MTHFS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MTHFS
Entrez Gene ID	10588
Full Name	methenyltetrahydrofolate synthetase
Synonyms	HsT19268
General protein information	Preferred Names methenyltetrahydrofolate synthetase Names 5-formyltetrahydrofolate cyclo-ligase 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) methenyl-THF synthetase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q25.1
Summary	The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
Disorder MIM:	604197

mRNA and Protein(s)

mRNA	Protein	Name
NM_001199758.1	NP_001186687.1	5-formyltetrahydrofolate cyclo-ligase isoform b
NM_006441.3	NP_006432.1	5-formyltetrahydrofolate cyclo-ligase isoform a
NM_006441.4	NP_006432.1	5-formyltetrahydrofolate cyclo-ligase isoform a

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MTHFS	XP_005618484.1
Rattus norvegicus (Norway rat)	Mthfs	NP_001009349.1
Drosophila melanogaster (fruit fly)	CG34424	NP_001097432.1
Caenorhabditis elegans (roundworm)	CELE_Y106G6E.4	NP_492692.1
Kluyveromyces lactis	KLLA0A10285g	XP_451450.1
Arabidopsis thaliana (thale cress)	5-FCL	NP_568284.1
	MTHFS	XP_002804953.1
Magnaporthe oryzae (rice blast fungus)	MGG_14781	XP_003714404.1
Oryza sativa (rice)	Os07g0578600	NP_001060095.1
Bos taurus (cattle)	MTHFS	NP_001069084.1
Mus musculus (house mouse)	Mthfs	NP_081105.1
Gallus gallus (chicken)	MTHFS	NP_001264555.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006824	XP_308920.4
Neurospora crassa	NCU06353	XP_962387.1
Danio rerio (zebrafish)	LOC100332843	XP_002662791.1
Saccharomyces cerevisiae (baker's yeast)	FAU1	NP_011110.1
Homo sapiens (human)	MTHFS	NP_006432.1
Pan troglodytes (chimpanzee)	MTHFS	XP_001154891.1
Mus musculus (house mouse)	Gm2382	NP_001122073.1
Eremothecium gossypii	AGOS_ADL385C	NP_983711.1
Xenopus tropicalis (tropical clawed frog)	mthfs	NP_001120248.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study of chronic periodontitis in a general German population.
Teumer A, Holtfreter B, V?lker U, Petersmann A, Nauck M, Biffar R, V?lzke H, Kroemer HK, Meisel P, Homuth G, Kocher T
Journal of clinical periodontology40(11)977-85(2013 Nov)

The impact of 5,10-methenyltetrahydrofolate synthetase polymorphism on diabetic nephropathy in the Taiwanese population.
Lin CJ, Wen MJ, Hung YJ, Pei D, Kuo SW, Hsieh CH
Genetic testing and molecular biomarkers16(2)142-5(2012 Feb)

Expression of conjoined genes: another mechanism for gene regulation in eukaryotes.
Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y, Fujikake T, Takeda T, Taylor TD
PloS one5(10)e13284(2010 Oct)

Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Hazra A, Fuchs CS, Kawasaki T, Kirkner GJ, Hunter DJ, Ogino S
Cancer causes & control : CCC21(3)331-45(2010 Mar)

Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues.
Wu D, Li Y, Song G, Cheng C, Zhang R, Joachimiak A, Shaw N, Liu ZJ
Cancer research69(18)7294-301(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The intronic Single nucleotide polymorphism in MTHFS had no significant effect on the risk of diabetic nephropathy in Taiwanese patients with T2D.
Title: The impact of 5,10-methenyltetrahydrofolate synthetase polymorphism on diabetic nephropathy in the Taiwanese population.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.

Observational study of gene-disease association. (HuGE Navigator)
Title: Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.

The following MTHFS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MTHFS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12103	NM_006441.4 Latest version!	Homo sapiens methenyltetrahydrofolate synthetase (MTHFS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21010	NM_001199758.1 Latest version!	Homo sapiens methenyltetrahydrofolate synthetase (MTHFS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu12103	NM_006441.3	Homo sapiens methenyltetrahydrofolate synthetase (MTHFS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MTHFS ( NM_006441.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006432.1 Homo sapiens methenyltetrahydrofolate synthetase (MTHFS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12103
Clone ID Related Accession (Same CDS sequence)	NM_006441.3 , NM_006441.4
Accession Version	NM_006441.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	5-formyltetrahydrofolate cyclo-ligase isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC019921.1, L38928.1, AC021483.11 and AL109717.1. On Dec 16, 2010 this sequence version replaced NM_006441.2. Transcript Variant: This variant (1) encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC019921.1, ERR279825.764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CAGCGGTGAG CAGCGCCAAG CGGAGCCTGC GGGGAGAGCT GAAGCAGCGT 
CTGCGGGCGA TGAGTGCCGA GGAGCGGCTA CGCCAGTCCC GCGTACTGAG CCAGAAGGTG 
ATTGCCCACA GTGAGTATCA AAAGTCCAAA AGAATTTCCA TCTTTCTGAG CATGCAAGAT 
GAAATTGAGA CAGAAGAGAT CATCAAGGAC ATTTTCCAAC GAGGCAAAAT CTGCTTCATC 
CCTCGGTACC GGTTCCAGAG CAATCACATG GATATGGTGA GAATAGAATC ACCAGAGGAA 
ATTTCTTTAC TTCCCAAAAC ATCCTGGAAT ATCCCTCAGC CTGGTGAGGG TGATGTTCGG 
GAGGAGGCCT TGTCCACAGG GGGACTTGAT CTCATCTTCA TGCCAGGCCT TGGGTTTGAC 
AAACATGGCA ACCGACTGGG GAGGGGCAAG GGCTACTATG ATGCCTATCT GAAGCGCTGT 
TTGCAGCATC AGGAAGTGAA GCCCTACACC CTGGCGTTGG CTTTCAAAGA ACAGATTTGC 
CTCCAGGTCC CAGTGAATGA AAACGACATG AAGGTAGATG AAGTCCTTTA CGAAGACTCG 
TCAACAGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006432.1
CDS	62..673
Translation	MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA

Target ORF information:

RefSeq Version	NM_006441.3
Organism	Homo sapiens(human)
Definition	Homo sapiens methenyltetrahydrofolate synthetase (MTHFS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006441.3

ORF Insert Sequence:

ATGGCGGCGG CAGCGGTGAG CAGCGCCAAG CGGAGCCTGC GGGGAGAGCT GAAGCAGCGT 
CTGCGGGCGA TGAGTGCCGA GGAGCGGCTA CGCCAGTCCC GCGTACTGAG CCAGAAGGTG 
ATTGCCCACA GTGAGTATCA AAAGTCCAAA AGAATTTCCA TCTTTCTGAG CATGCAAGAT 
GAAATTGAGA CAGAAGAGAT CATCAAGGAC ATTTTCCAAC GAGGCAAAAT CTGCTTCATC 
CCTCGGTACC GGTTCCAGAG CAATCACATG GATATGGTGA GAATAGAATC ACCAGAGGAA 
ATTTCTTTAC TTCCCAAAAC ATCCTGGAAT ATCCCTCAGC CTGGTGAGGG TGATGTTCGG 
GAGGAGGCCT TGTCCACAGG GGGACTTGAT CTCATCTTCA TGCCAGGCCT TGGGTTTGAC 
AAACATGGCA ACCGACTGGG GAGGGGCAAG GGCTACTATG ATGCCTATCT GAAGCGCTGT 
TTGCAGCATC AGGAAGTGAA GCCCTACACC CTGGCGTTGG CTTTCAAAGA ACAGATTTGC 
CTCCAGGTCC CAGTGAATGA AAACGACATG AAGGTAGATG AAGTCCTTTA CGAAGACTCG 
TCAACAGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTHFS ( NM_006441.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006432.1 Homo sapiens methenyltetrahydrofolate synthetase (MTHFS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12103
Clone ID Related Accession (Same CDS sequence)	NM_006441.3 , NM_006441.4
Accession Version	NM_006441.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-29
Organism	Homo sapiens(human)
Product	5-formyltetrahydrofolate cyclo-ligase isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC019921.1, L38928.1, AC021483.11 and AL109717.1. On Nov 30, 2019 this sequence version replaced NM_006441.3. Transcript Variant: This variant (1) encodes the longer isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB996141.1, L38928.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CAGCGGTGAG CAGCGCCAAG CGGAGCCTGC GGGGAGAGCT GAAGCAGCGT 
CTGCGGGCGA TGAGTGCCGA GGAGCGGCTA CGCCAGTCCC GCGTACTGAG CCAGAAGGTG 
ATTGCCCACA GTGAGTATCA AAAGTCCAAA AGAATTTCCA TCTTTCTGAG CATGCAAGAT 
GAAATTGAGA CAGAAGAGAT CATCAAGGAC ATTTTCCAAC GAGGCAAAAT CTGCTTCATC 
CCTCGGTACC GGTTCCAGAG CAATCACATG GATATGGTGA GAATAGAATC ACCAGAGGAA 
ATTTCTTTAC TTCCCAAAAC ATCCTGGAAT ATCCCTCAGC CTGGTGAGGG TGATGTTCGG 
GAGGAGGCCT TGTCCACAGG GGGACTTGAT CTCATCTTCA TGCCAGGCCT TGGGTTTGAC 
AAACATGGCA ACCGACTGGG GAGGGGCAAG GGCTACTATG ATGCCTATCT GAAGCGCTGT 
TTGCAGCATC AGGAAGTGAA GCCCTACACC CTGGCGTTGG CTTTCAAAGA ACAGATTTGC 
CTCCAGGTCC CAGTGAATGA AAACGACATG AAGGTAGATG AAGTCCTTTA CGAAGACTCG 
TCAACAGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006432.1
CDS	27..638
Translation	MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA

Target ORF information:

RefSeq Version	NM_006441.4
Organism	Homo sapiens(human)
Definition	Homo sapiens methenyltetrahydrofolate synthetase (MTHFS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006441.4

ORF Insert Sequence:

ATGGCGGCGG CAGCGGTGAG CAGCGCCAAG CGGAGCCTGC GGGGAGAGCT GAAGCAGCGT 
CTGCGGGCGA TGAGTGCCGA GGAGCGGCTA CGCCAGTCCC GCGTACTGAG CCAGAAGGTG 
ATTGCCCACA GTGAGTATCA AAAGTCCAAA AGAATTTCCA TCTTTCTGAG CATGCAAGAT 
GAAATTGAGA CAGAAGAGAT CATCAAGGAC ATTTTCCAAC GAGGCAAAAT CTGCTTCATC 
CCTCGGTACC GGTTCCAGAG CAATCACATG GATATGGTGA GAATAGAATC ACCAGAGGAA 
ATTTCTTTAC TTCCCAAAAC ATCCTGGAAT ATCCCTCAGC CTGGTGAGGG TGATGTTCGG 
GAGGAGGCCT TGTCCACAGG GGGACTTGAT CTCATCTTCA TGCCAGGCCT TGGGTTTGAC 
AAACATGGCA ACCGACTGGG GAGGGGCAAG GGCTACTATG ATGCCTATCT GAAGCGCTGT 
TTGCAGCATC AGGAAGTGAA GCCCTACACC CTGGCGTTGG CTTTCAAAGA ACAGATTTGC 
CTCCAGGTCC CAGTGAATGA AAACGACATG AAGGTAGATG AAGTCCTTTA CGAAGACTCG 
TCAACAGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTHFS ( NM_001199758.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186687.1 Homo sapiens methenyltetrahydrofolate synthetase (MTHFS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21010
Clone ID Related Accession (Same CDS sequence)	NM_001199758.1
Accession Version	NM_001199758.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	5-formyltetrahydrofolate cyclo-ligase isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM313547.1, CB995322.1, L38928.1, AC021483.11 and AL109717.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.537779.1, SRR1163658.247626.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAAGATG AAATTGAGAC AGAAGAGATC ATCAAGGACA TTTTCCAACG AGGCAAAATC 
TGCTTCATCC CTCGGTACCG GTTCCAGAGC AATCACATGG ATATGGTGAG AATAGAATCA 
CCAGAGGAAA TTTCTTTACT TCCCAAAACA TCCTGGAATA TCCCTCAGCC TGGTGAGGGT 
GATGTTCGGG AGGAGGCCTT GTCCACAGGG GGACTTGATC TCATCTTCAT GCCAGGCCTT 
GGGTTTGACA AACATGGCAA CCGACTGGGG AGGGGCAAGG GCTACTATGA TGCCTATCTG 
AAGCGCTGTT TGCAGCATCA GGAAGTGAAG CCCTACACCC TGGCGTTGGC TTTCAAAGAA 
CAGATTTGCC TCCAGGTCCC AGTGAATGAA AACGACATGA AGGTAGATGA AGTCCTTTAC 
GAAGACTCGT CAACAGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186687.1
CDS	180..620
Translation	MQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA

Target ORF information:

RefSeq Version	NM_001199758.1
Organism	Homo sapiens(human)
Definition	Homo sapiens methenyltetrahydrofolate synthetase (MTHFS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199758.1

ORF Insert Sequence:

ATGCAAGATG AAATTGAGAC AGAAGAGATC ATCAAGGACA TTTTCCAACG AGGCAAAATC 
TGCTTCATCC CTCGGTACCG GTTCCAGAGC AATCACATGG ATATGGTGAG AATAGAATCA 
CCAGAGGAAA TTTCTTTACT TCCCAAAACA TCCTGGAATA TCCCTCAGCC TGGTGAGGGT 
GATGTTCGGG AGGAGGCCTT GTCCACAGGG GGACTTGATC TCATCTTCAT GCCAGGCCTT 
GGGTTTGACA AACATGGCAA CCGACTGGGG AGGGGCAAGG GCTACTATGA TGCCTATCTG 
AAGCGCTGTT TGCAGCATCA GGAAGTGAAG CCCTACACCC TGGCGTTGGC TTTCAAAGAA 
CAGATTTGCC TCCAGGTCCC AGTGAATGAA AACGACATGA AGGTAGATGA AGTCCTTTAC 
GAAGACTCGT CAACAGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study of chronic periodontitis in a general German population.
Journal of clinical periodontology40(11)977-85(2013 Nov)
Teumer A,Holtfreter B,V?lker U,Petersmann A,Nauck M,Biffar R,V?lzke H,Kroemer HK,Meisel P,Homuth G,Kocher T

The impact of 5,10-methenyltetrahydrofolate synthetase polymorphism on diabetic nephropathy in the Taiwanese population.
Genetic testing and molecular biomarkers16(2)142-5(2012 Feb)
Lin CJ,Wen MJ,Hung YJ,Pei D,Kuo SW,Hsieh CH

Expression of conjoined genes: another mechanism for gene regulation in eukaryotes.
PloS one5(10)e13284(2010 Oct)
Prakash T,Sharma VK,Adati N,Ozawa R,Kumar N,Nishida Y,Fujikake T,Takeda T,Taylor TD

Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Cancer causes & control : CCC21(3)331-45(2010 Mar)
Hazra A,Fuchs CS,Kawasaki T,Kirkner GJ,Hunter DJ,Ogino S

Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues.
Cancer research69(18)7294-301(2009 Sep)
Wu D,Li Y,Song G,Cheng C,Zhang R,Joachimiak A,Shaw N,Liu ZJ

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MTHFS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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