATC 
AGAGAATGTA ATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001072992.1
CDS	54..1331
Translation	MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL

Target ORF information:

RefSeq Version	NM_001079524.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079524.2

ORF Insert Sequence:

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGGTATTA AAACTGCCTT CACCAGAAAA 
TGTGGGGAGA CAGCTTTCAT TGCACCGCAG TGTGAAATGA TTCCAATTGA ATGGGTTTGC 
AGAAGAATAG CAACTGGTTC TTTTCTCAAA AGAAATCCTG GTGTCAAGGA AGGATATAAG 
TTTTACCCAC CTAAAGTGGA GTTGTTTTTC AAGGATGATG CCAATAATGA CCCACAGTGG 
TCTGAGGAAC AGCTGATTGC TGCAAAATTT TGCTTTGCTG GACTTCTTAT AGGCCAGACT 
GAAGTGGATA TCATGAGTCA TGCTACACAG GCTATATTTG AAATACTGGA GAAATCCTGG 
TTGCCCCAGA ATTGTACACT GGTTGATATG AAGATTGAAT TTGGTGTTGA TGTAACCACC 
AAAGAAATTG TTCTTGCTGA TGTTATTGAC AATGATTCCT GGAGACTCTG GCCATCAGGA 
GATCGAAGCC AACAGAAAGA CAAACAGTCT TATCGGGACC TCAAAGAAGT AACTCCTGAA 
GGGCTCCAAA TGGTAAAGAA AAACTTTGAG TGGGTTGCAG AGAGAGTAGA GTTGCTTTTG 
AAATCAGAAA GTCAGTGCAG GGTTGTAGTG TTGATGGGCT CTACTTCTGA TCTTGGTCAC 
TGTGAAAAAA TCAAGAAGGC CTGTGGAAAT TTTGGCATTC CATGTGAACT TCGAGTAACA 
TCTGCGCATA AAGGACCAGA TGAAACTCTG AGGATTAAAG CTGAGTATGA AGGGGATGGC 
ATTCCTACTG TATTTGTGGC AGTGGCAGGC AGAAGTAATG GTTTGGGACC AGTGATGTCT 
GGGAACACTG CATATCCAGT TATCAGCTGT CCTCCCCTCA CACCAGACTG GGGAGTTCAG 
GATGTGTGGT CTTCTCTTCG ACTACCCAGT GGTCTTGGCT GTTCAACCGT ACTTTCTCCA 
GAAGGATCAG CTCAATTTGC TGCTCAGATA TTTGGGTTAA GCAACCATTT GGTATGGAGC 
AAACTGCGAG CAAGCATTTT GAACACATGG ATTTCCTTGA AGCAGGCTGA CAAGAAAATC 
AGAGAATGTA ATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAICS ( NM_006452.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006443.1 Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 2, mRNA.

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CloneID	OHu30205
Clone ID Related Accession (Same CDS sequence)	NM_001079524.1 , NM_001079524.2 , NM_006452.3
Accession Version	NM_006452.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	multifunctional protein ADE2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN337183.1, BC010273.1, AC114766.5 and AA669362.1. On Dec 8, 2006 this sequence version replaced NM_006452.2. Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the CDS, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.41909.1, SRR1660805.175198.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGGTATTA AAACTGCCTT CACCAGAAAA 
TGTGGGGAGA CAGCTTTCAT TGCACCGCAG TGTGAAATGA TTCCAATTGA ATGGGTTTGC 
AGAAGAATAG CAACTGGTTC TTTTCTCAAA AGAAATCCTG GTGTCAAGGA AGGATATAAG 
TTTTACCCAC CTAAAGTGGA GTTGTTTTTC AAGGATGATG CCAATAATGA CCCACAGTGG 
TCTGAGGAAC AGCTGATTGC TGCAAAATTT TGCTTTGCTG GACTTCTTAT AGGCCAGACT 
GAAGTGGATA TCATGAGTCA TGCTACACAG GCTATATTTG AAATACTGGA GAAATCCTGG 
TTGCCCCAGA ATTGTACACT GGTTGATATG AAGATTGAAT TTGGTGTTGA TGTAACCACC 
AAAGAAATTG TTCTTGCTGA TGTTATTGAC AATGATTCCT GGAGACTCTG GCCATCAGGA 
GATCGAAGCC AACAGAAAGA CAAACAGTCT TATCGGGACC TCAAAGAAGT AACTCCTGAA 
GGGCTCCAAA TGGTAAAGAA AAACTTTGAG TGGGTTGCAG AGAGAGTAGA GTTGCTTTTG 
AAATCAGAAA GTCAGTGCAG GGTTGTAGTG TTGATGGGCT CTACTTCTGA TCTTGGTCAC 
TGTGAAAAAA TCAAGAAGGC CTGTGGAAAT TTTGGCATTC CATGTGAACT TCGAGTAACA 
TCTGCGCATA AAGGACCAGA TGAAACTCTG AGGATTAAAG CTGAGTATGA AGGGGATGGC 
ATTCCTACTG TATTTGTGGC AGTGGCAGGC AGAAGTAATG GTTTGGGACC AGTGATGTCT 
GGGAACACTG CATATCCAGT TATCAGCTGT CCTCCCCTCA CACCAGACTG GGGAGTTCAG 
GATGTGTGGT CTTCTCTTCG ACTACCCAGT GGTCTTGGCT GTTCAACCGT ACTTTCTCCA 
GAAGGATCAG CTCAATTTGC TGCTCAGATA TTTGGGTTAA GCAACCATTT GGTATGGAGC 
AAACTGCGAG CAAGCATTTT GAACACATGG ATTTCCTTGA AGCAGGCTGA CAAGAAAATC 
AGAGAATGTA ATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006443.1
CDS	232..1509
Translation	MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL

Target ORF information:

RefSeq Version	NM_006452.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006452.3

ORF Insert Sequence:

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGGTATTA AAACTGCCTT CACCAGAAAA 
TGTGGGGAGA CAGCTTTCAT TGCACCGCAG TGTGAAATGA TTCCAATTGA ATGGGTTTGC 
AGAAGAATAG CAACTGGTTC TTTTCTCAAA AGAAATCCTG GTGTCAAGGA AGGATATAAG 
TTTTACCCAC CTAAAGTGGA GTTGTTTTTC AAGGATGATG CCAATAATGA CCCACAGTGG 
TCTGAGGAAC AGCTGATTGC TGCAAAATTT TGCTTTGCTG GACTTCTTAT AGGCCAGACT 
GAAGTGGATA TCATGAGTCA TGCTACACAG GCTATATTTG AAATACTGGA GAAATCCTGG 
TTGCCCCAGA ATTGTACACT GGTTGATATG AAGATTGAAT TTGGTGTTGA TGTAACCACC 
AAAGAAATTG TTCTTGCTGA TGTTATTGAC AATGATTCCT GGAGACTCTG GCCATCAGGA 
GATCGAAGCC AACAGAAAGA CAAACAGTCT TATCGGGACC TCAAAGAAGT AACTCCTGAA 
GGGCTCCAAA TGGTAAAGAA AAACTTTGAG TGGGTTGCAG AGAGAGTAGA GTTGCTTTTG 
AAATCAGAAA GTCAGTGCAG GGTTGTAGTG TTGATGGGCT CTACTTCTGA TCTTGGTCAC 
TGTGAAAAAA TCAAGAAGGC CTGTGGAAAT TTTGGCATTC CATGTGAACT TCGAGTAACA 
TCTGCGCATA AAGGACCAGA TGAAACTCTG AGGATTAAAG CTGAGTATGA AGGGGATGGC 
ATTCCTACTG TATTTGTGGC AGTGGCAGGC AGAAGTAATG GTTTGGGACC AGTGATGTCT 
GGGAACACTG CATATCCAGT TATCAGCTGT CCTCCCCTCA CACCAGACTG GGGAGTTCAG 
GATGTGTGGT CTTCTCTTCG ACTACCCAGT GGTCTTGGCT GTTCAACCGT ACTTTCTCCA 
GAAGGATCAG CTCAATTTGC TGCTCAGATA TTTGGGTTAA GCAACCATTT GGTATGGAGC 
AAACTGCGAG CAAGCATTTT GAACACATGG ATTTCCTTGA AGCAGGCTGA CAAGAAAATC 
AGAGAATGTA ATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAICS ( NM_001079525.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001072993.1 Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 1, mRNA.

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CloneID	OHu05356
Clone ID Related Accession (Same CDS sequence)	NM_001079525.2 , NM_001079525.1
Accession Version	NM_001079525.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	multifunctional protein ADE2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB503040.1, CF994644.1, CR749824.1, AC068620.5, BM807012.1, AC114766.5 and AA669362.1. Transcript Variant: This variant (1) represents one of the longest transcripts and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR749824.1, SRR1803617.217542.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGTTACCT CATATAAGTC AAATCGTATT 
AAAACTGCCT TCACCAGAAA ATGTGGGGAG ACAGCTTTCA TTGCACCGCA GTGTGAAATG 
ATTCCAATTG AATGGGTTTG CAGAAGAATA GCAACTGGTT CTTTTCTCAA AAGAAATCCT 
GGTGTCAAGG AAGGATATAA GTTTTACCCA CCTAAAGTGG AGTTGTTTTT CAAGGATGAT 
GCCAATAATG ACCCACAGTG GTCTGAGGAA CAGCTGATTG CTGCAAAATT TTGCTTTGCT 
GGACTTCTTA TAGGCCAGAC TGAAGTGGAT ATCATGAGTC ATGCTACACA GGCTATATTT 
GAAATACTGG AGAAATCCTG GTTGCCCCAG AATTGTACAC TGGTTGATAT GAAGATTGAA 
TTTGGTGTTG ATGTAACCAC CAAAGAAATT GTTCTTGCTG ATGTTATTGA CAATGATTCC 
TGGAGACTCT GGCCATCAGG AGATCGAAGC CAACAGAAAG ACAAACAGTC TTATCGGGAC 
CTCAAAGAAG TAACTCCTGA AGGGCTCCAA ATGGTAAAGA AAAACTTTGA GTGGGTTGCA 
GAGAGAGTAG AGTTGCTTTT GAAATCAGAA AGTCAGTGCA GGGTTGTAGT GTTGATGGGC 
TCTACTTCTG ATCTTGGTCA CTGTGAAAAA ATCAAGAAGG CCTGTGGAAA TTTTGGCATT 
CCATGTGAAC TTCGAGTAAC ATCTGCGCAT AAAGGACCAG ATGAAACTCT GAGGATTAAA 
GCTGAGTATG AAGGGGATGG CATTCCTACT GTATTTGTGG CAGTGGCAGG CAGAAGTAAT 
GGTTTGGGAC CAGTGATGTC TGGGAACACT GCATATCCAG TTATCAGCTG TCCTCCCCTC 
ACACCAGACT GGGGAGTTCA GGATGTGTGG TCTTCTCTTC GACTACCCAG TGGTCTTGGC 
TGTTCAACCG TACTTTCTCC AGAAGGATCA GCTCAATTTG CTGCTCAGAT ATTTGGGTTA 
AGCAACCATT TGGTATGGAG CAAACTGCGA GCAAGCATTT TGAACACATG GATTTCCTTG 
AAGCAGGCTG ACAAGAAAAT CAGAGAATGT AATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001072993.1
CDS	211..1509
Translation	MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAVTSYKSNRIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL

Target ORF information:

RefSeq Version	NM_001079525.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079525.1

ORF Insert Sequence:

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGTTACCT CATATAAGTC AAATCGTATT 
AAAACTGCCT TCACCAGAAA ATGTGGGGAG ACAGCTTTCA TTGCACCGCA GTGTGAAATG 
ATTCCAATTG AATGGGTTTG CAGAAGAATA GCAACTGGTT CTTTTCTCAA AAGAAATCCT 
GGTGTCAAGG AAGGATATAA GTTTTACCCA CCTAAAGTGG AGTTGTTTTT CAAGGATGAT 
GCCAATAATG ACCCACAGTG GTCTGAGGAA CAGCTGATTG CTGCAAAATT TTGCTTTGCT 
GGACTTCTTA TAGGCCAGAC TGAAGTGGAT ATCATGAGTC ATGCTACACA GGCTATATTT 
GAAATACTGG AGAAATCCTG GTTGCCCCAG AATTGTACAC TGGTTGATAT GAAGATTGAA 
TTTGGTGTTG ATGTAACCAC CAAAGAAATT GTTCTTGCTG ATGTTATTGA CAATGATTCC 
TGGAGACTCT GGCCATCAGG AGATCGAAGC CAACAGAAAG ACAAACAGTC TTATCGGGAC 
CTCAAAGAAG TAACTCCTGA AGGGCTCCAA ATGGTAAAGA AAAACTTTGA GTGGGTTGCA 
GAGAGAGTAG AGTTGCTTTT GAAATCAGAA AGTCAGTGCA GGGTTGTAGT GTTGATGGGC 
TCTACTTCTG ATCTTGGTCA CTGTGAAAAA ATCAAGAAGG CCTGTGGAAA TTTTGGCATT 
CCATGTGAAC TTCGAGTAAC ATCTGCGCAT AAAGGACCAG ATGAAACTCT GAGGATTAAA 
GCTGAGTATG AAGGGGATGG CATTCCTACT GTATTTGTGG CAGTGGCAGG CAGAAGTAAT 
GGTTTGGGAC CAGTGATGTC TGGGAACACT GCATATCCAG TTATCAGCTG TCCTCCCCTC 
ACACCAGACT GGGGAGTTCA GGATGTGTGG TCTTCTCTTC GACTACCCAG TGGTCTTGGC 
TGTTCAACCG TACTTTCTCC AGAAGGATCA GCTCAATTTG CTGCTCAGAT ATTTGGGTTA 
AGCAACCATT TGGTATGGAG CAAACTGCGA GCAAGCATTT TGAACACATG GATTTCCTTG 
AAGCAGGCTG ACAAGAAAAT CAGAGAATGT AATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAICS ( XM_011534366.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011532668.1 Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu64181
Clone ID Related Accession (Same CDS sequence)	XM_011534366.1
Accession Version	XM_011534366.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	multifunctional protein ADE2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGGTATTA AAACTGCCTT CACCAGAAAA 
TGTGGGGAGA CAGCTTTCAT TGCACCGCAG TGTGAAATGA TTCCAATTGA ATGGGTTTGC 
AGAAGAATAG CAACTGGTTC TTTTCTCAAA AGAAATCCTG GTGTCAAGGA AGGATATAAG 
TTTTACCCAC CTAAAGTGGA GTTGTTTTTC AAGGATGATG CCAATAATGA CCCACAGTGG 
TCTGAGGAAC AGCTGATTGC TGCAAAATTT TGCTTTGCTG GACTTCTTAT AGGCCAGACT 
GAAGTGGATA TCATGAGTCA TGCTACACAG GCTATATTTG AAATACTGGA GAAATCCTGG 
TTGCCCCAGA ATTGTACACT GGTTGATATG AAGATTGAAT TTGGTGTTGA TGTAACCACC 
AAAGAAATTG TTCTTGCTGA TGTTATTGAC AATGATTCCT GGAGACTCTG GCCATCAGGA 
GATCGAAGCC AACAGAAAGA CAAACAGTCT TATCGGGACC TCAAAGAAGT AACTCCTGAA 
GGGCTCCAAA TGGTAAAGAA AAACTTTGAG TGGGTTGCAG AGAGAGTAGA GTTGCTTTTG 
AAATCAGAAA GTCAGTGCAG GGTTGTAGTG TTGATGGGCT CTACTTCTGA TCTTGGTCAC 
TGTGAAAAAA TCAAGAAGGC CTGTGGAAAT TTTGGCATTC CATGTGAACT TCGAGTAACA 
TCTGCGCATA AAGGACCAGA TGAAACTCTG AGGATTAAAG CTGAGTATGA AGGTCTTGGC 
TGTTCAACCG TACTTTCTCC AGAAGGATCA GCTCAATTTG CTGCTCAGAT ATTTGGGTTA 
AGCAACCATT TGGTATGGAG CAAACTGCGA GCAAGCATTT TGAACACATG GATTTCCTTG 
AAGCAGGCTG ACAAGAAAAT CAGAGAATGT AATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011532668.1
CDS	52..1170
Translation	MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL

Target ORF information:

RefSeq Version	XM_011534366.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011534366.1

ORF Insert Sequence:

ATGGCGACAG CTGAGGTACT GAACATTGGT AAAAAATTAT ATGAGGGTAA AACAAAAGAA 
GTCTACGAAT TGTTAGACAG TCCAGGAAAA GTCCTCCTGC AGTCCAAGGA CCAGATTACA 
GCAGGAAATG CAGCTAGAAA AAACCACCTG GAAGGAAAAG CTGCAATCTC AAATAAAATC 
ACCAGTTGTA TTTTTCAGTT ATTACAGGAA GCAGGTATTA AAACTGCCTT CACCAGAAAA 
TGTGGGGAGA CAGCTTTCAT TGCACCGCAG TGTGAAATGA TTCCAATTGA ATGGGTTTGC 
AGAAGAATAG CAACTGGTTC TTTTCTCAAA AGAAATCCTG GTGTCAAGGA AGGATATAAG 
TTTTACCCAC CTAAAGTGGA GTTGTTTTTC AAGGATGATG CCAATAATGA CCCACAGTGG 
TCTGAGGAAC AGCTGATTGC TGCAAAATTT TGCTTTGCTG GACTTCTTAT AGGCCAGACT 
GAAGTGGATA TCATGAGTCA TGCTACACAG GCTATATTTG AAATACTGGA GAAATCCTGG 
TTGCCCCAGA ATTGTACACT GGTTGATATG AAGATTGAAT TTGGTGTTGA TGTAACCACC 
AAAGAAATTG TTCTTGCTGA TGTTATTGAC AATGATTCCT GGAGACTCTG GCCATCAGGA 
GATCGAAGCC AACAGAAAGA CAAACAGTCT TATCGGGACC TCAAAGAAGT AACTCCTGAA 
GGGCTCCAAA TGGTAAAGAA AAACTTTGAG TGGGTTGCAG AGAGAGTAGA GTTGCTTTTG 
AAATCAGAAA GTCAGTGCAG GGTTGTAGTG TTGATGGGCT CTACTTCTGA TCTTGGTCAC 
TGTGAAAAAA TCAAGAAGGC CTGTGGAAAT TTTGGCATTC CATGTGAACT TCGAGTAACA 
TCTGCGCATA AAGGACCAGA TGAAACTCTG AGGATTAAAG CTGAGTATGA AGGTCTTGGC 
TGTTCAACCG TACTTTCTCC AGAAGGATCA GCTCAATTTG CTGCTCAGAT ATTTGGGTTA 
AGCAACCATT TGGTATGGAG CAAACTGCGA GCAAGCATTT TGAACACATG GATTTCCTTG 
AAGCAGGCTG ACAAGAAAAT CAGAGAATGT AATTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.
Oncotarget6(27)23445-61(2015 Sep)
Goswami MT,Chen G,Chakravarthi BV,Pathi SS,Anand SK,Carskadon SL,Giordano TJ,Chinnaiyan AM,Thomas DG,Palanisamy N,Beer DG,Varambally S

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PAICS cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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